Structural basis for specific flagellin recognition by the NLR protein NAIP5 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01

AUTHORS

Xinru Yang, Fan Yang, Weiguang Wang, Guangzhong Lin, Zehan Hu, Zhifu Han, Yijun Qi, Liman Zhang, Jiawei Wang, Sen-Fang Sui, Jijie Chai

ABSTRACT

The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive. Here we report the structure of a bacterial flagellin derivative in complex with the NLR proteins NAIP5 and NLRC4 determined by cryo-electron microscopy at 4.28 Å resolution. The structure revealed that the flagellin derivative forms two parallel helices interacting with multiple domains including BIR1 and LRR of NAIP5. Binding to NAIP5 results in a nearly complete burial of the flagellin derivative, thus stabilizing the active conformation of NAIP5. The extreme C-terminal side of the flagellin is anchored to a sterically constrained binding pocket of NAIP5, which likely acts as a structural determinant for discrimination of different bacterial flagellins by NAIP5, a notion further supported by biochemical data. Taken together, our results shed light on the molecular mechanisms underlying NLR ligand perception. More... »

PAGES

35

References to SciGraph publications

  • 2012-09. Prevention of overfitting in cryo-EM structure determination in NATURE METHODS
  • 2011-09. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus in NATURE
  • 2006-06. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf in NATURE IMMUNOLOGY
  • 2015-10. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling in NATURE
  • 2006-06. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages in NATURE IMMUNOLOGY
  • 2017-03. Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses in NATURE METHODS
  • 2008-10. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin in NATURE IMMUNOLOGY
  • 2014-01. Quantifying the local resolution of cryo-EM density maps in NATURE METHODS
  • 2017-04. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy in NATURE METHODS
  • 2010-04. Conformational change of flagellin for polymorphic supercoiling of the flagellar filament in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-09. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity in NATURE
  • 2015-10. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death in NATURE
  • 2012-04. Sensing and reacting to microbes through the inflammasomes in NATURE IMMUNOLOGY
  • 2000-12. Structural basis of IAP recognition by Smac/DIABLO in NATURE
  • 2013-06. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM in NATURE METHODS
  • 2011-09. Impact factors: China's academic autocracy must go in NATURE
  • 2012-04. Regulation of inflammasome signaling in NATURE IMMUNOLOGY
  • 2015-12. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion in CELL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2017.148

    DOI

    http://dx.doi.org/10.1038/cr.2017.148

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1093048219

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29182158


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Xinru", 
            "id": "sg:person.013670367737.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013670367737.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "State Key Laboratory of Membrane Biology, Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Fan", 
            "id": "sg:person.01233242033.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233242033.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Weiguang", 
            "id": "sg:person.0622152605.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622152605.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Guangzhong", 
            "id": "sg:person.0726535347.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726535347.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Zehan", 
            "id": "sg:person.01006460674.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006460674.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "Zhifu", 
            "id": "sg:person.01221751111.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221751111.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qi", 
            "givenName": "Yijun", 
            "id": "sg:person.0704252060.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704252060.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Liman", 
            "id": "sg:person.01334732205.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334732205.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Jiawei", 
            "id": "sg:person.011162064574.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011162064574.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "State Key Laboratory of Membrane Biology, Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sui", 
            "givenName": "Sen-Fang", 
            "id": "sg:person.012775653777.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012775653777.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cologne", 
              "id": "https://www.grid.ac/institutes/grid.6190.e", 
              "name": [
                "Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China", 
                "Max-Planck Institute for Plant Breeding Research, 50829 Cologne, Germany", 
                "Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chai", 
            "givenName": "Jijie", 
            "id": "sg:person.01342040611.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342040611.97"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1107/s0907444910007493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000235100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444910007493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000235100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000526904", 
              "https://doi.org/10.1038/nsmb.1774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000526904", 
              "https://doi.org/10.1038/nsmb.1774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0913087107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000627560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.272278.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001874310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2015.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003063255", 
              "https://doi.org/10.1038/cr.2015.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003684283", 
              "https://doi.org/10.1038/ni.2231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005509983", 
              "https://doi.org/10.1038/ni.2237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20151809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006774338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007171888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.02.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007981535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac5789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008174987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009301311", 
              "https://doi.org/10.1038/nmeth.2727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009302090", 
              "https://doi.org/10.1038/nature10394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00599-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012632196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013464857", 
              "https://doi.org/10.1038/nature10510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35050012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013741960", 
              "https://doi.org/10.1038/35050012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35050012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013741960", 
              "https://doi.org/10.1038/35050012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015203449", 
              "https://doi.org/10.1038/nature15541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2008.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016954035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032712-095944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017513661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2012.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019988217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2015.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020552806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/477407b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021626853", 
              "https://doi.org/10.1038/477407b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023121489", 
              "https://doi.org/10.1038/nature15514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026804427", 
              "https://doi.org/10.1038/ni.1646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1236381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027290062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.01.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031371585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0502040102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032046377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889808006985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032551326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20071239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032891500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033803512", 
              "https://doi.org/10.1038/ni1346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033803512", 
              "https://doi.org/10.1038/ni1346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/imr.12293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034939043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.393512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035850449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2015.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036290868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1306376110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039654348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039911850", 
              "https://doi.org/10.1038/ni1344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039911850", 
              "https://doi.org/10.1038/ni1344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2006.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040267501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac5489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040328673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-031210-101405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040658091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041024070", 
              "https://doi.org/10.1038/nmeth.2115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaf6395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043772239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00069-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046234181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00069-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046234181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.0020018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049201704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050203089", 
              "https://doi.org/10.1038/nmeth.2472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.17755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050754283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(99)01609-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052518370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2011.11.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052958331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20160006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053634329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.15.00303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060842198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1301549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078787641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129281", 
              "https://doi.org/10.1038/nmeth.4187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129281", 
              "https://doi.org/10.1038/nmeth.4187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129286", 
              "https://doi.org/10.1038/nmeth.4193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2017.03.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084743908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1006574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091282335"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-01", 
        "datePublishedReg": "2018-01-01", 
        "description": "The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive. Here we report the structure of a bacterial flagellin derivative in complex with the NLR proteins NAIP5 and NLRC4 determined by cryo-electron microscopy at 4.28 \u00c5 resolution. The structure revealed that the flagellin derivative forms two parallel helices interacting with multiple domains including BIR1 and LRR of NAIP5. Binding to NAIP5 results in a nearly complete burial of the flagellin derivative, thus stabilizing the active conformation of NAIP5. The extreme C-terminal side of the flagellin is anchored to a sterically constrained binding pocket of NAIP5, which likely acts as a structural determinant for discrimination of different bacterial flagellins by NAIP5, a notion further supported by biochemical data. Taken together, our results shed light on the molecular mechanisms underlying NLR ligand perception.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cr.2017.148", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1107753", 
            "issn": [
              "1001-0602", 
              "1748-7838"
            ], 
            "name": "Cell Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "28"
          }
        ], 
        "name": "Structural basis for specific flagellin recognition by the NLR protein NAIP5", 
        "pagination": "35", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "79c9116fe34d0651f78403c2ad0d8e6ec5ce0e1c67e0da0edb04b013db4f7146"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29182158"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9425763"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cr.2017.148"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1093048219"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cr.2017.148", 
          "https://app.dimensions.ai/details/publication/pub.1093048219"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T18:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000436.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/cr2017148"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.148'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.148'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.148'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.148'


     

    This table displays all metadata directly associated to this object as RDF triples.

    329 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cr.2017.148 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N485bf873d3b7470785b8c61832a95899
    4 schema:citation sg:pub.10.1038/35050012
    5 sg:pub.10.1038/477407b
    6 sg:pub.10.1038/cr.2015.139
    7 sg:pub.10.1038/nature10394
    8 sg:pub.10.1038/nature10510
    9 sg:pub.10.1038/nature15514
    10 sg:pub.10.1038/nature15541
    11 sg:pub.10.1038/ni.1646
    12 sg:pub.10.1038/ni.2231
    13 sg:pub.10.1038/ni.2237
    14 sg:pub.10.1038/ni1344
    15 sg:pub.10.1038/ni1346
    16 sg:pub.10.1038/nmeth.2115
    17 sg:pub.10.1038/nmeth.2472
    18 sg:pub.10.1038/nmeth.2727
    19 sg:pub.10.1038/nmeth.4187
    20 sg:pub.10.1038/nmeth.4193
    21 sg:pub.10.1038/nsmb.1774
    22 https://doi.org/10.1016/j.cell.2010.01.040
    23 https://doi.org/10.1016/j.coi.2015.01.010
    24 https://doi.org/10.1016/j.immuni.2017.03.016
    25 https://doi.org/10.1016/j.jmb.2011.11.010
    26 https://doi.org/10.1016/j.jsb.2006.05.009
    27 https://doi.org/10.1016/j.jsb.2012.09.006
    28 https://doi.org/10.1016/j.molcel.2014.02.018
    29 https://doi.org/10.1016/j.str.2008.03.005
    30 https://doi.org/10.1016/j.str.2015.10.001
    31 https://doi.org/10.1016/s0962-8924(99)01609-8
    32 https://doi.org/10.1016/s1047-8477(03)00069-8
    33 https://doi.org/10.1016/s1097-2765(02)00599-3
    34 https://doi.org/10.1073/pnas.0502040102
    35 https://doi.org/10.1073/pnas.0913087107
    36 https://doi.org/10.1073/pnas.1306376110
    37 https://doi.org/10.1074/jbc.m112.393512
    38 https://doi.org/10.1084/jem.20051659
    39 https://doi.org/10.1084/jem.20071239
    40 https://doi.org/10.1084/jem.20151809
    41 https://doi.org/10.1084/jem.20160006
    42 https://doi.org/10.1101/gad.272278.115
    43 https://doi.org/10.1105/tpc.15.00303
    44 https://doi.org/10.1107/s0021889808006985
    45 https://doi.org/10.1107/s0907444909052925
    46 https://doi.org/10.1107/s0907444910007493
    47 https://doi.org/10.1111/imr.12293
    48 https://doi.org/10.1126/science.1236381
    49 https://doi.org/10.1126/science.aac5489
    50 https://doi.org/10.1126/science.aac5789
    51 https://doi.org/10.1126/science.aaf6395
    52 https://doi.org/10.1146/annurev-immunol-031210-101405
    53 https://doi.org/10.1146/annurev-immunol-032712-095944
    54 https://doi.org/10.1371/journal.ppat.0020018
    55 https://doi.org/10.1371/journal.ppat.1006574
    56 https://doi.org/10.4049/jimmunol.1301549
    57 https://doi.org/10.7554/elife.17755
    58 schema:datePublished 2018-01
    59 schema:datePublishedReg 2018-01-01
    60 schema:description The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive. Here we report the structure of a bacterial flagellin derivative in complex with the NLR proteins NAIP5 and NLRC4 determined by cryo-electron microscopy at 4.28 Å resolution. The structure revealed that the flagellin derivative forms two parallel helices interacting with multiple domains including BIR1 and LRR of NAIP5. Binding to NAIP5 results in a nearly complete burial of the flagellin derivative, thus stabilizing the active conformation of NAIP5. The extreme C-terminal side of the flagellin is anchored to a sterically constrained binding pocket of NAIP5, which likely acts as a structural determinant for discrimination of different bacterial flagellins by NAIP5, a notion further supported by biochemical data. Taken together, our results shed light on the molecular mechanisms underlying NLR ligand perception.
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree true
    64 schema:isPartOf N04b36baff0f84840bdbb9bdc4307901d
    65 N7b7ace24d8e641caa95e310b4b273b65
    66 sg:journal.1107753
    67 schema:name Structural basis for specific flagellin recognition by the NLR protein NAIP5
    68 schema:pagination 35
    69 schema:productId N0412a96121b04c6a92a806c478769471
    70 N29f9952a98d140f3a2f133e6cca71bd5
    71 Nadbb4a2f24a643168fa408c34cc5b3f0
    72 Ne746541704bd4caab128a45d0e1a097a
    73 Nefd8ed80bd44430981c7380f2e626ec6
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093048219
    75 https://doi.org/10.1038/cr.2017.148
    76 schema:sdDatePublished 2019-04-10T18:58
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher N69f24c20f0254eab9df55127e1095953
    79 schema:url https://www.nature.com/articles/cr2017148
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N03f43d8cf87b490ab54f9193640d1724 rdf:first sg:person.012775653777.02
    84 rdf:rest N3cc818d244504ae3a83d70b8240429da
    85 N0412a96121b04c6a92a806c478769471 schema:name readcube_id
    86 schema:value 79c9116fe34d0651f78403c2ad0d8e6ec5ce0e1c67e0da0edb04b013db4f7146
    87 rdf:type schema:PropertyValue
    88 N04b36baff0f84840bdbb9bdc4307901d schema:volumeNumber 28
    89 rdf:type schema:PublicationVolume
    90 N29f9952a98d140f3a2f133e6cca71bd5 schema:name nlm_unique_id
    91 schema:value 9425763
    92 rdf:type schema:PropertyValue
    93 N3cc818d244504ae3a83d70b8240429da rdf:first sg:person.01342040611.97
    94 rdf:rest rdf:nil
    95 N485bf873d3b7470785b8c61832a95899 rdf:first sg:person.013670367737.50
    96 rdf:rest Nf734d9bcc08447cab3ca7df8ec9127ad
    97 N62b53d4de1eb4dfb975c3155c9de7fa3 rdf:first sg:person.0704252060.15
    98 rdf:rest N85a66e8afb5248bc9f510545f8202e8d
    99 N69f24c20f0254eab9df55127e1095953 schema:name Springer Nature - SN SciGraph project
    100 rdf:type schema:Organization
    101 N69fcfa4d45b342fc809ce0f4c238b71f rdf:first sg:person.011162064574.53
    102 rdf:rest N03f43d8cf87b490ab54f9193640d1724
    103 N6f4ce4ecb5104269afcba1acea77d7d0 rdf:first sg:person.0622152605.24
    104 rdf:rest Nae68794d370748488c9a604063273d73
    105 N7b7ace24d8e641caa95e310b4b273b65 schema:issueNumber 1
    106 rdf:type schema:PublicationIssue
    107 N85a66e8afb5248bc9f510545f8202e8d rdf:first sg:person.01334732205.12
    108 rdf:rest N69fcfa4d45b342fc809ce0f4c238b71f
    109 Nadbb4a2f24a643168fa408c34cc5b3f0 schema:name dimensions_id
    110 schema:value pub.1093048219
    111 rdf:type schema:PropertyValue
    112 Nae68794d370748488c9a604063273d73 rdf:first sg:person.0726535347.79
    113 rdf:rest Ndc385f5cee7c4277897716871b2db492
    114 Ndc385f5cee7c4277897716871b2db492 rdf:first sg:person.01006460674.21
    115 rdf:rest Nf5c82f8dee144dec9c0fa57503128d71
    116 Ne0ba534f6a114f468906be3f0cd33ca9 schema:name Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA
    117 rdf:type schema:Organization
    118 Ne746541704bd4caab128a45d0e1a097a schema:name doi
    119 schema:value 10.1038/cr.2017.148
    120 rdf:type schema:PropertyValue
    121 Nefd8ed80bd44430981c7380f2e626ec6 schema:name pubmed_id
    122 schema:value 29182158
    123 rdf:type schema:PropertyValue
    124 Nf5c82f8dee144dec9c0fa57503128d71 rdf:first sg:person.01221751111.64
    125 rdf:rest N62b53d4de1eb4dfb975c3155c9de7fa3
    126 Nf734d9bcc08447cab3ca7df8ec9127ad rdf:first sg:person.01233242033.90
    127 rdf:rest N6f4ce4ecb5104269afcba1acea77d7d0
    128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    129 schema:name Biological Sciences
    130 rdf:type schema:DefinedTerm
    131 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    132 schema:name Biochemistry and Cell Biology
    133 rdf:type schema:DefinedTerm
    134 sg:journal.1107753 schema:issn 1001-0602
    135 1748-7838
    136 schema:name Cell Research
    137 rdf:type schema:Periodical
    138 sg:person.01006460674.21 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    139 schema:familyName Hu
    140 schema:givenName Zehan
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006460674.21
    142 rdf:type schema:Person
    143 sg:person.011162064574.53 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    144 schema:familyName Wang
    145 schema:givenName Jiawei
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011162064574.53
    147 rdf:type schema:Person
    148 sg:person.01221751111.64 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    149 schema:familyName Han
    150 schema:givenName Zhifu
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221751111.64
    152 rdf:type schema:Person
    153 sg:person.01233242033.90 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    154 schema:familyName Yang
    155 schema:givenName Fan
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233242033.90
    157 rdf:type schema:Person
    158 sg:person.012775653777.02 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    159 schema:familyName Sui
    160 schema:givenName Sen-Fang
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012775653777.02
    162 rdf:type schema:Person
    163 sg:person.01334732205.12 schema:affiliation Ne0ba534f6a114f468906be3f0cd33ca9
    164 schema:familyName Zhang
    165 schema:givenName Liman
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334732205.12
    167 rdf:type schema:Person
    168 sg:person.01342040611.97 schema:affiliation https://www.grid.ac/institutes/grid.6190.e
    169 schema:familyName Chai
    170 schema:givenName Jijie
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342040611.97
    172 rdf:type schema:Person
    173 sg:person.013670367737.50 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    174 schema:familyName Yang
    175 schema:givenName Xinru
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013670367737.50
    177 rdf:type schema:Person
    178 sg:person.0622152605.24 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    179 schema:familyName Wang
    180 schema:givenName Weiguang
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622152605.24
    182 rdf:type schema:Person
    183 sg:person.0704252060.15 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    184 schema:familyName Qi
    185 schema:givenName Yijun
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704252060.15
    187 rdf:type schema:Person
    188 sg:person.0726535347.79 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    189 schema:familyName Lin
    190 schema:givenName Guangzhong
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726535347.79
    192 rdf:type schema:Person
    193 sg:pub.10.1038/35050012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013741960
    194 https://doi.org/10.1038/35050012
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/477407b schema:sameAs https://app.dimensions.ai/details/publication/pub.1021626853
    197 https://doi.org/10.1038/477407b
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/cr.2015.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003063255
    200 https://doi.org/10.1038/cr.2015.139
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nature10394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009302090
    203 https://doi.org/10.1038/nature10394
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nature10510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013464857
    206 https://doi.org/10.1038/nature10510
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nature15514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023121489
    209 https://doi.org/10.1038/nature15514
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nature15541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015203449
    212 https://doi.org/10.1038/nature15541
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/ni.1646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026804427
    215 https://doi.org/10.1038/ni.1646
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/ni.2231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003684283
    218 https://doi.org/10.1038/ni.2231
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/ni.2237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005509983
    221 https://doi.org/10.1038/ni.2237
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/ni1344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039911850
    224 https://doi.org/10.1038/ni1344
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ni1346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033803512
    227 https://doi.org/10.1038/ni1346
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nmeth.2115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041024070
    230 https://doi.org/10.1038/nmeth.2115
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nmeth.2472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203089
    233 https://doi.org/10.1038/nmeth.2472
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nmeth.2727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009301311
    236 https://doi.org/10.1038/nmeth.2727
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nmeth.4187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129281
    239 https://doi.org/10.1038/nmeth.4187
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nmeth.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129286
    242 https://doi.org/10.1038/nmeth.4193
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/nsmb.1774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000526904
    245 https://doi.org/10.1038/nsmb.1774
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.cell.2010.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031371585
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.coi.2015.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020552806
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.immuni.2017.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084743908
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.jmb.2011.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052958331
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.jsb.2006.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040267501
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.jsb.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019988217
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.molcel.2014.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007981535
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.str.2008.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016954035
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.str.2015.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036290868
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0962-8924(99)01609-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052518370
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s1047-8477(03)00069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046234181
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s1097-2765(02)00599-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012632196
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1073/pnas.0502040102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032046377
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1073/pnas.0913087107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000627560
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1073/pnas.1306376110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039654348
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1074/jbc.m112.393512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035850449
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1084/jem.20051659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007171888
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1084/jem.20071239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032891500
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1084/jem.20151809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006774338
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1084/jem.20160006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053634329
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1101/gad.272278.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001874310
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1105/tpc.15.00303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060842198
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1107/s0021889808006985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032551326
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1111/imr.12293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034939043
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1126/science.1236381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027290062
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1126/science.aac5489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040328673
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1126/science.aac5789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008174987
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1126/science.aaf6395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043772239
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1146/annurev-immunol-031210-101405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040658091
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1146/annurev-immunol-032712-095944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017513661
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1371/journal.ppat.0020018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049201704
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1371/journal.ppat.1006574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091282335
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.4049/jimmunol.1301549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078787641
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.7554/elife.17755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050754283
    318 rdf:type schema:CreativeWork
    319 https://www.grid.ac/institutes/grid.12527.33 schema:alternateName Tsinghua University
    320 schema:name Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    321 Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    322 State Key Laboratory of Membrane Biology, Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    323 rdf:type schema:Organization
    324 https://www.grid.ac/institutes/grid.6190.e schema:alternateName University of Cologne
    325 schema:name Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    326 Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    327 Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany
    328 Max-Planck Institute for Plant Breeding Research, 50829 Cologne, Germany
    329 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...