The FBW7-KLF2 axis regulates endothelial functions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04-09

AUTHORS

Yongchao Zhao, Yi Sun

ABSTRACT

FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.

PAGES

741-743

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2013.50

DOI

http://dx.doi.org/10.1038/cr.2013.50

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003149250

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23567558


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "F-Box Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "F-Box-WD Repeat-Containing Protein 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycogen Synthase Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycogen Synthase Kinase 3 beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kruppel-Like Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofibromatosis 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Protein p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Yongchao", 
        "id": "sg:person.01304472406.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304472406.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA", 
          "id": "http://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Yi", 
        "id": "sg:person.0653315700.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653315700.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrc2290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042298247", 
          "https://doi.org/10.1038/nrc2290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012125651", 
          "https://doi.org/10.1038/nature09732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2013.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007692465", 
          "https://doi.org/10.1038/cr.2013.42"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011835838", 
          "https://doi.org/10.1038/nsmb.2217"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04-09", 
    "datePublishedReg": "2013-04-09", 
    "description": "FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/cr.2013.50", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1107753", 
        "issn": [
          "1001-0602", 
          "1748-7838"
        ], 
        "name": "Cell Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "Fbw7 tumor suppressor", 
      "transcription factor KLF2", 
      "tumor suppressor", 
      "endothelial differentiation", 
      "cell research", 
      "Recent studies", 
      "tumor cells", 
      "FBW7", 
      "suppressor", 
      "KLF2", 
      "oncoprotein", 
      "differentiation", 
      "cells", 
      "function", 
      "growth", 
      "degradation", 
      "endothelial function", 
      "survival", 
      "axis", 
      "RAS axis", 
      "study", 
      "research", 
      "issues"
    ], 
    "name": "The FBW7-KLF2 axis regulates endothelial functions", 
    "pagination": "741-743", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003149250"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cr.2013.50"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23567558"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cr.2013.50", 
      "https://app.dimensions.ai/details/publication/pub.1003149250"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/cr.2013.50"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2013.50'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2013.50'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2013.50'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2013.50'


 

This table displays all metadata directly associated to this object as RDF triples.

183 TRIPLES      21 PREDICATES      71 URIs      59 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cr.2013.50 schema:about N18ca3a3628f24e65a3b3c47c32c7ae40
2 N26e39b6bbf2e41c49bdbe0c05c6f3c65
3 N292733cb54d2474d88e857de52887237
4 N30f2f013a7b24b2bb005a059e15ad599
5 N4069141795994f60b4074f3f550dbed1
6 N43bb28309685432db9cc8dbb7078cb65
7 N4fce200abd3d40c0803457a5418f6edd
8 N66f4a45d6d35472abf538e85de72fa4f
9 N6e10441283b54c64973c3725e603a11f
10 N77e6e04cec9f4a3cb4d4aebb2c74878c
11 N7aab0190d73e4728ad1c92b9ec5007ab
12 N7ec1a34a99664e778ca7fd2001e092b0
13 N8f168d3584ef493f97b3645ef13beeaa
14 N9eff5bb5eba44505a525cfffb7b1b9a7
15 Na046c4df1331455e84796522c42c5364
16 Na6ca5652119945a3a82dcb406a32dadd
17 Nce796e89c53d4074869eb86b96f3aea4
18 Nddfa066fe0604280b7b90fe1c0284cda
19 Nf3365e6f74514b80b155dd3565b42bd4
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N8f1aa1c152c6465ba61fa88352cd0da9
23 schema:citation sg:pub.10.1038/cr.2013.42
24 sg:pub.10.1038/nature09732
25 sg:pub.10.1038/nrc2290
26 sg:pub.10.1038/nsmb.2217
27 schema:datePublished 2013-04-09
28 schema:datePublishedReg 2013-04-09
29 schema:description FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N4606b4c4f31748ddb6b80e491728fc42
33 N7dee7e0de1aa4ca088dc714e42f538ae
34 sg:journal.1107753
35 schema:keywords FBW7
36 Fbw7 tumor suppressor
37 KLF2
38 RAS axis
39 Recent studies
40 axis
41 cell research
42 cells
43 degradation
44 differentiation
45 endothelial differentiation
46 endothelial function
47 function
48 growth
49 issues
50 oncoprotein
51 research
52 study
53 suppressor
54 survival
55 transcription factor KLF2
56 tumor cells
57 tumor suppressor
58 schema:name The FBW7-KLF2 axis regulates endothelial functions
59 schema:pagination 741-743
60 schema:productId N462a708d7afb4b36960b174c5bdf1faa
61 Nc0c1c6ea5f064adba85d4b5311e5262c
62 Ndc880320c48b44248d9afabc41e1dca8
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003149250
64 https://doi.org/10.1038/cr.2013.50
65 schema:sdDatePublished 2022-10-01T06:39
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N446e2d2fe28746758aa5e2b0687d1074
68 schema:url https://doi.org/10.1038/cr.2013.50
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N18ca3a3628f24e65a3b3c47c32c7ae40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Cell Differentiation
74 rdf:type schema:DefinedTerm
75 N26e39b6bbf2e41c49bdbe0c05c6f3c65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Glycogen Synthase Kinase 3 beta
77 rdf:type schema:DefinedTerm
78 N292733cb54d2474d88e857de52887237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Cell Proliferation
80 rdf:type schema:DefinedTerm
81 N30f2f013a7b24b2bb005a059e15ad599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Neurofibromatosis 1
83 rdf:type schema:DefinedTerm
84 N4069141795994f60b4074f3f550dbed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name F-Box-WD Repeat-Containing Protein 7
86 rdf:type schema:DefinedTerm
87 N43bb28309685432db9cc8dbb7078cb65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Kruppel-Like Transcription Factors
89 rdf:type schema:DefinedTerm
90 N446e2d2fe28746758aa5e2b0687d1074 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N4606b4c4f31748ddb6b80e491728fc42 schema:issueNumber 6
93 rdf:type schema:PublicationIssue
94 N462a708d7afb4b36960b174c5bdf1faa schema:name doi
95 schema:value 10.1038/cr.2013.50
96 rdf:type schema:PropertyValue
97 N4fce200abd3d40c0803457a5418f6edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Oncogene Proteins
99 rdf:type schema:DefinedTerm
100 N66f4a45d6d35472abf538e85de72fa4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Genes, Tumor Suppressor
102 rdf:type schema:DefinedTerm
103 N6e10441283b54c64973c3725e603a11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Ubiquitin-Protein Ligases
105 rdf:type schema:DefinedTerm
106 N77e6e04cec9f4a3cb4d4aebb2c74878c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name RNA, Small Interfering
108 rdf:type schema:DefinedTerm
109 N7aab0190d73e4728ad1c92b9ec5007ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Glycogen Synthase Kinase 3
111 rdf:type schema:DefinedTerm
112 N7dee7e0de1aa4ca088dc714e42f538ae schema:volumeNumber 23
113 rdf:type schema:PublicationVolume
114 N7ec1a34a99664e778ca7fd2001e092b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name F-Box Proteins
116 rdf:type schema:DefinedTerm
117 N8a5b0c5d8c01487f9e46c645d5131752 rdf:first sg:person.0653315700.70
118 rdf:rest rdf:nil
119 N8f168d3584ef493f97b3645ef13beeaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 N8f1aa1c152c6465ba61fa88352cd0da9 rdf:first sg:person.01304472406.33
123 rdf:rest N8a5b0c5d8c01487f9e46c645d5131752
124 N9eff5bb5eba44505a525cfffb7b1b9a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Neovascularization, Pathologic
126 rdf:type schema:DefinedTerm
127 Na046c4df1331455e84796522c42c5364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Endothelial Cells
129 rdf:type schema:DefinedTerm
130 Na6ca5652119945a3a82dcb406a32dadd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Oncogene Protein p21(ras)
132 rdf:type schema:DefinedTerm
133 Nc0c1c6ea5f064adba85d4b5311e5262c schema:name pubmed_id
134 schema:value 23567558
135 rdf:type schema:PropertyValue
136 Nce796e89c53d4074869eb86b96f3aea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name RNA Interference
138 rdf:type schema:DefinedTerm
139 Ndc880320c48b44248d9afabc41e1dca8 schema:name dimensions_id
140 schema:value pub.1003149250
141 rdf:type schema:PropertyValue
142 Nddfa066fe0604280b7b90fe1c0284cda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cell Cycle Proteins
144 rdf:type schema:DefinedTerm
145 Nf3365e6f74514b80b155dd3565b42bd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Movement
147 rdf:type schema:DefinedTerm
148 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
149 schema:name Biological Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biochemistry and Cell Biology
153 rdf:type schema:DefinedTerm
154 sg:journal.1107753 schema:issn 1001-0602
155 1748-7838
156 schema:name Cell Research
157 schema:publisher Springer Nature
158 rdf:type schema:Periodical
159 sg:person.01304472406.33 schema:affiliation grid-institutes:grid.214458.e
160 schema:familyName Zhao
161 schema:givenName Yongchao
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304472406.33
163 rdf:type schema:Person
164 sg:person.0653315700.70 schema:affiliation grid-institutes:grid.214458.e
165 schema:familyName Sun
166 schema:givenName Yi
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653315700.70
168 rdf:type schema:Person
169 sg:pub.10.1038/cr.2013.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007692465
170 https://doi.org/10.1038/cr.2013.42
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nature09732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012125651
173 https://doi.org/10.1038/nature09732
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nrc2290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042298247
176 https://doi.org/10.1038/nrc2290
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nsmb.2217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011835838
179 https://doi.org/10.1038/nsmb.2217
180 rdf:type schema:CreativeWork
181 grid-institutes:grid.214458.e schema:alternateName Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA
182 schema:name Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA
183 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...