CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05-15

AUTHORS

Yongchao Zhao, Yi Sun

ABSTRACT

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients. More... »

PAGES

1224-1226

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2012.79

DOI

http://dx.doi.org/10.1038/cr.2012.79

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015835049

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22584258


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