Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Hanbing Zhong, Danyang Wang, Nan Wang, Yesenia Rios, Haigen Huang, Song Li, Xinrong Wu, Shuo Lin

ABSTRACT

Blood vessels normally maintain stereotyped lumen diameters and their stable structures are crucial for vascular function. However, very little is known about the molecular mechanisms controlling the maintenance of vessel diameters and the integrity of endothelial cells. We investigated this issue in zebrafish embryos by a chemical genetics approach. Small molecule libraries were screened using live Tg(kdrl:GRCFP)(zn1) transgenic embryos in which endothelial cells are specifically labeled with GFP. By analyzing the effects of compounds on the morphology and function of embryonic blood vessels after lumen formation, PP1, a putative Src kinase inhibitor, was identified as capable of specifically reducing vascular lumen size by interrupting endothelial-cell integrity. The inhibitory effect is not due to Src or general VEGF signaling inhibition because another Src inhibitor and Src morpholino as well as several VEGFR inhibitors failed to produce a similar phenotype. After profiling a panel of 22 representative mammalian kinases and surveying published data, we selected a few possible new candidates. Combinational analysis of these candidate kinase inhibitors established that PP1 induced endothelial collapse by inhibiting both the VEGFR2 and MAP kinase pathways. More importantly, combinatory use of two clinically approved drugs Dasatinib and Sunitinib produced the same phenotype. This is the first study to elucidate the pathways controlling maintenance of endothelial integrity using a chemical genetics approach, indicating that endothelial integrity is controlled by the combined action of the VEGFR2 and MAP kinase pathways. Our results also suggest the possible side effect of the combination of two anticancer drugs on the circulatory system. More... »

PAGES

1080

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2011.41

DOI

http://dx.doi.org/10.1038/cr.2011.41

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024986521

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21423276


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Nonmammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor Receptor-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Peking University", 
          "id": "https://www.grid.ac/institutes/grid.11135.37", 
          "name": [
            "Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen University Town, Shenzhen 518055, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhong", 
        "givenName": "Hanbing", 
        "id": "sg:person.01256255735.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256255735.22"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wang", 
        "givenName": "Danyang", 
        "type": "Person"
      }, 
      {
        "familyName": "Wang", 
        "givenName": "Nan", 
        "id": "sg:person.0613507442.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613507442.60"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Rios", 
        "givenName": "Yesenia", 
        "id": "sg:person.0714067515.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714067515.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Huang", 
        "givenName": "Haigen", 
        "id": "sg:person.01174070073.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174070073.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Li", 
        "givenName": "Song", 
        "id": "sg:person.0672442776.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672442776.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wu", 
        "givenName": "Xinrong", 
        "id": "sg:person.01033634515.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033634515.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lin", 
        "givenName": "Shuo", 
        "id": "sg:person.011413572257.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413572257.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1038/sj.mn.7800164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000328748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2008.01.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002290917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2000.9995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002490052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002849976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0300011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002849976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003215518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0705253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004995544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.mn.7800175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006052909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2009.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006078540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.02.156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007986056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016767348", 
          "https://doi.org/10.1038/nchembio.117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aja.1002030302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017782944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.2.695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018746276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020804427", 
          "https://doi.org/10.1038/nature04923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020804427", 
          "https://doi.org/10.1038/nature04923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2009.10.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024033802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024946989", 
          "https://doi.org/10.1038/nature08889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024946989", 
          "https://doi.org/10.1038/nature08889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2009.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029223335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029467419", 
          "https://doi.org/10.1038/nbt1358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037678065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037678065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0712195105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037961542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/rrs-120025567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041119807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65038-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041595067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000068685.72914.7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042005150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000068685.72914.7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042005150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.05.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047377309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.23.9018-9027.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049315292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5364.734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062560949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074631315", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075003320", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075010759", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082425451", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-07", 
    "datePublishedReg": "2011-07-01", 
    "description": "Blood vessels normally maintain stereotyped lumen diameters and their stable structures are crucial for vascular function. However, very little is known about the molecular mechanisms controlling the maintenance of vessel diameters and the integrity of endothelial cells. We investigated this issue in zebrafish embryos by a chemical genetics approach. Small molecule libraries were screened using live Tg(kdrl:GRCFP)(zn1) transgenic embryos in which endothelial cells are specifically labeled with GFP. By analyzing the effects of compounds on the morphology and function of embryonic blood vessels after lumen formation, PP1, a putative Src kinase inhibitor, was identified as capable of specifically reducing vascular lumen size by interrupting endothelial-cell integrity. The inhibitory effect is not due to Src or general VEGF signaling inhibition because another Src inhibitor and Src morpholino as well as several VEGFR inhibitors failed to produce a similar phenotype. After profiling a panel of 22 representative mammalian kinases and surveying published data, we selected a few possible new candidates. Combinational analysis of these candidate kinase inhibitors established that PP1 induced endothelial collapse by inhibiting both the VEGFR2 and MAP kinase pathways. More importantly, combinatory use of two clinically approved drugs Dasatinib and Sunitinib produced the same phenotype. This is the first study to elucidate the pathways controlling maintenance of endothelial integrity using a chemical genetics approach, indicating that endothelial integrity is controlled by the combined action of the VEGFR2 and MAP kinase pathways. Our results also suggest the possible side effect of the combination of two anticancer drugs on the circulatory system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cr.2011.41", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5014487", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2496343", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1107753", 
        "issn": [
          "1001-0602", 
          "1748-7838"
        ], 
        "name": "Cell Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity", 
    "pagination": "1080", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7708bc4b7cc2e5f9def1c197c7809122763682da09706228595f2c78adb63174"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21423276"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9425763"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cr.2011.41"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024986521"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cr.2011.41", 
      "https://app.dimensions.ai/details/publication/pub.1024986521"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000438.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/cr201141"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.41'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.41'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.41'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.41'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      70 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cr.2011.41 schema:about N2f58961478324bd497867a73867c86fb
2 N4b14f1dade9e4b7a90867f35dae1e165
3 N501a081628204a9dbb98def000048f31
4 N5944f9ec1c27406eb1f8cf11c77be464
5 N5accd99e8a2447c68ebc9fa0b0620aba
6 N6bac21fa2b474158b400b2d49ea96b35
7 N76fff0e1338f4498bda4821ff23c6eed
8 N9bb3fddae990485e94769b430e53297f
9 Nb2feaf238cae440f9e9757a1121ba92b
10 Nd77479b7e0cf4a6f98600497b23d8713
11 Ndbf91f5562db4521a80420870f8be83f
12 Ne684a1dfa0b14eb6a35a5384f4c538de
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author Nc9d561064a374c5bbe8af45acf5613b9
16 schema:citation sg:pub.10.1038/nature04923
17 sg:pub.10.1038/nature08889
18 sg:pub.10.1038/nbt1358
19 sg:pub.10.1038/nchembio.117
20 https://app.dimensions.ai/details/publication/pub.1074631315
21 https://app.dimensions.ai/details/publication/pub.1075003320
22 https://app.dimensions.ai/details/publication/pub.1075010759
23 https://app.dimensions.ai/details/publication/pub.1082425451
24 https://doi.org/10.1002/aja.1002030302
25 https://doi.org/10.1006/dbio.2000.9995
26 https://doi.org/10.1016/j.bbrc.2007.02.156
27 https://doi.org/10.1016/j.cub.2006.05.046
28 https://doi.org/10.1016/j.devcel.2009.01.013
29 https://doi.org/10.1016/j.devcel.2009.08.011
30 https://doi.org/10.1016/j.ydbio.2008.01.038
31 https://doi.org/10.1016/j.ydbio.2009.10.035
32 https://doi.org/10.1016/s0002-9440(10)65038-9
33 https://doi.org/10.1038/sj.bjp.0705253
34 https://doi.org/10.1038/sj.embor.7400386
35 https://doi.org/10.1038/sj.mn.7800164
36 https://doi.org/10.1038/sj.mn.7800175
37 https://doi.org/10.1042/bst0300011
38 https://doi.org/10.1073/pnas.0712195105
39 https://doi.org/10.1074/jbc.271.2.695
40 https://doi.org/10.1081/rrs-120025567
41 https://doi.org/10.1126/science.280.5364.734
42 https://doi.org/10.1128/mcb.20.23.9018-9027.2000
43 https://doi.org/10.1161/01.atv.0000068685.72914.7e
44 https://doi.org/10.1172/jci39837
45 schema:datePublished 2011-07
46 schema:datePublishedReg 2011-07-01
47 schema:description Blood vessels normally maintain stereotyped lumen diameters and their stable structures are crucial for vascular function. However, very little is known about the molecular mechanisms controlling the maintenance of vessel diameters and the integrity of endothelial cells. We investigated this issue in zebrafish embryos by a chemical genetics approach. Small molecule libraries were screened using live Tg(kdrl:GRCFP)(zn1) transgenic embryos in which endothelial cells are specifically labeled with GFP. By analyzing the effects of compounds on the morphology and function of embryonic blood vessels after lumen formation, PP1, a putative Src kinase inhibitor, was identified as capable of specifically reducing vascular lumen size by interrupting endothelial-cell integrity. The inhibitory effect is not due to Src or general VEGF signaling inhibition because another Src inhibitor and Src morpholino as well as several VEGFR inhibitors failed to produce a similar phenotype. After profiling a panel of 22 representative mammalian kinases and surveying published data, we selected a few possible new candidates. Combinational analysis of these candidate kinase inhibitors established that PP1 induced endothelial collapse by inhibiting both the VEGFR2 and MAP kinase pathways. More importantly, combinatory use of two clinically approved drugs Dasatinib and Sunitinib produced the same phenotype. This is the first study to elucidate the pathways controlling maintenance of endothelial integrity using a chemical genetics approach, indicating that endothelial integrity is controlled by the combined action of the VEGFR2 and MAP kinase pathways. Our results also suggest the possible side effect of the combination of two anticancer drugs on the circulatory system.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N6b0ab9b013de4226b3bd0eb6852ccde5
52 N8f07ceb499994c709dca54ac9bb188c5
53 sg:journal.1107753
54 schema:name Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity
55 schema:pagination 1080
56 schema:productId N15936ff364bc41bea8dfd37566f31239
57 N8bcd50e106d24115b01ee1d9af99deb2
58 N91a779ebeb0b48caabf2de1cdf5cb18a
59 Nb6072e58338b428ea9520aabcd3f61fb
60 Nd0bd91a5d62e4883aa92f6249c89f878
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024986521
62 https://doi.org/10.1038/cr.2011.41
63 schema:sdDatePublished 2019-04-11T00:56
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nfe65f32fbeda478b93ceac9ebd62a488
66 schema:url https://www.nature.com/articles/cr201141
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0df2ff63e3474a35b20fb70da1343880 rdf:first sg:person.01033634515.08
71 rdf:rest N5478cf222f9841d997ab4546f246e7e3
72 N15936ff364bc41bea8dfd37566f31239 schema:name dimensions_id
73 schema:value pub.1024986521
74 rdf:type schema:PropertyValue
75 N1f0895bf4d744a10b06305dafd289160 rdf:first sg:person.0613507442.60
76 rdf:rest N2424380e2a744840b38bd8f676966fe2
77 N212d4d070194460a8c9ad220ce00b5c4 rdf:first Nfebbb5d218d1499a8e19804dd698b530
78 rdf:rest N1f0895bf4d744a10b06305dafd289160
79 N2424380e2a744840b38bd8f676966fe2 rdf:first sg:person.0714067515.45
80 rdf:rest N3eaffb11b96c4452b4d61b6af755a547
81 N2f58961478324bd497867a73867c86fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name MAP Kinase Signaling System
83 rdf:type schema:DefinedTerm
84 N3eaffb11b96c4452b4d61b6af755a547 rdf:first sg:person.01174070073.26
85 rdf:rest Ne8caca80a3794ecabd4027189ec255f7
86 N4b14f1dade9e4b7a90867f35dae1e165 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Pyrimidines
88 rdf:type schema:DefinedTerm
89 N501a081628204a9dbb98def000048f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Animals
91 rdf:type schema:DefinedTerm
92 N5478cf222f9841d997ab4546f246e7e3 rdf:first sg:person.011413572257.58
93 rdf:rest rdf:nil
94 N5944f9ec1c27406eb1f8cf11c77be464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name src-Family Kinases
96 rdf:type schema:DefinedTerm
97 N5accd99e8a2447c68ebc9fa0b0620aba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Enzyme Inhibitors
99 rdf:type schema:DefinedTerm
100 N6b0ab9b013de4226b3bd0eb6852ccde5 schema:volumeNumber 21
101 rdf:type schema:PublicationVolume
102 N6bac21fa2b474158b400b2d49ea96b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Endothelial Cells
104 rdf:type schema:DefinedTerm
105 N76fff0e1338f4498bda4821ff23c6eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Pyrazoles
107 rdf:type schema:DefinedTerm
108 N8bcd50e106d24115b01ee1d9af99deb2 schema:name readcube_id
109 schema:value 7708bc4b7cc2e5f9def1c197c7809122763682da09706228595f2c78adb63174
110 rdf:type schema:PropertyValue
111 N8f07ceb499994c709dca54ac9bb188c5 schema:issueNumber 7
112 rdf:type schema:PublicationIssue
113 N91a779ebeb0b48caabf2de1cdf5cb18a schema:name nlm_unique_id
114 schema:value 9425763
115 rdf:type schema:PropertyValue
116 N9bb3fddae990485e94769b430e53297f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Embryo, Nonmammalian
118 rdf:type schema:DefinedTerm
119 Nb2feaf238cae440f9e9757a1121ba92b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Neovascularization, Physiologic
121 rdf:type schema:DefinedTerm
122 Nb6072e58338b428ea9520aabcd3f61fb schema:name pubmed_id
123 schema:value 21423276
124 rdf:type schema:PropertyValue
125 Nc9d561064a374c5bbe8af45acf5613b9 rdf:first sg:person.01256255735.22
126 rdf:rest N212d4d070194460a8c9ad220ce00b5c4
127 Nd0bd91a5d62e4883aa92f6249c89f878 schema:name doi
128 schema:value 10.1038/cr.2011.41
129 rdf:type schema:PropertyValue
130 Nd77479b7e0cf4a6f98600497b23d8713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Mitogen-Activated Protein Kinases
132 rdf:type schema:DefinedTerm
133 Ndbf91f5562db4521a80420870f8be83f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Vascular Endothelial Growth Factor Receptor-2
135 rdf:type schema:DefinedTerm
136 Ne684a1dfa0b14eb6a35a5384f4c538de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Zebrafish
138 rdf:type schema:DefinedTerm
139 Ne8caca80a3794ecabd4027189ec255f7 rdf:first sg:person.0672442776.26
140 rdf:rest N0df2ff63e3474a35b20fb70da1343880
141 Nfe65f32fbeda478b93ceac9ebd62a488 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nfebbb5d218d1499a8e19804dd698b530 schema:familyName Wang
144 schema:givenName Danyang
145 rdf:type schema:Person
146 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
147 schema:name Biological Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
150 schema:name Biochemistry and Cell Biology
151 rdf:type schema:DefinedTerm
152 sg:grant.2496343 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.41
153 rdf:type schema:MonetaryGrant
154 sg:grant.5014487 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.41
155 rdf:type schema:MonetaryGrant
156 sg:journal.1107753 schema:issn 1001-0602
157 1748-7838
158 schema:name Cell Research
159 rdf:type schema:Periodical
160 sg:person.01033634515.08 schema:familyName Wu
161 schema:givenName Xinrong
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033634515.08
163 rdf:type schema:Person
164 sg:person.011413572257.58 schema:familyName Lin
165 schema:givenName Shuo
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413572257.58
167 rdf:type schema:Person
168 sg:person.01174070073.26 schema:familyName Huang
169 schema:givenName Haigen
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174070073.26
171 rdf:type schema:Person
172 sg:person.01256255735.22 schema:affiliation https://www.grid.ac/institutes/grid.11135.37
173 schema:familyName Zhong
174 schema:givenName Hanbing
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256255735.22
176 rdf:type schema:Person
177 sg:person.0613507442.60 schema:familyName Wang
178 schema:givenName Nan
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613507442.60
180 rdf:type schema:Person
181 sg:person.0672442776.26 schema:familyName Li
182 schema:givenName Song
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672442776.26
184 rdf:type schema:Person
185 sg:person.0714067515.45 schema:familyName Rios
186 schema:givenName Yesenia
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714067515.45
188 rdf:type schema:Person
189 sg:pub.10.1038/nature04923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020804427
190 https://doi.org/10.1038/nature04923
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nature08889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024946989
193 https://doi.org/10.1038/nature08889
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nbt1358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029467419
196 https://doi.org/10.1038/nbt1358
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nchembio.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016767348
199 https://doi.org/10.1038/nchembio.117
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1074631315 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1075003320 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1075010759 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1082425451 schema:CreativeWork
205 https://doi.org/10.1002/aja.1002030302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782944
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1006/dbio.2000.9995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002490052
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.bbrc.2007.02.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007986056
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.cub.2006.05.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047377309
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.devcel.2009.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006078540
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.devcel.2009.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029223335
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ydbio.2008.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290917
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.ydbio.2009.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024033802
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0002-9440(10)65038-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041595067
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1038/sj.bjp.0705253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004995544
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1038/sj.embor.7400386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003215518
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1038/sj.mn.7800164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000328748
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1038/sj.mn.7800175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006052909
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1042/bst0300011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002849976
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.0712195105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037961542
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1074/jbc.271.2.695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018746276
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1081/rrs-120025567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041119807
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/science.280.5364.734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062560949
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1128/mcb.20.23.9018-9027.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049315292
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1161/01.atv.0000068685.72914.7e schema:sameAs https://app.dimensions.ai/details/publication/pub.1042005150
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1172/jci39837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037678065
246 rdf:type schema:CreativeWork
247 https://www.grid.ac/institutes/grid.11135.37 schema:alternateName Peking University
248 schema:name Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University, Shenzhen Graduate School, Shenzhen University Town, Shenzhen 518055, China.
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...