Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10

AUTHORS

R David Hawkins, Gary C Hon, Chuhu Yang, Jessica E Antosiewicz-Bourget, Leonard K Lee, Que-Minh Ngo, Sarit Klugman, Keith A Ching, Lee E Edsall, Zhen Ye, Samantha Kuan, Pengzhi Yu, Hui Liu, Xinmin Zhang, Roland D Green, Victor V Lobanenkov, Ron Stewart, James A Thomson, Bing Ren

ABSTRACT

Pluripotency, the ability of a cell to differentiate and give rise to all embryonic lineages, defines a small number of mammalian cell types such as embryonic stem (ES) cells. While it has been generally held that pluripotency is the product of a transcriptional regulatory network that activates and maintains the expression of key stem cell genes, accumulating evidence is pointing to a critical role for epigenetic processes in establishing and safeguarding the pluripotency of ES cells, as well as maintaining the identity of differentiated cell types. In order to better understand the role of epigenetic mechanisms in pluripotency, we have examined the dynamics of chromatin modifications genome-wide in human ES cells (hESCs) undergoing differentiation into a mesendodermal lineage. We found that chromatin modifications at promoters remain largely invariant during differentiation, except at a small number of promoters where a dynamic switch between acetylation and methylation at H3K27 marks the transition between activation and silencing of gene expression, suggesting a hierarchy in cell fate commitment over most differentially expressed genes. We also mapped over 50 000 potential enhancers, and observed much greater dynamics in chromatin modifications, especially H3K4me1 and H3K27ac, which correlate with expression of their potential target genes. Further analysis of these enhancers revealed potentially key transcriptional regulators of pluripotency and a chromatin signature indicative of a poised state that may confer developmental competence in hESCs. Our results provide new evidence supporting the role of chromatin modifications in defining enhancers and pluripotency. More... »

PAGES

1393

References to SciGraph publications

  • 2010-10. Epigenetic modifications in pluripotent and differentiated cells in NATURE BIOTECHNOLOGY
  • 2008-01. Reprogramming of human somatic cells to pluripotency with defined factors in NATURE
  • 2006-09. Insulators: exploiting transcriptional and epigenetic mechanisms in NATURE REVIEWS GENETICS
  • 2002-12. BMP4 initiates human embryonic stem cell differentiation to trophoblast in NATURE BIOTECHNOLOGY
  • 2011-06. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA in NATURE
  • 2007-02. NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 in ONCOGENE
  • 2007-01. Nanog and transcriptional networks in embryonic stem cell pluripotency in CELL RESEARCH
  • 2006-05. Chromatin signatures of pluripotent cell lines in NATURE CELL BIOLOGY
  • 2009-02. ChIP-seq accurately predicts tissue-specific activity of enhancers in NATURE
  • 2010-09-03. Transcriptional Regulatory Networks in Embryonic Stem Cells in EPIGENETICS AND DISEASE
  • 2007-03. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome in NATURE GENETICS
  • 2009-05. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2005-08. A high-resolution map of active promoters in the human genome in NATURE
  • 2011-02. A unique chromatin signature uncovers early developmental enhancers in humans in NATURE
  • 2008-07. Combinatorial patterns of histone acetylations and methylations in the human genome in NATURE GENETICS
  • 2007-08. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2006-08. Feeder-independent culture of human embryonic stem cells in NATURE METHODS
  • 2005-11. Building the mammalian heart from two sources of myocardial cells in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2011.146

    DOI

    http://dx.doi.org/10.1038/cr.2011.146

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008604014

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21876557


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