A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Yanqun Chen, Bin Wu, Liangliang Xu, Huapeng Li, Jianhong Xia, Wenguang Yin, Zhuo Li, Dawei Shi, Song Li, Shuo Lin, Xiaodong Shu, Duanqing Pei

ABSTRACT

Sorting nexins (SNXs) are phosphoinositide-binding proteins implicated in the sorting of various membrane proteins in vitro, but the in vivo functions of them remain largely unknown. We reported previously that SNX10 is a unique member of the SNX family genes in that it has vacuolation activity in cells. We investigate the biological function of SNX10 by loss-of-function assay in this study and demonstrate that SNX10 is required for the formation of primary cilia in cultured cells. In zebrafish, SNX10 is involved in ciliogenesis in the Kupffer's vesicle and essential for left-right patterning of visceral organs. Mechanistically, SNX10 interacts with V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated. Like SNX10, V-ATPase regulates ciliogenesis in vitro and in vivo and does so synergistically with SNX10. We further discover that SNX10 and V-ATPase regulate the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. These results identify an SNX10/V-ATPase-regulated vesicular trafficking pathway that is crucial for ciliogenesis, and reveal that SNX10/V-ATPase, through the regulation of cilia formation in various organs, play an essential role during early embryonic development. More... »

PAGES

cr2011134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2011.134

DOI

http://dx.doi.org/10.1038/cr.2011.134

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018147382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21844891


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Patterning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Centrosome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cilia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Morphogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sorting Nexins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vacuolar Proton-Translocating ATPases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vacuoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rab GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Science and Technology of China", 
          "id": "https://www.grid.ac/institutes/grid.59053.3a", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China", 
            "School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yanqun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Science and Technology of China", 
          "id": "https://www.grid.ac/institutes/grid.59053.3a", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China", 
            "School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Bin", 
        "id": "sg:person.0711164161.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711164161.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Liangliang", 
        "id": "sg:person.0757277361.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757277361.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Huapeng", 
        "id": "sg:person.01001202623.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001202623.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Jianhong", 
        "id": "sg:person.01073525761.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073525761.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yin", 
        "givenName": "Wenguang", 
        "id": "sg:person.01141641161.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141641161.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zhuo", 
        "id": "sg:person.01207754361.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207754361.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fujian Agriculture and Forestry University", 
          "id": "https://www.grid.ac/institutes/grid.256111.0", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China", 
            "School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Dawei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University", 
          "id": "https://www.grid.ac/institutes/grid.11135.37", 
          "name": [
            "Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, Guangdong 518055, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Song", 
        "id": "sg:person.0672442776.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672442776.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University", 
          "id": "https://www.grid.ac/institutes/grid.11135.37", 
          "name": [
            "Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, Guangdong 518055, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Shuo", 
        "id": "sg:person.011413572257.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413572257.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shu", 
        "givenName": "Xiaodong", 
        "id": "sg:person.0601102121.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601102121.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Institutes of Biomedicine and Health", 
          "id": "https://www.grid.ac/institutes/grid.428926.3", 
          "name": [
            "CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pei", 
        "givenName": "Duanqing", 
        "id": "sg:person.01261314332.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261314332.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1167/iovs.08-2743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000088548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-008-0030-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000842087", 
          "https://doi.org/10.1007/s10517-008-0030-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10517-008-0030-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000842087", 
          "https://doi.org/10.1007/s10517-008-0030-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000993219", 
          "https://doi.org/10.1038/nrm2427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.15.2.363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001806407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13238-011-1004-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002164563", 
          "https://doi.org/10.1007/s13238-011-1004-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13238-011-1004-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002164563", 
          "https://doi.org/10.1007/s13238-011-1004-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2006.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003373973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007238621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2009.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008276542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015791990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016398543", 
          "https://doi.org/10.1038/nature08895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016398543", 
          "https://doi.org/10.1038/nature08895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016764389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418037a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021745988", 
          "https://doi.org/10.1038/418037a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418037a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021745988", 
          "https://doi.org/10.1038/418037a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418037a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021745988", 
          "https://doi.org/10.1038/418037a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200703047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021780932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01044-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022499126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.69.040705.141236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025273003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026157995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2008.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026353370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e02-03-0145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026676750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028478435", 
          "https://doi.org/10.1038/nrm2272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genet.39.073003.105049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030823753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.21521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034961020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.conb.2008.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035264117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036565472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddn277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036876979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1124534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036983994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.135.4.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038164437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0607974103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041929911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045774050", 
          "https://doi.org/10.1038/ncb1706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045774050", 
          "https://doi.org/10.1038/ncb1706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2008.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046898802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047736653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2006020181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047777643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2006020181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047777643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.03.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048069636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m608884200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049194929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052535970", 
          "https://doi.org/10.1038/ncb1966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052535970", 
          "https://doi.org/10.1038/ncb1966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053367126", 
          "https://doi.org/10.1038/nrm2278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5264.1008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/01301st03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074763446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083343186", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-02", 
    "datePublishedReg": "2012-02-01", 
    "description": "Sorting nexins (SNXs) are phosphoinositide-binding proteins implicated in the sorting of various membrane proteins in vitro, but the in vivo functions of them remain largely unknown. We reported previously that SNX10 is a unique member of the SNX family genes in that it has vacuolation activity in cells. We investigate the biological function of SNX10 by loss-of-function assay in this study and demonstrate that SNX10 is required for the formation of primary cilia in cultured cells. In zebrafish, SNX10 is involved in ciliogenesis in the Kupffer's vesicle and essential for left-right patterning of visceral organs. Mechanistically, SNX10 interacts with V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated. Like SNX10, V-ATPase regulates ciliogenesis in vitro and in vivo and does so synergistically with SNX10. We further discover that SNX10 and V-ATPase regulate the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. These results identify an SNX10/V-ATPase-regulated vesicular trafficking pathway that is crucial for ciliogenesis, and reveal that SNX10/V-ATPase, through the regulation of cilia formation in various organs, play an essential role during early embryonic development.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cr.2011.134", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4956245", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4926888", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4951899", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4906880", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1107753", 
        "issn": [
          "1001-0602", 
          "1748-7838"
        ], 
        "name": "Cell Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo", 
    "pagination": "cr2011134", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5677489e02e9b49b95d5e1d1de4091832e4e4786893d5fba954ce9f99987d2a4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21844891"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9425763"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cr.2011.134"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018147382"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cr.2011.134", 
      "https://app.dimensions.ai/details/publication/pub.1018147382"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/cr2011134"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.134'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.134'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.134'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.134'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      84 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cr.2011.134 schema:about N136023ee212a475891e148be37b67298
2 N2864ffa8a2b44918899982d1ac945f1b
3 N2b99f24fc39643e893c83184c8c15660
4 N32b2ef93953a4665a17c5ae77efe6a72
5 N3633cfd35c7b44cd8d12a9dfa303fcd0
6 N3a22cd4612a14bb69cfa55a097100dd8
7 N49eca180b9f4495dbff1104618003c13
8 N56f968c59fe04107a8031042266518ac
9 N72f06592e4bf43559888d9307b609712
10 N72f7dc159eaa430e8a97b34c626230bf
11 N8377362de0fd48ccb8e22e6909291299
12 N92c5555b73e643f0b80d3fc556f6e8c1
13 N9471245953844d53a46efc21369e88b5
14 Nb6e031edfa244a39bd0fbb7810f96ab3
15 Nd7ee77c243e34d6cbde7a62099efe0bb
16 Nf76b10efc45848e18b92dfeff8c585f3
17 Nf867e51500fe44eea50bb5c10fd64eee
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N0db718f090aa4570a2f4ba9a9da59ef9
21 schema:citation sg:pub.10.1007/s10517-008-0030-9
22 sg:pub.10.1007/s13238-011-1004-7
23 sg:pub.10.1038/418037a
24 sg:pub.10.1038/nature08895
25 sg:pub.10.1038/ncb1706
26 sg:pub.10.1038/ncb1966
27 sg:pub.10.1038/nrm2272
28 sg:pub.10.1038/nrm2278
29 sg:pub.10.1038/nrm2427
30 https://app.dimensions.ai/details/publication/pub.1083343186
31 https://doi.org/10.1002/dvdy.21521
32 https://doi.org/10.1016/j.bbalip.2006.04.011
33 https://doi.org/10.1016/j.ceb.2008.03.015
34 https://doi.org/10.1016/j.cell.2007.03.053
35 https://doi.org/10.1016/j.cell.2007.06.027
36 https://doi.org/10.1016/j.cell.2009.03.023
37 https://doi.org/10.1016/j.conb.2008.10.001
38 https://doi.org/10.1016/j.devcel.2008.07.004
39 https://doi.org/10.1016/j.tcb.2009.04.002
40 https://doi.org/10.1073/pnas.0607974103
41 https://doi.org/10.1074/jbc.m608884200
42 https://doi.org/10.1083/jcb.135.4.913
43 https://doi.org/10.1083/jcb.15.2.363
44 https://doi.org/10.1083/jcb.200703047
45 https://doi.org/10.1091/mbc.e02-03-0145
46 https://doi.org/10.1093/hmg/ddn277
47 https://doi.org/10.1126/science.1124534
48 https://doi.org/10.1126/science.272.5264.1008
49 https://doi.org/10.1128/mcb.01044-10
50 https://doi.org/10.1146/annurev.genet.39.073003.105049
51 https://doi.org/10.1146/annurev.physiol.69.040705.141236
52 https://doi.org/10.1167/iovs.08-2743
53 https://doi.org/10.1242/dev.00436
54 https://doi.org/10.1242/dev.01240
55 https://doi.org/10.1242/dev.01663
56 https://doi.org/10.1242/dev.02341
57 https://doi.org/10.1681/asn.2006020181
58 https://doi.org/10.2144/01301st03
59 schema:datePublished 2012-02
60 schema:datePublishedReg 2012-02-01
61 schema:description Sorting nexins (SNXs) are phosphoinositide-binding proteins implicated in the sorting of various membrane proteins in vitro, but the in vivo functions of them remain largely unknown. We reported previously that SNX10 is a unique member of the SNX family genes in that it has vacuolation activity in cells. We investigate the biological function of SNX10 by loss-of-function assay in this study and demonstrate that SNX10 is required for the formation of primary cilia in cultured cells. In zebrafish, SNX10 is involved in ciliogenesis in the Kupffer's vesicle and essential for left-right patterning of visceral organs. Mechanistically, SNX10 interacts with V-ATPase complex and targets it to the centrosome where ciliogenesis is initiated. Like SNX10, V-ATPase regulates ciliogenesis in vitro and in vivo and does so synergistically with SNX10. We further discover that SNX10 and V-ATPase regulate the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. These results identify an SNX10/V-ATPase-regulated vesicular trafficking pathway that is crucial for ciliogenesis, and reveal that SNX10/V-ATPase, through the regulation of cilia formation in various organs, play an essential role during early embryonic development.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N8816d7315ecd4ad3a538e9a169df6c35
66 Nfef07e5ab58c48ddbd2bff37cab9ddf9
67 sg:journal.1107753
68 schema:name A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo
69 schema:pagination cr2011134
70 schema:productId N28b663e08d7549d5af53d0dd7ff6fb93
71 N34b5bdf150a5482c895b13cc27775615
72 N3be6caec934c4db69020cd5c2dae0d01
73 Na0afce5fca6d4ab9a5f98ba84c0e42d0
74 Nf13ae8d06de24f36af591b25b2e9f8d2
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018147382
76 https://doi.org/10.1038/cr.2011.134
77 schema:sdDatePublished 2019-04-11T01:46
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N3fb8dbe97f1041b88d3f438e58255d38
80 schema:url http://www.nature.com/articles/cr2011134
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0db718f090aa4570a2f4ba9a9da59ef9 rdf:first N65b53a6e98c141a28a429e82b0bddaea
85 rdf:rest N2652139ca3e649d7ae46ac836c9a2975
86 N136023ee212a475891e148be37b67298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Body Patterning
88 rdf:type schema:DefinedTerm
89 N2652139ca3e649d7ae46ac836c9a2975 rdf:first sg:person.0711164161.76
90 rdf:rest N69318ed0a5ad4a349564d160b3b96e4a
91 N2802ac436aa74fe9a9b942b732f32adb rdf:first N9f7485a2012f48c7ba3b47b2cf41c4e3
92 rdf:rest N97df852b03384228bad3dc815202d710
93 N2864ffa8a2b44918899982d1ac945f1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Zebrafish
95 rdf:type schema:DefinedTerm
96 N28b663e08d7549d5af53d0dd7ff6fb93 schema:name pubmed_id
97 schema:value 21844891
98 rdf:type schema:PropertyValue
99 N2b99f24fc39643e893c83184c8c15660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cilia
101 rdf:type schema:DefinedTerm
102 N32b2ef93953a4665a17c5ae77efe6a72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Centrosome
104 rdf:type schema:DefinedTerm
105 N34b5bdf150a5482c895b13cc27775615 schema:name readcube_id
106 schema:value 5677489e02e9b49b95d5e1d1de4091832e4e4786893d5fba954ce9f99987d2a4
107 rdf:type schema:PropertyValue
108 N3633cfd35c7b44cd8d12a9dfa303fcd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name RNA Interference
110 rdf:type schema:DefinedTerm
111 N3a22cd4612a14bb69cfa55a097100dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Vacuolar Proton-Translocating ATPases
113 rdf:type schema:DefinedTerm
114 N3be6caec934c4db69020cd5c2dae0d01 schema:name dimensions_id
115 schema:value pub.1018147382
116 rdf:type schema:PropertyValue
117 N3fb8dbe97f1041b88d3f438e58255d38 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N3fccf8c203314532a2a4bdc6b4d73389 rdf:first sg:person.01001202623.54
120 rdf:rest Ndacbd9ba16bf4992b442672d3a06790c
121 N49eca180b9f4495dbff1104618003c13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Zebrafish Proteins
123 rdf:type schema:DefinedTerm
124 N56f968c59fe04107a8031042266518ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N65b53a6e98c141a28a429e82b0bddaea schema:affiliation https://www.grid.ac/institutes/grid.59053.3a
128 schema:familyName Chen
129 schema:givenName Yanqun
130 rdf:type schema:Person
131 N69318ed0a5ad4a349564d160b3b96e4a rdf:first sg:person.0757277361.23
132 rdf:rest N3fccf8c203314532a2a4bdc6b4d73389
133 N72f06592e4bf43559888d9307b609712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Line, Tumor
135 rdf:type schema:DefinedTerm
136 N72f7dc159eaa430e8a97b34c626230bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 N81a506529422487f8fbab9a4776c846b rdf:first sg:person.01207754361.17
140 rdf:rest N2802ac436aa74fe9a9b942b732f32adb
141 N8377362de0fd48ccb8e22e6909291299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Morphogenesis
143 rdf:type schema:DefinedTerm
144 N87136e9592094c888521db8a664258c3 rdf:first sg:person.01141641161.46
145 rdf:rest N81a506529422487f8fbab9a4776c846b
146 N8816d7315ecd4ad3a538e9a169df6c35 schema:issueNumber 2
147 rdf:type schema:PublicationIssue
148 N92c5555b73e643f0b80d3fc556f6e8c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Sorting Nexins
150 rdf:type schema:DefinedTerm
151 N9471245953844d53a46efc21369e88b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Embryonic Development
153 rdf:type schema:DefinedTerm
154 N97df852b03384228bad3dc815202d710 rdf:first sg:person.0672442776.26
155 rdf:rest Ne1c939af3c6e48c0a86088470723b0d8
156 N9f7485a2012f48c7ba3b47b2cf41c4e3 schema:affiliation https://www.grid.ac/institutes/grid.256111.0
157 schema:familyName Shi
158 schema:givenName Dawei
159 rdf:type schema:Person
160 Na0afce5fca6d4ab9a5f98ba84c0e42d0 schema:name nlm_unique_id
161 schema:value 9425763
162 rdf:type schema:PropertyValue
163 Naa563af67c2843c99976a505e572b381 rdf:first sg:person.0601102121.04
164 rdf:rest Ne57b3e88b57146af94ce037ee5152c8c
165 Nb6e031edfa244a39bd0fbb7810f96ab3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Protein Binding
167 rdf:type schema:DefinedTerm
168 Nd7ee77c243e34d6cbde7a62099efe0bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Vacuoles
170 rdf:type schema:DefinedTerm
171 Ndacbd9ba16bf4992b442672d3a06790c rdf:first sg:person.01073525761.41
172 rdf:rest N87136e9592094c888521db8a664258c3
173 Ne1c939af3c6e48c0a86088470723b0d8 rdf:first sg:person.011413572257.58
174 rdf:rest Naa563af67c2843c99976a505e572b381
175 Ne57b3e88b57146af94ce037ee5152c8c rdf:first sg:person.01261314332.39
176 rdf:rest rdf:nil
177 Nf13ae8d06de24f36af591b25b2e9f8d2 schema:name doi
178 schema:value 10.1038/cr.2011.134
179 rdf:type schema:PropertyValue
180 Nf76b10efc45848e18b92dfeff8c585f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name rab GTP-Binding Proteins
182 rdf:type schema:DefinedTerm
183 Nf867e51500fe44eea50bb5c10fd64eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name RNA, Small Interfering
185 rdf:type schema:DefinedTerm
186 Nfef07e5ab58c48ddbd2bff37cab9ddf9 schema:volumeNumber 22
187 rdf:type schema:PublicationVolume
188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
189 schema:name Biological Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biochemistry and Cell Biology
193 rdf:type schema:DefinedTerm
194 sg:grant.4906880 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.134
195 rdf:type schema:MonetaryGrant
196 sg:grant.4926888 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.134
197 rdf:type schema:MonetaryGrant
198 sg:grant.4951899 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.134
199 rdf:type schema:MonetaryGrant
200 sg:grant.4956245 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.134
201 rdf:type schema:MonetaryGrant
202 sg:journal.1107753 schema:issn 1001-0602
203 1748-7838
204 schema:name Cell Research
205 rdf:type schema:Periodical
206 sg:person.01001202623.54 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
207 schema:familyName Li
208 schema:givenName Huapeng
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001202623.54
210 rdf:type schema:Person
211 sg:person.01073525761.41 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
212 schema:familyName Xia
213 schema:givenName Jianhong
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073525761.41
215 rdf:type schema:Person
216 sg:person.011413572257.58 schema:affiliation https://www.grid.ac/institutes/grid.11135.37
217 schema:familyName Lin
218 schema:givenName Shuo
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413572257.58
220 rdf:type schema:Person
221 sg:person.01141641161.46 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
222 schema:familyName Yin
223 schema:givenName Wenguang
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141641161.46
225 rdf:type schema:Person
226 sg:person.01207754361.17 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
227 schema:familyName Li
228 schema:givenName Zhuo
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207754361.17
230 rdf:type schema:Person
231 sg:person.01261314332.39 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
232 schema:familyName Pei
233 schema:givenName Duanqing
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261314332.39
235 rdf:type schema:Person
236 sg:person.0601102121.04 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
237 schema:familyName Shu
238 schema:givenName Xiaodong
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601102121.04
240 rdf:type schema:Person
241 sg:person.0672442776.26 schema:affiliation https://www.grid.ac/institutes/grid.11135.37
242 schema:familyName Li
243 schema:givenName Song
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672442776.26
245 rdf:type schema:Person
246 sg:person.0711164161.76 schema:affiliation https://www.grid.ac/institutes/grid.59053.3a
247 schema:familyName Wu
248 schema:givenName Bin
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711164161.76
250 rdf:type schema:Person
251 sg:person.0757277361.23 schema:affiliation https://www.grid.ac/institutes/grid.428926.3
252 schema:familyName Xu
253 schema:givenName Liangliang
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757277361.23
255 rdf:type schema:Person
256 sg:pub.10.1007/s10517-008-0030-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000842087
257 https://doi.org/10.1007/s10517-008-0030-9
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s13238-011-1004-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002164563
260 https://doi.org/10.1007/s13238-011-1004-7
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/418037a schema:sameAs https://app.dimensions.ai/details/publication/pub.1021745988
263 https://doi.org/10.1038/418037a
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature08895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016398543
266 https://doi.org/10.1038/nature08895
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ncb1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045774050
269 https://doi.org/10.1038/ncb1706
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/ncb1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052535970
272 https://doi.org/10.1038/ncb1966
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nrm2272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028478435
275 https://doi.org/10.1038/nrm2272
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nrm2278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053367126
278 https://doi.org/10.1038/nrm2278
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nrm2427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000993219
281 https://doi.org/10.1038/nrm2427
282 rdf:type schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1083343186 schema:CreativeWork
284 https://doi.org/10.1002/dvdy.21521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034961020
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.bbalip.2006.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003373973
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.ceb.2008.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046898802
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.cell.2007.03.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048069636
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.cell.2007.06.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015791990
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.cell.2009.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047736653
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.conb.2008.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035264117
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.devcel.2008.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026353370
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.tcb.2009.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008276542
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1073/pnas.0607974103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041929911
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m608884200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049194929
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1083/jcb.135.4.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038164437
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1083/jcb.15.2.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001806407
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1083/jcb.200703047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021780932
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1091/mbc.e02-03-0145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026676750
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/hmg/ddn277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036876979
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.1124534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036983994
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.272.5264.1008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553006
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/mcb.01044-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022499126
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1146/annurev.genet.39.073003.105049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030823753
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.physiol.69.040705.141236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025273003
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1167/iovs.08-2743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000088548
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1242/dev.00436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036565472
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1242/dev.01240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026157995
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1242/dev.01663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007238621
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1242/dev.02341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016764389
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1681/asn.2006020181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047777643
337 rdf:type schema:CreativeWork
338 https://doi.org/10.2144/01301st03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074763446
339 rdf:type schema:CreativeWork
340 https://www.grid.ac/institutes/grid.11135.37 schema:alternateName Peking University
341 schema:name Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, Guangdong 518055, China
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.256111.0 schema:alternateName Fujian Agriculture and Forestry University
344 schema:name CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China
345 School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.428926.3 schema:alternateName Guangzhou Institutes of Biomedicine and Health
348 schema:name CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China
349 rdf:type schema:Organization
350 https://www.grid.ac/institutes/grid.59053.3a schema:alternateName University of Science and Technology of China
351 schema:name CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China
352 School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...