Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-03

AUTHORS

Jian Wang, Yao Song, Yan Zhang, Han Xiao, Qiang Sun, Ning Hou, Shuilong Guo, Youliang Wang, Kaiji Fan, Dawei Zhan, Lagabaiyila Zha, Yang Cao, Zhenhua Li, Xuan Cheng, Youyi Zhang, Xiao Yang

ABSTRACT

Recent studies have begun to reveal critical roles of microRNAs (miRNAs) in the pathogenesis of cardiac hypertrophy and dysfunction. In this study, we tested whether a transforming growth factor-β (TGF-β)-regulated miRNA played a pivotal role in the development of cardiac hypertrophy and heart failure (HF). We observed that miR-27b was upregulated in hearts of cardiomyocyte-specific Smad4 knockout mice, which developed cardiac hypertrophy. In vitro experiments showed that the miR-27b expression could be inhibited by TGF-β1 and that its overexpression promoted hypertrophic cell growth, while the miR-27b suppression led to inhibition of the hypertrophic cell growth caused by phenylephrine (PE) treatment. Furthermore, the analysis of transgenic mice with cardiomyocyte-specific overexpression of miR-27b revealed that miR-27b overexpression was sufficient to induce cardiac hypertrophy and dysfunction. We validated the peroxisome proliferator-activated receptor-γ (PPAR-γ) as a direct target of miR-27b in cardiomyocyte. Consistently, the miR-27b transgenic mice displayed significantly lower levels of PPAR-γ than the control mice. Furthermore, in vivo silencing of miR-27b using a specific antagomir in a pressure-overload-induced mouse model of HF increased cardiac PPAR-γ expression, attenuated cardiac hypertrophy and dysfunction. The results of our study demonstrate that TGF-β1-regulated miR-27b is involved in the regulation of cardiac hypertrophy, and validate miR-27b as an efficient therapeutic target for cardiac diseases. More... »

PAGES

cr2011132

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2011.132

DOI

http://dx.doi.org/10.1038/cr.2011.132

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021510307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21844895


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiomegaly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smad4 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jian", 
        "id": "sg:person.01206612727.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206612727.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Yao", 
        "id": "sg:person.01161222730.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161222730.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yan", 
        "id": "sg:person.01056322711.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056322711.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiao", 
        "givenName": "Han", 
        "id": "sg:person.01351054501.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351054501.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Qiang", 
        "id": "sg:person.0767153502.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767153502.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hou", 
        "givenName": "Ning", 
        "id": "sg:person.01055111325.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055111325.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Shuilong", 
        "id": "sg:person.0635352176.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635352176.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Youliang", 
        "id": "sg:person.0762302267.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762302267.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Kaiji", 
        "id": "sg:person.01313220353.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313220353.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Affiliated Hospital of Chinese PLA General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414889.8", 
          "name": [
            "The First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhan", 
        "givenName": "Dawei", 
        "id": "sg:person.01076530667.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076530667.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zha", 
        "givenName": "Lagabaiyila", 
        "id": "sg:person.01144644067.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144644067.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Yang", 
        "id": "sg:person.01212757267.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212757267.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zhenhua", 
        "id": "sg:person.01261072467.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261072467.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Xuan", 
        "id": "sg:person.01123224525.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123224525.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Youyi", 
        "id": "sg:person.01172354001.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172354001.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Jiao Tong University", 
          "id": "https://www.grid.ac/institutes/grid.16821.3c", 
          "name": [
            "State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China", 
            "Model Organism Division, E-institutes of Shanghai Universities, Shanghai Jiao Tong University, Shanghai 200240, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Xiao", 
        "id": "sg:person.01305566325.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305566325.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001734455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005341571", 
          "https://doi.org/10.1038/nrm1983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005341571", 
          "https://doi.org/10.1038/nrm1983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0811371106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007681304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc4001.097186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007936203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000185833.42544.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008178357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000185833.42544.06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008178357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.814145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009086036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.066399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011870814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0509109102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013447998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(03)00044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014060807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6101(03)00044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014060807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000207919.83894.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014913730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000207919.83894.9d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014913730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016221287", 
          "https://doi.org/10.1038/nm1582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0710228105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016635775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000202804.84885.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017927961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000202804.84885.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017927961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019774382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019774382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0608791103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020189282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.09.098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021339825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.108.823070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022013407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.108.823070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022013407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000257913.42552.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023946827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000257913.42552.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023946827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000257913.42552.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023946827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.24.2863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023974361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024609722", 
          "https://doi.org/10.1038/nrm2297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gene.10029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026929162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m604818200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026966050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028723946", 
          "https://doi.org/10.1038/nature07511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc1002.105225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030347687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032968651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.109.928424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033283826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034279941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034279941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.061170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035835848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.110.964684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036529837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0805038105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037197562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.769984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037391639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.060839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042737131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043367437", 
          "https://doi.org/10.1038/ncb2126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044567185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2007.04876.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049356972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2007.06.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049761405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000179226.34112.6d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053140618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000179226.34112.6d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053140618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053573273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1085242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062455274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00578.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063194191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci14190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063415253"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-03", 
    "datePublishedReg": "2012-03-01", 
    "description": "Recent studies have begun to reveal critical roles of microRNAs (miRNAs) in the pathogenesis of cardiac hypertrophy and dysfunction. In this study, we tested whether a transforming growth factor-\u03b2 (TGF-\u03b2)-regulated miRNA played a pivotal role in the development of cardiac hypertrophy and heart failure (HF). We observed that miR-27b was upregulated in hearts of cardiomyocyte-specific Smad4 knockout mice, which developed cardiac hypertrophy. In vitro experiments showed that the miR-27b expression could be inhibited by TGF-\u03b21 and that its overexpression promoted hypertrophic cell growth, while the miR-27b suppression led to inhibition of the hypertrophic cell growth caused by phenylephrine (PE) treatment. Furthermore, the analysis of transgenic mice with cardiomyocyte-specific overexpression of miR-27b revealed that miR-27b overexpression was sufficient to induce cardiac hypertrophy and dysfunction. We validated the peroxisome proliferator-activated receptor-\u03b3 (PPAR-\u03b3) as a direct target of miR-27b in cardiomyocyte. Consistently, the miR-27b transgenic mice displayed significantly lower levels of PPAR-\u03b3 than the control mice. Furthermore, in vivo silencing of miR-27b using a specific antagomir in a pressure-overload-induced mouse model of HF increased cardiac PPAR-\u03b3 expression, attenuated cardiac hypertrophy and dysfunction. The results of our study demonstrate that TGF-\u03b21-regulated miR-27b is involved in the regulation of cardiac hypertrophy, and validate miR-27b as an efficient therapeutic target for cardiac diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cr.2011.132", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5006520", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4969613", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5072080", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4955789", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6980077", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6979738", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7580457", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1107753", 
        "issn": [
          "1001-0602", 
          "1748-7838"
        ], 
        "name": "Cell Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice", 
    "pagination": "cr2011132", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "667c6af8ad61c20a765b20f99ac18a0e8d993acf018b2bf38ee99f94e691b3cc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21844895"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9425763"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cr.2011.132"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021510307"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cr.2011.132", 
      "https://app.dimensions.ai/details/publication/pub.1021510307"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/cr2011132"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.132'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.132'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.132'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2011.132'


 

This table displays all metadata directly associated to this object as RDF triples.

380 TRIPLES      21 PREDICATES      79 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cr.2011.132 schema:about N0562bc6d73ca4baeb48fa926dac5b93b
2 N744b71d9209c40eeaba8fc9bdb94472d
3 N7d34ba2c4d8942f8ab7c7bc113bf323b
4 N7d578b006714457993b4b831eb24322d
5 N9f341db7e4f642a99446bf377577a3a0
6 Nbd4d98c269ac45c69021c8010934f38c
7 Ncbd4469099a84818b41c57ed5dab90ce
8 Nee187d7fcb394ba484dfe4b249f3b5d0
9 anzsrc-for:11
10 anzsrc-for:1102
11 schema:author Nd170aa418c3f4ddf8e35be3432b93b36
12 schema:citation sg:pub.10.1038/nature07511
13 sg:pub.10.1038/ncb2126
14 sg:pub.10.1038/nm1582
15 sg:pub.10.1038/nrm1983
16 sg:pub.10.1038/nrm2297
17 https://doi.org/10.1002/gene.10029
18 https://doi.org/10.1002/hep.22982
19 https://doi.org/10.1016/j.bbrc.2009.09.098
20 https://doi.org/10.1016/j.cardiores.2007.06.027
21 https://doi.org/10.1016/s1359-6101(03)00044-3
22 https://doi.org/10.1073/pnas.0509109102
23 https://doi.org/10.1073/pnas.0608791103
24 https://doi.org/10.1073/pnas.0710228105
25 https://doi.org/10.1073/pnas.0805038105
26 https://doi.org/10.1073/pnas.0811371106
27 https://doi.org/10.1074/jbc.m109.066399
28 https://doi.org/10.1074/jbc.m604818200
29 https://doi.org/10.1093/cvr/cvq264
30 https://doi.org/10.1093/nar/gkn032
31 https://doi.org/10.1111/j.1440-1681.2007.04876.x
32 https://doi.org/10.1126/science.1085242
33 https://doi.org/10.1126/science.1139089
34 https://doi.org/10.1152/ajpheart.00578.2001
35 https://doi.org/10.1158/0008-5472.can-06-0507
36 https://doi.org/10.1161/01.cir.101.24.2863
37 https://doi.org/10.1161/01.res.0000179226.34112.6d
38 https://doi.org/10.1161/01.res.0000185833.42544.06
39 https://doi.org/10.1161/01.res.0000202804.84885.d0
40 https://doi.org/10.1161/01.res.0000207919.83894.9d
41 https://doi.org/10.1161/01.res.0000257913.42552.23
42 https://doi.org/10.1161/circheartfailure.108.823070
43 https://doi.org/10.1161/circresaha.109.200451
44 https://doi.org/10.1161/circulationaha.108.769984
45 https://doi.org/10.1161/circulationaha.108.814145
46 https://doi.org/10.1161/circulationaha.109.928424
47 https://doi.org/10.1161/circulationaha.110.964684
48 https://doi.org/10.1161/hc1002.105225
49 https://doi.org/10.1161/hc4001.097186
50 https://doi.org/10.1172/jci14190
51 https://doi.org/10.1172/jci36154
52 https://doi.org/10.2353/ajpath.2007.060839
53 https://doi.org/10.2353/ajpath.2007.061170
54 schema:datePublished 2012-03
55 schema:datePublishedReg 2012-03-01
56 schema:description Recent studies have begun to reveal critical roles of microRNAs (miRNAs) in the pathogenesis of cardiac hypertrophy and dysfunction. In this study, we tested whether a transforming growth factor-β (TGF-β)-regulated miRNA played a pivotal role in the development of cardiac hypertrophy and heart failure (HF). We observed that miR-27b was upregulated in hearts of cardiomyocyte-specific Smad4 knockout mice, which developed cardiac hypertrophy. In vitro experiments showed that the miR-27b expression could be inhibited by TGF-β1 and that its overexpression promoted hypertrophic cell growth, while the miR-27b suppression led to inhibition of the hypertrophic cell growth caused by phenylephrine (PE) treatment. Furthermore, the analysis of transgenic mice with cardiomyocyte-specific overexpression of miR-27b revealed that miR-27b overexpression was sufficient to induce cardiac hypertrophy and dysfunction. We validated the peroxisome proliferator-activated receptor-γ (PPAR-γ) as a direct target of miR-27b in cardiomyocyte. Consistently, the miR-27b transgenic mice displayed significantly lower levels of PPAR-γ than the control mice. Furthermore, in vivo silencing of miR-27b using a specific antagomir in a pressure-overload-induced mouse model of HF increased cardiac PPAR-γ expression, attenuated cardiac hypertrophy and dysfunction. The results of our study demonstrate that TGF-β1-regulated miR-27b is involved in the regulation of cardiac hypertrophy, and validate miR-27b as an efficient therapeutic target for cardiac diseases.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N6cbf6e8a7fa04a55b9fe52d442f4c415
61 N7784dae949b74b879d2d2cbf99b871d4
62 sg:journal.1107753
63 schema:name Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice
64 schema:pagination cr2011132
65 schema:productId N19307ea98b9d4619b8098a338e71e76f
66 N710290a00868413285c42b6730f77850
67 N7c6b4d8ac5df456ea92e209d27310ad0
68 Nc8138ec476274617a5e5cfe82bc595d5
69 Nd6ec95ac7852499e928a0bf34f90c755
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021510307
71 https://doi.org/10.1038/cr.2011.132
72 schema:sdDatePublished 2019-04-10T20:34
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Ne76b667cab1b4725ba52778ebdf0ab75
75 schema:url http://www.nature.com/articles/cr2011132
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N03260efa0b5f4f4284b4232d2eeeaafa schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
80 rdf:type schema:Organization
81 N0562bc6d73ca4baeb48fa926dac5b93b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Mice, Transgenic
83 rdf:type schema:DefinedTerm
84 N10ef2ba7ac5a407d8683b0dad62f84f4 rdf:first sg:person.01313220353.92
85 rdf:rest N126ca8322b7b453c90b9f0a46e8615a7
86 N126ca8322b7b453c90b9f0a46e8615a7 rdf:first sg:person.01076530667.03
87 rdf:rest N768a259a3fb542ceb60ffd6decc3a05e
88 N19307ea98b9d4619b8098a338e71e76f schema:name nlm_unique_id
89 schema:value 9425763
90 rdf:type schema:PropertyValue
91 N393b24e2bb19433db73d02ea87b2d7dc schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
92 rdf:type schema:Organization
93 N3bcb05fb41aa4aa2b34a7cc9619d41d9 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
94 rdf:type schema:Organization
95 N3e594a2d345f48a4a2ac7fc58ba2c35d rdf:first sg:person.01172354001.01
96 rdf:rest Ne29562e988b248f791746cf01d80094d
97 N4da4a337a2d74891a2b06ee5619b1a9b schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
98 rdf:type schema:Organization
99 N4e110bde270a4955a4c1ff7b5223d4f7 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
100 rdf:type schema:Organization
101 N4fb8f208158a4ae18070c0d9ef756bc2 rdf:first sg:person.0767153502.74
102 rdf:rest N90617d647ad5457d8c38918bd66c03ca
103 N50f15c942e424cc7abe4d6247f937732 rdf:first sg:person.0635352176.72
104 rdf:rest Nccf5523b3f58430085fd3ee45f837c04
105 N56693a1dca2045958d110f6a44780a63 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
106 rdf:type schema:Organization
107 N59e95204062b4acb9c7d594102761bf8 rdf:first sg:person.01351054501.23
108 rdf:rest N4fb8f208158a4ae18070c0d9ef756bc2
109 N608abc112bc240ae812395b919ee2480 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
110 rdf:type schema:Organization
111 N6cbf6e8a7fa04a55b9fe52d442f4c415 schema:issueNumber 3
112 rdf:type schema:PublicationIssue
113 N707c589d7f8d4396a512408d9e49364a schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
114 rdf:type schema:Organization
115 N710290a00868413285c42b6730f77850 schema:name dimensions_id
116 schema:value pub.1021510307
117 rdf:type schema:PropertyValue
118 N744b71d9209c40eeaba8fc9bdb94472d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N768a259a3fb542ceb60ffd6decc3a05e rdf:first sg:person.01144644067.18
122 rdf:rest Nbdc3917651b645cb982fd6de5888ceb1
123 N7784dae949b74b879d2d2cbf99b871d4 schema:volumeNumber 22
124 rdf:type schema:PublicationVolume
125 N7c6b4d8ac5df456ea92e209d27310ad0 schema:name doi
126 schema:value 10.1038/cr.2011.132
127 rdf:type schema:PropertyValue
128 N7d34ba2c4d8942f8ab7c7bc113bf323b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name MicroRNAs
130 rdf:type schema:DefinedTerm
131 N7d578b006714457993b4b831eb24322d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Myocytes, Cardiac
133 rdf:type schema:DefinedTerm
134 N84145becebed45078b62e31eab63c89c rdf:first sg:person.01161222730.85
135 rdf:rest Nec0db6f6081746528718be5a7586f893
136 N8d76b92da42e4323913b9128f5bc5ddc schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
137 rdf:type schema:Organization
138 N90617d647ad5457d8c38918bd66c03ca rdf:first sg:person.01055111325.34
139 rdf:rest N50f15c942e424cc7abe4d6247f937732
140 N9f341db7e4f642a99446bf377577a3a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Transforming Growth Factor beta
142 rdf:type schema:DefinedTerm
143 Nb1d74473bb8549328fdff7bf476b06d2 rdf:first sg:person.01123224525.34
144 rdf:rest N3e594a2d345f48a4a2ac7fc58ba2c35d
145 Nbd4d98c269ac45c69021c8010934f38c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cardiomegaly
147 rdf:type schema:DefinedTerm
148 Nbdc3917651b645cb982fd6de5888ceb1 rdf:first sg:person.01212757267.73
149 rdf:rest Nf8ea649c29104cca872414c8c1d2ab0a
150 Nc8138ec476274617a5e5cfe82bc595d5 schema:name pubmed_id
151 schema:value 21844895
152 rdf:type schema:PropertyValue
153 Ncbd4469099a84818b41c57ed5dab90ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Smad4 Protein
155 rdf:type schema:DefinedTerm
156 Nccf5523b3f58430085fd3ee45f837c04 rdf:first sg:person.0762302267.88
157 rdf:rest N10ef2ba7ac5a407d8683b0dad62f84f4
158 Nd170aa418c3f4ddf8e35be3432b93b36 rdf:first sg:person.01206612727.26
159 rdf:rest N84145becebed45078b62e31eab63c89c
160 Nd6ec95ac7852499e928a0bf34f90c755 schema:name readcube_id
161 schema:value 667c6af8ad61c20a765b20f99ac18a0e8d993acf018b2bf38ee99f94e691b3cc
162 rdf:type schema:PropertyValue
163 Nddaedf62e2c24cfb9eb519c638df9103 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
164 rdf:type schema:Organization
165 Ne29562e988b248f791746cf01d80094d rdf:first sg:person.01305566325.24
166 rdf:rest rdf:nil
167 Ne76b667cab1b4725ba52778ebdf0ab75 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 Nea610a210d3142c4ac8248b227209b68 schema:name State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
170 rdf:type schema:Organization
171 Nec0db6f6081746528718be5a7586f893 rdf:first sg:person.01056322711.85
172 rdf:rest N59e95204062b4acb9c7d594102761bf8
173 Nee187d7fcb394ba484dfe4b249f3b5d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice
175 rdf:type schema:DefinedTerm
176 Nf8ea649c29104cca872414c8c1d2ab0a rdf:first sg:person.01261072467.03
177 rdf:rest Nb1d74473bb8549328fdff7bf476b06d2
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
182 schema:name Cardiorespiratory Medicine and Haematology
183 rdf:type schema:DefinedTerm
184 sg:grant.4955789 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
185 rdf:type schema:MonetaryGrant
186 sg:grant.4969613 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
187 rdf:type schema:MonetaryGrant
188 sg:grant.5006520 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
189 rdf:type schema:MonetaryGrant
190 sg:grant.5072080 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
191 rdf:type schema:MonetaryGrant
192 sg:grant.6979738 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
193 rdf:type schema:MonetaryGrant
194 sg:grant.6980077 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
195 rdf:type schema:MonetaryGrant
196 sg:grant.7580457 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2011.132
197 rdf:type schema:MonetaryGrant
198 sg:journal.1107753 schema:issn 1001-0602
199 1748-7838
200 schema:name Cell Research
201 rdf:type schema:Periodical
202 sg:person.01055111325.34 schema:affiliation N4da4a337a2d74891a2b06ee5619b1a9b
203 schema:familyName Hou
204 schema:givenName Ning
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055111325.34
206 rdf:type schema:Person
207 sg:person.01056322711.85 schema:affiliation N03260efa0b5f4f4284b4232d2eeeaafa
208 schema:familyName Zhang
209 schema:givenName Yan
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056322711.85
211 rdf:type schema:Person
212 sg:person.01076530667.03 schema:affiliation https://www.grid.ac/institutes/grid.414889.8
213 schema:familyName Zhan
214 schema:givenName Dawei
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076530667.03
216 rdf:type schema:Person
217 sg:person.01123224525.34 schema:affiliation Nddaedf62e2c24cfb9eb519c638df9103
218 schema:familyName Cheng
219 schema:givenName Xuan
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123224525.34
221 rdf:type schema:Person
222 sg:person.01144644067.18 schema:affiliation N8d76b92da42e4323913b9128f5bc5ddc
223 schema:familyName Zha
224 schema:givenName Lagabaiyila
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144644067.18
226 rdf:type schema:Person
227 sg:person.01161222730.85 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
228 schema:familyName Song
229 schema:givenName Yao
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161222730.85
231 rdf:type schema:Person
232 sg:person.01172354001.01 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
233 schema:familyName Zhang
234 schema:givenName Youyi
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172354001.01
236 rdf:type schema:Person
237 sg:person.01206612727.26 schema:affiliation N393b24e2bb19433db73d02ea87b2d7dc
238 schema:familyName Wang
239 schema:givenName Jian
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206612727.26
241 rdf:type schema:Person
242 sg:person.01212757267.73 schema:affiliation N56693a1dca2045958d110f6a44780a63
243 schema:familyName Cao
244 schema:givenName Yang
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212757267.73
246 rdf:type schema:Person
247 sg:person.01261072467.03 schema:affiliation N608abc112bc240ae812395b919ee2480
248 schema:familyName Li
249 schema:givenName Zhenhua
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261072467.03
251 rdf:type schema:Person
252 sg:person.01305566325.24 schema:affiliation https://www.grid.ac/institutes/grid.16821.3c
253 schema:familyName Yang
254 schema:givenName Xiao
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305566325.24
256 rdf:type schema:Person
257 sg:person.01313220353.92 schema:affiliation N3bcb05fb41aa4aa2b34a7cc9619d41d9
258 schema:familyName Fan
259 schema:givenName Kaiji
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313220353.92
261 rdf:type schema:Person
262 sg:person.01351054501.23 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
263 schema:familyName Xiao
264 schema:givenName Han
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351054501.23
266 rdf:type schema:Person
267 sg:person.0635352176.72 schema:affiliation N707c589d7f8d4396a512408d9e49364a
268 schema:familyName Guo
269 schema:givenName Shuilong
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635352176.72
271 rdf:type schema:Person
272 sg:person.0762302267.88 schema:affiliation N4e110bde270a4955a4c1ff7b5223d4f7
273 schema:familyName Wang
274 schema:givenName Youliang
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762302267.88
276 rdf:type schema:Person
277 sg:person.0767153502.74 schema:affiliation Nea610a210d3142c4ac8248b227209b68
278 schema:familyName Sun
279 schema:givenName Qiang
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767153502.74
281 rdf:type schema:Person
282 sg:pub.10.1038/nature07511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028723946
283 https://doi.org/10.1038/nature07511
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/ncb2126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043367437
286 https://doi.org/10.1038/ncb2126
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nm1582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016221287
289 https://doi.org/10.1038/nm1582
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrm1983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005341571
292 https://doi.org/10.1038/nrm1983
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrm2297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024609722
295 https://doi.org/10.1038/nrm2297
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/gene.10029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026929162
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/hep.22982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053573273
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.bbrc.2009.09.098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021339825
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.cardiores.2007.06.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049761405
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s1359-6101(03)00044-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014060807
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.0509109102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013447998
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.0608791103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020189282
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.0710228105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016635775
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.0805038105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037197562
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.0811371106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007681304
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m109.066399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011870814
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.m604818200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026966050
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/cvr/cvq264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044567185
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/nar/gkn032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032968651
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1440-1681.2007.04876.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049356972
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1085242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448182
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.1139089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455274
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1152/ajpheart.00578.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063194191
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/0008-5472.can-06-0507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001734455
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1161/01.cir.101.24.2863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023974361
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1161/01.res.0000179226.34112.6d schema:sameAs https://app.dimensions.ai/details/publication/pub.1053140618
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/01.res.0000185833.42544.06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008178357
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1161/01.res.0000202804.84885.d0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017927961
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1161/01.res.0000207919.83894.9d schema:sameAs https://app.dimensions.ai/details/publication/pub.1014913730
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1161/01.res.0000257913.42552.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023946827
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1161/circheartfailure.108.823070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022013407
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1161/circresaha.109.200451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034279941
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1161/circulationaha.108.769984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037391639
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1161/circulationaha.108.814145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009086036
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1161/circulationaha.109.928424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033283826
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1161/circulationaha.110.964684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036529837
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1161/hc1002.105225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030347687
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1161/hc4001.097186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007936203
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1172/jci14190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063415253
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1172/jci36154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019774382
366 rdf:type schema:CreativeWork
367 https://doi.org/10.2353/ajpath.2007.060839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042737131
368 rdf:type schema:CreativeWork
369 https://doi.org/10.2353/ajpath.2007.061170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035835848
370 rdf:type schema:CreativeWork
371 https://www.grid.ac/institutes/grid.16821.3c schema:alternateName Shanghai Jiao Tong University
372 schema:name Model Organism Division, E-institutes of Shanghai Universities, Shanghai Jiao Tong University, Shanghai 200240, China
373 State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, China
374 rdf:type schema:Organization
375 https://www.grid.ac/institutes/grid.414889.8 schema:alternateName First Affiliated Hospital of Chinese PLA General Hospital
376 schema:name The First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.419897.a schema:alternateName Ministry of Education of the People's Republic of China
379 schema:name Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing 100191, China
380 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...