Overlapping expression of microRNAs in human embryonic colon and colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Mariano Monzo, Alfons Navarro, Eva Bandres, Rosa Artells, Isabel Moreno, Bernat Gel, Rafael Ibeas, Jose Moreno, Francisco Martinez, Tania Diaz, Antonio Martinez, Olga Balagué, Jesus Garcia-Foncillas

ABSTRACT

MicroRNAs (miRNAs) are essential for regulating cell differentiation and maintaining the pluripotent state of stem cells. Although dysregulation of specific miRNAs has been associated with certain types of cancer, to date no evidence has linked miRNA expression in embryonic and tumor tissues. We assessed the expression of mature miRNAs in human embryonic colon tissue, and in colorectal cancer and paired normal colon tissue. Overlapping miRNA expression was detected between embryonic colonic mucosa and colorectal cancer. We have found that the miR-17-92 cluster and its target, E2F1, exhibit a similar pattern of expression in human colon development and colonic carcinogenesis, regulating cell proliferation in both cases. In situ hybridization confirmed the high level of expression of miR-17-5p in the crypt progenitor compartment. We conclude that miRNA pathways play a major role in both embryonic development and neoplastic transformation of the colonic epithelium. More... »

PAGES

cr200881

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2008.81

DOI

http://dx.doi.org/10.1038/cr.2008.81

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003277282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18607389


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2008.81'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2008.81'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2008.81'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2008.81'


 

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