TGF-β signaling in vascular biology and dysfunction View Full Text


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Article Info

DATE

2008-12-30

AUTHORS

Marie-José Goumans, Zhen Liu, Peter ten Dijke

ABSTRACT

Transforming growth factor (TGF)-β family members are multifunctional cytokines that elicit their effects on cells, including endothelial and mural cells, via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knock-out mouse models for TGF-β family signaling pathway components have revealed their critical importance in proper yolk sac angiogenesis. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular syndromes such as hereditary hemorrhagic telangiectasia, primary pulmonary hypertension and Marfan syndrome. In this review, we present recent advances in our understanding of the role of TGF-β receptor signaling in vascular biology and disease, and discuss how this may be applied for therapy. More... »

PAGES

116-127

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2008.326

    DOI

    http://dx.doi.org/10.1038/cr.2008.326

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053181335

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19114994


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