STAT3 as a target for inducing apoptosis in solid and hematological tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-01-29

AUTHORS

Khandaker Al Zaid Siddiquee, James Turkson

ABSTRACT

Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented. More... »

PAGES

254-267

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2008.18

    DOI

    http://dx.doi.org/10.1038/cr.2008.18

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008695398

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18227858


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