Homologous recombination in DNA repair and DNA damage tolerance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-01

AUTHORS

Xuan Li, Wolf-Dietrich Heyer

ABSTRACT

Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition, recombination provides critical support for DNA replication in the recovery of stalled or broken replication forks, contributing to tolerance of DNA damage. A central core of proteins, most critically the RecA homolog Rad51, catalyzes the key reactions that typify HR: homology search and DNA strand invasion. The diverse functions of recombination are reflected in the need for context-specific factors that perform supplemental functions in conjunction with the core proteins. The inability to properly repair complex DNA damage and resolve DNA replication stress leads to genomic instability and contributes to cancer etiology. Mutations in the BRCA2 recombination gene cause predisposition to breast and ovarian cancer as well as Fanconi anemia, a cancer predisposition syndrome characterized by a defect in the repair of DNA interstrand crosslinks. The cellular functions of recombination are also germane to DNA-based treatment modalities of cancer, which target replicating cells by the direct or indirect induction of DNA lesions that are substrates for recombination pathways. This review focuses on mechanistic aspects of HR relating to DSB and ICL repair as well as replication fork support. More... »

PAGES

cr20081

References to SciGraph publications

  • 2007-05. Homology-driven chromatin remodeling by human RAD54 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-06. Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-02. The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction in NATURE
  • 2003-12. The Bloom's syndrome helicase suppresses crossing over during homologous recombination in NATURE
  • 2004-10. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 in NATURE
  • 2005-09. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M in NATURE GENETICS
  • 2005-09. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-04. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 in NATURE
  • 2002-11. Insights into DNA recombination from the structure of a RAD51–BRCA2 complex in NATURE
  • 1998-01. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A in NATURE
  • 2002-09. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO in NATURE
  • 2003-09. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation in NATURE
  • 2006-10. Mechanism of homologous recombination: mediators and helicases take on regulatory functions in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2005-03. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair in NATURE
  • 2007-08. Rad54 dissociates homologous recombination intermediates by branch migration in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2003-03. Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51–ssDNA nucleoprotein filament in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2000-06. Frequent chromosomal translocations induced by DNA double-strand breaks in NATURE
  • 2007-06. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-08. Rad54 protein promotes branch migration of Holliday junctions in NATURE
  • 1998-05. Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins in NATURE
  • 2005-07. SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase in NATURE
  • 2003-03. RecQ helicases: caretakers of the genome in NATURE REVIEWS CANCER
  • 2000-06. MUS81 encodes a novel Helix-hairpin-Helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae in MOLECULAR GENETICS AND GENOMICS
  • 2007-08. Break-induced replication and telomerase-independent telomere maintenance require Pol32 in NATURE
  • 2007-02. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 in NATURE GENETICS
  • 2007-02. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer in NATURE GENETICS
  • 2003-05. DNA helicase Srs2 disrupts the Rad51 presynaptic filament in NATURE
  • 2003-06. Molecular views of recombination proteins and their control in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-07. Antitumour drugs impede DNA uncoiling by topoisomerase I in NATURE
  • 2002-06. Cellular roles of DNA topoisomerases: a molecular perspective in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-08. Crystal structure of a Rad51 filament in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2003-02. BRCA2-dependent and independent formation of RAD51 nuclear foci in ONCOGENE
  • 2000-12. Telomere maintenance by recombination in human cells in NATURE GENETICS
  • 1998-01. Stimulation by Rad52 of yeast Rad51- mediated recombination in NATURE
  • 2001-05. Genome maintenance mechanisms for preventing cancer in NATURE
  • 2002-02. Human Genome and Diseases:¶Double-strand breaks and translocations in cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2006-12. Replisome assembly and the direct restart of stalled replication forks in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-02. Replication fork reactivation downstream of a blocked nascent leading strand in NATURE
  • 2003-05. The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2008.1

    DOI

    http://dx.doi.org/10.1038/cr.2008.1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040825790

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18166982


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