The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Wenwen Xu, TạMinh Hiếu, Subramaniam Malarkannan, Li Wang

ABSTRACT

Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are considered a breakthrough in cancer therapy. Despite the success, the relatively low response rate (20-30%) warrants efforts to identify and overcome additional immune-suppressive pathways. Among the expanding list of T cell inhibitory regulators, V domain immunoglobulin suppressor of T cell activation (VISTA) is a unique B7 family checkpoint that regulates a broad spectrum of immune responses. Here, we summarize recent advances that highlight the structure, expression, and multi-faceted immunomodulatory mechanisms of VISTA in the context of autoimmunity, inflammation, and anti-tumor immunity. More... »

PAGES

438-446

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cmi.2017.148

    DOI

    http://dx.doi.org/10.1038/cmi.2017.148

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100684304

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29375120


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