Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-10

AUTHORS

Haidong Tang, Mingzhao Zhu, Jian Qiao, Yang-Xin Fu

ABSTRACT

Tertiary lymphoid structures (TLS) often develop at sites of persistent inflammation, including cancers and autoimmune diseases. In most cases, the presence of TLS correlates with active immune responses. Because of their proximity to pathological loci, TLS are an intriguing target for the manipulation of immune responses. For several years, it has become clear that lymphotoxin (LT) signalling plays critical roles in lymphoid tissue organogenesis and maintenance. In the current review, we will discuss the role of LT signalling in the development of TLS. With a focus on cancers and autoimmune diseases, we will highlight the correlations between TLS and disease progression. We will also discuss the current efforts and potential directions for manipulating TLS for immunotherapies. More... »

PAGES

809-818

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cmi.2017.13

    DOI

    http://dx.doi.org/10.1038/cmi.2017.13

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084863938

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28413217


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