Current advances in humanized mouse models View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05

AUTHORS

Ryoji Ito, Takeshi Takahashi, Ikumi Katano, Mamoru Ito

ABSTRACT

Humanized mouse models that have received human cells or tissue transplants are extremely useful in basic and applied human disease research. Highly immunodeficient mice, which do not reject xenografts and support cell and tissue differentiation and growth, are indispensable for generating additional appropriate models. Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rγ(null) gene (e.g., NOD/SCID/γc(null) and Rag2(null)γc(null) mice). These strains show not only a high rate of human cell engraftment, but also generate well-differentiated multilineage human hematopoietic cells after human hematopoietic stem cell (HSC) transplantation. These humanized mice facilitate the analysis of human hematology and immunology in vivo. However, human hematopoietic cells developed from HSCs are not always phenotypically and functionally identical to those in humans. More recently, a new series of immunodeficient mice compensates for these disadvantages. These mice were generated by genetically introducing human cytokine genes into NOD/SCID/γc(null) and Rag2(null)γc(null) mice. In this review, we describe the current knowledge of human hematopoietic cells developed in these mice. Various human disease mouse models using these humanized mice are summarized. More... »

PAGES

cmi20122

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cmi.2012.2

    DOI

    http://dx.doi.org/10.1038/cmi.2012.2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040402567

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22327211


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