Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Thanh-Nhan Nguyen-Pham, Mi-Seon Lim, Truc Anh Thi Nguyen, Youn-Kyung Lee, Chun-Ji Jin, Hyun Ju Lee, Cheol Yi Hong, Jae-Sook Ahn, Deok-Hwan Yang, Yeo-Kyeoung Kim, Ik-Joo Chung, Byoung Chul Park, Hyeoung-Joon Kim, Je-Jung Lee

ABSTRACT

The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to negatively regulate DC migration. The goal of this study was to investigate the combinations of TLR agonists and interferons (IFNs) that most effectively regulate CD38 and CD74 expression on DCs. Synergistic TLR agonist stimulation in combination with IFN-α and IFN-γ was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of IL-12p70. An in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability, similar to that observed in cells expressing CD38, CD74 and CCR7. The results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production. More... »

PAGES

cmi20117

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cmi.2011.7

DOI

http://dx.doi.org/10.1038/cmi.2011.7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022184048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21423200


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