Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Thanh-Nhan Nguyen-Pham, Deok-Hwan Yang, Truc-Anh Thi Nguyen, Mi-Seon Lim, Cheol Yi Hong, Mi-Hyun Kim, Hyun Ju Lee, Youn-Kyung Lee, Duck Cho, Soo-Young Bae, Jae-Sook Ahn, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Je-Jung Lee

ABSTRACT

Dendritic cell (DC)-based vaccines continue to be considered an attractive tool for cancer immunotherapy. DCs require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1 (Th1) or Th2 responses. DCs play a role in natural killer (NK) cell activation, and NK cells are also able to activate and induce the maturation of DCs. We investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions occur. DCs that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce IL-12p70. NK cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte responses. Our data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses, which suggests that these cells may be useful for cancer immunotherapy. More... »

PAGES

cmi201123

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cmi.2011.23

DOI

http://dx.doi.org/10.1038/cmi.2011.23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017775712

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21822297


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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cmi.2011.23'


 

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