HLA‐A*31:01 and HLA‐B*15:02 as Genetic Markers for Carbamazepine Hypersensitivity in Children View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Ursula Amstutz, Colin J.D. Ross, Lucila I. Castro-Pastrana, Michael J. Rieder, Neil H. Shear, Michael R. Hayden, Bruce C. Carleton,

ABSTRACT

The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ). Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers for CBZ hypersensitivity in Asian and European patients. To replicate these genetic associations in pediatric patients from North America with a diverse ethnic background, we investigated HLA-A 31:01 and HLA-B 15:02 in 42 children with CBZ hypersensitivity and 91 CBZ-tolerant children from across Canada. HLA-A 31:01 was significantly associated with CBZ-HSS (odds ratio (OR): 26.4, P = 0.0025) and maculopapular exanthema (MPE) (OR: 8.6, P = 0.0037) but not with CBZ-SJS. Conversely, HLA-B 15:02 was associated with CBZ-SJS (OR: 38.6, P = 0.002) but not HSS or MPE. This study is the first to demonstrate the association of HLA-A 31:01 with CBZ hypersensitivity in children, providing important replication of this association and highlighting the importance of HLA-A 31:01 as a predictive biomarker across various ancestries. More... »

PAGES

142-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.2013.55

DOI

http://dx.doi.org/10.1038/clpt.2013.55

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014864454

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23588310


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