Case Definition and Phenotype Standardization in Drug‐Induced Liver Injury View Full Text


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Article Info

DATE

2011-05-04

AUTHORS

GP Aithal, PB Watkins, RJ Andrade, D Larrey, M Molokhia, H Takikawa, CM Hunt, RA Wilke, M Avigan, N Kaplowitz, E Bjornsson, AK Daly

ABSTRACT

Drug-induced liver injury (DILI) is the most frequent reason cited for the withdrawal of approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are being established. In order to gain the maximum scientific benefit from these efforts, the definitions and terminology related to the clinical phenotypes of DILI must be harmonized. For this purpose, an international DILI Expert Working Group of clinicians and scientists reviewed current DILI terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute DILI. Consensus was established with respect to the threshold criteria for definition of a case as being DILI, the pattern of liver injury, causality assessment, severity, and chronicity. Consensus was also reached on approaches to characterizing DILI in the setting of chronic liver diseases, including autoimmune hepatitis (AIH). More... »

PAGES

806-815

References to SciGraph publications

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  • 2007-05-15. Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis in THE PHARMACOGENOMICS JOURNAL
  • 2009-05-31. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin in NATURE GENETICS
  • 2007-05-29. Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991–2006 in ARCHIVES OF VIROLOGY
  • 2010-01-27. Infliximab-related hepatitis: discussion of a case and review of the literature in INTERNAL AND EMERGENCY MEDICINE
  • 2010-06. Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™ in DRUG SAFETY
  • 2009-09-21. Pharmacogenetics of Idiosyncratic Adverse Drug Reactions in ADVERSE DRUG REACTIONS
  • 2010-07-18. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury in NATURE GENETICS
  • 2010-08. Preempting and preventing drug-induced liver injury in NATURE GENETICS
  • 2009-11-03. Autoimmune Hepatitis–PBC Overlap Syndrome: A Simplified Scoring System May Assist in the Diagnosis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-01. Drug-Induced Liver Injury Network (DILIN) Prospective Study in DRUG SAFETY
  • 2011-01-19. The Emerging Role of Electronic Medical Records in Pharmacogenomics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Journal

    TITLE

    Clinical Pharmacology & Therapeutics

    ISSUE

    6

    VOLUME

    89

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/clpt.2011.58

    DOI

    http://dx.doi.org/10.1038/clpt.2011.58

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048980159

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21544079


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