Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

Z Desta, Y Kreutz, A T Nguyen, L Li, T Skaar, L K Kamdem, N L Henry, D F Hayes, A M Storniolo, V Stearns, E Hoffmann, R F Tyndale, D A Flockhart

ABSTRACT

The associations between plasma letrozole concentrations and CYP2A6 and CYP3A5 genetic variants were tested in the Exemestane and Letrozole Pharmacogenomics (ELPH) trial. ELPH is a multicenter, open-label prospective clinical trial in women randomly assigned (n≈250 in each arm) to receive 2 years of treatment with either oral letrozole (2.5 mg/day) or oral exemestane (25 mg/day). CYP2A6 and CYP3A showed effects on letrozole metabolism in vitro. DNA samples were genotyped for variants in the CYP2A6 and CYP3A5 genes. Plasma letrozole concentrations showed high interpatient variability (>10-fold) and were associated significantly with CYP2A6 genotypes (P<0.0001), body mass index (BMI) (P<0.0001), and age (P=0.0035). However, CYP3A5 genotypes showed no association with plasma letrozole concentrations. These data suggest that CYP2A6 is the principal clearance mechanism for letrozole in vivo. CYP2A6 metabolic status, along with BMI and age, may serve as a biomarker of the efficacy of letrozole treatment or a predictor of adverse effects. More... »

PAGES

693-700

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.2011.174

DOI

http://dx.doi.org/10.1038/clpt.2011.174

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049545512

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21975350


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Androstadienes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aryl Hydrocarbon Hydroxylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 CYP2A6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 CYP3A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitriles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacogenetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postmenopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desta", 
        "givenName": "Z", 
        "id": "sg:person.012531261177.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012531261177.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kreutz", 
        "givenName": "Y", 
        "id": "sg:person.0607526245.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607526245.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "A T", 
        "id": "sg:person.01311271015.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311271015.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "L", 
        "id": "sg:person.011674102657.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011674102657.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skaar", 
        "givenName": "T", 
        "id": "sg:person.01327606223.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327606223.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamdem", 
        "givenName": "L K", 
        "id": "sg:person.01105145057.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105145057.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Michigan Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412590.b", 
          "name": [
            "Comprehensive Cancer Center, University of Michigan Health System Department of Internal Medicine and Breast Oncology Program Ann Arbor Michigan USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henry", 
        "givenName": "N L", 
        "id": "sg:person.01042733643.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Michigan Medicine", 
          "id": "https://www.grid.ac/institutes/grid.412590.b", 
          "name": [
            "Comprehensive Cancer Center, University of Michigan Health System Department of Internal Medicine and Breast Oncology Program Ann Arbor Michigan USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayes", 
        "givenName": "D F", 
        "id": "sg:person.015665434432.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015665434432.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Storniolo", 
        "givenName": "A M", 
        "id": "sg:person.01011023657.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011023657.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Department of Oncology Baltimore Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stearns", 
        "givenName": "V", 
        "id": "sg:person.01145244423.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145244423.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto Department of Pharmacology and Toxicology Toronto Ontario Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffmann", 
        "givenName": "E", 
        "id": "sg:person.01065752722.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065752722.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto Department of Pharmacology and Toxicology Toronto Ontario Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tyndale", 
        "givenName": "R F", 
        "id": "sg:person.01027276476.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027276476.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Indiana University Department of Medicine Indianapolis Indiana USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flockhart", 
        "givenName": "D A", 
        "id": "sg:person.011340630414.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011340630414.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/0960327107082224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000884082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0960327107082224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000884082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-009-0935-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004399438", 
          "https://doi.org/10.1007/s00280-009-0935-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-009-0935-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004399438", 
          "https://doi.org/10.1007/s00280-009-0935-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2009.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007173839", 
          "https://doi.org/10.1038/tpj.2009.11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdd.273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012734698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/pgs.09.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013310970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.08.8617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018605357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00498250903171395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018793266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.109.031393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019835905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.clpt.2006.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022765052", 
          "https://doi.org/10.1016/j.clpt.2006.01.008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.01123-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029152883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2010.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029774637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031645888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031645888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-0760(90)90460-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035818288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036118248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2009.19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039222742", 
          "https://doi.org/10.1038/clpt.2009.19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2009.19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039222742", 
          "https://doi.org/10.1038/clpt.2009.19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djg108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046611030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-5221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047774233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047902372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9774-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049384206", 
          "https://doi.org/10.1007/s10549-007-9774-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9774-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049384206", 
          "https://doi.org/10.1007/s10549-007-9774-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.57.1.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051366472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052588989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.3266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052759010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01213011-200503000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060333037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01213011-200503000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060333037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01213011-200503000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060333037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3282f3606e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3282f3606e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3282f3606e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.3.751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075891276", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-11", 
    "datePublishedReg": "2011-11-01", 
    "description": "The associations between plasma letrozole concentrations and CYP2A6 and CYP3A5 genetic variants were tested in the Exemestane and Letrozole Pharmacogenomics (ELPH) trial. ELPH is a multicenter, open-label prospective clinical trial in women randomly assigned (n\u2248250 in each arm) to receive 2 years of treatment with either oral letrozole (2.5 mg/day) or oral exemestane (25 mg/day). CYP2A6 and CYP3A showed effects on letrozole metabolism in vitro. DNA samples were genotyped for variants in the CYP2A6 and CYP3A5 genes. Plasma letrozole concentrations showed high interpatient variability (>10-fold) and were associated significantly with CYP2A6 genotypes (P<0.0001), body mass index (BMI) (P<0.0001), and age (P=0.0035). However, CYP3A5 genotypes showed no association with plasma letrozole concentrations. These data suggest that CYP2A6 is the principal clearance mechanism for letrozole in vivo. CYP2A6 metabolic status, along with BMI and age, may serve as a biomarker of the efficacy of letrozole treatment or a predictor of adverse effects.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/clpt.2011.174", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2689487", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683954", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690863", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2424015", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423963", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519294", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423971", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "90"
      }
    ], 
    "name": "Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age", 
    "pagination": "693-700", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ec05b6f1ba3d28912c821ba157c0ee28b98e5aa06fcf0ed2a17955fb0770e0da"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21975350"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/clpt.2011.174"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049545512"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/clpt.2011.174", 
      "https://app.dimensions.ai/details/publication/pub.1049545512"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000293.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://onlinelibrary.wiley.com/doi/10.1038/clpt.2011.174/abstract"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/clpt.2011.174'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/clpt.2011.174'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/clpt.2011.174'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/clpt.2011.174'


 

This table displays all metadata directly associated to this object as RDF triples.

350 TRIPLES      21 PREDICATES      78 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/clpt.2011.174 schema:about N0135e0bf6cca429bade0fdab05beac36
2 N12d973424d4a4835a46485f5f2c71fcc
3 N156c6b5658f646269f0cf5dbb9733e3b
4 N33459e59b09d49a28bc07634343ff450
5 N4c4bceab61734fd98778af5099197c02
6 N564bbbda69cb4658b8fe9e20e5be911a
7 N63e93faf8b5b4b59a23f75d97576f39c
8 N825946bba67c4d7d825df007af971e7f
9 N8492c20520ce42d481e1c618c87d7dad
10 N8eaea3e61d684d3dae242da209c61203
11 N8f4053845ad14afe8f0993e24a4cc189
12 N9aea26fc187e4f078bf90b11c7cda492
13 Nad551029452c469ead4725f2b571f398
14 Nb34dfbb27fda4d8eb20038bb6255929a
15 Nb8ac8c9894fd4c5084d2de47e83c70e2
16 Nba6560d9054b4081a0a1540857ef5892
17 Nc189a6405eac44d4baee38587032acc0
18 Ncfd3008fa8fa4e828261046491e5c900
19 Neaaa979a02394314946f182f1447a8c3
20 Nedc71243d6ea43e6b1c8b5dd625048a1
21 Nf5081f0d3d634aea8498cd58baf62d81
22 Nfd8f83b1a0d249c181e672d513728524
23 Nff02019d932a422ba9ef8894272f2d49
24 anzsrc-for:11
25 anzsrc-for:1103
26 schema:author N98e063d2e10a470caf246f67f5c09ff2
27 schema:citation sg:pub.10.1007/s00280-009-0935-7
28 sg:pub.10.1007/s10549-007-9774-6
29 sg:pub.10.1016/j.clpt.2006.01.008
30 sg:pub.10.1038/clpt.2009.19
31 sg:pub.10.1038/tpj.2009.11
32 https://app.dimensions.ai/details/publication/pub.1075891276
33 https://doi.org/10.1002/bdd.273
34 https://doi.org/10.1002/cncr.25385
35 https://doi.org/10.1002/humu.20698
36 https://doi.org/10.1016/0960-0760(90)90460-3
37 https://doi.org/10.1016/j.fertnstert.2010.06.008
38 https://doi.org/10.1056/nejmoa052258
39 https://doi.org/10.1093/jnci/djg108
40 https://doi.org/10.1093/jnci/dji005
41 https://doi.org/10.1097/01213011-200503000-00008
42 https://doi.org/10.1097/fpc.0b013e3282f3606e
43 https://doi.org/10.1124/dmd.109.031393
44 https://doi.org/10.1124/pr.57.1.3
45 https://doi.org/10.1128/aac.01123-08
46 https://doi.org/10.1158/1078-0432.ccr-07-5221
47 https://doi.org/10.1177/0960327107082224
48 https://doi.org/10.1200/jco.20.3.751
49 https://doi.org/10.1200/jco.2005.03.3266
50 https://doi.org/10.1200/jco.2006.08.8617
51 https://doi.org/10.2217/pgs.09.144
52 https://doi.org/10.3109/00498250903171395
53 schema:datePublished 2011-11
54 schema:datePublishedReg 2011-11-01
55 schema:description The associations between plasma letrozole concentrations and CYP2A6 and CYP3A5 genetic variants were tested in the Exemestane and Letrozole Pharmacogenomics (ELPH) trial. ELPH is a multicenter, open-label prospective clinical trial in women randomly assigned (n≈250 in each arm) to receive 2 years of treatment with either oral letrozole (2.5 mg/day) or oral exemestane (25 mg/day). CYP2A6 and CYP3A showed effects on letrozole metabolism in vitro. DNA samples were genotyped for variants in the CYP2A6 and CYP3A5 genes. Plasma letrozole concentrations showed high interpatient variability (>10-fold) and were associated significantly with CYP2A6 genotypes (P<0.0001), body mass index (BMI) (P<0.0001), and age (P=0.0035). However, CYP3A5 genotypes showed no association with plasma letrozole concentrations. These data suggest that CYP2A6 is the principal clearance mechanism for letrozole in vivo. CYP2A6 metabolic status, along with BMI and age, may serve as a biomarker of the efficacy of letrozole treatment or a predictor of adverse effects.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf Nb964b87dae9d4f43b88ed5837840b42e
60 Nd5c0ad0e8d93420aab9d67ca1b1e02c7
61 sg:journal.1017409
62 schema:name Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age
63 schema:pagination 693-700
64 schema:productId N15f6a6a9c14f44fd8fe270578627a30b
65 N743ad537c02f48b08b35c122563766b5
66 N7edaeb69ddf945cfac80cc68f9e643e4
67 Na6454aa789af47d8a792d3ab99221d97
68 Nb37798c50b0f4c6a865e886fa55c4fdf
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049545512
70 https://doi.org/10.1038/clpt.2011.174
71 schema:sdDatePublished 2019-04-11T00:45
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N0e171ace656d4e43bf712ca26daf4f2e
74 schema:url http://onlinelibrary.wiley.com/doi/10.1038/clpt.2011.174/abstract
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0135e0bf6cca429bade0fdab05beac36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Antineoplastic Agents
80 rdf:type schema:DefinedTerm
81 N0e171ace656d4e43bf712ca26daf4f2e schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N12d973424d4a4835a46485f5f2c71fcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Breast Neoplasms
85 rdf:type schema:DefinedTerm
86 N156c6b5658f646269f0cf5dbb9733e3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Pharmacogenetics
88 rdf:type schema:DefinedTerm
89 N15f6a6a9c14f44fd8fe270578627a30b schema:name dimensions_id
90 schema:value pub.1049545512
91 rdf:type schema:PropertyValue
92 N195b1a08cd97425eb0ee973ac8b74a48 rdf:first sg:person.01145244423.36
93 rdf:rest Ne50d89c689b9445cb9169dfa05d3fe19
94 N1ae953998952425f8e70d867fdc59baf rdf:first sg:person.01011023657.40
95 rdf:rest N195b1a08cd97425eb0ee973ac8b74a48
96 N264ee1df526d45b9a20173fbe62b772b rdf:first sg:person.015665434432.85
97 rdf:rest N1ae953998952425f8e70d867fdc59baf
98 N27a66140932e443795254635b95664ae rdf:first sg:person.01027276476.49
99 rdf:rest Nb074b9d7a8dd41c5ac4030e06fe2daed
100 N33459e59b09d49a28bc07634343ff450 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Prospective Studies
102 rdf:type schema:DefinedTerm
103 N40eedc6ff4d24f77b9fcb11e45d472e3 rdf:first sg:person.0607526245.79
104 rdf:rest Nc7d3e1ec1c9b4df7b3c55cd1031346d1
105 N4c4bceab61734fd98778af5099197c02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Aged, 80 and over
107 rdf:type schema:DefinedTerm
108 N564bbbda69cb4658b8fe9e20e5be911a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cross-Over Studies
110 rdf:type schema:DefinedTerm
111 N63e93faf8b5b4b59a23f75d97576f39c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Genotype
113 rdf:type schema:DefinedTerm
114 N6a12001ffe304986977b408c1eb3e090 rdf:first sg:person.01042733643.27
115 rdf:rest N264ee1df526d45b9a20173fbe62b772b
116 N743ad537c02f48b08b35c122563766b5 schema:name readcube_id
117 schema:value ec05b6f1ba3d28912c821ba157c0ee28b98e5aa06fcf0ed2a17955fb0770e0da
118 rdf:type schema:PropertyValue
119 N7edaeb69ddf945cfac80cc68f9e643e4 schema:name nlm_unique_id
120 schema:value 0372741
121 rdf:type schema:PropertyValue
122 N825946bba67c4d7d825df007af971e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Aged
124 rdf:type schema:DefinedTerm
125 N8492c20520ce42d481e1c618c87d7dad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Genetic Variation
127 rdf:type schema:DefinedTerm
128 N8eaea3e61d684d3dae242da209c61203 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N8f4053845ad14afe8f0993e24a4cc189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Androstadienes
133 rdf:type schema:DefinedTerm
134 N98e063d2e10a470caf246f67f5c09ff2 rdf:first sg:person.012531261177.48
135 rdf:rest N40eedc6ff4d24f77b9fcb11e45d472e3
136 N9aea26fc187e4f078bf90b11c7cda492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Age Factors
138 rdf:type schema:DefinedTerm
139 Na6454aa789af47d8a792d3ab99221d97 schema:name pubmed_id
140 schema:value 21975350
141 rdf:type schema:PropertyValue
142 Nabe0ed4644be4e83a11a3c6c65bad3b1 rdf:first sg:person.011674102657.38
143 rdf:rest Nd8681b1d056d462ca00ae0a5e1ebc243
144 Nad551029452c469ead4725f2b571f398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Administration, Oral
146 rdf:type schema:DefinedTerm
147 Nb074b9d7a8dd41c5ac4030e06fe2daed rdf:first sg:person.011340630414.35
148 rdf:rest rdf:nil
149 Nb34dfbb27fda4d8eb20038bb6255929a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cytochrome P-450 CYP3A
151 rdf:type schema:DefinedTerm
152 Nb37798c50b0f4c6a865e886fa55c4fdf schema:name doi
153 schema:value 10.1038/clpt.2011.174
154 rdf:type schema:PropertyValue
155 Nb8ac8c9894fd4c5084d2de47e83c70e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Nitriles
157 rdf:type schema:DefinedTerm
158 Nb964b87dae9d4f43b88ed5837840b42e schema:issueNumber 5
159 rdf:type schema:PublicationIssue
160 Nba6560d9054b4081a0a1540857ef5892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Postmenopause
162 rdf:type schema:DefinedTerm
163 Nc189a6405eac44d4baee38587032acc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Body Mass Index
165 rdf:type schema:DefinedTerm
166 Nc7d3e1ec1c9b4df7b3c55cd1031346d1 rdf:first sg:person.01311271015.66
167 rdf:rest Nabe0ed4644be4e83a11a3c6c65bad3b1
168 Ncbc76a62d5e74f61ac8bb312573b5a8b rdf:first sg:person.01105145057.18
169 rdf:rest N6a12001ffe304986977b408c1eb3e090
170 Ncfd3008fa8fa4e828261046491e5c900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nd5c0ad0e8d93420aab9d67ca1b1e02c7 schema:volumeNumber 90
174 rdf:type schema:PublicationVolume
175 Nd8681b1d056d462ca00ae0a5e1ebc243 rdf:first sg:person.01327606223.37
176 rdf:rest Ncbc76a62d5e74f61ac8bb312573b5a8b
177 Ne50d89c689b9445cb9169dfa05d3fe19 rdf:first sg:person.01065752722.82
178 rdf:rest N27a66140932e443795254635b95664ae
179 Neaaa979a02394314946f182f1447a8c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Cytochrome P-450 CYP2A6
181 rdf:type schema:DefinedTerm
182 Nedc71243d6ea43e6b1c8b5dd625048a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Triazoles
184 rdf:type schema:DefinedTerm
185 Nf5081f0d3d634aea8498cd58baf62d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Aryl Hydrocarbon Hydroxylases
187 rdf:type schema:DefinedTerm
188 Nfd8f83b1a0d249c181e672d513728524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Middle Aged
190 rdf:type schema:DefinedTerm
191 Nff02019d932a422ba9ef8894272f2d49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Adult
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
198 schema:name Clinical Sciences
199 rdf:type schema:DefinedTerm
200 sg:grant.2423963 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
201 rdf:type schema:MonetaryGrant
202 sg:grant.2423971 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
203 rdf:type schema:MonetaryGrant
204 sg:grant.2424015 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
205 rdf:type schema:MonetaryGrant
206 sg:grant.2519294 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
207 rdf:type schema:MonetaryGrant
208 sg:grant.2683954 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
209 rdf:type schema:MonetaryGrant
210 sg:grant.2689487 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
211 rdf:type schema:MonetaryGrant
212 sg:grant.2690863 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2011.174
213 rdf:type schema:MonetaryGrant
214 sg:journal.1017409 schema:issn 0009-9236
215 1532-6535
216 schema:name Clinical Pharmacology & Therapeutics
217 rdf:type schema:Periodical
218 sg:person.01011023657.40 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
219 schema:familyName Storniolo
220 schema:givenName A M
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011023657.40
222 rdf:type schema:Person
223 sg:person.01027276476.49 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
224 schema:familyName Tyndale
225 schema:givenName R F
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027276476.49
227 rdf:type schema:Person
228 sg:person.01042733643.27 schema:affiliation https://www.grid.ac/institutes/grid.412590.b
229 schema:familyName Henry
230 schema:givenName N L
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27
232 rdf:type schema:Person
233 sg:person.01065752722.82 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
234 schema:familyName Hoffmann
235 schema:givenName E
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065752722.82
237 rdf:type schema:Person
238 sg:person.01105145057.18 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
239 schema:familyName Kamdem
240 schema:givenName L K
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105145057.18
242 rdf:type schema:Person
243 sg:person.011340630414.35 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
244 schema:familyName Flockhart
245 schema:givenName D A
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011340630414.35
247 rdf:type schema:Person
248 sg:person.01145244423.36 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
249 schema:familyName Stearns
250 schema:givenName V
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145244423.36
252 rdf:type schema:Person
253 sg:person.011674102657.38 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
254 schema:familyName Li
255 schema:givenName L
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011674102657.38
257 rdf:type schema:Person
258 sg:person.012531261177.48 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
259 schema:familyName Desta
260 schema:givenName Z
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012531261177.48
262 rdf:type schema:Person
263 sg:person.01311271015.66 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
264 schema:familyName Nguyen
265 schema:givenName A T
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311271015.66
267 rdf:type schema:Person
268 sg:person.01327606223.37 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
269 schema:familyName Skaar
270 schema:givenName T
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327606223.37
272 rdf:type schema:Person
273 sg:person.015665434432.85 schema:affiliation https://www.grid.ac/institutes/grid.412590.b
274 schema:familyName Hayes
275 schema:givenName D F
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015665434432.85
277 rdf:type schema:Person
278 sg:person.0607526245.79 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
279 schema:familyName Kreutz
280 schema:givenName Y
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607526245.79
282 rdf:type schema:Person
283 sg:pub.10.1007/s00280-009-0935-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004399438
284 https://doi.org/10.1007/s00280-009-0935-7
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s10549-007-9774-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049384206
287 https://doi.org/10.1007/s10549-007-9774-6
288 rdf:type schema:CreativeWork
289 sg:pub.10.1016/j.clpt.2006.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022765052
290 https://doi.org/10.1016/j.clpt.2006.01.008
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/clpt.2009.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039222742
293 https://doi.org/10.1038/clpt.2009.19
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/tpj.2009.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007173839
296 https://doi.org/10.1038/tpj.2009.11
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1075891276 schema:CreativeWork
299 https://doi.org/10.1002/bdd.273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012734698
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/cncr.25385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031645888
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/humu.20698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052588989
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0960-0760(90)90460-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818288
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.fertnstert.2010.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029774637
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1056/nejmoa052258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047902372
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/jnci/djg108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046611030
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/jnci/dji005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036118248
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/01213011-200503000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060333037
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/fpc.0b013e3282f3606e schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340545
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1124/dmd.109.031393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019835905
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1124/pr.57.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051366472
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1128/aac.01123-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029152883
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1158/1078-0432.ccr-07-5221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047774233
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1177/0960327107082224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000884082
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1200/jco.20.3.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202793
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1200/jco.2005.03.3266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052759010
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1200/jco.2006.08.8617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018605357
334 rdf:type schema:CreativeWork
335 https://doi.org/10.2217/pgs.09.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013310970
336 rdf:type schema:CreativeWork
337 https://doi.org/10.3109/00498250903171395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018793266
338 rdf:type schema:CreativeWork
339 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
340 schema:name University of Toronto Department of Pharmacology and Toxicology Toronto Ontario Canada
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
343 schema:name Indiana University Department of Medicine Indianapolis Indiana USA
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.412590.b schema:alternateName Michigan Medicine
346 schema:name Comprehensive Cancer Center, University of Michigan Health System Department of Internal Medicine and Breast Oncology Program Ann Arbor Michigan USA
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.469474.c schema:alternateName Johns Hopkins Medicine
349 schema:name Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Department of Oncology Baltimore Maryland USA
350 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...