A Common 5′‐UTR Variant in MATE2‐K Is Associated With Poor Response to Metformin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

J H Choi, S W Yee, A H Ramirez, K M Morrissey, G H Jang, P J Joski, J A Mefford, S E Hesselson, A Schlessinger, G Jenkins, R A Castro, S J Johns, D Stryke, A Sali, T E Ferrin, J S Witte, P‐Y Kwok, D M Roden, R A Wilke, C A McCarty, R L Davis, K M Giacomini

ABSTRACT

Multidrug and toxin extrusion 2 (MATE2-K (SLC47A2)), a polyspecific organic cation exporter, facilitates the renal elimination of the antidiabetes drug metformin. In this study, we characterized genetic variants of MATE2-K, determined their association with metformin response, and elucidated their impact by means of a comparative protein structure model. Four nonsynonymous variants and four variants in the MATE2-K basal promoter region were identified from ethnically diverse populations. Two nonsynonymous variants-c.485C>T and c.1177G>A-were shown to be associated with significantly lower metformin uptake and reduction in protein expression levels. MATE2-K basal promoter haplotypes containing the most common variant, g.-130G>A (>26% allele frequency), were associated with a significant increase in luciferase activities and reduced binding to the transcriptional repressor myeloid zinc finger 1 (MZF-1). Patients with diabetes who were homozygous for g.-130A had a significantly poorer response to metformin treatment, assessed as relative change in glycated hemoglobin (HbA1c) (-0.027 (-0.076, 0.033)), as compared with carriers of the reference allele, g.-130G (-0.15 (-0.17, -0.13)) (P=0.002). Our study showed that MATE2-K plays a role in the antidiabetes response to metformin. More... »

PAGES

674-684

References to SciGraph publications

  • 2008-02. Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2008-11. Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1996. Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1 in MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT
  • 2009-01. Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity in JOURNAL OF HUMAN GENETICS
  • 2011-02. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes in NATURE GENETICS
  • 2009-04. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function in THE PHARMACOGENOMICS JOURNAL
  • 1997-08. Transcriptional regulation during myelopoiesis in MOLECULAR BIOLOGY REPORTS
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2009-09. The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2010-10. Structure of a cation-bound multidrug and toxic compound extrusion transporter in NATURE
  • 2011-03. Pharmacogenomics at the Tipping Point: Challenges and Opportunities in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-08. Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus in THE PHARMACOGENOMICS JOURNAL
  • 2008-09. Development of a Large‐Scale De‐Identified DNA Biobank to Enable Personalized Medicine in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-03. The Emerging Role of Electronic Medical Records in Pharmacogenomics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/clpt.2011.165

    DOI

    http://dx.doi.org/10.1038/clpt.2011.165

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001118933

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21956618


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