Functional Characterization of Liver Enhancers That Regulate Drug‐Associated Transporters View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

MJ Kim, P Skewes‐Cox, H Fukushima, S Hesselson, SW Yee, LB Ramsey, L Nguyen, JL Eshragh, RA Castro, CC Wen, D Stryke, SJ Johns, TE Ferrin, P‐Y Kwok, MV Relling, KM Giacomini, DL Kroetz, N Ahituv

ABSTRACT

Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics and liver-specific transcription factor binding site (TFBS) analyses, we identified evolutionary conserved regions (ECRs) surrounding nine liver membrane transporters that interact with commonly used pharmaceuticals. The top 50 ECRs were screened for enhancer activity in vivo, of which five--located around ABCB11, SLC10A1, SLCO1B1, SLCO1A2, and SLC47A1--exhibited significant enhancer activity. Common variants identified in a large ethnically diverse cohort (n = 272) were assayed for differential enhancer activity, and three variants were found to have significant effects on reporter activity as compared with the reference allele. In addition, one variant was associated with reduced SLCO1A2 mRNA expression levels in human liver tissues, and another was associated with increased methotrexate (MTX) clearance in patients. This work provides a general model for the rapid characterization of liver enhancers and identifies associations between enhancer variants and drug response. More... »

PAGES

571-578

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.2010.353

DOI

http://dx.doi.org/10.1038/clpt.2010.353

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047311871

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21368754


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP Binding Cassette Subfamily B Member 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP-Binding Cassette Transporters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Continental Population Groups", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organic Anion Transporters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organic Cation Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmaceutical Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Institute for Human Genetics San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "MJ", 
        "id": "sg:person.013474666314.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474666314.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "University of California, San Francisco Biological and Medical Informatics Program San Francisco California USA", 
            "University of California, San Francisco Department of Biochemistry and Biophysics San Francisco California USA", 
            "Howard Hughes Medical Institute Chevy Chase Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skewes\u2010Cox", 
        "givenName": "P", 
        "id": "sg:person.01076063016.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076063016.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukushima", 
        "givenName": "H", 
        "id": "sg:person.0622724074.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622724074.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Cardiovascular Research Institute San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hesselson", 
        "givenName": "S", 
        "id": "sg:person.01233726020.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233726020.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yee", 
        "givenName": "SW", 
        "id": "sg:person.011607076742.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011607076742.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St Jude Children's Research Hospital Pharmaceutical Sciences Department Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramsey", 
        "givenName": "LB", 
        "id": "sg:person.01353776400.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353776400.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Institute for Human Genetics San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "L", 
        "id": "sg:person.07547454477.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547454477.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Cardiovascular Research Institute San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eshragh", 
        "givenName": "JL", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro", 
        "givenName": "RA", 
        "id": "sg:person.011521257622.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011521257622.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wen", 
        "givenName": "CC", 
        "id": "sg:person.015727237602.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015727237602.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Pharmaceutical Chemistry San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stryke", 
        "givenName": "D", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Pharmaceutical Chemistry San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johns", 
        "givenName": "SJ", 
        "id": "sg:person.01007000346.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007000346.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Department of Pharmaceutical Chemistry San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrin", 
        "givenName": "TE", 
        "id": "sg:person.01206300250.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206300250.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Cardiovascular Research Institute San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwok", 
        "givenName": "P\u2010Y", 
        "id": "sg:person.01221224024.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221224024.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "St Jude Children's Research Hospital Pharmaceutical Sciences Department Memphis Tennessee USA", 
            "University of Tennessee Health Science Center Department of Clinical Pharmacy Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Relling", 
        "givenName": "MV", 
        "id": "sg:person.01041051470.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041051470.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Institute for Human Genetics San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giacomini", 
        "givenName": "KM", 
        "id": "sg:person.012416265214.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012416265214.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Institute for Human Genetics San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroetz", 
        "givenName": "DL", 
        "id": "sg:person.0620612751.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620612751.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA", 
            "University of California, San Francisco Institute for Human Genetics San Francisco California USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahituv", 
        "givenName": "N", 
        "id": "sg:person.0637155372.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637155372.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2008.20.4156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000217754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00498250801986951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002060757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.105.008748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002402832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2009.00430.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004360578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/yakushi.129.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005667502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005982807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-006-9159-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007600266", 
          "https://doi.org/10.1007/s11095-006-9159-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008233346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.104.003301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008490732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009061596", 
          "https://doi.org/10.1038/nature05295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009061596", 
          "https://doi.org/10.1038/nature05295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009061596", 
          "https://doi.org/10.1038/nature05295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.108.146449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009749845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-003-0813-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010236864", 
          "https://doi.org/10.1007/s00210-003-0813-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.106.013615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011060955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.108.147207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012962283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.107.043117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016693634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m411092200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017932263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.21145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018746849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.21145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018746849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.06.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020687969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.106.104364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022062471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.180601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022605725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci30558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022767489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025416063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.104.007146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027010047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2008.01.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029283363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2008.19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030527830", 
          "https://doi.org/10.1038/tpj.2008.19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032014011", 
          "https://doi.org/10.1038/sj.mp.4001926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032014011", 
          "https://doi.org/10.1038/sj.mp.4001926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/erm.09.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033757514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033854664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023847521767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036039228", 
          "https://doi.org/10.1023/a:1023847521767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2007.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036736950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-59524-0_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037794192", 
          "https://doi.org/10.1007/978-3-642-59524-0_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0030007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039517858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.16.5471-5477.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039687256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042444027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044241737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045974968", 
          "https://doi.org/10.1038/nature03022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045974968", 
          "https://doi.org/10.1038/nature03022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0006942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047363881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049513504", 
          "https://doi.org/10.1038/nrd3028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049513504", 
          "https://doi.org/10.1038/nrd3028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10430349950017734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059202919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000230418.28091.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000230418.28091.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000230418.28091.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000230418.28091.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3280ef698f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3280ef698f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e3280ef698f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328330eeca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328330eeca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328330eeca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0b013e328330eeca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074682036", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077438741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077475000", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089160809400419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077731972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089160809400419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077731972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082463753", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-04", 
    "datePublishedReg": "2011-04-01", 
    "description": "Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics and liver-specific transcription factor binding site (TFBS) analyses, we identified evolutionary conserved regions (ECRs) surrounding nine liver membrane transporters that interact with commonly used pharmaceuticals. The top 50 ECRs were screened for enhancer activity in vivo, of which five--located around ABCB11, SLC10A1, SLCO1B1, SLCO1A2, and SLC47A1--exhibited significant enhancer activity. Common variants identified in a large ethnically diverse cohort (n = 272) were assayed for differential enhancer activity, and three variants were found to have significant effects on reporter activity as compared with the reference allele. In addition, one variant was associated with reduced SLCO1A2 mRNA expression levels in human liver tissues, and another was associated with increased methotrexate (MTX) clearance in patients. This work provides a general model for the rapid characterization of liver enhancers and identifies associations between enhancer variants and drug response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/clpt.2010.353", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2634271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705115", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690890", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2529362", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696056", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2527964", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "89"
      }
    ], 
    "name": "Functional Characterization of Liver Enhancers That Regulate Drug\u2010Associated Transporters", 
    "pagination": "571-578", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e1612223f23f3bd099b2a173367ed9270d6f6227af34567bb69af156fe4654f0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21368754"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/clpt.2010.353"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047311871"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/clpt.2010.353", 
      "https://app.dimensions.ai/details/publication/pub.1047311871"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000293.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://onlinelibrary.wiley.com/doi/10.1038/clpt.2010.353/abstract"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/clpt.2010.353'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/clpt.2010.353'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/clpt.2010.353'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/clpt.2010.353'


 

This table displays all metadata directly associated to this object as RDF triples.

455 TRIPLES      21 PREDICATES      99 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/clpt.2010.353 schema:about N01bd5d24ed53452c8b7abc46b90ed14a
2 N02686d5a660a4dcc987dc445be481da1
3 N16a773c655a447aeb9a5083921e22711
4 N16c7ca79e23e4df2aaacbc96fab4101d
5 N1bbaa609546c4788a552ed4cdaf08746
6 N236cf1472b684b31ac7458d8fbb04f23
7 N2d94a025e97a4c0ba4f6f10d408e72ed
8 N3eeeb0c032524f5a8b6de36036dfb1c7
9 N41938cc013f84eafb5aab9d33ea476a7
10 N43324f2436774475a3386e91fc40ba54
11 N6965174095224387a0a742ba98468b2f
12 N7d42931e572842de93b97d10c140018b
13 N7d9a099ccfc14ee891a335800b657442
14 N7e8af6f3256942a68cb2a813230bb13b
15 N82f416b701f4499280ab89429a17b131
16 N858f33406d8c48cf96739cf52459572e
17 N913512545fd24766a0c175b10799511b
18 Nad0ed5647d144719b2dbc8914dcb521b
19 Nb088dc56455748649d9c60b816c9f91c
20 Ne1056fa64d444497a46f62268fa8f311
21 Ne6349674fc114221a222f9b37cc05ae2
22 Nefb5a8a94c364cd0824122fd34e9b478
23 Nfd6c457ce2eb4825b017dc6a407dd5f6
24 anzsrc-for:06
25 anzsrc-for:0604
26 schema:author N1d9980196e7e45b9963d84dba68ae347
27 schema:citation sg:pub.10.1007/978-3-642-59524-0_3
28 sg:pub.10.1007/s00210-003-0813-5
29 sg:pub.10.1007/s11095-006-9159-2
30 sg:pub.10.1023/a:1023847521767
31 sg:pub.10.1038/nature03022
32 sg:pub.10.1038/nature05295
33 sg:pub.10.1038/nrd3028
34 sg:pub.10.1038/sj.mp.4001926
35 sg:pub.10.1038/tpj.2008.19
36 https://app.dimensions.ai/details/publication/pub.1074682036
37 https://app.dimensions.ai/details/publication/pub.1077438741
38 https://app.dimensions.ai/details/publication/pub.1077475000
39 https://app.dimensions.ai/details/publication/pub.1082463753
40 https://doi.org/10.1002/humu.21145
41 https://doi.org/10.1016/j.bcp.2007.04.010
42 https://doi.org/10.1016/j.canlet.2005.06.051
43 https://doi.org/10.1016/j.ejphar.2008.01.042
44 https://doi.org/10.1053/j.gastro.2006.02.034
45 https://doi.org/10.1074/jbc.m411092200
46 https://doi.org/10.1080/00498250801986951
47 https://doi.org/10.1089/10430349950017734
48 https://doi.org/10.1093/hmg/ddi261
49 https://doi.org/10.1093/nar/gkg108
50 https://doi.org/10.1093/nar/gkg585
51 https://doi.org/10.1093/nar/gkp866
52 https://doi.org/10.1097/01.fpc.0000230418.28091.76
53 https://doi.org/10.1097/fpc.0b013e3280ef698f
54 https://doi.org/10.1097/fpc.0b013e328330eeca
55 https://doi.org/10.1101/gr.180601
56 https://doi.org/10.1111/j.1476-5381.2009.00430.x
57 https://doi.org/10.1124/dmd.104.003301
58 https://doi.org/10.1124/dmd.105.008748
59 https://doi.org/10.1124/dmd.106.013615
60 https://doi.org/10.1124/jpet.106.104364
61 https://doi.org/10.1124/jpet.108.146449
62 https://doi.org/10.1124/jpet.108.147207
63 https://doi.org/10.1124/mol.104.007146
64 https://doi.org/10.1124/mol.107.043117
65 https://doi.org/10.1128/mcb.21.16.5471-5477.2001
66 https://doi.org/10.1158/0008-5472.can-06-0769
67 https://doi.org/10.1172/jci30558
68 https://doi.org/10.1177/030089160809400419
69 https://doi.org/10.1200/jco.2008.20.4156
70 https://doi.org/10.1248/yakushi.129.231
71 https://doi.org/10.1371/journal.pbio.0030007
72 https://doi.org/10.1371/journal.pone.0006942
73 https://doi.org/10.1586/erm.09.72
74 schema:datePublished 2011-04
75 schema:datePublishedReg 2011-04-01
76 schema:description Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics and liver-specific transcription factor binding site (TFBS) analyses, we identified evolutionary conserved regions (ECRs) surrounding nine liver membrane transporters that interact with commonly used pharmaceuticals. The top 50 ECRs were screened for enhancer activity in vivo, of which five--located around ABCB11, SLC10A1, SLCO1B1, SLCO1A2, and SLC47A1--exhibited significant enhancer activity. Common variants identified in a large ethnically diverse cohort (n = 272) were assayed for differential enhancer activity, and three variants were found to have significant effects on reporter activity as compared with the reference allele. In addition, one variant was associated with reduced SLCO1A2 mRNA expression levels in human liver tissues, and another was associated with increased methotrexate (MTX) clearance in patients. This work provides a general model for the rapid characterization of liver enhancers and identifies associations between enhancer variants and drug response.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N277c2af773d44cfab75ae8dafb7cef45
81 N2f8fc2f1b38f4390b22342ab3c769fd5
82 sg:journal.1017409
83 schema:name Functional Characterization of Liver Enhancers That Regulate Drug‐Associated Transporters
84 schema:pagination 571-578
85 schema:productId N16c28ad6013541b4829d64b46484acfa
86 N1baec6b312814458b7b7d357d6fa52de
87 N4022a12b984d4ef4b322acbdcdb15f2b
88 N736ce3bfb65946cea062745a272313f3
89 N85dfcac3f13043999eb8e2dc958b9592
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047311871
91 https://doi.org/10.1038/clpt.2010.353
92 schema:sdDatePublished 2019-04-10T17:09
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N6ef75357b9ed49fc90f6698473a342ca
95 schema:url http://onlinelibrary.wiley.com/doi/10.1038/clpt.2010.353/abstract
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N01bd5d24ed53452c8b7abc46b90ed14a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Conserved Sequence
101 rdf:type schema:DefinedTerm
102 N02686d5a660a4dcc987dc445be481da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mice
104 rdf:type schema:DefinedTerm
105 N16a773c655a447aeb9a5083921e22711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Biological Transport
107 rdf:type schema:DefinedTerm
108 N16c28ad6013541b4829d64b46484acfa schema:name dimensions_id
109 schema:value pub.1047311871
110 rdf:type schema:PropertyValue
111 N16c7ca79e23e4df2aaacbc96fab4101d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Organic Cation Transport Proteins
113 rdf:type schema:DefinedTerm
114 N199e4fa1e6804676b621069514ebf269 rdf:first sg:person.07547454477.26
115 rdf:rest Nd52f20f9147d453f832f36af1f353270
116 N1baec6b312814458b7b7d357d6fa52de schema:name nlm_unique_id
117 schema:value 0372741
118 rdf:type schema:PropertyValue
119 N1bbaa609546c4788a552ed4cdaf08746 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name RNA, Messenger
121 rdf:type schema:DefinedTerm
122 N1d9980196e7e45b9963d84dba68ae347 rdf:first sg:person.013474666314.94
123 rdf:rest Nfa4a723cdb90475182a991f97749c22a
124 N1e0689688b2141a881e09b27ad5748d4 rdf:first sg:person.01206300250.36
125 rdf:rest Nef893d527c564973bd23abe04c96b975
126 N21b9372d09cf45a09d739f762fcb7c96 rdf:first sg:person.01353776400.13
127 rdf:rest N199e4fa1e6804676b621069514ebf269
128 N236cf1472b684b31ac7458d8fbb04f23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Genetic Variation
130 rdf:type schema:DefinedTerm
131 N277c2af773d44cfab75ae8dafb7cef45 schema:volumeNumber 89
132 rdf:type schema:PublicationVolume
133 N2d94a025e97a4c0ba4f6f10d408e72ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N2f8fc2f1b38f4390b22342ab3c769fd5 schema:issueNumber 4
137 rdf:type schema:PublicationIssue
138 N334f5bd7f7484a73a81dcd757e7034bc rdf:first sg:person.012416265214.38
139 rdf:rest N8301ea3778d643af9cf76cc2e66d7a48
140 N3eeeb0c032524f5a8b6de36036dfb1c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Methotrexate
142 rdf:type schema:DefinedTerm
143 N4022a12b984d4ef4b322acbdcdb15f2b schema:name pubmed_id
144 schema:value 21368754
145 rdf:type schema:PropertyValue
146 N41938cc013f84eafb5aab9d33ea476a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 N43324f2436774475a3386e91fc40ba54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name ATP Binding Cassette Subfamily B Member 11
151 rdf:type schema:DefinedTerm
152 N4badc1c00d3a4d49925ec3ce826b7694 rdf:first N4f8dbd3c56984204b73befa3fe50505e
153 rdf:rest Nc08b48b007ae4288841a7740058f3333
154 N4d8ff6433029409c983c51ebafd30012 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
155 schema:familyName Eshragh
156 schema:givenName JL
157 rdf:type schema:Person
158 N4f8dbd3c56984204b73befa3fe50505e schema:affiliation https://www.grid.ac/institutes/grid.266102.1
159 schema:familyName Stryke
160 schema:givenName D
161 rdf:type schema:Person
162 N6965174095224387a0a742ba98468b2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Alleles
164 rdf:type schema:DefinedTerm
165 N6ef75357b9ed49fc90f6698473a342ca schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 N736ce3bfb65946cea062745a272313f3 schema:name readcube_id
168 schema:value e1612223f23f3bd099b2a173367ed9270d6f6227af34567bb69af156fe4654f0
169 rdf:type schema:PropertyValue
170 N7d42931e572842de93b97d10c140018b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Polymorphism, Single Nucleotide
172 rdf:type schema:DefinedTerm
173 N7d9a099ccfc14ee891a335800b657442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Gene Expression Regulation
175 rdf:type schema:DefinedTerm
176 N7e8af6f3256942a68cb2a813230bb13b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Male
178 rdf:type schema:DefinedTerm
179 N7fde5e20071f4acaa64cfae6f4cd1511 rdf:first sg:person.011607076742.49
180 rdf:rest N21b9372d09cf45a09d739f762fcb7c96
181 N82f416b701f4499280ab89429a17b131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name ATP-Binding Cassette Transporters
183 rdf:type schema:DefinedTerm
184 N8301ea3778d643af9cf76cc2e66d7a48 rdf:first sg:person.0620612751.83
185 rdf:rest N9b7703730973404884f732434dde739c
186 N858f33406d8c48cf96739cf52459572e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Genomics
188 rdf:type schema:DefinedTerm
189 N85dfcac3f13043999eb8e2dc958b9592 schema:name doi
190 schema:value 10.1038/clpt.2010.353
191 rdf:type schema:PropertyValue
192 N913512545fd24766a0c175b10799511b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Female
194 rdf:type schema:DefinedTerm
195 N9993e4ab12674505a4d7b94ab5e54b1d rdf:first sg:person.015727237602.45
196 rdf:rest N4badc1c00d3a4d49925ec3ce826b7694
197 N9b7703730973404884f732434dde739c rdf:first sg:person.0637155372.91
198 rdf:rest rdf:nil
199 N9d9d394f472b4fca814507129812adfe rdf:first sg:person.011521257622.73
200 rdf:rest N9993e4ab12674505a4d7b94ab5e54b1d
201 Nad0ed5647d144719b2dbc8914dcb521b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Organic Anion Transporters
203 rdf:type schema:DefinedTerm
204 Nb088dc56455748649d9c60b816c9f91c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Transcription Factors
206 rdf:type schema:DefinedTerm
207 Nbe2d76ac77f7448ba9f9894eeaa9b1ac rdf:first sg:person.0622724074.93
208 rdf:rest Nc001fc4f56f34d09b1be4ebab5168d87
209 Nc001fc4f56f34d09b1be4ebab5168d87 rdf:first sg:person.01233726020.84
210 rdf:rest N7fde5e20071f4acaa64cfae6f4cd1511
211 Nc08b48b007ae4288841a7740058f3333 rdf:first sg:person.01007000346.17
212 rdf:rest N1e0689688b2141a881e09b27ad5748d4
213 Nd085db9dd90a4343ab826c7664345b6d rdf:first sg:person.01041051470.29
214 rdf:rest N334f5bd7f7484a73a81dcd757e7034bc
215 Nd52f20f9147d453f832f36af1f353270 rdf:first N4d8ff6433029409c983c51ebafd30012
216 rdf:rest N9d9d394f472b4fca814507129812adfe
217 Ne1056fa64d444497a46f62268fa8f311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Pharmaceutical Preparations
219 rdf:type schema:DefinedTerm
220 Ne6349674fc114221a222f9b37cc05ae2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Binding Sites
222 rdf:type schema:DefinedTerm
223 Nef893d527c564973bd23abe04c96b975 rdf:first sg:person.01221224024.09
224 rdf:rest Nd085db9dd90a4343ab826c7664345b6d
225 Nefb5a8a94c364cd0824122fd34e9b478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Continental Population Groups
227 rdf:type schema:DefinedTerm
228 Nfa4a723cdb90475182a991f97749c22a rdf:first sg:person.01076063016.42
229 rdf:rest Nbe2d76ac77f7448ba9f9894eeaa9b1ac
230 Nfd6c457ce2eb4825b017dc6a407dd5f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
231 schema:name Liver
232 rdf:type schema:DefinedTerm
233 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
234 schema:name Biological Sciences
235 rdf:type schema:DefinedTerm
236 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
237 schema:name Genetics
238 rdf:type schema:DefinedTerm
239 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
240 rdf:type schema:MonetaryGrant
241 sg:grant.2527964 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
242 rdf:type schema:MonetaryGrant
243 sg:grant.2529362 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
244 rdf:type schema:MonetaryGrant
245 sg:grant.2634271 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
246 rdf:type schema:MonetaryGrant
247 sg:grant.2690866 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
248 rdf:type schema:MonetaryGrant
249 sg:grant.2690890 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
250 rdf:type schema:MonetaryGrant
251 sg:grant.2696056 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
252 rdf:type schema:MonetaryGrant
253 sg:grant.2705115 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2010.353
254 rdf:type schema:MonetaryGrant
255 sg:journal.1017409 schema:issn 0009-9236
256 1532-6535
257 schema:name Clinical Pharmacology & Therapeutics
258 rdf:type schema:Periodical
259 sg:person.01007000346.17 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
260 schema:familyName Johns
261 schema:givenName SJ
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007000346.17
263 rdf:type schema:Person
264 sg:person.01041051470.29 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
265 schema:familyName Relling
266 schema:givenName MV
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041051470.29
268 rdf:type schema:Person
269 sg:person.01076063016.42 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
270 schema:familyName Skewes‐Cox
271 schema:givenName P
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076063016.42
273 rdf:type schema:Person
274 sg:person.011521257622.73 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
275 schema:familyName Castro
276 schema:givenName RA
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011521257622.73
278 rdf:type schema:Person
279 sg:person.011607076742.49 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
280 schema:familyName Yee
281 schema:givenName SW
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011607076742.49
283 rdf:type schema:Person
284 sg:person.01206300250.36 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
285 schema:familyName Ferrin
286 schema:givenName TE
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206300250.36
288 rdf:type schema:Person
289 sg:person.01221224024.09 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
290 schema:familyName Kwok
291 schema:givenName P‐Y
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221224024.09
293 rdf:type schema:Person
294 sg:person.01233726020.84 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
295 schema:familyName Hesselson
296 schema:givenName S
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233726020.84
298 rdf:type schema:Person
299 sg:person.012416265214.38 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
300 schema:familyName Giacomini
301 schema:givenName KM
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012416265214.38
303 rdf:type schema:Person
304 sg:person.013474666314.94 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
305 schema:familyName Kim
306 schema:givenName MJ
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474666314.94
308 rdf:type schema:Person
309 sg:person.01353776400.13 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
310 schema:familyName Ramsey
311 schema:givenName LB
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353776400.13
313 rdf:type schema:Person
314 sg:person.015727237602.45 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
315 schema:familyName Wen
316 schema:givenName CC
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015727237602.45
318 rdf:type schema:Person
319 sg:person.0620612751.83 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
320 schema:familyName Kroetz
321 schema:givenName DL
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620612751.83
323 rdf:type schema:Person
324 sg:person.0622724074.93 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
325 schema:familyName Fukushima
326 schema:givenName H
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622724074.93
328 rdf:type schema:Person
329 sg:person.0637155372.91 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
330 schema:familyName Ahituv
331 schema:givenName N
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637155372.91
333 rdf:type schema:Person
334 sg:person.07547454477.26 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
335 schema:familyName Nguyen
336 schema:givenName L
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07547454477.26
338 rdf:type schema:Person
339 sg:pub.10.1007/978-3-642-59524-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037794192
340 https://doi.org/10.1007/978-3-642-59524-0_3
341 rdf:type schema:CreativeWork
342 sg:pub.10.1007/s00210-003-0813-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010236864
343 https://doi.org/10.1007/s00210-003-0813-5
344 rdf:type schema:CreativeWork
345 sg:pub.10.1007/s11095-006-9159-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007600266
346 https://doi.org/10.1007/s11095-006-9159-2
347 rdf:type schema:CreativeWork
348 sg:pub.10.1023/a:1023847521767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036039228
349 https://doi.org/10.1023/a:1023847521767
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nature03022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045974968
352 https://doi.org/10.1038/nature03022
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/nature05295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009061596
355 https://doi.org/10.1038/nature05295
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/nrd3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049513504
358 https://doi.org/10.1038/nrd3028
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/sj.mp.4001926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032014011
361 https://doi.org/10.1038/sj.mp.4001926
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/tpj.2008.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030527830
364 https://doi.org/10.1038/tpj.2008.19
365 rdf:type schema:CreativeWork
366 https://app.dimensions.ai/details/publication/pub.1074682036 schema:CreativeWork
367 https://app.dimensions.ai/details/publication/pub.1077438741 schema:CreativeWork
368 https://app.dimensions.ai/details/publication/pub.1077475000 schema:CreativeWork
369 https://app.dimensions.ai/details/publication/pub.1082463753 schema:CreativeWork
370 https://doi.org/10.1002/humu.21145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018746849
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.bcp.2007.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036736950
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/j.canlet.2005.06.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020687969
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/j.ejphar.2008.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029283363
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1053/j.gastro.2006.02.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005982807
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.m411092200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017932263
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1080/00498250801986951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002060757
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1089/10430349950017734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202919
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1093/hmg/ddi261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008233346
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/nar/gkg108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042444027
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1093/nar/gkg585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025416063
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/nar/gkp866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044241737
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1097/01.fpc.0000230418.28091.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060328268
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1097/fpc.0b013e3280ef698f schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340501
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1097/fpc.0b013e328330eeca schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340751
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1101/gr.180601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022605725
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1111/j.1476-5381.2009.00430.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004360578
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1124/dmd.104.003301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008490732
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1124/dmd.105.008748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002402832
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1124/dmd.106.013615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011060955
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1124/jpet.106.104364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022062471
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1124/jpet.108.146449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009749845
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1124/jpet.108.147207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012962283
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1124/mol.104.007146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027010047
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1124/mol.107.043117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016693634
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1128/mcb.21.16.5471-5477.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039687256
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1158/0008-5472.can-06-0769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033854664
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1172/jci30558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022767489
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1177/030089160809400419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077731972
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1200/jco.2008.20.4156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000217754
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1248/yakushi.129.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005667502
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1371/journal.pbio.0030007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039517858
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1371/journal.pone.0006942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047363881
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1586/erm.09.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033757514
437 rdf:type schema:CreativeWork
438 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
439 schema:name St Jude Children's Research Hospital Pharmaceutical Sciences Department Memphis Tennessee USA
440 rdf:type schema:Organization
441 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
442 schema:name University of California, San Francisco Cardiovascular Research Institute San Francisco California USA
443 University of California, San Francisco Department of Bioengineering and Therapeutic Sciences San Francisco California USA
444 University of California, San Francisco Department of Pharmaceutical Chemistry San Francisco California USA
445 University of California, San Francisco Institute for Human Genetics San Francisco California USA
446 rdf:type schema:Organization
447 https://www.grid.ac/institutes/grid.267301.1 schema:alternateName University of Tennessee Health Science Center
448 schema:name St Jude Children's Research Hospital Pharmaceutical Sciences Department Memphis Tennessee USA
449 University of Tennessee Health Science Center Department of Clinical Pharmacy Memphis Tennessee USA
450 rdf:type schema:Organization
451 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
452 schema:name Howard Hughes Medical Institute Chevy Chase Maryland USA
453 University of California, San Francisco Biological and Medical Informatics Program San Francisco California USA
454 University of California, San Francisco Department of Biochemistry and Biophysics San Francisco California USA
455 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...