Pharmacogenetic Pathway Analysis of Docetaxel Elimination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

SD Baker, J Verweij, GA Cusatis, RH Schaik, S Marsh, SJ Orwick, RM Franke, S Hu, EG Schuetz, V Lamba, WA Messersmith, AC Wolff, MA Carducci, A Sparreboom

ABSTRACT

The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five genes involved in drug elimination. Among the transfected models investigated, OATP1B3 (SLCO1B3) was identified as the most efficient influx transporter for docetaxel. None of the observed genotypes (SLCO1B3, ABCB1, and ABCC2) was related with docetaxel clearance in 92 white patients (P > 0.17). However, the simultaneous presence of the CYP3A4*1B and CYP3A5*1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test). This haplotype was also associated with increased midazolam clearance in another population (P = 0.0198). An analysis of the CYP3A locus among CEPH-HapMap samples revealed that CYP3A4*1B is present exclusively among a subset of CYP3A5 expressors. Therefore, future studies should first stratify the population on the basis of CYP3A5 genotype and then compare CYP3A activity between individuals with and without the CYP3A4*1B allele. More... »

PAGES

155-163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.2008.95

DOI

http://dx.doi.org/10.1038/clpt.2008.95

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009151094

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18509327


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 CYP3A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 Enzyme System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Clearance Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacogenetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taxoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenopus laevis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "SD", 
        "id": "sg:person.014334666047.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014334666047.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Erasmus MC\u2013Daniel den Hoed Cancer Center Department of Medical Oncology Rotterdam The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verweij", 
        "givenName": "J", 
        "id": "sg:person.01236641403.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236641403.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Oncology Baltimore Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cusatis", 
        "givenName": "GA", 
        "id": "sg:person.01222231306.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222231306.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Chemistry Erasmus MC Rotterdam The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schaik", 
        "givenName": "RH", 
        "id": "sg:person.015736046213.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015736046213.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Washington University School of Medicine Department of Medicine St. Louis Missouri USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marsh", 
        "givenName": "S", 
        "id": "sg:person.01231016344.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231016344.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orwick", 
        "givenName": "SJ", 
        "id": "sg:person.0767271253.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767271253.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franke", 
        "givenName": "RM", 
        "id": "sg:person.01350052111.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350052111.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "S", 
        "id": "sg:person.0613343333.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613343333.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuetz", 
        "givenName": "EG", 
        "id": "sg:person.01270316226.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270316226.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamba", 
        "givenName": "V", 
        "id": "sg:person.01061723357.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061723357.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Oncology Baltimore Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Messersmith", 
        "givenName": "WA", 
        "id": "sg:person.01221726245.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221726245.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Oncology Baltimore Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolff", 
        "givenName": "AC", 
        "id": "sg:person.012056130172.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012056130172.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Oncology Baltimore Maryland USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carducci", 
        "givenName": "MA", 
        "id": "sg:person.01266317743.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266317743.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sparreboom", 
        "givenName": "A", 
        "id": "sg:person.016247331557.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016247331557.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/jnci/91.18.1587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004405543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005218085", 
          "https://doi.org/10.1038/sj.clpt.6100011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.coc.0000225411.95479.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005489451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.coc.0000225411.95479.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005489451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.62.1.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010841314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci33435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010926043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014017201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014860180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.clpt.2006.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014970307", 
          "https://doi.org/10.1016/j.clpt.2006.08.012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015714511", 
          "https://doi.org/10.1038/sj.clpt.6100476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00498250310001609165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016493949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trim.2005.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017364573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00612.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017520224", 
          "https://doi.org/10.1111/j.1523-1755.2005.00612.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1523-1755.2005.00612.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017520224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019807196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2008.94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022136871", 
          "https://doi.org/10.1038/clpt.2008.94"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.03.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024344655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2007.10.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026621346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030004118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030694071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.8.630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032710965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-4230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032824914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035145870", 
          "https://doi.org/10.1038/sj.clpt.6100019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-0815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036288067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1067/mcp.2000.111948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036354098", 
          "https://doi.org/10.1067/mcp.2000.111948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/em.10199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037173041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037435334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038750552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042531997", 
          "https://doi.org/10.2165/00003088-200645030-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645030-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042531997", 
          "https://doi.org/10.2165/00003088-200645030-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ab.2003.09.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042992792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645010-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043445170", 
          "https://doi.org/10.2165/00003088-200645010-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645010-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043445170", 
          "https://doi.org/10.2165/00003088-200645010-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200645010-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043445170", 
          "https://doi.org/10.2165/00003088-200645010-00002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045919669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046655247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-7646(03)00005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046858056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1368-7646(03)00005-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046858056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.4752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049105554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.clpt.2006.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050720057", 
          "https://doi.org/10.1016/j.clpt.2006.02.003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1211/0022357055966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053364736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425255.1.3.429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053643391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425255.1.3.429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053643391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/342666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058639472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-199810000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-199810000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-199810000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-200207000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-200207000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008571-200207000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060289940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000114744.08559.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000114744.08559.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.fpc.0000114744.08559.92", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060328124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157016307781115485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069198327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.4.8.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074724696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075157255", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075185034", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075250652", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.1.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083201635"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-02", 
    "datePublishedReg": "2009-02-01", 
    "description": "The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five genes involved in drug elimination. Among the transfected models investigated, OATP1B3 (SLCO1B3) was identified as the most efficient influx transporter for docetaxel. None of the observed genotypes (SLCO1B3, ABCB1, and ABCC2) was related with docetaxel clearance in 92 white patients (P > 0.17). However, the simultaneous presence of the CYP3A4*1B and CYP3A5*1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test). This haplotype was also associated with increased midazolam clearance in another population (P = 0.0198). An analysis of the CYP3A locus among CEPH-HapMap samples revealed that CYP3A4*1B is present exclusively among a subset of CYP3A5 expressors. Therefore, future studies should first stratify the population on the basis of CYP3A5 genotype and then compare CYP3A activity between individuals with and without the CYP3A4*1B allele.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/clpt.2008.95", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438791", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2690867", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "85"
      }
    ], 
    "name": "Pharmacogenetic Pathway Analysis of Docetaxel Elimination", 
    "pagination": "155-163", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2b98e24d57a40d763e2d64678bd10a22fad5368a4edf0aedd324f3eb0c9ca715"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18509327"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/clpt.2008.95"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009151094"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/clpt.2008.95", 
      "https://app.dimensions.ai/details/publication/pub.1009151094"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://onlinelibrary.wiley.com/doi/10.1038/clpt.2008.95/abstract"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/clpt.2008.95'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/clpt.2008.95'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/clpt.2008.95'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/clpt.2008.95'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      99 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/clpt.2008.95 schema:about N151243978d75461286e52cce647edb72
2 N21d458d509414b91a566cd8438bb077d
3 N24ba4f12391b46e8b64d701abb19087b
4 N42be63fcf4cd4a2d8fe65b58852e2fae
5 N5638fc559d164f388324e8f47c9c6f28
6 N56901f5b01334f0fbf7e71c3807e4df4
7 N7b062ed185f0427285f8c61090acd7ab
8 N824f9771ff7346ba8ad8a1b7f51145d8
9 N830b10f816ea41b58f25e135d5107038
10 N857b4d9f150648afb6cce415d54bdb28
11 N8766706f08d842a491b5c65d1a34d0bd
12 Nad07bb95f94b44e0b6a9fb73877c1117
13 Nba8f4b5f8c384993a236840ec3c478b1
14 Nc663d511d0e14895b9726d349c44a323
15 Nccc8546c0120408280105951c1046b00
16 Nd1225c8748a445bbbb7bb6518412c560
17 Nd81ff89be3644f27a23f16dc86f8d2b9
18 Ndecda0c81fd54e049e93f255bb62668d
19 Ndf824a844f6841109d3189e0bafef16b
20 Ne299e2f35888450ea7abafdfbd1ace2d
21 Ne7755795df7d4280acd34144a930b65e
22 anzsrc-for:06
23 anzsrc-for:0604
24 schema:author N64c6ec2c98534cfeba10dd4f773e15b9
25 schema:citation sg:pub.10.1016/j.clpt.2006.02.003
26 sg:pub.10.1016/j.clpt.2006.08.012
27 sg:pub.10.1038/clpt.2008.94
28 sg:pub.10.1038/sj.clpt.6100011
29 sg:pub.10.1038/sj.clpt.6100019
30 sg:pub.10.1038/sj.clpt.6100476
31 sg:pub.10.1067/mcp.2000.111948
32 sg:pub.10.1111/j.1523-1755.2005.00612.x
33 sg:pub.10.2165/00003088-200645010-00002
34 sg:pub.10.2165/00003088-200645030-00002
35 https://app.dimensions.ai/details/publication/pub.1074724696
36 https://app.dimensions.ai/details/publication/pub.1075157255
37 https://app.dimensions.ai/details/publication/pub.1075185034
38 https://app.dimensions.ai/details/publication/pub.1075250652
39 https://doi.org/10.1002/em.10199
40 https://doi.org/10.1002/ijc.21013
41 https://doi.org/10.1016/j.ab.2003.09.038
42 https://doi.org/10.1016/j.bbrc.2005.09.020
43 https://doi.org/10.1016/j.canlet.2007.10.040
44 https://doi.org/10.1016/j.trim.2005.08.001
45 https://doi.org/10.1016/s1368-7646(03)00005-0
46 https://doi.org/10.1080/00498250310001609165
47 https://doi.org/10.1086/342666
48 https://doi.org/10.1093/jnci/91.18.1587
49 https://doi.org/10.1093/jnci/94.8.630
50 https://doi.org/10.1097/00008571-199810000-00004
51 https://doi.org/10.1097/00008571-200207000-00003
52 https://doi.org/10.1097/01.coc.0000225411.95479.b4
53 https://doi.org/10.1097/01.fpc.0000114744.08559.92
54 https://doi.org/10.1111/j.1523-1755.2005.00612.x
55 https://doi.org/10.1124/mol.62.1.162
56 https://doi.org/10.1158/1078-0432.ccr-04-1371
57 https://doi.org/10.1158/1078-0432.ccr-05-0520
58 https://doi.org/10.1158/1078-0432.ccr-05-1942
59 https://doi.org/10.1158/1078-0432.ccr-05-2069
60 https://doi.org/10.1158/1078-0432.ccr-05-2649
61 https://doi.org/10.1158/1078-0432.ccr-06-0815
62 https://doi.org/10.1158/1078-0432.ccr-06-1352
63 https://doi.org/10.1158/1078-0432.ccr-06-2345
64 https://doi.org/10.1158/1078-0432.ccr-07-4230
65 https://doi.org/10.1172/jci33435
66 https://doi.org/10.1200/jco.1998.16.1.187
67 https://doi.org/10.1200/jco.2002.01.025
68 https://doi.org/10.1200/jco.2005.03.082
69 https://doi.org/10.1200/jco.2006.10.4752
70 https://doi.org/10.1211/0022357055966
71 https://doi.org/10.1517/17425255.1.3.429
72 https://doi.org/10.2174/157016307781115485
73 https://doi.org/10.4161/cbt.4.8.1867
74 schema:datePublished 2009-02
75 schema:datePublishedReg 2009-02-01
76 schema:description The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five genes involved in drug elimination. Among the transfected models investigated, OATP1B3 (SLCO1B3) was identified as the most efficient influx transporter for docetaxel. None of the observed genotypes (SLCO1B3, ABCB1, and ABCC2) was related with docetaxel clearance in 92 white patients (P > 0.17). However, the simultaneous presence of the CYP3A4*1B and CYP3A5*1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test). This haplotype was also associated with increased midazolam clearance in another population (P = 0.0198). An analysis of the CYP3A locus among CEPH-HapMap samples revealed that CYP3A4*1B is present exclusively among a subset of CYP3A5 expressors. Therefore, future studies should first stratify the population on the basis of CYP3A5 genotype and then compare CYP3A activity between individuals with and without the CYP3A4*1B allele.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N0387c84f5623432d8c8086dbcd74e3aa
81 N2113df0621964baaa08c5bc0674e4e4f
82 sg:journal.1017409
83 schema:name Pharmacogenetic Pathway Analysis of Docetaxel Elimination
84 schema:pagination 155-163
85 schema:productId N1a854957306c441d99e86c72ed30ee4b
86 N4d22f1ea25d34538bae38d6a3c155768
87 N9c7c0d71c23c433eb0d9d050489da1e2
88 Nc7eef6327274491985f01dbf01e75015
89 Nfc81260bfd3644d9a7174b517eb308b4
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009151094
91 https://doi.org/10.1038/clpt.2008.95
92 schema:sdDatePublished 2019-04-10T15:28
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Na6799e4882dd473eb08c9e90ef3b2f83
95 schema:url http://onlinelibrary.wiley.com/doi/10.1038/clpt.2008.95/abstract
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N022867e37acf4614813d6fe62a575836 rdf:first sg:person.016247331557.17
100 rdf:rest rdf:nil
101 N0387c84f5623432d8c8086dbcd74e3aa schema:volumeNumber 85
102 rdf:type schema:PublicationVolume
103 N0a8ddd11f99e48378035eb9d1a6644fa schema:name Department of Clinical Chemistry Erasmus MC Rotterdam The Netherlands
104 rdf:type schema:Organization
105 N151243978d75461286e52cce647edb72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Cell Line
107 rdf:type schema:DefinedTerm
108 N1a854957306c441d99e86c72ed30ee4b schema:name readcube_id
109 schema:value 2b98e24d57a40d763e2d64678bd10a22fad5368a4edf0aedd324f3eb0c9ca715
110 rdf:type schema:PropertyValue
111 N1adab03f6fed4c85b0deb8d36c2bc810 rdf:first sg:person.01270316226.96
112 rdf:rest N61efdde6710b43a393f4a610cf5fd39e
113 N1cc6f22bca834deb9805b6fb3527bd5e schema:name Erasmus MC–Daniel den Hoed Cancer Center Department of Medical Oncology Rotterdam The Netherlands
114 rdf:type schema:Organization
115 N2113df0621964baaa08c5bc0674e4e4f schema:issueNumber 2
116 rdf:type schema:PublicationIssue
117 N21d458d509414b91a566cd8438bb077d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged
119 rdf:type schema:DefinedTerm
120 N24ba4f12391b46e8b64d701abb19087b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Membrane Transport Proteins
122 rdf:type schema:DefinedTerm
123 N417fb79302eb44f6ab25e8859107b07f rdf:first sg:person.01221726245.27
124 rdf:rest Nf80e26a44d7543498f5d7d25edbc58e7
125 N42be63fcf4cd4a2d8fe65b58852e2fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Signal Transduction
127 rdf:type schema:DefinedTerm
128 N4d22f1ea25d34538bae38d6a3c155768 schema:name dimensions_id
129 schema:value pub.1009151094
130 rdf:type schema:PropertyValue
131 N53399d6d3c9541f99f97d4251dc49de8 rdf:first sg:person.01236641403.86
132 rdf:rest Ndfcd9c33f6e04a419c615b4264934445
133 N5638fc559d164f388324e8f47c9c6f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Female
135 rdf:type schema:DefinedTerm
136 N56901f5b01334f0fbf7e71c3807e4df4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Xenopus laevis
138 rdf:type schema:DefinedTerm
139 N61efdde6710b43a393f4a610cf5fd39e rdf:first sg:person.01061723357.32
140 rdf:rest N417fb79302eb44f6ab25e8859107b07f
141 N64c6ec2c98534cfeba10dd4f773e15b9 rdf:first sg:person.014334666047.33
142 rdf:rest N53399d6d3c9541f99f97d4251dc49de8
143 N66141c74df0943009c0ef207609de4d2 rdf:first sg:person.01350052111.67
144 rdf:rest Nbe67ae915d50481591755323a6832b19
145 N6aef7e55088f4c438f313deb7d2efee8 rdf:first sg:person.01266317743.88
146 rdf:rest N022867e37acf4614813d6fe62a575836
147 N7b062ed185f0427285f8c61090acd7ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cytochrome P-450 Enzyme System
149 rdf:type schema:DefinedTerm
150 N824f9771ff7346ba8ad8a1b7f51145d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aged, 80 and over
152 rdf:type schema:DefinedTerm
153 N830b10f816ea41b58f25e135d5107038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Young Adult
155 rdf:type schema:DefinedTerm
156 N857b4d9f150648afb6cce415d54bdb28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Male
158 rdf:type schema:DefinedTerm
159 N8766706f08d842a491b5c65d1a34d0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 N9c7c0d71c23c433eb0d9d050489da1e2 schema:name pubmed_id
163 schema:value 18509327
164 rdf:type schema:PropertyValue
165 Na6799e4882dd473eb08c9e90ef3b2f83 schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 Nad07bb95f94b44e0b6a9fb73877c1117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Taxoids
169 rdf:type schema:DefinedTerm
170 Nb7e76cce554342f789527827e5ec616c rdf:first sg:person.01231016344.35
171 rdf:rest Nce256086254c42b6b81569d4607a04a9
172 Nba8f4b5f8c384993a236840ec3c478b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Gene Frequency
174 rdf:type schema:DefinedTerm
175 Nbe67ae915d50481591755323a6832b19 rdf:first sg:person.0613343333.24
176 rdf:rest N1adab03f6fed4c85b0deb8d36c2bc810
177 Nc663d511d0e14895b9726d349c44a323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cytochrome P-450 CYP3A
179 rdf:type schema:DefinedTerm
180 Nc7eef6327274491985f01dbf01e75015 schema:name nlm_unique_id
181 schema:value 0372741
182 rdf:type schema:PropertyValue
183 Nccc8546c0120408280105951c1046b00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Metabolic Clearance Rate
185 rdf:type schema:DefinedTerm
186 Nce256086254c42b6b81569d4607a04a9 rdf:first sg:person.0767271253.39
187 rdf:rest N66141c74df0943009c0ef207609de4d2
188 Nd1225c8748a445bbbb7bb6518412c560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Pharmacogenetics
190 rdf:type schema:DefinedTerm
191 Nd81ff89be3644f27a23f16dc86f8d2b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Humans
193 rdf:type schema:DefinedTerm
194 Ndecda0c81fd54e049e93f255bb62668d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Genetic Variation
196 rdf:type schema:DefinedTerm
197 Ndf824a844f6841109d3189e0bafef16b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Middle Aged
199 rdf:type schema:DefinedTerm
200 Ndfcd9c33f6e04a419c615b4264934445 rdf:first sg:person.01222231306.06
201 rdf:rest Nfe9db03d78444e3c87d6cfb9110cec43
202 Ne299e2f35888450ea7abafdfbd1ace2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Animals
204 rdf:type schema:DefinedTerm
205 Ne7755795df7d4280acd34144a930b65e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Dogs
207 rdf:type schema:DefinedTerm
208 Nf80e26a44d7543498f5d7d25edbc58e7 rdf:first sg:person.012056130172.16
209 rdf:rest N6aef7e55088f4c438f313deb7d2efee8
210 Nfc81260bfd3644d9a7174b517eb308b4 schema:name doi
211 schema:value 10.1038/clpt.2008.95
212 rdf:type schema:PropertyValue
213 Nfe9db03d78444e3c87d6cfb9110cec43 rdf:first sg:person.015736046213.16
214 rdf:rest Nb7e76cce554342f789527827e5ec616c
215 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
216 schema:name Biological Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
219 schema:name Genetics
220 rdf:type schema:DefinedTerm
221 sg:grant.2438791 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2008.95
222 rdf:type schema:MonetaryGrant
223 sg:grant.2690867 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.2008.95
224 rdf:type schema:MonetaryGrant
225 sg:journal.1017409 schema:issn 0009-9236
226 1532-6535
227 schema:name Clinical Pharmacology & Therapeutics
228 rdf:type schema:Periodical
229 sg:person.01061723357.32 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
230 schema:familyName Lamba
231 schema:givenName V
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061723357.32
233 rdf:type schema:Person
234 sg:person.012056130172.16 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
235 schema:familyName Wolff
236 schema:givenName AC
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012056130172.16
238 rdf:type schema:Person
239 sg:person.01221726245.27 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
240 schema:familyName Messersmith
241 schema:givenName WA
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221726245.27
243 rdf:type schema:Person
244 sg:person.01222231306.06 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
245 schema:familyName Cusatis
246 schema:givenName GA
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222231306.06
248 rdf:type schema:Person
249 sg:person.01231016344.35 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
250 schema:familyName Marsh
251 schema:givenName S
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231016344.35
253 rdf:type schema:Person
254 sg:person.01236641403.86 schema:affiliation N1cc6f22bca834deb9805b6fb3527bd5e
255 schema:familyName Verweij
256 schema:givenName J
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236641403.86
258 rdf:type schema:Person
259 sg:person.01266317743.88 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
260 schema:familyName Carducci
261 schema:givenName MA
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266317743.88
263 rdf:type schema:Person
264 sg:person.01270316226.96 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
265 schema:familyName Schuetz
266 schema:givenName EG
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270316226.96
268 rdf:type schema:Person
269 sg:person.01350052111.67 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
270 schema:familyName Franke
271 schema:givenName RM
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350052111.67
273 rdf:type schema:Person
274 sg:person.014334666047.33 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
275 schema:familyName Baker
276 schema:givenName SD
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014334666047.33
278 rdf:type schema:Person
279 sg:person.015736046213.16 schema:affiliation N0a8ddd11f99e48378035eb9d1a6644fa
280 schema:familyName Schaik
281 schema:givenName RH
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015736046213.16
283 rdf:type schema:Person
284 sg:person.016247331557.17 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
285 schema:familyName Sparreboom
286 schema:givenName A
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016247331557.17
288 rdf:type schema:Person
289 sg:person.0613343333.24 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
290 schema:familyName Hu
291 schema:givenName S
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613343333.24
293 rdf:type schema:Person
294 sg:person.0767271253.39 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
295 schema:familyName Orwick
296 schema:givenName SJ
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767271253.39
298 rdf:type schema:Person
299 sg:pub.10.1016/j.clpt.2006.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050720057
300 https://doi.org/10.1016/j.clpt.2006.02.003
301 rdf:type schema:CreativeWork
302 sg:pub.10.1016/j.clpt.2006.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014970307
303 https://doi.org/10.1016/j.clpt.2006.08.012
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/clpt.2008.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022136871
306 https://doi.org/10.1038/clpt.2008.94
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/sj.clpt.6100011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005218085
309 https://doi.org/10.1038/sj.clpt.6100011
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/sj.clpt.6100019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035145870
312 https://doi.org/10.1038/sj.clpt.6100019
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/sj.clpt.6100476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015714511
315 https://doi.org/10.1038/sj.clpt.6100476
316 rdf:type schema:CreativeWork
317 sg:pub.10.1067/mcp.2000.111948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036354098
318 https://doi.org/10.1067/mcp.2000.111948
319 rdf:type schema:CreativeWork
320 sg:pub.10.1111/j.1523-1755.2005.00612.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017520224
321 https://doi.org/10.1111/j.1523-1755.2005.00612.x
322 rdf:type schema:CreativeWork
323 sg:pub.10.2165/00003088-200645010-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043445170
324 https://doi.org/10.2165/00003088-200645010-00002
325 rdf:type schema:CreativeWork
326 sg:pub.10.2165/00003088-200645030-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042531997
327 https://doi.org/10.2165/00003088-200645030-00002
328 rdf:type schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1074724696 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1075157255 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1075185034 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1075250652 schema:CreativeWork
333 https://doi.org/10.1002/em.10199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037173041
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/ijc.21013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046655247
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.ab.2003.09.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042992792
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.bbrc.2005.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019807196
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.canlet.2007.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026621346
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.trim.2005.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017364573
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s1368-7646(03)00005-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046858056
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1080/00498250310001609165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016493949
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1086/342666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058639472
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1093/jnci/91.18.1587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004405543
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1093/jnci/94.8.630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032710965
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1097/00008571-199810000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060289610
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1097/00008571-200207000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060289940
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/01.coc.0000225411.95479.b4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005489451
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1097/01.fpc.0000114744.08559.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060328124
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1111/j.1523-1755.2005.00612.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017520224
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1124/mol.62.1.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010841314
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1158/1078-0432.ccr-04-1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045919669
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1158/1078-0432.ccr-05-0520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014860180
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1158/1078-0432.ccr-05-1942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038750552
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1158/1078-0432.ccr-05-2069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037435334
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1158/1078-0432.ccr-05-2649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030694071
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1158/1078-0432.ccr-06-0815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036288067
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/1078-0432.ccr-06-1352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030004118
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/1078-0432.ccr-06-2345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014017201
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/1078-0432.ccr-07-4230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032824914
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1172/jci33435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010926043
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1200/jco.1998.16.1.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083201635
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1200/jco.2002.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202900
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1200/jco.2005.03.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024344655
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1200/jco.2006.10.4752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049105554
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1211/0022357055966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053364736
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1517/17425255.1.3.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053643391
398 rdf:type schema:CreativeWork
399 https://doi.org/10.2174/157016307781115485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069198327
400 rdf:type schema:CreativeWork
401 https://doi.org/10.4161/cbt.4.8.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293832
402 rdf:type schema:CreativeWork
403 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
404 schema:name St. Jude Children's Research Hospital Department of Pharmaceutical Sciences Memphis Tennessee USA
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
407 schema:name Washington University School of Medicine Department of Medicine St. Louis Missouri USA
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.469474.c schema:alternateName Johns Hopkins Medicine
410 schema:name The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Oncology Baltimore Maryland USA
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...