Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-01

AUTHORS

Parnian Zia‐Amirhosseini, Joseph C Ojingwa, Hildegard Spahn‐Langguth, Antony F McDonagh, Leslie Z Benet

ABSTRACT

The in vivo stability of tolmetin-plasma protein adducts was characterized in six healthy human volunteers after a 400 mg single dose and after a multiple-dose regimen of 400 mg tolmetin every 12 hours for 10 days. Although the mean +/- SD maximum bound concentration was only 2.72 +/- 0.98 ng drug/mg protein after a single dose, it was almost an order of magnitude higher after multiple dosing. The protein adduct exhibited an average half-life of 4.8 +/- 0.9 days in contrast to the much shorter 5-hour half-lives for tolmetin and its glucuronide. More... »

PAGES

21-27

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.1994.5

DOI

http://dx.doi.org/10.1038/clpt.1994.5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015911834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8299313


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tolmetin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "University of California Department of Pharmacy and the Liver Center San Francisco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zia\u2010Amirhosseini", 
        "givenName": "Parnian", 
        "id": "sg:person.01145322074.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145322074.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Department of Pharmacy and the Liver Center San Francisco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ojingwa", 
        "givenName": "Joseph C", 
        "id": "sg:person.01267734726.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267734726.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Department of Pharmacy and the Liver Center San Francisco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spahn\u2010Langguth", 
        "givenName": "Hildegard", 
        "id": "sg:person.01052720414.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052720414.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Department of Pharmacy and the Liver Center San Francisco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McDonagh", 
        "givenName": "Antony F", 
        "id": "sg:person.01152214650.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152214650.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of California Department of Pharmacy and the Liver Center San Francisco"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benet", 
        "givenName": "Leslie Z", 
        "id": "sg:person.01177105500.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177105500.25"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1994-01", 
    "datePublishedReg": "1994-01-01", 
    "description": "The in vivo stability of tolmetin-plasma protein adducts was characterized in six healthy human volunteers after a 400 mg single dose and after a multiple-dose regimen of 400 mg tolmetin every 12 hours for 10 days. Although the mean +/- SD maximum bound concentration was only 2.72 +/- 0.98 ng drug/mg protein after a single dose, it was almost an order of magnitude higher after multiple dosing. The protein adduct exhibited an average half-life of 4.8 +/- 0.9 days in contrast to the much shorter 5-hour half-lives for tolmetin and its glucuronide.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/clpt.1994.5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2511675", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1017409", 
        "issn": [
          "0009-9236", 
          "1532-6535"
        ], 
        "name": "Clinical Pharmacology & Therapeutics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing", 
    "pagination": "21-27", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4bd1624b8b13037b894441df1792e6c6e593c9b87742c6c13d06974c165d210d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8299313"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0372741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/clpt.1994.5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015911834"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/clpt.1994.5", 
      "https://app.dimensions.ai/details/publication/pub.1015911834"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000027.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://onlinelibrary.wiley.com/doi/10.1038/clpt.1994.5/abstract"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/clpt.1994.5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/clpt.1994.5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/clpt.1994.5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/clpt.1994.5'


 

This table displays all metadata directly associated to this object as RDF triples.

138 TRIPLES      20 PREDICATES      37 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/clpt.1994.5 schema:about N35d795e7a0d642c7b8e2a9a7846803fb
2 N3e318a697b2b4356bbcd1f8e6c9eef16
3 Na67ea5548cdd47858d3fa6e65b61f52f
4 Ncf5cdb06a1744d6abbda5a4f89d9e9e9
5 Ndf49497bde6e445eb021535bd4308b8b
6 Ne530672b2d914fa5b6c4b96f9993d73d
7 Ned1683b78b434bd5adc93df873671831
8 Nfe5fa8a2f1b344d28fada5b13bc588da
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N20a6143a0588440ca9485fe3bdb054a4
12 schema:datePublished 1994-01
13 schema:datePublishedReg 1994-01-01
14 schema:description The in vivo stability of tolmetin-plasma protein adducts was characterized in six healthy human volunteers after a 400 mg single dose and after a multiple-dose regimen of 400 mg tolmetin every 12 hours for 10 days. Although the mean +/- SD maximum bound concentration was only 2.72 +/- 0.98 ng drug/mg protein after a single dose, it was almost an order of magnitude higher after multiple dosing. The protein adduct exhibited an average half-life of 4.8 +/- 0.9 days in contrast to the much shorter 5-hour half-lives for tolmetin and its glucuronide.
15 schema:genre research_article
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf N083f1ab06ede4134a910790da79b8e90
19 N29debe7128b843849df797bc7f80bde1
20 sg:journal.1017409
21 schema:name Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing
22 schema:pagination 21-27
23 schema:productId N21b414d74608408f9b9b61df7b385159
24 N30a5f17d9d924c4e86d361305986cae1
25 N6c739dec6a1349b69cbce5a1c18c4961
26 N94800cdf229d48cfbbd8b3127e57036c
27 Nb60fbecd83c2409484f9d1a7714764ba
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015911834
29 https://doi.org/10.1038/clpt.1994.5
30 schema:sdDatePublished 2019-04-10T16:57
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N3038c122a917419194f7c2bf38ab2131
33 schema:url http://onlinelibrary.wiley.com/doi/10.1038/clpt.1994.5/abstract
34 sgo:license sg:explorer/license/
35 sgo:sdDataset articles
36 rdf:type schema:ScholarlyArticle
37 N083f1ab06ede4134a910790da79b8e90 schema:issueNumber 1
38 rdf:type schema:PublicationIssue
39 N20a6143a0588440ca9485fe3bdb054a4 rdf:first sg:person.01145322074.16
40 rdf:rest N471f657408a5403997fa7e3a41cb33ef
41 N21b414d74608408f9b9b61df7b385159 schema:name pubmed_id
42 schema:value 8299313
43 rdf:type schema:PropertyValue
44 N29debe7128b843849df797bc7f80bde1 schema:volumeNumber 55
45 rdf:type schema:PublicationVolume
46 N2fa951ac56514875bae02c70c55596fb schema:name University of California Department of Pharmacy and the Liver Center San Francisco
47 rdf:type schema:Organization
48 N3038c122a917419194f7c2bf38ab2131 schema:name Springer Nature - SN SciGraph project
49 rdf:type schema:Organization
50 N30a5f17d9d924c4e86d361305986cae1 schema:name doi
51 schema:value 10.1038/clpt.1994.5
52 rdf:type schema:PropertyValue
53 N359c2035d53a49959078acc5cc2b5ccc rdf:first sg:person.01052720414.09
54 rdf:rest N9dbee7ca227a4a70b3faa7acafe76a41
55 N35d795e7a0d642c7b8e2a9a7846803fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Humans
57 rdf:type schema:DefinedTerm
58 N3e318a697b2b4356bbcd1f8e6c9eef16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Drug Administration Schedule
60 rdf:type schema:DefinedTerm
61 N471f657408a5403997fa7e3a41cb33ef rdf:first sg:person.01267734726.10
62 rdf:rest N359c2035d53a49959078acc5cc2b5ccc
63 N6c739dec6a1349b69cbce5a1c18c4961 schema:name nlm_unique_id
64 schema:value 0372741
65 rdf:type schema:PropertyValue
66 N8b495d6b93df4771b5b7c26caf387787 schema:name University of California Department of Pharmacy and the Liver Center San Francisco
67 rdf:type schema:Organization
68 N94800cdf229d48cfbbd8b3127e57036c schema:name readcube_id
69 schema:value 4bd1624b8b13037b894441df1792e6c6e593c9b87742c6c13d06974c165d210d
70 rdf:type schema:PropertyValue
71 N9b9d8248055b4ac8b4d53adf83d7811e schema:name University of California Department of Pharmacy and the Liver Center San Francisco
72 rdf:type schema:Organization
73 N9dbee7ca227a4a70b3faa7acafe76a41 rdf:first sg:person.01152214650.33
74 rdf:rest Nd48d7378f0a847b2a67da66708f9ebaa
75 Na67ea5548cdd47858d3fa6e65b61f52f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Blood Proteins
77 rdf:type schema:DefinedTerm
78 Nb4e1c84ea7ad4c4fa4f2e04b9b3b66cf schema:name University of California Department of Pharmacy and the Liver Center San Francisco
79 rdf:type schema:Organization
80 Nb60fbecd83c2409484f9d1a7714764ba schema:name dimensions_id
81 schema:value pub.1015911834
82 rdf:type schema:PropertyValue
83 Ncf5cdb06a1744d6abbda5a4f89d9e9e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Protein Binding
85 rdf:type schema:DefinedTerm
86 Nd48d7378f0a847b2a67da66708f9ebaa rdf:first sg:person.01177105500.25
87 rdf:rest rdf:nil
88 Ndf49497bde6e445eb021535bd4308b8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Female
90 rdf:type schema:DefinedTerm
91 Ne530672b2d914fa5b6c4b96f9993d73d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 Ne9d90817380e4c3e9c799d08ed6f56f2 schema:name University of California Department of Pharmacy and the Liver Center San Francisco
95 rdf:type schema:Organization
96 Ned1683b78b434bd5adc93df873671831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Tolmetin
98 rdf:type schema:DefinedTerm
99 Nfe5fa8a2f1b344d28fada5b13bc588da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Adult
101 rdf:type schema:DefinedTerm
102 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
103 schema:name Biological Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
106 schema:name Biochemistry and Cell Biology
107 rdf:type schema:DefinedTerm
108 sg:grant.2511675 http://pending.schema.org/fundedItem sg:pub.10.1038/clpt.1994.5
109 rdf:type schema:MonetaryGrant
110 sg:journal.1017409 schema:issn 0009-9236
111 1532-6535
112 schema:name Clinical Pharmacology & Therapeutics
113 rdf:type schema:Periodical
114 sg:person.01052720414.09 schema:affiliation Nb4e1c84ea7ad4c4fa4f2e04b9b3b66cf
115 schema:familyName Spahn‐Langguth
116 schema:givenName Hildegard
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052720414.09
118 rdf:type schema:Person
119 sg:person.01145322074.16 schema:affiliation N2fa951ac56514875bae02c70c55596fb
120 schema:familyName Zia‐Amirhosseini
121 schema:givenName Parnian
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145322074.16
123 rdf:type schema:Person
124 sg:person.01152214650.33 schema:affiliation N9b9d8248055b4ac8b4d53adf83d7811e
125 schema:familyName McDonagh
126 schema:givenName Antony F
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152214650.33
128 rdf:type schema:Person
129 sg:person.01177105500.25 schema:affiliation Ne9d90817380e4c3e9c799d08ed6f56f2
130 schema:familyName Benet
131 schema:givenName Leslie Z
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177105500.25
133 rdf:type schema:Person
134 sg:person.01267734726.10 schema:affiliation N8b495d6b93df4771b5b7c26caf387787
135 schema:familyName Ojingwa
136 schema:givenName Joseph C
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267734726.10
138 rdf:type schema:Person
 




Preview window. Press ESC to close (or click here)


...