Short‐term effects of denopamine on anaerobic threshold and related parameters in patients with chronic heart failure: A double‐blind crossover study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

Yasuhiro Satoh, Koichi Taniguchi, Akira Koike, Hiromasa Adachi, Takashi Yajima, Tomohiro Iizumi, Tatsuo Shiigai, Michiaki Hiroe, Fumiaki Marumo

ABSTRACT

BACKGROUND: The short-term effects of denopamine, an orally available beta-stimulant, on exercise capacity were studied in patients with chronic heart failure. METHODS AND RESULTS: Nineteen patients entered the study. Three patients had ischemic heart disease, 13 had dilated cardiomyopathy, and three had valvular disease; 16 patients were in New York Heart Association class II, and three patients were in New York Heart Association class III. Symptom-limited exercise testing (ramp protocol) on a bicycle ergometer with gas exchange analysis was conducted 1 hour after oral administration of either 20 mg denopamine or placebo. Drug administration sequence was randomly assigned in a double-blind crossover method, with 1 week between drugs. Peak VO2 was 20.4 +/- 3.2 and 21.2 +/- 3.1 ml/min/kg, respectively, for those administered the placebo and the drug, and anaerobic threshold was 13.1 +/- 2.1 and 14.0 +/- 2.0 ml/min/kg. There was a significant increase in peak VO2 (p < 0.05) and anaerobic threshold (p < 0.01) with denopamine, whereas no significant change was observed in peak work rate or exercise time. Denopamine increased heart rate in patients with atrial fibrillation but had little effect on heart rate in patients with sinus rhythm. CONCLUSION: Data obtained from gas exchange analysis are more sensitive and potentially more useful in the detection of short-term changes in exercise capacity than data obtained from either exercise time or peak work rate, indexes that are commonly used to assess drug therapy. Patients with mild-to-moderate heart failure with sinus rhythm, but not those with atrial fibrillation because of its frequent induction of tachycardia, may be good candidates for denopamine therapy. More... »

PAGES

562-569

References to SciGraph publications

  • 1992-02. What do the newer inotropic drugs have to offer? in CARDIOVASCULAR DRUGS AND THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/clpt.1993.70

    DOI

    http://dx.doi.org/10.1038/clpt.1993.70

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010544248

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8098276


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adrenergic beta-Agonists", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anaerobic Threshold", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Pressure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiotonic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chronic Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Double-Blind Method", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ethanolamines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Satoh", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.013343331432.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013343331432.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taniguchi", 
            "givenName": "Koichi", 
            "id": "sg:person.013676263312.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013676263312.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koike", 
            "givenName": "Akira", 
            "id": "sg:person.01016716641.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016716641.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adachi", 
            "givenName": "Hiromasa", 
            "id": "sg:person.013141023572.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013141023572.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yajima", 
            "givenName": "Takashi", 
            "id": "sg:person.01062627536.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062627536.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iizumi", 
            "givenName": "Tomohiro", 
            "id": "sg:person.0731276403.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731276403.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiigai", 
            "givenName": "Tatsuo", 
            "id": "sg:person.0745052134.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745052134.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiroe", 
            "givenName": "Michiaki", 
            "id": "sg:person.0714645765.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714645765.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Second Department of Internal Medicine Tokyo Medical and Dental University"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marumo", 
            "givenName": "Fumiaki", 
            "id": "sg:person.01321000403.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321000403.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1097/00001573-199106000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9149(91)90194-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031077433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-199103000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036021886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00005344-199103000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036021886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jjp.42.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039799468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00050911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049995369", 
              "https://doi.org/10.1007/bf00050911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00050911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049995369", 
              "https://doi.org/10.1007/bf00050911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.36.1.185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051999056"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1993-05", 
        "datePublishedReg": "1993-05-01", 
        "description": "BACKGROUND: The short-term effects of denopamine, an orally available beta-stimulant, on exercise capacity were studied in patients with chronic heart failure.\nMETHODS AND RESULTS: Nineteen patients entered the study. Three patients had ischemic heart disease, 13 had dilated cardiomyopathy, and three had valvular disease; 16 patients were in New York Heart Association class II, and three patients were in New York Heart Association class III. Symptom-limited exercise testing (ramp protocol) on a bicycle ergometer with gas exchange analysis was conducted 1 hour after oral administration of either 20 mg denopamine or placebo. Drug administration sequence was randomly assigned in a double-blind crossover method, with 1 week between drugs. Peak VO2 was 20.4 +/- 3.2 and 21.2 +/- 3.1 ml/min/kg, respectively, for those administered the placebo and the drug, and anaerobic threshold was 13.1 +/- 2.1 and 14.0 +/- 2.0 ml/min/kg. There was a significant increase in peak VO2 (p < 0.05) and anaerobic threshold (p < 0.01) with denopamine, whereas no significant change was observed in peak work rate or exercise time. Denopamine increased heart rate in patients with atrial fibrillation but had little effect on heart rate in patients with sinus rhythm.\nCONCLUSION: Data obtained from gas exchange analysis are more sensitive and potentially more useful in the detection of short-term changes in exercise capacity than data obtained from either exercise time or peak work rate, indexes that are commonly used to assess drug therapy. Patients with mild-to-moderate heart failure with sinus rhythm, but not those with atrial fibrillation because of its frequent induction of tachycardia, may be good candidates for denopamine therapy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/clpt.1993.70", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1017409", 
            "issn": [
              "0009-9236", 
              "1532-6535"
            ], 
            "name": "Clinical Pharmacology & Therapeutics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "53"
          }
        ], 
        "name": "Short\u2010term effects of denopamine on anaerobic threshold and related parameters in patients with chronic heart failure: A double\u2010blind crossover study", 
        "pagination": "562-569", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "323ba10c77b34e58309aeaa37dc8f3e0e9821709de4014abb27731ec245975ea"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8098276"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0372741"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/clpt.1993.70"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010544248"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/clpt.1993.70", 
          "https://app.dimensions.ai/details/publication/pub.1010544248"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000018.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://onlinelibrary.wiley.com/doi/10.1038/clpt.1993.70/abstract"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/clpt.1993.70'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/clpt.1993.70'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/clpt.1993.70'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/clpt.1993.70'


     

    This table displays all metadata directly associated to this object as RDF triples.

    204 TRIPLES      21 PREDICATES      50 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/clpt.1993.70 schema:about N38bdb8d5f41f46ecb27a8e64588c5468
    2 N49eb3d30cb71491b90eba37acc278287
    3 N52a35a70a79f4b65ade50d0ee8a39b12
    4 N554556a741564abda636917ea2627a09
    5 N5d6cc1681040409886ef8dc7cdf2efe7
    6 N62f362fa3eda44dfa023d21513505587
    7 N6d5dcfceb8074bcbab6a134cfbcea442
    8 N6f19d757255548ceaa636e2f59f4dbe8
    9 N7d78cb6a4a984b92845eeb9b3a887762
    10 N81814dba6d514062b98f2d6ddf52d6f1
    11 N8bb2872315ae498aab5c1d602f5acc51
    12 N9ab931ccc39d48c39ac099756f178a84
    13 Nb94dc2a0b72f40b19b0c1fff5ddabd95
    14 Nc62f31bd092f40b283f95083189f9edf
    15 Ncbfe26ed4846458ab93a67e03e9a6748
    16 anzsrc-for:11
    17 anzsrc-for:1102
    18 schema:author Ne325579e0afd40e1b3265f35b70cf98b
    19 schema:citation sg:pub.10.1007/bf00050911
    20 https://doi.org/10.1016/0002-9149(91)90194-p
    21 https://doi.org/10.1097/00001573-199106000-00009
    22 https://doi.org/10.1097/00005344-199103000-00013
    23 https://doi.org/10.1161/01.res.36.1.185
    24 https://doi.org/10.1254/jjp.42.87
    25 schema:datePublished 1993-05
    26 schema:datePublishedReg 1993-05-01
    27 schema:description BACKGROUND: The short-term effects of denopamine, an orally available beta-stimulant, on exercise capacity were studied in patients with chronic heart failure. METHODS AND RESULTS: Nineteen patients entered the study. Three patients had ischemic heart disease, 13 had dilated cardiomyopathy, and three had valvular disease; 16 patients were in New York Heart Association class II, and three patients were in New York Heart Association class III. Symptom-limited exercise testing (ramp protocol) on a bicycle ergometer with gas exchange analysis was conducted 1 hour after oral administration of either 20 mg denopamine or placebo. Drug administration sequence was randomly assigned in a double-blind crossover method, with 1 week between drugs. Peak VO2 was 20.4 +/- 3.2 and 21.2 +/- 3.1 ml/min/kg, respectively, for those administered the placebo and the drug, and anaerobic threshold was 13.1 +/- 2.1 and 14.0 +/- 2.0 ml/min/kg. There was a significant increase in peak VO2 (p < 0.05) and anaerobic threshold (p < 0.01) with denopamine, whereas no significant change was observed in peak work rate or exercise time. Denopamine increased heart rate in patients with atrial fibrillation but had little effect on heart rate in patients with sinus rhythm. CONCLUSION: Data obtained from gas exchange analysis are more sensitive and potentially more useful in the detection of short-term changes in exercise capacity than data obtained from either exercise time or peak work rate, indexes that are commonly used to assess drug therapy. Patients with mild-to-moderate heart failure with sinus rhythm, but not those with atrial fibrillation because of its frequent induction of tachycardia, may be good candidates for denopamine therapy.
    28 schema:genre research_article
    29 schema:inLanguage en
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N03937d67de594c8d9b2c62181238b7ae
    32 N04a7fd9402d24570a7d92dbe9420b249
    33 sg:journal.1017409
    34 schema:name Short‐term effects of denopamine on anaerobic threshold and related parameters in patients with chronic heart failure: A double‐blind crossover study
    35 schema:pagination 562-569
    36 schema:productId N18e5cc14a10f458fb5763177e9e744b2
    37 N5b6428c0a3484640bd0f1aafb9bbd824
    38 N9c845b05c1194144990ba65389fced67
    39 Ne5cc37f0c4424fc09e09162e29c1d0a9
    40 Nec7957ea41534b70804db2a7580ae533
    41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010544248
    42 https://doi.org/10.1038/clpt.1993.70
    43 schema:sdDatePublished 2019-04-11T01:24
    44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    45 schema:sdPublisher N1e03ab957c0a40f0bdec78fb9739e5b6
    46 schema:url http://onlinelibrary.wiley.com/doi/10.1038/clpt.1993.70/abstract
    47 sgo:license sg:explorer/license/
    48 sgo:sdDataset articles
    49 rdf:type schema:ScholarlyArticle
    50 N03937d67de594c8d9b2c62181238b7ae schema:volumeNumber 53
    51 rdf:type schema:PublicationVolume
    52 N04a7fd9402d24570a7d92dbe9420b249 schema:issueNumber 5
    53 rdf:type schema:PublicationIssue
    54 N0f7c8033acc9436c8e0c983e98e792f1 rdf:first sg:person.0731276403.91
    55 rdf:rest N251dec7a0d8541e49bb7ac34fda8755f
    56 N18e5cc14a10f458fb5763177e9e744b2 schema:name nlm_unique_id
    57 schema:value 0372741
    58 rdf:type schema:PropertyValue
    59 N1beec8c5755e44bf98aceea0fe1d69ec rdf:first sg:person.0714645765.11
    60 rdf:rest N62f6c8a65a7740ba8d92fcd4518456b4
    61 N1e03ab957c0a40f0bdec78fb9739e5b6 schema:name Springer Nature - SN SciGraph project
    62 rdf:type schema:Organization
    63 N251dec7a0d8541e49bb7ac34fda8755f rdf:first sg:person.0745052134.59
    64 rdf:rest N1beec8c5755e44bf98aceea0fe1d69ec
    65 N38bdb8d5f41f46ecb27a8e64588c5468 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    66 schema:name Heart Diseases
    67 rdf:type schema:DefinedTerm
    68 N4645ffbcb61f417587d0a2e7f4efbd38 rdf:first sg:person.01016716641.04
    69 rdf:rest Neb1b879d030c4c26a3daaddb6da86acb
    70 N49eb3d30cb71491b90eba37acc278287 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    71 schema:name Double-Blind Method
    72 rdf:type schema:DefinedTerm
    73 N52a35a70a79f4b65ade50d0ee8a39b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Female
    75 rdf:type schema:DefinedTerm
    76 N554556a741564abda636917ea2627a09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Heart Rate
    78 rdf:type schema:DefinedTerm
    79 N58aea8c7149643a78c443707354c53f3 rdf:first sg:person.013676263312.52
    80 rdf:rest N4645ffbcb61f417587d0a2e7f4efbd38
    81 N5b6428c0a3484640bd0f1aafb9bbd824 schema:name readcube_id
    82 schema:value 323ba10c77b34e58309aeaa37dc8f3e0e9821709de4014abb27731ec245975ea
    83 rdf:type schema:PropertyValue
    84 N5d6cc1681040409886ef8dc7cdf2efe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Adrenergic beta-Agonists
    86 rdf:type schema:DefinedTerm
    87 N62f362fa3eda44dfa023d21513505587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Aged
    89 rdf:type schema:DefinedTerm
    90 N62f6c8a65a7740ba8d92fcd4518456b4 rdf:first sg:person.01321000403.00
    91 rdf:rest rdf:nil
    92 N6d5dcfceb8074bcbab6a134cfbcea442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Cardiotonic Agents
    94 rdf:type schema:DefinedTerm
    95 N6f19d757255548ceaa636e2f59f4dbe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Middle Aged
    97 rdf:type schema:DefinedTerm
    98 N7d78cb6a4a984b92845eeb9b3a887762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Chronic Disease
    100 rdf:type schema:DefinedTerm
    101 N81814dba6d514062b98f2d6ddf52d6f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Male
    103 rdf:type schema:DefinedTerm
    104 N8bb2872315ae498aab5c1d602f5acc51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Anaerobic Threshold
    106 rdf:type schema:DefinedTerm
    107 N9ab931ccc39d48c39ac099756f178a84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 N9c845b05c1194144990ba65389fced67 schema:name dimensions_id
    111 schema:value pub.1010544248
    112 rdf:type schema:PropertyValue
    113 Nb94dc2a0b72f40b19b0c1fff5ddabd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Ethanolamines
    115 rdf:type schema:DefinedTerm
    116 Nc62f31bd092f40b283f95083189f9edf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Adult
    118 rdf:type schema:DefinedTerm
    119 Ncbfe26ed4846458ab93a67e03e9a6748 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Blood Pressure
    121 rdf:type schema:DefinedTerm
    122 Ne325579e0afd40e1b3265f35b70cf98b rdf:first sg:person.013343331432.52
    123 rdf:rest N58aea8c7149643a78c443707354c53f3
    124 Ne5cc37f0c4424fc09e09162e29c1d0a9 schema:name pubmed_id
    125 schema:value 8098276
    126 rdf:type schema:PropertyValue
    127 Neb1b879d030c4c26a3daaddb6da86acb rdf:first sg:person.013141023572.58
    128 rdf:rest Nedba6b0f3fed4b229de7e0f529b8ace8
    129 Nec7957ea41534b70804db2a7580ae533 schema:name doi
    130 schema:value 10.1038/clpt.1993.70
    131 rdf:type schema:PropertyValue
    132 Nedba6b0f3fed4b229de7e0f529b8ace8 rdf:first sg:person.01062627536.65
    133 rdf:rest N0f7c8033acc9436c8e0c983e98e792f1
    134 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Medical and Health Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Cardiorespiratory Medicine and Haematology
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1017409 schema:issn 0009-9236
    141 1532-6535
    142 schema:name Clinical Pharmacology & Therapeutics
    143 rdf:type schema:Periodical
    144 sg:person.01016716641.04 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    145 schema:familyName Koike
    146 schema:givenName Akira
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016716641.04
    148 rdf:type schema:Person
    149 sg:person.01062627536.65 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    150 schema:familyName Yajima
    151 schema:givenName Takashi
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062627536.65
    153 rdf:type schema:Person
    154 sg:person.013141023572.58 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    155 schema:familyName Adachi
    156 schema:givenName Hiromasa
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013141023572.58
    158 rdf:type schema:Person
    159 sg:person.01321000403.00 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    160 schema:familyName Marumo
    161 schema:givenName Fumiaki
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321000403.00
    163 rdf:type schema:Person
    164 sg:person.013343331432.52 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    165 schema:familyName Satoh
    166 schema:givenName Yasuhiro
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013343331432.52
    168 rdf:type schema:Person
    169 sg:person.013676263312.52 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    170 schema:familyName Taniguchi
    171 schema:givenName Koichi
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013676263312.52
    173 rdf:type schema:Person
    174 sg:person.0714645765.11 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    175 schema:familyName Hiroe
    176 schema:givenName Michiaki
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714645765.11
    178 rdf:type schema:Person
    179 sg:person.0731276403.91 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    180 schema:familyName Iizumi
    181 schema:givenName Tomohiro
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731276403.91
    183 rdf:type schema:Person
    184 sg:person.0745052134.59 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    185 schema:familyName Shiigai
    186 schema:givenName Tatsuo
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745052134.59
    188 rdf:type schema:Person
    189 sg:pub.10.1007/bf00050911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049995369
    190 https://doi.org/10.1007/bf00050911
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1016/0002-9149(91)90194-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1031077433
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1097/00001573-199106000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057062
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1097/00005344-199103000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036021886
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1161/01.res.36.1.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051999056
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1254/jjp.42.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039799468
    201 rdf:type schema:CreativeWork
    202 https://www.grid.ac/institutes/grid.265073.5 schema:alternateName Tokyo Medical and Dental University
    203 schema:name Second Department of Internal Medicine Tokyo Medical and Dental University
    204 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...