Fludrocortisone suppression of sympathetic nervous activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-01

AUTHORS

Joseph L Izzo, David Horwitz, William J Lawton, Harry R Keiser

ABSTRACT

Fludrocortisone depressed plasma norepinephrine in normal subjects but to a lesser degree than it depressed renin activity or urinary aldosterone excretion. Sympathetic nervous reactivity (defined as upright/supine plasma norepinephrine) was decreased more than supine plasma norepinephrine. Pretreatment supine plasma norepinephrine (but not plasma renin activity or aldosterone excretion) correlated with blood pressure changes during fludrocortisone dosing, which suggests participation of the sympathetic nervous system in the blood pressure elevations reported during exogenous steroid administration or primary aldosteronism. Suppression of sympathetic nervous activity and reactivity by fludrocortisone tends to explain its limited usefulness in patients with autonomic dysfunction and postural hypotension. More... »

PAGES

102-106

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.1983.15

DOI

http://dx.doi.org/10.1038/clpt.1983.15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038669874

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6336684


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