Phencyclidine disposition after intravenous and oral doses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-05

AUTHORS

C Edgar Cook, Dolores R Brine, A Robert Jeffcoat, Judith M Hill, Monroe E Wall, Mario Perez‐Reyes, Stephanie R Di Guiseppi

ABSTRACT

[3H]-Phencyclidine (PCP) hydrochloride was given in intravenous (0.1 or 1 mg) or oral (1 mg) doses to male subjects. After 1 mg IV, drug and metabolites were recovered in urine (72.8 +/- 4.0% of dose), feces (4.7 +/- 0.9%), and perspiration. Fecal excretion was low (3.4 +/- 0.4%) after oral dosing and oral bioavailability was estimated at 72%. PCP comprised 16% of urinary radioactivity with 31% consisting of enzymatically hydrolyzable conjugates of hydroxylated metabolites. Both cis and trans isomers of 4-phenyl-4-(1-piperidinyl)cyclohexanol were found. Maximum average plasma PCP concentrations of 2.7 to 2.9 ng/ml were observed after oral and intravenous 1-mg doses. Blood/plasma ratios were approximately 1.0 and plasma binding was about 65%. Parent drug was found in saliva. Apparent terminal phase half-lifes averaged 21 +/- 3 hr (harmonic mean 17 hr, range 7 to 46 hr). The volume of distribution averaged 6.2 +/- 0.3 l/kg. Renal clearances were variable, but the average was 9% of the total clearance. Thus, PCP is cleared principally by metabolism. More... »

PAGES

625-634

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/clpt.1982.87

DOI

http://dx.doi.org/10.1038/clpt.1982.87

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003514382

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7075111


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176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743743565.90
177 rdf:type schema:Person
 




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