Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

M Dietel, K Jöhrens, Mv Laffert, M Hummel, H Bläker, B M Müller, A Lehmann, C Denkert, F L Heppner, A Koch, C Sers, I Anagnostopoulos

ABSTRACT

The increasing importance of targeting drugs in the treatment of several tumor entities (breast, colon, lung, malignant melanoma (MM), lymphoma, and so on) and the necessity of a companion diagnostic (human epidermal growth factor receptor 2, Kirsten rat sarcoma viral oncogene, epidermal growth factor receptor (EGFR), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), and so on) is leading to new challenges for surgical pathology. As all the biomarkers to be specifically detected are tissue based, a precise and reliable diagnostic is absolutely crucial. To meet this challenge, surgical pathology has adapted a number of molecular methods (semi-quantitative immunohistochemistry, fluorescence in situ hybridization), PCR and its multiple variants, (pyro/Sanger) sequencing, next-generation sequencing, DNA-arrays, methylation analyses, and so on) to be applicable for formalin-fixed paraffin-embedded (FFPE) tissue. To read a patients' tissue as 'deeply' as possible and to obtain information on morphological, genetic, proteomic as well as epigenetic background is the actual task of pathologists and molecular biologists in order to provide the clinicians with information relevant for individualized medicine. The intensified cooperation of clinicians and pathologists will provide the basis of improved clinical drug selection as well as guide development of new cancer gene therapies and molecularly targeted drugs by research units and the pharmaceutical industry. This review will give some information on (1) biomarker detection methods adapted to FFPE tissue, (2) the potency of predictive pathology in tumor detection and treatment and (3) the implications of pathology on the development of new drugs in molecularly targeted and gene therapies. More... »

PAGES

211

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cgt.2013.13

DOI

http://dx.doi.org/10.1038/cgt.2013.13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006733151

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23492822


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Diagnostic Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dietel", 
        "givenName": "M", 
        "id": "sg:person.01340546577.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340546577.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f6hrens", 
        "givenName": "K", 
        "id": "sg:person.0745150257.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745150257.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laffert", 
        "givenName": "Mv", 
        "id": "sg:person.01241010556.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241010556.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hummel", 
        "givenName": "M", 
        "id": "sg:person.0615736477.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615736477.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bl\u00e4ker", 
        "givenName": "H", 
        "id": "sg:person.0714717401.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714717401.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "B M", 
        "id": "sg:person.01053660155.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053660155.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehmann", 
        "givenName": "A", 
        "id": "sg:person.0600453713.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600453713.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Denkert", 
        "givenName": "C", 
        "id": "sg:person.01052576706.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052576706.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Neuropathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heppner", 
        "givenName": "F L", 
        "id": "sg:person.01153074764.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153074764.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Neuropathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koch", 
        "givenName": "A", 
        "id": "sg:person.015466675212.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015466675212.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sers", 
        "givenName": "C", 
        "id": "sg:person.0665247717.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665247717.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Institute of Pathology, Charit\u00e9, University Medicine Berlin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anagnostopoulos", 
        "givenName": "I", 
        "id": "sg:person.01225532512.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225532512.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ccr.2012.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000147670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/41.5.8385683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001023510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/41.5.8385683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001023510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12308-012-0138-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001401640", 
          "https://doi.org/10.1007/s12308-012-0138-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12308-012-0138-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001401640", 
          "https://doi.org/10.1007/s12308-012-0138-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001422633", 
          "https://doi.org/10.1038/nrc1319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001422633", 
          "https://doi.org/10.1038/nrc1319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-3248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002048830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1096-9896(200109)195:1<66::aid-path921>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002434228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ab.2010.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002797957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003369625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003457415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181c4dedb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003976586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-008-0479-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004246339", 
          "https://doi.org/10.1007/s00418-008-0479-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-008-0479-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004246339", 
          "https://doi.org/10.1007/s00418-008-0479-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.43.3755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004454297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004846070", 
          "https://doi.org/10.1038/nature11219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-006-0189-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958225", 
          "https://doi.org/10.1007/s00428-006-0189-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-006-0189-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958225", 
          "https://doi.org/10.1007/s00428-006-0189-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2754-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005321664", 
          "https://doi.org/10.1245/s10434-012-2754-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007957167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00292-001-0496-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008318653", 
          "https://doi.org/10.1007/s00292-001-0496-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00292-001-0496-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008318653", 
          "https://doi.org/10.1007/s00292-001-0496-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011814571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e31815e8b60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012021500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0904554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012351385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2012-200716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013768944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8613066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014028622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1121343109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014174095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181f1c8de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014214560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/jmoldx.2010.090079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015396397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182233e06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016561333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3182233e06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016561333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017221313", 
          "https://doi.org/10.1038/nature05945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2010.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017571950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2009.010629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017583865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/clc.2006.n.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017662611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e31826d8f66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018491008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018593229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70232-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020094634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-012-1204-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021519519", 
          "https://doi.org/10.1007/s00428-012-1204-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021619375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0022751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021924349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0828-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022345880", 
          "https://doi.org/10.1007/s00428-009-0828-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0828-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022345880", 
          "https://doi.org/10.1007/s00428-009-0828-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0828-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022345880", 
          "https://doi.org/10.1007/s00428-009-0828-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023535411", 
          "https://doi.org/10.1186/1471-2407-12-558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70489-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024631546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9205-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024742629", 
          "https://doi.org/10.1007/s10555-010-9205-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9205-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024742629", 
          "https://doi.org/10.1007/s10555-010-9205-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.6497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024766199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-010-1000-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024974511", 
          "https://doi.org/10.1007/s00428-010-1000-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-010-1000-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024974511", 
          "https://doi.org/10.1007/s00428-010-1000-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djs427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024980640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.3414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025173270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0804385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025462530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026339294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.32.4327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027360666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35106108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028715647", 
          "https://doi.org/10.1038/35106108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35106108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028715647", 
          "https://doi.org/10.1038/35106108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029128387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029207836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.7116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031599680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81683-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031899717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/jmoldx.2008.070178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032459376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0b013e31823e5357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032473018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0b013e31823e5357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032473018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032628685", 
          "https://doi.org/10.1038/nrc2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1013224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033367810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jto.0b013e3181d86ebf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033618632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871070", 
          "https://doi.org/10.1038/25292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871070", 
          "https://doi.org/10.1038/25292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-04-214957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035145509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035319148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2012.01865.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036881950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038400003", 
          "https://doi.org/10.1038/ng1060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038400003", 
          "https://doi.org/10.1038/ng1060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041406511", 
          "https://doi.org/10.1038/nature03546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041406511", 
          "https://doi.org/10.1038/nature03546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0781-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129373", 
          "https://doi.org/10.1007/s00401-010-0781-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0781-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129373", 
          "https://doi.org/10.1007/s00401-010-0781-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363558a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043263395", 
          "https://doi.org/10.1038/363558a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0854-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844064", 
          "https://doi.org/10.1007/s00428-009-0854-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0854-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844064", 
          "https://doi.org/10.1007/s00428-009-0854-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0854-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844064", 
          "https://doi.org/10.1007/s00428-009-0854-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044214059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-06-429597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044823384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1014209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044873328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200001133420201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045953445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0042164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046318639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046456325", 
          "https://doi.org/10.1038/nrc1567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046456325", 
          "https://doi.org/10.1038/nrc1567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-008-0656-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046880226", 
          "https://doi.org/10.1007/s00428-008-0656-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-008-0656-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046880226", 
          "https://doi.org/10.1007/s00428-008-0656-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-008-0455-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047349518", 
          "https://doi.org/10.1007/s00401-008-0455-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047607151", 
          "https://doi.org/10.1038/nature07968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047607151", 
          "https://doi.org/10.1038/nature07968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199412013312208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047620795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047690225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2008.122572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049243054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0596-561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051513257", 
          "https://doi.org/10.1038/nm0596-561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexmp.2009.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052144791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000334827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052944065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcpst1cthzs3psz", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053540350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3798106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6695174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8484122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3001539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062686825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2003-032050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074774885", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082592115", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082617884", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04", 
    "datePublishedReg": "2013-04-01", 
    "description": "The increasing importance of targeting drugs in the treatment of several tumor entities (breast, colon, lung, malignant melanoma (MM), lymphoma, and so on) and the necessity of a companion diagnostic (human epidermal growth factor receptor 2, Kirsten rat sarcoma viral oncogene, epidermal growth factor receptor (EGFR), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), and so on) is leading to new challenges for surgical pathology. As all the biomarkers to be specifically detected are tissue based, a precise and reliable diagnostic is absolutely crucial. To meet this challenge, surgical pathology has adapted a number of molecular methods (semi-quantitative immunohistochemistry, fluorescence in situ hybridization), PCR and its multiple variants, (pyro/Sanger) sequencing, next-generation sequencing, DNA-arrays, methylation analyses, and so on) to be applicable for formalin-fixed paraffin-embedded (FFPE) tissue. To read a patients' tissue as 'deeply' as possible and to obtain information on morphological, genetic, proteomic as well as epigenetic background is the actual task of pathologists and molecular biologists in order to provide the clinicians with information relevant for individualized medicine. The intensified cooperation of clinicians and pathologists will provide the basis of improved clinical drug selection as well as guide development of new cancer gene therapies and molecularly targeted drugs by research units and the pharmaceutical industry. This review will give some information on (1) biomarker detection methods adapted to FFPE tissue, (2) the potency of predictive pathology in tumor detection and treatment and (3) the implications of pathology on the development of new drugs in molecularly targeted and gene therapies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cgt.2013.13", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1112008", 
        "issn": [
          "0929-1903", 
          "1476-5500"
        ], 
        "name": "Cancer Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance", 
    "pagination": "211", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "201267d5b6ce12e3018bde23998d6b34ca8766e69e17a580f2a0ad127ae0ab65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23492822"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9432230"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cgt.2013.13"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006733151"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cgt.2013.13", 
      "https://app.dimensions.ai/details/publication/pub.1006733151"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/cgt201313"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cgt.2013.13'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cgt.2013.13'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cgt.2013.13'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cgt.2013.13'


 

This table displays all metadata directly associated to this object as RDF triples.

475 TRIPLES      21 PREDICATES      128 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cgt.2013.13 schema:about N142c35e13eee46f2a90426d8d71d3ecb
2 N248938ee34794422b7dbb38081954f5e
3 N4103c34c54ed46aa82255d86ef2df3c0
4 N4d5f5f59ceeb4758973d4d55a8e62fe6
5 N89645b71eba540b8ad1bf8ce1803c3ba
6 Nb12f3a3e2fda47ab84de79d65ec765bd
7 Nbdd5ab8beb7242409861be4d6f15165c
8 anzsrc-for:11
9 anzsrc-for:1112
10 schema:author N0feaa06603da432d85a8d416384da214
11 schema:citation sg:pub.10.1007/s00292-001-0496-y
12 sg:pub.10.1007/s00401-007-0243-4
13 sg:pub.10.1007/s00401-008-0455-2
14 sg:pub.10.1007/s00401-010-0781-z
15 sg:pub.10.1007/s00418-008-0479-7
16 sg:pub.10.1007/s00428-006-0189-2
17 sg:pub.10.1007/s00428-008-0656-z
18 sg:pub.10.1007/s00428-009-0828-5
19 sg:pub.10.1007/s00428-009-0854-3
20 sg:pub.10.1007/s00428-010-1000-y
21 sg:pub.10.1007/s00428-012-1204-4
22 sg:pub.10.1007/s10555-010-9205-8
23 sg:pub.10.1007/s12308-012-0138-8
24 sg:pub.10.1038/25292
25 sg:pub.10.1038/35106108
26 sg:pub.10.1038/363558a0
27 sg:pub.10.1038/nature03546
28 sg:pub.10.1038/nature05945
29 sg:pub.10.1038/nature07968
30 sg:pub.10.1038/nature11219
31 sg:pub.10.1038/ng1060
32 sg:pub.10.1038/nm0596-561
33 sg:pub.10.1038/nrc1319
34 sg:pub.10.1038/nrc1567
35 sg:pub.10.1038/nrc2088
36 sg:pub.10.1186/1471-2407-12-558
37 sg:pub.10.1245/s10434-012-2754-z
38 https://app.dimensions.ai/details/publication/pub.1074774885
39 https://app.dimensions.ai/details/publication/pub.1082592115
40 https://app.dimensions.ai/details/publication/pub.1082617884
41 https://doi.org/10.1002/1096-9896(200109)195:1<66::aid-path921>3.0.co;2-f
42 https://doi.org/10.1002/cncr.24181
43 https://doi.org/10.1016/j.ab.2010.01.014
44 https://doi.org/10.1016/j.ccr.2012.03.007
45 https://doi.org/10.1016/j.critrevonc.2010.12.005
46 https://doi.org/10.1016/j.yexmp.2009.09.009
47 https://doi.org/10.1016/s0092-8674(00)81683-9
48 https://doi.org/10.1016/s1470-2045(11)70232-7
49 https://doi.org/10.1016/s1470-2045(12)70489-8
50 https://doi.org/10.1053/gast.1996.v110.pm8613066
51 https://doi.org/10.1056/nejm199412013312208
52 https://doi.org/10.1056/nejm200001133420201
53 https://doi.org/10.1056/nejmc1013224
54 https://doi.org/10.1056/nejmoa043331
55 https://doi.org/10.1056/nejmoa0804385
56 https://doi.org/10.1056/nejmoa0808710
57 https://doi.org/10.1056/nejmoa0904554
58 https://doi.org/10.1056/nejmoa1014209
59 https://doi.org/10.1073/pnas.1121343109
60 https://doi.org/10.1093/annonc/mdp322
61 https://doi.org/10.1093/annonc/mds334
62 https://doi.org/10.1093/annonc/mds357
63 https://doi.org/10.1093/jnci/djh034
64 https://doi.org/10.1093/jnci/djs427
65 https://doi.org/10.1097/jto.0b013e31815e8b60
66 https://doi.org/10.1097/jto.0b013e3181c4dedb
67 https://doi.org/10.1097/jto.0b013e3181d86ebf
68 https://doi.org/10.1097/jto.0b013e3181f1c8de
69 https://doi.org/10.1097/jto.0b013e31826d8f66
70 https://doi.org/10.1097/pas.0b013e3182233e06
71 https://doi.org/10.1097/ppo.0b013e31823e5357
72 https://doi.org/10.1111/j.1399-0004.2012.01865.x
73 https://doi.org/10.1126/science.3798106
74 https://doi.org/10.1126/science.6695174
75 https://doi.org/10.1126/science.8484122
76 https://doi.org/10.1126/scitranslmed.3001539
77 https://doi.org/10.1136/jclinpath-2012-200716
78 https://doi.org/10.1158/1078-0432.ccr-08-0168
79 https://doi.org/10.1158/1078-0432.ccr-08-3248
80 https://doi.org/10.1158/1078-0432.ccr-10-0851
81 https://doi.org/10.1158/1078-0432.ccr-11-0926
82 https://doi.org/10.1159/000334827
83 https://doi.org/10.1177/41.5.8385683
84 https://doi.org/10.1182/blood-2009-04-214957
85 https://doi.org/10.1182/blood-2012-06-429597
86 https://doi.org/10.1200/jco.2005.04.3414
87 https://doi.org/10.1200/jco.2007.14.7116
88 https://doi.org/10.1200/jco.2009.23.6497
89 https://doi.org/10.1200/jco.2009.27.1825
90 https://doi.org/10.1200/jco.2010.32.4327
91 https://doi.org/10.1200/jco.2011.35.2245
92 https://doi.org/10.1200/jco.2012.43.3755
93 https://doi.org/10.1210/jc.2003-032050
94 https://doi.org/10.1309/ajcpst1cthzs3psz
95 https://doi.org/10.1371/journal.pone.0015661
96 https://doi.org/10.1371/journal.pone.0022751
97 https://doi.org/10.1371/journal.pone.0042164
98 https://doi.org/10.1373/clinchem.2008.122572
99 https://doi.org/10.2353/jmoldx.2008.070178
100 https://doi.org/10.2353/jmoldx.2010.090079
101 https://doi.org/10.3324/haematol.2009.010629
102 https://doi.org/10.3816/clc.2006.n.030
103 schema:datePublished 2013-04
104 schema:datePublishedReg 2013-04-01
105 schema:description The increasing importance of targeting drugs in the treatment of several tumor entities (breast, colon, lung, malignant melanoma (MM), lymphoma, and so on) and the necessity of a companion diagnostic (human epidermal growth factor receptor 2, Kirsten rat sarcoma viral oncogene, epidermal growth factor receptor (EGFR), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), and so on) is leading to new challenges for surgical pathology. As all the biomarkers to be specifically detected are tissue based, a precise and reliable diagnostic is absolutely crucial. To meet this challenge, surgical pathology has adapted a number of molecular methods (semi-quantitative immunohistochemistry, fluorescence in situ hybridization), PCR and its multiple variants, (pyro/Sanger) sequencing, next-generation sequencing, DNA-arrays, methylation analyses, and so on) to be applicable for formalin-fixed paraffin-embedded (FFPE) tissue. To read a patients' tissue as 'deeply' as possible and to obtain information on morphological, genetic, proteomic as well as epigenetic background is the actual task of pathologists and molecular biologists in order to provide the clinicians with information relevant for individualized medicine. The intensified cooperation of clinicians and pathologists will provide the basis of improved clinical drug selection as well as guide development of new cancer gene therapies and molecularly targeted drugs by research units and the pharmaceutical industry. This review will give some information on (1) biomarker detection methods adapted to FFPE tissue, (2) the potency of predictive pathology in tumor detection and treatment and (3) the implications of pathology on the development of new drugs in molecularly targeted and gene therapies.
106 schema:genre research_article
107 schema:inLanguage en
108 schema:isAccessibleForFree true
109 schema:isPartOf Na5a85f3b178149528e33858a0d7723d4
110 Nb5042b271d414062a2e9772ea9241353
111 sg:journal.1112008
112 schema:name Predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance
113 schema:pagination 211
114 schema:productId N04b0110f9bc3467b89c812f4cd8d8fa3
115 N072cf01c4f0947c0806fe1d74dfafd0a
116 N21afa438f39544bd87fc40a04df9b31d
117 N7119e633041342da898d674422e838d6
118 Nc3b5b58bcf04486386b7c81a2f68a5c2
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006733151
120 https://doi.org/10.1038/cgt.2013.13
121 schema:sdDatePublished 2019-04-10T21:25
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N2874a18a6ab54d3dadd22210e83f8b81
124 schema:url https://www.nature.com/articles/cgt201313
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N04b0110f9bc3467b89c812f4cd8d8fa3 schema:name readcube_id
129 schema:value 201267d5b6ce12e3018bde23998d6b34ca8766e69e17a580f2a0ad127ae0ab65
130 rdf:type schema:PropertyValue
131 N072cf01c4f0947c0806fe1d74dfafd0a schema:name pubmed_id
132 schema:value 23492822
133 rdf:type schema:PropertyValue
134 N0d60dc0171c54378a49480cc803e4331 rdf:first sg:person.01053660155.19
135 rdf:rest N9a6112e463784eb388d0187f5e164060
136 N0feaa06603da432d85a8d416384da214 rdf:first sg:person.01340546577.39
137 rdf:rest Ncfe214420d59461daa3b715a6dc6fa4e
138 N142c35e13eee46f2a90426d8d71d3ecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Neoplasms
140 rdf:type schema:DefinedTerm
141 N21afa438f39544bd87fc40a04df9b31d schema:name dimensions_id
142 schema:value pub.1006733151
143 rdf:type schema:PropertyValue
144 N23342e49eada41329c43bed71ad6447a rdf:first sg:person.01052576706.33
145 rdf:rest Nc3a2bc8345c74bc593ad76b63be4c15f
146 N248938ee34794422b7dbb38081954f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Genetic Therapy
148 rdf:type schema:DefinedTerm
149 N2874a18a6ab54d3dadd22210e83f8b81 schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 N4103c34c54ed46aa82255d86ef2df3c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Precision Medicine
153 rdf:type schema:DefinedTerm
154 N4d5f5f59ceeb4758973d4d55a8e62fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Molecular Targeted Therapy
156 rdf:type schema:DefinedTerm
157 N7119e633041342da898d674422e838d6 schema:name doi
158 schema:value 10.1038/cgt.2013.13
159 rdf:type schema:PropertyValue
160 N881bc05dd1614d91b5e24abaa9d44a39 rdf:first sg:person.01241010556.95
161 rdf:rest Naa88685b30ea4b709f93d8ab1fc618d8
162 N89645b71eba540b8ad1bf8ce1803c3ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 N8b7e3c2dc5594b78901a9e85ab758281 rdf:first sg:person.0714717401.53
166 rdf:rest N0d60dc0171c54378a49480cc803e4331
167 N9a6112e463784eb388d0187f5e164060 rdf:first sg:person.0600453713.83
168 rdf:rest N23342e49eada41329c43bed71ad6447a
169 Na5a85f3b178149528e33858a0d7723d4 schema:issueNumber 4
170 rdf:type schema:PublicationIssue
171 Na951bca4f3f646c1bf6d6ee105ad84f5 rdf:first sg:person.01225532512.46
172 rdf:rest rdf:nil
173 Naa88685b30ea4b709f93d8ab1fc618d8 rdf:first sg:person.0615736477.31
174 rdf:rest N8b7e3c2dc5594b78901a9e85ab758281
175 Nb12f3a3e2fda47ab84de79d65ec765bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Molecular Diagnostic Techniques
177 rdf:type schema:DefinedTerm
178 Nb5042b271d414062a2e9772ea9241353 schema:volumeNumber 20
179 rdf:type schema:PublicationVolume
180 Nbdd5ab8beb7242409861be4d6f15165c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Biomarkers, Tumor
182 rdf:type schema:DefinedTerm
183 Nc3a2bc8345c74bc593ad76b63be4c15f rdf:first sg:person.01153074764.27
184 rdf:rest Nf826fe0a99854cb0ac8a11d92480f9b2
185 Nc3b5b58bcf04486386b7c81a2f68a5c2 schema:name nlm_unique_id
186 schema:value 9432230
187 rdf:type schema:PropertyValue
188 Ncfe214420d59461daa3b715a6dc6fa4e rdf:first sg:person.0745150257.89
189 rdf:rest N881bc05dd1614d91b5e24abaa9d44a39
190 Nd242f36ed6d443ebb53dcd952e59d70f rdf:first sg:person.0665247717.59
191 rdf:rest Na951bca4f3f646c1bf6d6ee105ad84f5
192 Nf826fe0a99854cb0ac8a11d92480f9b2 rdf:first sg:person.015466675212.24
193 rdf:rest Nd242f36ed6d443ebb53dcd952e59d70f
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
198 schema:name Oncology and Carcinogenesis
199 rdf:type schema:DefinedTerm
200 sg:journal.1112008 schema:issn 0929-1903
201 1476-5500
202 schema:name Cancer Gene Therapy
203 rdf:type schema:Periodical
204 sg:person.01052576706.33 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
205 schema:familyName Denkert
206 schema:givenName C
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052576706.33
208 rdf:type schema:Person
209 sg:person.01053660155.19 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
210 schema:familyName Müller
211 schema:givenName B M
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053660155.19
213 rdf:type schema:Person
214 sg:person.01153074764.27 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
215 schema:familyName Heppner
216 schema:givenName F L
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153074764.27
218 rdf:type schema:Person
219 sg:person.01225532512.46 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
220 schema:familyName Anagnostopoulos
221 schema:givenName I
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225532512.46
223 rdf:type schema:Person
224 sg:person.01241010556.95 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
225 schema:familyName Laffert
226 schema:givenName Mv
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241010556.95
228 rdf:type schema:Person
229 sg:person.01340546577.39 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
230 schema:familyName Dietel
231 schema:givenName M
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340546577.39
233 rdf:type schema:Person
234 sg:person.015466675212.24 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
235 schema:familyName Koch
236 schema:givenName A
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015466675212.24
238 rdf:type schema:Person
239 sg:person.0600453713.83 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
240 schema:familyName Lehmann
241 schema:givenName A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600453713.83
243 rdf:type schema:Person
244 sg:person.0615736477.31 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
245 schema:familyName Hummel
246 schema:givenName M
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615736477.31
248 rdf:type schema:Person
249 sg:person.0665247717.59 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
250 schema:familyName Sers
251 schema:givenName C
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665247717.59
253 rdf:type schema:Person
254 sg:person.0714717401.53 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
255 schema:familyName Bläker
256 schema:givenName H
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714717401.53
258 rdf:type schema:Person
259 sg:person.0745150257.89 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
260 schema:familyName Jöhrens
261 schema:givenName K
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745150257.89
263 rdf:type schema:Person
264 sg:pub.10.1007/s00292-001-0496-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1008318653
265 https://doi.org/10.1007/s00292-001-0496-y
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
268 https://doi.org/10.1007/s00401-007-0243-4
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00401-008-0455-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047349518
271 https://doi.org/10.1007/s00401-008-0455-2
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s00401-010-0781-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043129373
274 https://doi.org/10.1007/s00401-010-0781-z
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s00418-008-0479-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004246339
277 https://doi.org/10.1007/s00418-008-0479-7
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s00428-006-0189-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958225
280 https://doi.org/10.1007/s00428-006-0189-2
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s00428-008-0656-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1046880226
283 https://doi.org/10.1007/s00428-008-0656-z
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00428-009-0828-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022345880
286 https://doi.org/10.1007/s00428-009-0828-5
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00428-009-0854-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043844064
289 https://doi.org/10.1007/s00428-009-0854-3
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/s00428-010-1000-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1024974511
292 https://doi.org/10.1007/s00428-010-1000-y
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s00428-012-1204-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021519519
295 https://doi.org/10.1007/s00428-012-1204-4
296 rdf:type schema:CreativeWork
297 sg:pub.10.1007/s10555-010-9205-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024742629
298 https://doi.org/10.1007/s10555-010-9205-8
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s12308-012-0138-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001401640
301 https://doi.org/10.1007/s12308-012-0138-8
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/25292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871070
304 https://doi.org/10.1038/25292
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/35106108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028715647
307 https://doi.org/10.1038/35106108
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/363558a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043263395
310 https://doi.org/10.1038/363558a0
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nature03546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041406511
313 https://doi.org/10.1038/nature03546
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/nature05945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017221313
316 https://doi.org/10.1038/nature05945
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/nature07968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047607151
319 https://doi.org/10.1038/nature07968
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nature11219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004846070
322 https://doi.org/10.1038/nature11219
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/ng1060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038400003
325 https://doi.org/10.1038/ng1060
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/nm0596-561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051513257
328 https://doi.org/10.1038/nm0596-561
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/nrc1319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001422633
331 https://doi.org/10.1038/nrc1319
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/nrc1567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046456325
334 https://doi.org/10.1038/nrc1567
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/nrc2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628685
337 https://doi.org/10.1038/nrc2088
338 rdf:type schema:CreativeWork
339 sg:pub.10.1186/1471-2407-12-558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023535411
340 https://doi.org/10.1186/1471-2407-12-558
341 rdf:type schema:CreativeWork
342 sg:pub.10.1245/s10434-012-2754-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005321664
343 https://doi.org/10.1245/s10434-012-2754-z
344 rdf:type schema:CreativeWork
345 https://app.dimensions.ai/details/publication/pub.1074774885 schema:CreativeWork
346 https://app.dimensions.ai/details/publication/pub.1082592115 schema:CreativeWork
347 https://app.dimensions.ai/details/publication/pub.1082617884 schema:CreativeWork
348 https://doi.org/10.1002/1096-9896(200109)195:1<66::aid-path921>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1002434228
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1002/cncr.24181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007957167
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.ab.2010.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002797957
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.ccr.2012.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000147670
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.critrevonc.2010.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017571950
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/j.yexmp.2009.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052144791
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0092-8674(00)81683-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031899717
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s1470-2045(11)70232-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020094634
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s1470-2045(12)70489-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024631546
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1053/gast.1996.v110.pm8613066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014028622
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1056/nejm199412013312208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047620795
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1056/nejm200001133420201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045953445
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1056/nejmc1013224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033367810
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1056/nejmoa043331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029207836
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1056/nejmoa0804385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025462530
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1056/nejmoa0808710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319148
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1056/nejmoa0904554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012351385
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1056/nejmoa1014209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044873328
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1073/pnas.1121343109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014174095
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1093/annonc/mdp322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042592360
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/annonc/mds334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011814571
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1093/annonc/mds357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018593229
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/jnci/djh034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029128387
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1093/jnci/djs427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024980640
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1097/jto.0b013e31815e8b60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012021500
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1097/jto.0b013e3181c4dedb schema:sameAs https://app.dimensions.ai/details/publication/pub.1003976586
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1097/jto.0b013e3181d86ebf schema:sameAs https://app.dimensions.ai/details/publication/pub.1033618632
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1097/jto.0b013e3181f1c8de schema:sameAs https://app.dimensions.ai/details/publication/pub.1014214560
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1097/jto.0b013e31826d8f66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018491008
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1097/pas.0b013e3182233e06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016561333
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1097/ppo.0b013e31823e5357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032473018
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1111/j.1399-0004.2012.01865.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036881950
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1126/science.3798106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621480
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1126/science.6695174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639430
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1126/science.8484122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655780
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1126/scitranslmed.3001539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062686825
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1136/jclinpath-2012-200716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013768944
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1158/1078-0432.ccr-08-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026339294
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1158/1078-0432.ccr-08-3248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002048830
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1158/1078-0432.ccr-10-0851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044214059
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1158/1078-0432.ccr-11-0926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003369625
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1159/000334827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944065
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1177/41.5.8385683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001023510
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1182/blood-2009-04-214957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035145509
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1182/blood-2012-06-429597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044823384
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1200/jco.2005.04.3414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025173270
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1200/jco.2007.14.7116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031599680
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1200/jco.2009.23.6497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024766199
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1200/jco.2009.27.1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003457415
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1200/jco.2010.32.4327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027360666
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1200/jco.2011.35.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021619375
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1200/jco.2012.43.3755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004454297
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1210/jc.2003-032050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287524
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1309/ajcpst1cthzs3psz schema:sameAs https://app.dimensions.ai/details/publication/pub.1053540350
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1371/journal.pone.0015661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047690225
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1371/journal.pone.0022751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021924349
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1371/journal.pone.0042164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046318639
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1373/clinchem.2008.122572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049243054
463 rdf:type schema:CreativeWork
464 https://doi.org/10.2353/jmoldx.2008.070178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032459376
465 rdf:type schema:CreativeWork
466 https://doi.org/10.2353/jmoldx.2010.090079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015396397
467 rdf:type schema:CreativeWork
468 https://doi.org/10.3324/haematol.2009.010629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017583865
469 rdf:type schema:CreativeWork
470 https://doi.org/10.3816/clc.2006.n.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017662611
471 rdf:type schema:CreativeWork
472 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
473 schema:name Institute of Neuropathology, Charité, University Medicine Berlin, Berlin, Germany
474 Institute of Pathology, Charité, University Medicine Berlin, Berlin, Germany
475 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...