Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-11

AUTHORS

William T Lee, Xin Sun, Te-Sha Tsai, Jacqueline L Johnson, Jodee A Gould, Daniel J Garama, Daniel J Gough, Matthew McKenzie, Ian A Trounce, Justin C St. John

ABSTRACT

Mitochondrial DNA copy number is strictly regulated during development as naive cells differentiate into mature cells to ensure that specific cell types have sufficient copies of mitochondrial DNA to perform their specialised functions. Mitochondrial DNA haplotypes are defined as specific regions of mitochondrial DNA that cluster with other mitochondrial sequences to show the phylogenetic origins of maternal lineages. Mitochondrial DNA haplotypes are associated with a range of phenotypes and disease. To understand how mitochondrial DNA haplotypes induce these characteristics, we used four embryonic stem cell lines that have the same set of chromosomes but possess different mitochondrial DNA haplotypes. We show that mitochondrial DNA haplotypes influence changes in chromosomal gene expression and affinity for nuclear-encoded mitochondrial DNA replication factors to modulate mitochondrial DNA copy number, two events that act synchronously during differentiation. Global DNA methylation analysis showed that each haplotype induces distinct DNA methylation patterns, which, when modulated by DNA demethylation agents, resulted in skewed gene expression patterns that highlight the effectiveness of the new DNA methylation patterns established by each haplotype. The haplotypes differentially regulate α-ketoglutarate, a metabolite from the TCA cycle that modulates the TET family of proteins, which catalyse the transition from 5-methylcytosine, indicative of DNA methylation, to 5-hydroxymethylcytosine, indicative of DNA demethylation. Our outcomes show that mitochondrial DNA haplotypes differentially modulate chromosomal gene expression patterns of naive and differentiating cells by establishing mitochondrial DNA haplotype-specific DNA methylation patterns. More... »

PAGES

cddiscovery201762

References to SciGraph publications

  • 1994-07. Estimating the pattern of nucleotide substitution in JOURNAL OF MOLECULAR EVOLUTION
  • 2013-12. The regulation of mitochondrial DNA copy number in glioblastoma cells in CELL DEATH & DIFFERENTIATION
  • 2008-02. A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes in NATURE GENETICS
  • 1997-02. Viable offspring derived from fetal and adult mammalian cells in NATURE
  • 2016-12. The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus) in BMC GENETICS
  • 1996-04. Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II in NATURE GENETICS
  • 2013-08. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells in NATURE
  • 2016-12. Mitochondrial DNA plasticity is an essential inducer of tumorigenesis in CELL DEATH DISCOVERY
  • 2010-10. Epigenetic modifications as therapeutic targets in NATURE BIOTECHNOLOGY
  • 2005-06. Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2015-02-26. Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny in CELL DEATH & DISEASE
  • 2011-04. Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2009-06. The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation in STEM CELL REVIEWS AND REPORTS
  • 2016-12. Artificial selection reveals the energetic expense of producing larger eggs in FRONTIERS IN ZOOLOGY
  • 2009-09. Mitochondrial gene replacement in primate offspring and embryonic stem cells in NATURE
  • 1998-03. Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cddiscovery.2017.62

    DOI

    http://dx.doi.org/10.1038/cddiscovery.2017.62

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091523957

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28900542


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