RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-29

AUTHORS

Goodwin G Jinesh, Ashish M Kamat

ABSTRACT

Cancer stem cells evade apoptotic death by blebbishield emergency program, which constructs blebbishields from apoptotic bodies and drives cellular transformation. Von Hippel-Lindau (VHL) plays both tumor suppressor and oncogenic roles, and the reason behind is poorly understood. Here we demonstrate that dimers and trimers of p19-VHL interact with RalBP1 to construct blebbishields. Expression of RalBP1, p19-VHL, and high-molecular weight VHL is required to evade apoptosis by blebbishield-mediated transformation. In contrast, p30-VHL plays a tumor suppressor role by inhibiting blebbishield-mediated transformation. Furthermore, target genes of VHL that suppress oxidative stress were elevated during blebbishield-mediated cellular transformation. Thus, RalBP1 and p19-VHL play an oncogenic role, whereas p30-VHL plays a tumor suppressor role during the blebbishield emergency program by regulating oxidative stress management genes. More... »

PAGES

17023

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cddiscovery.2017.23

DOI

http://dx.doi.org/10.1038/cddiscovery.2017.23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085708566

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28580172


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