IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03

AUTHORS

Kai-Kai Chang, Li-Bing Liu, Li-Ping Jin, Bing Zhang, Jie Mei, Hui Li, Chun-Yan Wei, Wen-Jie Zhou, Xiao-Yong Zhu, Jun Shao, Da-Jin Li, Ming-Qing Li

ABSTRACT

Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10+Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-β. Compared with peripheral CD4+ T cells, endometrial CD4+ T cells highly expressed IL-27 receptors, especially the ectopic endometrium. Under external (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and local (estrogen, IL-6 and TGF-β) environmental regulation, IL-27 from macrophages and endometrial stromal cells (ESCs) induces IL-10 production in Th17 cells in vitro and in vivo. This process may be mediated through the interaction between c-musculoaponeurotic fibrosarconna (c-Maf) and retinoic acid-related orphan receptor gamma t (RORγt), and associated with the upregulation of downstream B lymphocyte-induced maturation protein-1 (Blimp-1). IL-10+Th17 cells, in turn, stimulate the proliferation and implantation of ectopic lesions and accelerate the progression of endometriosis. These results suggest that IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 and promoting the rapid growth and implantation of ectopic lesions. This finding provides a scientific basis for potential therapeutic strategies aimed at preventing the development of endometriosis, especially for patients with high levels of IL-10+Th17 cells. More... »

PAGES

e2666

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cddis.2017.95

DOI

http://dx.doi.org/10.1038/cddis.2017.95

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084127900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28300844


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometriosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Receptor Subfamily 1, Group F, Member 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positive Regulatory Domain I-Binding Factor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-maf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th17 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China", 
            "Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Kai-Kai", 
        "id": "sg:person.0647742145.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647742145.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Li-Bing", 
        "id": "sg:person.014744201754.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014744201754.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tongji University", 
          "id": "https://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People\u2019s Republic of China", 
            "Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Li-Ping", 
        "id": "sg:person.07763550667.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07763550667.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Bing", 
        "id": "sg:person.010240473545.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010240473545.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mei", 
        "givenName": "Jie", 
        "id": "sg:person.016165605611.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016165605611.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tongji University", 
          "id": "https://www.grid.ac/institutes/grid.24516.34", 
          "name": [
            "Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hui", 
        "id": "sg:person.015042503567.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015042503567.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Chun-Yan", 
        "id": "sg:person.011633434545.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011633434545.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China", 
            "Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Wen-Jie", 
        "id": "sg:person.0713236735.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713236735.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Xiao-Yong", 
        "id": "sg:person.01117067713.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117067713.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shao", 
        "givenName": "Jun", 
        "id": "sg:person.07443113145.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07443113145.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China", 
            "Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Da-Jin", 
        "id": "sg:person.01046151712.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046151712.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People\u2019s Republic of China", 
            "Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, People\u2019s Republic of China", 
            "Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ming-Qing", 
        "id": "sg:person.0777154212.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777154212.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/eji.200636896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001261219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001933444", 
          "https://doi.org/10.1038/ni1539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2015.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002326504", 
          "https://doi.org/10.1038/mi.2015.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2015.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002326504", 
          "https://doi.org/10.1038/mi.2015.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2011.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006350806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(03)00051-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009959241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(03)00051-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009959241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2004.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010150340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201343479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013633967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014688516", 
          "https://doi.org/10.1038/nm1444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014688516", 
          "https://doi.org/10.1038/nm1444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/del516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017024487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2015.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017224214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201242942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017663718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019516627", 
          "https://doi.org/10.1038/ni1537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2567.2011.03471.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020855528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2012.01173.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021214515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021866428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20141520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027384755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20100410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027810000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2010.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028831446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029196724", 
          "https://doi.org/10.1038/ni.3309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0900123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034572957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2013.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035331892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035443919", 
          "https://doi.org/10.1038/ni.1912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.20.7711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036314466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00324-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037228391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2011.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039783871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/795976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040290265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042867144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042867144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043091576", 
          "https://doi.org/10.1038/cddis.2014.414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2002.tb02781.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048638855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2002.tb02781.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048638855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0023522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049527129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052196462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2161559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062525118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3007988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2007-0749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-13-0552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.4.2225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076635517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.174.4.2098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077004749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.181.4.2382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077685975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077852651", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077995624", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2305-5839.2015.06.08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079128576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1501138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079131032"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03", 
    "datePublishedReg": "2017-03-01", 
    "description": "Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10+Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-\u03b2. Compared with peripheral CD4+ T cells, endometrial CD4+ T cells highly expressed IL-27 receptors, especially the ectopic endometrium. Under external (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and local (estrogen, IL-6 and TGF-\u03b2) environmental regulation, IL-27 from macrophages and endometrial stromal cells (ESCs) induces IL-10 production in Th17 cells in vitro and in vivo. This process may be mediated through the interaction between c-musculoaponeurotic fibrosarconna (c-Maf) and retinoic acid-related orphan receptor gamma t (ROR\u03b3t), and associated with the upregulation of downstream B lymphocyte-induced maturation protein-1 (Blimp-1). IL-10+Th17 cells, in turn, stimulate the proliferation and implantation of ectopic lesions and accelerate the progression of endometriosis. These results suggest that IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 and promoting the rapid growth and implantation of ectopic lesions. This finding provides a scientific basis for potential therapeutic strategies aimed at preventing the development of endometriosis, especially for patients with high levels of IL-10+Th17 cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cddis.2017.95", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042939", 
        "issn": [
          "2041-4889"
        ], 
        "name": "Cell Death & Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "IL-27 triggers IL-10 production in Th17 cells via a c-Maf/ROR\u03b3t/Blimp-1 signal to promote the progression of endometriosis", 
    "pagination": "e2666", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4cc163471cc6d05727d6db9643257ea694b78a257176a445d97e68f24a407dbc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28300844"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101524092"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cddis.2017.95"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084127900"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cddis.2017.95", 
      "https://app.dimensions.ai/details/publication/pub.1084127900"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000552.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/cddis201795"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cddis.2017.95'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cddis.2017.95'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cddis.2017.95'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cddis.2017.95'


 

This table displays all metadata directly associated to this object as RDF triples.

364 TRIPLES      21 PREDICATES      91 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cddis.2017.95 schema:about N15111ccebd4746dcad6953279686c3a8
2 N36f91091cbc44e37827c38f114e19490
3 N379094f24d9544779d0f765d43e49dc6
4 N42f41a7df0a1428081401bf2a98cc6c4
5 N558763598f0442fda8776f268e8e6c5a
6 N56a88294ed8942778b776b379833df64
7 N6186297fdfe44168b1ea36e26e735125
8 N708b2acf554348cf856c15599c266bc0
9 N77bce9c02a4d47e18e284a2433d65e07
10 N77e5d063ee6d4381b526d7371bcae5ef
11 N8162e92dc1214ce8910b517310d61a5b
12 N897f2686fb984479accaf9f5649b93cc
13 N8ba5d01f41a54963935b4a6abf428829
14 N8bcbfdb379dc41bbb15fdcbbe14367e5
15 N9150e9e9e33540c3bfc602c05dc6b903
16 N9d0b6926dd4a4757be16d1a48e9c9aaa
17 Nce5bf71f65cf4ad8b58e9b36f5d52863
18 Nddaebdd3f9504a2bb377e94d0b185d73
19 Neb1c7934dc3342a7b10bc10156c164bc
20 Nf112f707dfc54e188df948915bff0856
21 anzsrc-for:11
22 anzsrc-for:1107
23 schema:author Nb1e6871c7c034fb89f29f8ca05f1d7ce
24 schema:citation sg:pub.10.1038/cddis.2014.414
25 sg:pub.10.1038/mi.2015.45
26 sg:pub.10.1038/ni.1912
27 sg:pub.10.1038/ni.3309
28 sg:pub.10.1038/ni1537
29 sg:pub.10.1038/ni1539
30 sg:pub.10.1038/nm1444
31 https://app.dimensions.ai/details/publication/pub.1077852651
32 https://app.dimensions.ai/details/publication/pub.1077995624
33 https://doi.org/10.1002/eji.200636896
34 https://doi.org/10.1002/eji.201242942
35 https://doi.org/10.1002/eji.201343479
36 https://doi.org/10.1016/j.ajpath.2013.10.023
37 https://doi.org/10.1016/j.autrev.2015.08.001
38 https://doi.org/10.1016/j.immuni.2004.08.018
39 https://doi.org/10.1016/j.immuni.2010.08.010
40 https://doi.org/10.1016/j.immuni.2011.01.020
41 https://doi.org/10.1016/j.immuni.2012.06.014
42 https://doi.org/10.1016/j.it.2011.06.007
43 https://doi.org/10.1016/j.stem.2008.08.002
44 https://doi.org/10.1016/s1074-7613(02)00324-2
45 https://doi.org/10.1016/s1471-4914(03)00051-0
46 https://doi.org/10.1073/pnas.86.20.7711
47 https://doi.org/10.1084/jem.20100410
48 https://doi.org/10.1084/jem.20141520
49 https://doi.org/10.1093/humrep/del516
50 https://doi.org/10.1111/j.1365-2567.2011.03471.x
51 https://doi.org/10.1111/j.1600-0897.2012.01173.x
52 https://doi.org/10.1111/j.1749-6632.2002.tb02781.x
53 https://doi.org/10.1126/science.1178334
54 https://doi.org/10.1126/science.2161559
55 https://doi.org/10.1126/scitranslmed.3007988
56 https://doi.org/10.1155/2015/795976
57 https://doi.org/10.1210/en.2007-0749
58 https://doi.org/10.1371/journal.pone.0023522
59 https://doi.org/10.1530/rep-13-0552
60 https://doi.org/10.3978/j.issn.2305-5839.2015.06.08
61 https://doi.org/10.4049/jimmunol.0900123
62 https://doi.org/10.4049/jimmunol.1501138
63 https://doi.org/10.4049/jimmunol.172.4.2225
64 https://doi.org/10.4049/jimmunol.174.4.2098
65 https://doi.org/10.4049/jimmunol.181.4.2382
66 schema:datePublished 2017-03
67 schema:datePublishedReg 2017-03-01
68 schema:description Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10<sup>+</sup>Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-β. Compared with peripheral CD4<sup>+</sup> T cells, endometrial CD4<sup>+</sup> T cells highly expressed IL-27 receptors, especially the ectopic endometrium. Under external (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) and local (estrogen, IL-6 and TGF-β) environmental regulation, IL-27 from macrophages and endometrial stromal cells (ESCs) induces IL-10 production in Th17 cells in vitro and in vivo. This process may be mediated through the interaction between c-musculoaponeurotic fibrosarconna (c-Maf) and retinoic acid-related orphan receptor gamma t (RORγt), and associated with the upregulation of downstream B lymphocyte-induced maturation protein-1 (Blimp-1). IL-10<sup>+</sup>Th17 cells, in turn, stimulate the proliferation and implantation of ectopic lesions and accelerate the progression of endometriosis. These results suggest that IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 and promoting the rapid growth and implantation of ectopic lesions. This finding provides a scientific basis for potential therapeutic strategies aimed at preventing the development of endometriosis, especially for patients with high levels of IL-10<sup>+</sup>Th17 cells.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N2c1ffe3f66444605b1fa7878c6c103e7
73 N650151a8887b4d398cf1bedd03f88cad
74 sg:journal.1042939
75 schema:name IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis
76 schema:pagination e2666
77 schema:productId N0d52e70ab2d24d119593e8202eb89622
78 N33b4be40bad046b7ba711eeafc380988
79 N6a3bf8c29cd24d67a96126d4e465303b
80 N9be646e9e0574aaf979336735a72b5ec
81 Nbeb37c19e9ed4ca8a3c2834c2dbea1a9
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127900
83 https://doi.org/10.1038/cddis.2017.95
84 schema:sdDatePublished 2019-04-11T02:21
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N4e5114fdef2d47efbc1b68c5ac2669ec
87 schema:url https://www.nature.com/articles/cddis201795
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N0d52e70ab2d24d119593e8202eb89622 schema:name dimensions_id
92 schema:value pub.1084127900
93 rdf:type schema:PropertyValue
94 N15111ccebd4746dcad6953279686c3a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Interleukin-6
96 rdf:type schema:DefinedTerm
97 N2c1ffe3f66444605b1fa7878c6c103e7 schema:issueNumber 3
98 rdf:type schema:PublicationIssue
99 N33b4be40bad046b7ba711eeafc380988 schema:name nlm_unique_id
100 schema:value 101524092
101 rdf:type schema:PropertyValue
102 N36f91091cbc44e37827c38f114e19490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name CD4-Positive T-Lymphocytes
104 rdf:type schema:DefinedTerm
105 N379094f24d9544779d0f765d43e49dc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Endometrium
107 rdf:type schema:DefinedTerm
108 N42f41a7df0a1428081401bf2a98cc6c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adult
110 rdf:type schema:DefinedTerm
111 N4555301410cf4d948bd649a37337eebd rdf:first sg:person.015042503567.30
112 rdf:rest Nc2f67daa8f19497ea0615caac55996ce
113 N4d7edbb3b2ce4b56ba57f568a66c09b3 rdf:first sg:person.014744201754.25
114 rdf:rest N9ebddc4f1f1345d791b5364b01623ecc
115 N4e5114fdef2d47efbc1b68c5ac2669ec schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N558763598f0442fda8776f268e8e6c5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N56a88294ed8942778b776b379833df64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Up-Regulation
122 rdf:type schema:DefinedTerm
123 N6186297fdfe44168b1ea36e26e735125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Female
125 rdf:type schema:DefinedTerm
126 N650151a8887b4d398cf1bedd03f88cad schema:volumeNumber 8
127 rdf:type schema:PublicationVolume
128 N6a3bf8c29cd24d67a96126d4e465303b schema:name doi
129 schema:value 10.1038/cddis.2017.95
130 rdf:type schema:PropertyValue
131 N708b2acf554348cf856c15599c266bc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proto-Oncogene Proteins c-maf
133 rdf:type schema:DefinedTerm
134 N77bce9c02a4d47e18e284a2433d65e07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Stromal Cells
136 rdf:type schema:DefinedTerm
137 N77e5d063ee6d4381b526d7371bcae5ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Macrophages
139 rdf:type schema:DefinedTerm
140 N80ca28cc794245a4b0f716d772c7c8e2 rdf:first sg:person.016165605611.77
141 rdf:rest N4555301410cf4d948bd649a37337eebd
142 N8162e92dc1214ce8910b517310d61a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cell Differentiation
144 rdf:type schema:DefinedTerm
145 N897f2686fb984479accaf9f5649b93cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Disease Progression
147 rdf:type schema:DefinedTerm
148 N8ba5d01f41a54963935b4a6abf428829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Repressor Proteins
150 rdf:type schema:DefinedTerm
151 N8bcbfdb379dc41bbb15fdcbbe14367e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Positive Regulatory Domain I-Binding Factor 1
153 rdf:type schema:DefinedTerm
154 N9150e9e9e33540c3bfc602c05dc6b903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Endometriosis
156 rdf:type schema:DefinedTerm
157 N9be646e9e0574aaf979336735a72b5ec schema:name pubmed_id
158 schema:value 28300844
159 rdf:type schema:PropertyValue
160 N9d0b6926dd4a4757be16d1a48e9c9aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Transforming Growth Factor beta
162 rdf:type schema:DefinedTerm
163 N9ebddc4f1f1345d791b5364b01623ecc rdf:first sg:person.07763550667.55
164 rdf:rest Nf300bac492e446b7a4d27ad021dd9ee2
165 Na35d44e4a3c54d0c82a16477e76c74a1 rdf:first sg:person.01046151712.26
166 rdf:rest Nef499b20206f4652966752b43a0385e5
167 Na8e52b85c47043f18ca4127af39baf26 schema:name Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People’s Republic of China
168 rdf:type schema:Organization
169 Nb1e6871c7c034fb89f29f8ca05f1d7ce rdf:first sg:person.0647742145.70
170 rdf:rest N4d7edbb3b2ce4b56ba57f568a66c09b3
171 Nbb8d05ec791a4fffa25374dce85feeeb rdf:first sg:person.07443113145.75
172 rdf:rest Na35d44e4a3c54d0c82a16477e76c74a1
173 Nbeb37c19e9ed4ca8a3c2834c2dbea1a9 schema:name readcube_id
174 schema:value 4cc163471cc6d05727d6db9643257ea694b78a257176a445d97e68f24a407dbc
175 rdf:type schema:PropertyValue
176 Nc2f67daa8f19497ea0615caac55996ce rdf:first sg:person.011633434545.19
177 rdf:rest Nd62ce741872948458f06ea8c98790129
178 Nce5bf71f65cf4ad8b58e9b36f5d52863 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Th17 Cells
180 rdf:type schema:DefinedTerm
181 Nd3a16c6da4ea4758b67337eb867ccaa3 rdf:first sg:person.01117067713.54
182 rdf:rest Nbb8d05ec791a4fffa25374dce85feeeb
183 Nd62ce741872948458f06ea8c98790129 rdf:first sg:person.0713236735.18
184 rdf:rest Nd3a16c6da4ea4758b67337eb867ccaa3
185 Nddaebdd3f9504a2bb377e94d0b185d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Nuclear Receptor Subfamily 1, Group F, Member 3
187 rdf:type schema:DefinedTerm
188 Neb1c7934dc3342a7b10bc10156c164bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Interleukins
190 rdf:type schema:DefinedTerm
191 Nef499b20206f4652966752b43a0385e5 rdf:first sg:person.0777154212.13
192 rdf:rest rdf:nil
193 Nf112f707dfc54e188df948915bff0856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Interleukin-10
195 rdf:type schema:DefinedTerm
196 Nf300bac492e446b7a4d27ad021dd9ee2 rdf:first sg:person.010240473545.93
197 rdf:rest N80ca28cc794245a4b0f716d772c7c8e2
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
202 schema:name Immunology
203 rdf:type schema:DefinedTerm
204 sg:journal.1042939 schema:issn 2041-4889
205 schema:name Cell Death & Disease
206 rdf:type schema:Periodical
207 sg:person.010240473545.93 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
208 schema:familyName Zhang
209 schema:givenName Bing
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010240473545.93
211 rdf:type schema:Person
212 sg:person.01046151712.26 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
213 schema:familyName Li
214 schema:givenName Da-Jin
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046151712.26
216 rdf:type schema:Person
217 sg:person.01117067713.54 schema:affiliation Na8e52b85c47043f18ca4127af39baf26
218 schema:familyName Zhu
219 schema:givenName Xiao-Yong
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117067713.54
221 rdf:type schema:Person
222 sg:person.011633434545.19 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
223 schema:familyName Wei
224 schema:givenName Chun-Yan
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011633434545.19
226 rdf:type schema:Person
227 sg:person.014744201754.25 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
228 schema:familyName Liu
229 schema:givenName Li-Bing
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014744201754.25
231 rdf:type schema:Person
232 sg:person.015042503567.30 schema:affiliation https://www.grid.ac/institutes/grid.24516.34
233 schema:familyName Li
234 schema:givenName Hui
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015042503567.30
236 rdf:type schema:Person
237 sg:person.016165605611.77 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
238 schema:familyName Mei
239 schema:givenName Jie
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016165605611.77
241 rdf:type schema:Person
242 sg:person.0647742145.70 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
243 schema:familyName Chang
244 schema:givenName Kai-Kai
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647742145.70
246 rdf:type schema:Person
247 sg:person.0713236735.18 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
248 schema:familyName Zhou
249 schema:givenName Wen-Jie
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713236735.18
251 rdf:type schema:Person
252 sg:person.07443113145.75 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
253 schema:familyName Shao
254 schema:givenName Jun
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07443113145.75
256 rdf:type schema:Person
257 sg:person.07763550667.55 schema:affiliation https://www.grid.ac/institutes/grid.24516.34
258 schema:familyName Jin
259 schema:givenName Li-Ping
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07763550667.55
261 rdf:type schema:Person
262 sg:person.0777154212.13 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
263 schema:familyName Li
264 schema:givenName Ming-Qing
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777154212.13
266 rdf:type schema:Person
267 sg:pub.10.1038/cddis.2014.414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043091576
268 https://doi.org/10.1038/cddis.2014.414
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/mi.2015.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002326504
271 https://doi.org/10.1038/mi.2015.45
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/ni.1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443919
274 https://doi.org/10.1038/ni.1912
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ni.3309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029196724
277 https://doi.org/10.1038/ni.3309
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ni1537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019516627
280 https://doi.org/10.1038/ni1537
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/ni1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001933444
283 https://doi.org/10.1038/ni1539
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nm1444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014688516
286 https://doi.org/10.1038/nm1444
287 rdf:type schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1077852651 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1077995624 schema:CreativeWork
290 https://doi.org/10.1002/eji.200636896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001261219
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1002/eji.201242942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017663718
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1002/eji.201343479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013633967
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.ajpath.2013.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035331892
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.autrev.2015.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017224214
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.immuni.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010150340
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.immuni.2010.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028831446
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.immuni.2011.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006350806
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.immuni.2012.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021866428
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.it.2011.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039783871
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.stem.2008.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052196462
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1074-7613(02)00324-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037228391
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s1471-4914(03)00051-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009959241
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.86.20.7711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036314466
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1084/jem.20100410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027810000
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1084/jem.20141520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027384755
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1093/humrep/del516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017024487
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1111/j.1365-2567.2011.03471.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020855528
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1111/j.1600-0897.2012.01173.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021214515
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1111/j.1749-6632.2002.tb02781.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048638855
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1126/science.1178334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042867144
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1126/science.2161559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525118
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1126/scitranslmed.3007988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688231
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1155/2015/795976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040290265
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1210/en.2007-0749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248794
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1371/journal.pone.0023522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049527129
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1530/rep-13-0552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717810
343 rdf:type schema:CreativeWork
344 https://doi.org/10.3978/j.issn.2305-5839.2015.06.08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079128576
345 rdf:type schema:CreativeWork
346 https://doi.org/10.4049/jimmunol.0900123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034572957
347 rdf:type schema:CreativeWork
348 https://doi.org/10.4049/jimmunol.1501138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079131032
349 rdf:type schema:CreativeWork
350 https://doi.org/10.4049/jimmunol.172.4.2225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076635517
351 rdf:type schema:CreativeWork
352 https://doi.org/10.4049/jimmunol.174.4.2098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077004749
353 rdf:type schema:CreativeWork
354 https://doi.org/10.4049/jimmunol.181.4.2382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077685975
355 rdf:type schema:CreativeWork
356 https://www.grid.ac/institutes/grid.24516.34 schema:alternateName Tongji University
357 schema:name Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, People’s Republic of China
358 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People’s Republic of China
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.8547.e schema:alternateName Fudan University
361 schema:name Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, People’s Republic of China
362 Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, People’s Republic of China
363 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, People’s Republic of China
364 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...