Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-15

AUTHORS

Stefan Meyer, Adam Stevens, Roberto Paredes, Marion Schneider, Michael J Walker, Andrew J K Williamson, Maria-Belen Gonzalez-Sanchez, Stephanie Smetsers, Vineet Dalal, Hsiang Ying Teng, Daniel J White, Sam Taylor, Joanne Muter, Andrew Pierce, Chiara de Leonibus, Davy A P Rockx, Martin A Rooimans, Elaine Spooncer, Stacey Stauffer, Kajal Biswas, Barbara Godthelp, Josephine Dorsman, Peter E Clayton, Shyam K Sharan, Anthony D Whetton

ABSTRACT

BRCA2 encodes a protein with a fundamental role in homologous recombination that is essential for normal development. Carrier status of mutations in BRCA2 is associated with familial breast and ovarian cancer, while bi-allelic BRCA2 mutations can cause Fanconi anemia (FA), a cancer predisposition syndrome with cellular cross-linker hypersensitivity. Cancers associated with BRCA2 mutations can acquire chemo-resistance on relapse. We modeled acquired cross-linker resistance with an FA-derived BRCA2-mutated acute myeloid leukemia (AML) platform. Associated with acquired cross-linker resistance was the expression of a functional BRCA2 protein variant lacking exon 5 and exon 7 (BRCA2ΔE5+7), implying a role for BRCA2 splicing for acquired chemo-resistance. Integrated network analysis of transcriptomic and proteomic differences for phenotyping of BRCA2 disruption infers impact on transcription and chromatin remodeling in addition to the DNA damage response. The striking overlap with transcriptional profiles of FA patient hematopoiesis and BRCA mutation associated ovarian cancer helps define and explicate the 'BRCAness' profile. More... »

PAGES

e2875

References to SciGraph publications

  • 2016-12. Alternative splicing and cell survival: from tissue homeostasis to disease in CELL DEATH & DIFFERENTIATION
  • 2008-02. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers in NATURE
  • 2013-01-16. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks in NATURE
  • 2012-12. Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma in FAMILIAL CANCER
  • 2012-03. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response in NATURE CELL BIOLOGY
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 2008-08. Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2 in NATURE MEDICINE
  • 2016-01. Investigating the effect of 28 BRCA1 and BRCA2 mutations on their related transcribed mRNA in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-11-20. The BRCA2 genetic variant IVS7 + 2T → G is a mutation in JOURNAL OF HUMAN GENETICS
  • 2016-10. Splicing controls the ubiquitin response during DNA double-strand break repair in CELL DEATH & DIFFERENTIATION
  • 2013-10. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012. Using Recombineering to Generate Point Mutations:galK-Based Positive–Negative Selection Method in GENE SYNTHESIS
  • 1981-03. Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia in NATURE
  • 2008-02. Resistance to therapy caused by intragenic deletion in BRCA2 in NATURE
  • 2009-06. A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS) in NATURE PROTOCOLS
  • 2010-06-15. Functional Analysis of Human BRCA2 Variants Using a Mouse Embryonic Stem Cell-Based Assay in CANCER SUSCEPTIBILITY
  • 2014-10. RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cddis.2017.264

    DOI

    http://dx.doi.org/10.1038/cddis.2017.264

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086036090

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28617445


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