PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07-28

AUTHORS

B Anta, A Pérez-Rodríguez, J Castro, C A García- Domínguez, S Ibiza, N Martínez, L M Durá, S Hernández, T Gragera, D Peña-Jiménez, M Yunta, N Zarich, P Crespo, J M Serrador, E Santos, A Muñoz, J L Oliva, J M Rojas-Cabañeros

ABSTRACT

The cyclopentenone prostaglandin A1 (PGA1) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA1 treatment; in these cells, the cellular demise was rescued by overexpression of either H-Ras or N-Ras. Consistently, the mutant H-Ras-C118S, defective for binding PGA1, did not produce cell death. Molecular analysis revealed a key role for the RAF-MEK-ERK signaling pathway in the apoptotic process through the induction of calpain activity and caspase-12 cleavage. We propose that PGA1 evokes a specific physiological cell death program, through H- and N-Ras, but not K-Ras, activation at endomembranes. Our results highlight a novel mechanism that may be of potential interest for tumor treatment. More... »

PAGES

e2311-e2311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cddis.2016.219

DOI

http://dx.doi.org/10.1038/cddis.2016.219

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010868951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27468687


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calpain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Signal-Regulated MAP Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Membranes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandins A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anta", 
        "givenName": "B", 
        "id": "sg:person.01007146344.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146344.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rez-Rodr\u00edguez", 
        "givenName": "A", 
        "id": "sg:person.0731063333.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731063333.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castro", 
        "givenName": "J", 
        "id": "sg:person.01305736544.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305736544.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda- Dom\u00ednguez", 
        "givenName": "C A", 
        "id": "sg:person.01256234667.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256234667.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "8Current address: Immunobiology Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal.", 
          "id": "http://www.grid.ac/institutes/grid.9983.b", 
          "name": [
            "Fundaci\u00f3n Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029, Madrid, Spain", 
            "8Current address: Immunobiology Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ibiza", 
        "givenName": "S", 
        "id": "sg:person.0662750133.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662750133.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "N", 
        "id": "sg:person.01071622710.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071622710.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dur\u00e1", 
        "givenName": "L M", 
        "id": "sg:person.01171510144.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171510144.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hern\u00e1ndez", 
        "givenName": "S", 
        "id": "sg:person.0741033144.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741033144.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gragera", 
        "givenName": "T", 
        "id": "sg:person.01372463267.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372463267.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pe\u00f1a-Jim\u00e9nez", 
        "givenName": "D", 
        "id": "sg:person.0703713446.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703713446.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yunta", 
        "givenName": "M", 
        "id": "sg:person.01130341506.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130341506.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zarich", 
        "givenName": "N", 
        "id": "sg:person.0707261110.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707261110.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Consejo Superior de Investigaciones Cientificas (CSIC)-IDICAN, Universidad de Cantabria, 39011, Santander, Spain", 
          "id": "http://www.grid.ac/institutes/grid.507090.b", 
          "name": [
            "Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Consejo Superior de Investigaciones Cientificas (CSIC)-IDICAN, Universidad de Cantabria, 39011, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crespo", 
        "givenName": "P", 
        "id": "sg:person.0670221020.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670221020.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departamento de Biolog\u00eda Celular e Inmunolog\u00eda, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO), CSIC-UAM, 28049, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.465524.4", 
          "name": [
            "Departamento de Biolog\u00eda Celular e Inmunolog\u00eda, Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO), CSIC-UAM, 28049, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serrador", 
        "givenName": "J M", 
        "id": "sg:person.01161101210.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161101210.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n del Cancer, IBMCC (CSIC-USAL), Universidad de Salamanca, 37007, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428472.f", 
          "name": [
            "Centro de Investigaci\u00f3n del Cancer, IBMCC (CSIC-USAL), Universidad de Salamanca, 37007, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santos", 
        "givenName": "E", 
        "id": "sg:person.01065110724.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065110724.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto de Investigaciones Biom\u00e9dicas \u2018Alberto Sols\u2019, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Aut\u00f3noma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.466793.9", 
          "name": [
            "Instituto de Investigaciones Biom\u00e9dicas \u2018Alberto Sols\u2019, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Aut\u00f3noma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mu\u00f1oz", 
        "givenName": "A", 
        "id": "sg:person.012076006300.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076006300.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliva", 
        "givenName": "J L", 
        "id": "sg:person.0755374310.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755374310.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.512888.e", 
          "name": [
            "Unidad de Biolog\u00eda Celular, Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rojas-Caba\u00f1eros", 
        "givenName": "J M", 
        "id": "sg:person.013424055465.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013424055465.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb1471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046087713", 
          "https://doi.org/10.1038/ncb1471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014393204", 
          "https://doi.org/10.1038/onc.2010.225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008463146", 
          "https://doi.org/10.1038/nrm2438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037231432", 
          "https://doi.org/10.1038/sj.onc.1209845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017026678", 
          "https://doi.org/10.1038/sj.onc.1208660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047596897", 
          "https://doi.org/10.1038/sj.onc.1201284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013154987", 
          "https://doi.org/10.1038/ncb783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/47513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020577355", 
          "https://doi.org/10.1038/47513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047740454", 
          "https://doi.org/10.1038/sj.onc.1203955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-007-7133-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011539475", 
          "https://doi.org/10.1007/s00018-007-7133-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07-28", 
    "datePublishedReg": "2016-07-28", 
    "description": "The cyclopentenone prostaglandin A1 (PGA1) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA1 treatment; in these cells, the cellular demise was rescued by overexpression of either H-Ras or N-Ras. Consistently, the mutant H-Ras-C118S, defective for binding PGA1, did not produce cell death. Molecular analysis revealed a key role for the RAF-MEK-ERK signaling pathway in the apoptotic process through the induction of calpain activity and caspase-12 cleavage. We propose that PGA1 evokes a specific physiological cell death program, through H- and N-Ras, but not K-Ras, activation at endomembranes. Our results highlight a novel mechanism that may be of potential interest for tumor treatment.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/cddis.2016.219", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8098779", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1042939", 
        "issn": [
          "2041-4889"
        ], 
        "name": "Cell Death & Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "N-ras", 
      "physiological cell death program", 
      "H-Ras", 
      "cell death", 
      "cell death program", 
      "specific activation", 
      "N-Ras isoforms", 
      "cellular endomembranes", 
      "cellular demise", 
      "cyclopentenone prostaglandin A1", 
      "death program", 
      "Raf-MEK", 
      "apoptotic process", 
      "caspase-12 cleavage", 
      "molecular analysis", 
      "novel mechanism", 
      "K-ras", 
      "endomembranes", 
      "cancer cells", 
      "apoptosis", 
      "PGA1 treatment", 
      "prostaglandin A1", 
      "activation", 
      "cells", 
      "key role", 
      "calpain activity", 
      "cytotoxic response", 
      "ERK", 
      "isoforms", 
      "overexpression", 
      "pathway", 
      "mechanism", 
      "inducer", 
      "cleavage", 
      "induction", 
      "potential interest", 
      "death", 
      "role", 
      "A1", 
      "activity", 
      "response", 
      "process", 
      "tumor treatment", 
      "demise", 
      "analysis", 
      "treatment", 
      "results", 
      "interest", 
      "program"
    ], 
    "name": "PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes", 
    "pagination": "e2311-e2311", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010868951"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cddis.2016.219"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27468687"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cddis.2016.219", 
      "https://app.dimensions.ai/details/publication/pub.1010868951"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_705.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/cddis.2016.219"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.219'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.219'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.219'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.219'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      98 URIs      80 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cddis.2016.219 schema:about N165112c5d01746c789918b43d95a8d18
2 N1e9c9ff43ab34530b909b5c9ea4cc09a
3 N1fceb4ead0814fc083bc3d90e1866387
4 N513a7dbdfc69475fba9cb19622dd49a6
5 N6830b5b851d94b28acb18fb9d1f7d82e
6 N68ec11ce43194c349d8e1cd7642ad2c9
7 N7b61367dfd364d60bdff89faa3dce0a0
8 N7e569b739471433b82d554796d4237af
9 N96ee0f75148140f69c7bdd8556bfba36
10 N998f329e21d143e79d2712caf44463ce
11 Nc17003192877441e8dba7cdeba85f2bf
12 Nc47a6ecdadbd4a8ca79e13fc21750fb7
13 Ncfbf7c1eca41407b9bae4b4b3a51a45a
14 Ne668845a93724dd29c3b97b6e03d9b9e
15 anzsrc-for:06
16 anzsrc-for:0601
17 schema:author Ndf30fafa075b433890a4d247fb144e1b
18 schema:citation sg:pub.10.1007/s00018-007-7133-8
19 sg:pub.10.1038/47513
20 sg:pub.10.1038/ncb1471
21 sg:pub.10.1038/ncb783
22 sg:pub.10.1038/nrm2438
23 sg:pub.10.1038/onc.2010.225
24 sg:pub.10.1038/sj.onc.1201284
25 sg:pub.10.1038/sj.onc.1203955
26 sg:pub.10.1038/sj.onc.1208660
27 sg:pub.10.1038/sj.onc.1209845
28 schema:datePublished 2016-07-28
29 schema:datePublishedReg 2016-07-28
30 schema:description The cyclopentenone prostaglandin A1 (PGA1) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA1 treatment; in these cells, the cellular demise was rescued by overexpression of either H-Ras or N-Ras. Consistently, the mutant H-Ras-C118S, defective for binding PGA1, did not produce cell death. Molecular analysis revealed a key role for the RAF-MEK-ERK signaling pathway in the apoptotic process through the induction of calpain activity and caspase-12 cleavage. We propose that PGA1 evokes a specific physiological cell death program, through H- and N-Ras, but not K-Ras, activation at endomembranes. Our results highlight a novel mechanism that may be of potential interest for tumor treatment.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N26c60d93835644d094a0b4d2fc5027ee
34 N36abdb622b7c442298b73573d6fb340a
35 sg:journal.1042939
36 schema:keywords A1
37 ERK
38 H-Ras
39 K-ras
40 N-Ras isoforms
41 N-ras
42 PGA1 treatment
43 Raf-MEK
44 activation
45 activity
46 analysis
47 apoptosis
48 apoptotic process
49 calpain activity
50 cancer cells
51 caspase-12 cleavage
52 cell death
53 cell death program
54 cells
55 cellular demise
56 cellular endomembranes
57 cleavage
58 cyclopentenone prostaglandin A1
59 cytotoxic response
60 death
61 death program
62 demise
63 endomembranes
64 inducer
65 induction
66 interest
67 isoforms
68 key role
69 mechanism
70 molecular analysis
71 novel mechanism
72 overexpression
73 pathway
74 physiological cell death program
75 potential interest
76 process
77 program
78 prostaglandin A1
79 response
80 results
81 role
82 specific activation
83 treatment
84 tumor treatment
85 schema:name PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes
86 schema:pagination e2311-e2311
87 schema:productId N022ab451804b484094d23e8194be56c4
88 N4b8933ae34a9465c88b86d9fc4894b07
89 Ne0b5823880164cc698197265d6d80d8a
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010868951
91 https://doi.org/10.1038/cddis.2016.219
92 schema:sdDatePublished 2022-09-02T16:00
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N138ad8da602f4538af8dca773464ce85
95 schema:url https://doi.org/10.1038/cddis.2016.219
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N01153cf0fa8d4d86a597f7392fab10f4 rdf:first sg:person.0755374310.20
100 rdf:rest Ne1fde4ac882b443fb44e04b342c077ba
101 N022ab451804b484094d23e8194be56c4 schema:name pubmed_id
102 schema:value 27468687
103 rdf:type schema:PropertyValue
104 N0d2966fc59c04368a909fc70782fd4fc rdf:first sg:person.0662750133.11
105 rdf:rest N0f6a4c635c7f463e8795570f2f40ffc8
106 N0f6a4c635c7f463e8795570f2f40ffc8 rdf:first sg:person.01071622710.67
107 rdf:rest Nd05b7bdde3834de694d058c137549cbd
108 N138ad8da602f4538af8dca773464ce85 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N165112c5d01746c789918b43d95a8d18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name ras Proteins
112 rdf:type schema:DefinedTerm
113 N1e9c9ff43ab34530b909b5c9ea4cc09a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Apoptosis
115 rdf:type schema:DefinedTerm
116 N1fceb4ead0814fc083bc3d90e1866387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Prostaglandins A
118 rdf:type schema:DefinedTerm
119 N26c60d93835644d094a0b4d2fc5027ee schema:volumeNumber 7
120 rdf:type schema:PublicationVolume
121 N2da98f44fdf5447b8cba7b9ed93d8105 rdf:first sg:person.01065110724.36
122 rdf:rest N3376458884d4464e855d992803420a85
123 N3376458884d4464e855d992803420a85 rdf:first sg:person.012076006300.84
124 rdf:rest N01153cf0fa8d4d86a597f7392fab10f4
125 N36abdb622b7c442298b73573d6fb340a schema:issueNumber 7
126 rdf:type schema:PublicationIssue
127 N46fe23da0cce45ef90a982491768ad88 rdf:first sg:person.01372463267.29
128 rdf:rest N5e30186bf652457e916fe363f43e003f
129 N48f808bb3f594fd4b2e7046108e458fc rdf:first sg:person.0731063333.22
130 rdf:rest Nd64252e667df4c22b72c985a9b406aa6
131 N4b8933ae34a9465c88b86d9fc4894b07 schema:name doi
132 schema:value 10.1038/cddis.2016.219
133 rdf:type schema:PropertyValue
134 N513a7dbdfc69475fba9cb19622dd49a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Neoplasms
136 rdf:type schema:DefinedTerm
137 N54c173deb7c248aa834d1d4da6148af2 rdf:first sg:person.01130341506.04
138 rdf:rest Ne996ebff7174470ab071bf49d2c9e3f4
139 N5e30186bf652457e916fe363f43e003f rdf:first sg:person.0703713446.77
140 rdf:rest N54c173deb7c248aa834d1d4da6148af2
141 N6830b5b851d94b28acb18fb9d1f7d82e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice
143 rdf:type schema:DefinedTerm
144 N68ec11ce43194c349d8e1cd7642ad2c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Fibroblasts
146 rdf:type schema:DefinedTerm
147 N7b61367dfd364d60bdff89faa3dce0a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cysteine
149 rdf:type schema:DefinedTerm
150 N7e569b739471433b82d554796d4237af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Calpain
152 rdf:type schema:DefinedTerm
153 N83e14cd081b84528ace3b64c4689a675 rdf:first sg:person.01161101210.21
154 rdf:rest N2da98f44fdf5447b8cba7b9ed93d8105
155 N848af2bd6fdb43d2997da6cd47ff781d rdf:first sg:person.01256234667.44
156 rdf:rest N0d2966fc59c04368a909fc70782fd4fc
157 N96ee0f75148140f69c7bdd8556bfba36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Extracellular Signal-Regulated MAP Kinases
159 rdf:type schema:DefinedTerm
160 N998f329e21d143e79d2712caf44463ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Enzyme Activation
162 rdf:type schema:DefinedTerm
163 Nc17003192877441e8dba7cdeba85f2bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Intracellular Membranes
165 rdf:type schema:DefinedTerm
166 Nc47a6ecdadbd4a8ca79e13fc21750fb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Animals
168 rdf:type schema:DefinedTerm
169 Ncfbf7c1eca41407b9bae4b4b3a51a45a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Embryo, Mammalian
171 rdf:type schema:DefinedTerm
172 Nd05b7bdde3834de694d058c137549cbd rdf:first sg:person.01171510144.09
173 rdf:rest Nf3fa3946faa34ab590b7dde9c3a7d272
174 Nd64252e667df4c22b72c985a9b406aa6 rdf:first sg:person.01305736544.45
175 rdf:rest N848af2bd6fdb43d2997da6cd47ff781d
176 Nde7558da559349abbc9588a858a8afb8 rdf:first sg:person.0670221020.11
177 rdf:rest N83e14cd081b84528ace3b64c4689a675
178 Ndf30fafa075b433890a4d247fb144e1b rdf:first sg:person.01007146344.46
179 rdf:rest N48f808bb3f594fd4b2e7046108e458fc
180 Ne0b5823880164cc698197265d6d80d8a schema:name dimensions_id
181 schema:value pub.1010868951
182 rdf:type schema:PropertyValue
183 Ne1fde4ac882b443fb44e04b342c077ba rdf:first sg:person.013424055465.15
184 rdf:rest rdf:nil
185 Ne668845a93724dd29c3b97b6e03d9b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cell Line, Tumor
187 rdf:type schema:DefinedTerm
188 Ne996ebff7174470ab071bf49d2c9e3f4 rdf:first sg:person.0707261110.08
189 rdf:rest Nde7558da559349abbc9588a858a8afb8
190 Nf3fa3946faa34ab590b7dde9c3a7d272 rdf:first sg:person.0741033144.55
191 rdf:rest N46fe23da0cce45ef90a982491768ad88
192 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biological Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biochemistry and Cell Biology
197 rdf:type schema:DefinedTerm
198 sg:grant.8098779 http://pending.schema.org/fundedItem sg:pub.10.1038/cddis.2016.219
199 rdf:type schema:MonetaryGrant
200 sg:journal.1042939 schema:issn 2041-4889
201 schema:name Cell Death & Disease
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01007146344.46 schema:affiliation grid-institutes:grid.512888.e
205 schema:familyName Anta
206 schema:givenName B
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007146344.46
208 rdf:type schema:Person
209 sg:person.01065110724.36 schema:affiliation grid-institutes:grid.428472.f
210 schema:familyName Santos
211 schema:givenName E
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065110724.36
213 rdf:type schema:Person
214 sg:person.01071622710.67 schema:affiliation grid-institutes:grid.512888.e
215 schema:familyName Martínez
216 schema:givenName N
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071622710.67
218 rdf:type schema:Person
219 sg:person.01130341506.04 schema:affiliation grid-institutes:grid.512888.e
220 schema:familyName Yunta
221 schema:givenName M
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130341506.04
223 rdf:type schema:Person
224 sg:person.01161101210.21 schema:affiliation grid-institutes:grid.465524.4
225 schema:familyName Serrador
226 schema:givenName J M
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161101210.21
228 rdf:type schema:Person
229 sg:person.01171510144.09 schema:affiliation grid-institutes:grid.512888.e
230 schema:familyName Durá
231 schema:givenName L M
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171510144.09
233 rdf:type schema:Person
234 sg:person.012076006300.84 schema:affiliation grid-institutes:grid.466793.9
235 schema:familyName Muñoz
236 schema:givenName A
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076006300.84
238 rdf:type schema:Person
239 sg:person.01256234667.44 schema:affiliation grid-institutes:grid.512888.e
240 schema:familyName García- Domínguez
241 schema:givenName C A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256234667.44
243 rdf:type schema:Person
244 sg:person.01305736544.45 schema:affiliation grid-institutes:grid.512888.e
245 schema:familyName Castro
246 schema:givenName J
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305736544.45
248 rdf:type schema:Person
249 sg:person.013424055465.15 schema:affiliation grid-institutes:grid.512888.e
250 schema:familyName Rojas-Cabañeros
251 schema:givenName J M
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013424055465.15
253 rdf:type schema:Person
254 sg:person.01372463267.29 schema:affiliation grid-institutes:grid.512888.e
255 schema:familyName Gragera
256 schema:givenName T
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372463267.29
258 rdf:type schema:Person
259 sg:person.0662750133.11 schema:affiliation grid-institutes:grid.9983.b
260 schema:familyName Ibiza
261 schema:givenName S
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662750133.11
263 rdf:type schema:Person
264 sg:person.0670221020.11 schema:affiliation grid-institutes:grid.507090.b
265 schema:familyName Crespo
266 schema:givenName P
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670221020.11
268 rdf:type schema:Person
269 sg:person.0703713446.77 schema:affiliation grid-institutes:grid.512888.e
270 schema:familyName Peña-Jiménez
271 schema:givenName D
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703713446.77
273 rdf:type schema:Person
274 sg:person.0707261110.08 schema:affiliation grid-institutes:grid.512888.e
275 schema:familyName Zarich
276 schema:givenName N
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707261110.08
278 rdf:type schema:Person
279 sg:person.0731063333.22 schema:affiliation grid-institutes:grid.512888.e
280 schema:familyName Pérez-Rodríguez
281 schema:givenName A
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731063333.22
283 rdf:type schema:Person
284 sg:person.0741033144.55 schema:affiliation grid-institutes:grid.512888.e
285 schema:familyName Hernández
286 schema:givenName S
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741033144.55
288 rdf:type schema:Person
289 sg:person.0755374310.20 schema:affiliation grid-institutes:grid.512888.e
290 schema:familyName Oliva
291 schema:givenName J L
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755374310.20
293 rdf:type schema:Person
294 sg:pub.10.1007/s00018-007-7133-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011539475
295 https://doi.org/10.1007/s00018-007-7133-8
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/47513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020577355
298 https://doi.org/10.1038/47513
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/ncb1471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046087713
301 https://doi.org/10.1038/ncb1471
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/ncb783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013154987
304 https://doi.org/10.1038/ncb783
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nrm2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008463146
307 https://doi.org/10.1038/nrm2438
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/onc.2010.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014393204
310 https://doi.org/10.1038/onc.2010.225
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/sj.onc.1201284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047596897
313 https://doi.org/10.1038/sj.onc.1201284
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/sj.onc.1203955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047740454
316 https://doi.org/10.1038/sj.onc.1203955
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/sj.onc.1208660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017026678
319 https://doi.org/10.1038/sj.onc.1208660
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/sj.onc.1209845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037231432
322 https://doi.org/10.1038/sj.onc.1209845
323 rdf:type schema:CreativeWork
324 grid-institutes:grid.428472.f schema:alternateName Centro de Investigación del Cancer, IBMCC (CSIC-USAL), Universidad de Salamanca, 37007, Salamanca, Spain
325 schema:name Centro de Investigación del Cancer, IBMCC (CSIC-USAL), Universidad de Salamanca, 37007, Salamanca, Spain
326 rdf:type schema:Organization
327 grid-institutes:grid.465524.4 schema:alternateName Departamento de Biología Celular e Inmunología, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, 28049, Madrid, Spain
328 schema:name Departamento de Biología Celular e Inmunología, Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, 28049, Madrid, Spain
329 rdf:type schema:Organization
330 grid-institutes:grid.466793.9 schema:alternateName Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain
331 schema:name Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029, Madrid, Spain
332 rdf:type schema:Organization
333 grid-institutes:grid.507090.b schema:alternateName Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Cientificas (CSIC)-IDICAN, Universidad de Cantabria, 39011, Santander, Spain
334 schema:name Departamento de Biologia Molecular, Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Cientificas (CSIC)-IDICAN, Universidad de Cantabria, 39011, Santander, Spain
335 rdf:type schema:Organization
336 grid-institutes:grid.512888.e schema:alternateName Unidad de Biología Celular, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain
337 schema:name Unidad de Biología Celular, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III, 28220, Madrid, Spain
338 rdf:type schema:Organization
339 grid-institutes:grid.9983.b schema:alternateName 8Current address: Immunobiology Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal.
340 schema:name 8Current address: Immunobiology Unit, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal.
341 Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029, Madrid, Spain
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...