A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

L Catrysse, M Farhang Ghahremani, L Vereecke, S A Youssef, C Mc Guire, M Sze, A Weber, M Heikenwalder, A de Bruin, R Beyaert, G van Loo

ABSTRACT

An important regulator of inflammatory signalling is the ubiquitin-editing protein A20 that acts as a break on nuclear factor-κB (NF-κB) activation, but also exerts important cytoprotective functions. A20 knockout mice are cachectic and die prematurely due to excessive multi-organ inflammation. To establish the importance of A20 in liver homeostasis and pathology, we developed a novel mouse line lacking A20 specifically in liver parenchymal cells. These mice spontaneously develop chronic liver inflammation but no fibrosis or hepatocellular carcinomas, illustrating an important role for A20 in normal liver tissue homeostasis. Hepatocyte-specific A20 knockout mice show sustained NF-κB-dependent gene expression in the liver upon tumor necrosis factor (TNF) or lipopolysaccharide injection, as well as hepatocyte apoptosis and lethality upon challenge with sublethal doses of TNF, demonstrating an essential role for A20 in the protection of mice against acute liver failure. Finally, chronic liver inflammation and enhanced hepatocyte apoptosis in hepatocyte-specific A20 knockout mice was associated with increased susceptibility to chemically or high fat-diet-induced hepatocellular carcinoma development. Together, these studies establish A20 as a crucial hepatoprotective factor. More... »

PAGES

e2250

References to SciGraph publications

  • 2004-09. NF-κB functions as a tumour promoter in inflammation-associated cancer in NATURE
  • 1998-03. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1 in NATURE
  • 2001-11. Inhibition of JNK activation through NF-κB target genes in NATURE
  • 2006-05. Nuclear factor-κB in cancer development and progression in NATURE
  • 2014-12. A20 controls intestinal homeostasis through cell-specific activities in NATURE COMMUNICATIONS
  • 2004-10. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses in NATURE IMMUNOLOGY
  • 2010-12. Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation in CELL DEATH & DIFFERENTIATION
  • 2015-12-09. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation in NATURE
  • 2009-06. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma in NATURE
  • 2009-04. Death receptor signal transducers: nodes of coordination in immune signaling networks in NATURE IMMUNOLOGY
  • 2011-02. NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2009-06. Frequent inactivation of A20 in B-cell lymphomas in NATURE
  • 2015-12. A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression in MOLECULAR CANCER
  • 2014. A20-An Omnipotent Protein in the Liver: Prometheus Myth Resolved? in THE MULTIPLE THERAPEUTIC TARGETS OF A20
  • 2015-12. Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cddis.2016.154

    DOI

    http://dx.doi.org/10.1038/cddis.2016.154

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048980381

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27253414


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chronic Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytoprotection", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Fat", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fas-Associated Death Domain Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "JNK Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor alpha-Induced Protein 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Catrysse", 
            "givenName": "L", 
            "id": "sg:person.0754423240.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754423240.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghahremani", 
            "givenName": "M Farhang", 
            "id": "sg:person.01345514644.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345514644.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vereecke", 
            "givenName": "L", 
            "id": "sg:person.01222056657.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222056657.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Utrecht University", 
              "id": "https://www.grid.ac/institutes/grid.5477.1", 
              "name": [
                "Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht NL-3584, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Youssef", 
            "givenName": "S A", 
            "id": "sg:person.01310765750.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310765750.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guire", 
            "givenName": "C Mc", 
            "id": "sg:person.016542315162.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542315162.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sze", 
            "givenName": "M", 
            "id": "sg:person.01057360223.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057360223.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Institute of Surgical Pathology, University Zurich, Zurich CH-8091, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber", 
            "givenName": "A", 
            "id": "sg:person.01041207623.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041207623.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Institute of Virology, Technische Universit\u00e4t M\u00fcnchen, Munich D-81675, Germany", 
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg D-69120, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heikenwalder", 
            "givenName": "M", 
            "id": "sg:person.0707721122.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707721122.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Utrecht University", 
              "id": "https://www.grid.ac/institutes/grid.5477.1", 
              "name": [
                "Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht NL-3584, The Netherlands", 
                "University Medical Center Groningen, Department of Pediatrics, University of Groningen, Groningen NL-9713, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Bruin", 
            "givenName": "A", 
            "id": "sg:person.01176032467.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176032467.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beyaert", 
            "givenName": "R", 
            "id": "sg:person.01245227503.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245227503.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ghent University", 
              "id": "https://www.grid.ac/institutes/grid.5342.0", 
              "name": [
                "Inflammation Research Center, VIB, Ghent B-9052, Belgium", 
                "Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Loo", 
            "givenName": "G", 
            "id": "sg:person.01337113032.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337113032.60"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.06.191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003519663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005924236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010173198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2014.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012515480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2012.01.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012544272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1526-968x(200002)26:2<151::aid-gene17>3.0.co;2-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013272092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013355947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0909781107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013444327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20090528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013643012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1000930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015115879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016547346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016547346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016562290", 
              "https://doi.org/10.1038/32681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016562290", 
              "https://doi.org/10.1038/32681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.11.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017966264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-015-0454-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018226685", 
              "https://doi.org/10.1186/s12943-015-0454-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019613270", 
              "https://doi.org/10.1038/ni.1714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019613270", 
              "https://doi.org/10.1038/ni.1714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023404075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.5.2976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023577614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025440392", 
              "https://doi.org/10.1038/ncomms6103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026224495", 
              "https://doi.org/10.1038/nature07969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026224495", 
              "https://doi.org/10.1038/nature07969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.26197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026862571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35104568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027741589", 
              "https://doi.org/10.1038/35104568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35104568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027741589", 
              "https://doi.org/10.1038/35104568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027908703", 
              "https://doi.org/10.1038/ni1110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027908703", 
              "https://doi.org/10.1038/ni1110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029113459", 
              "https://doi.org/10.1038/cdd.2010.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00521-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029513979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029945208", 
              "https://doi.org/10.1038/nature16165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jhep.2003.50011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031355451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.10.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035894017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0062223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037202325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038939615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038939615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.07.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039371323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-0398-6_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039430685", 
              "https://doi.org/10.1007/978-1-4939-0398-6_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.03.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039581000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20092474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040188986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2015.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040513475", 
              "https://doi.org/10.1038/cdd.2015.52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2011.02.065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040632699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041199006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042163603", 
              "https://doi.org/10.1038/nature02924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042163603", 
              "https://doi.org/10.1038/nature02924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043364117", 
              "https://doi.org/10.1038/nature04870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043364117", 
              "https://doi.org/10.1038/nature04870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043364117", 
              "https://doi.org/10.1038/nature04870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jhep.2002.31309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043620765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0017715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044967970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2010.213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045320248", 
              "https://doi.org/10.1038/nrgastro.2010.213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045721178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045721178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046315996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047607151", 
              "https://doi.org/10.1038/nature07968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047607151", 
              "https://doi.org/10.1038/nature07968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2013.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050399618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.284704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050734965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.2006.02416.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052140174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.03.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053704255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.279.5358.1954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062560011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5488.2350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062571052"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-06", 
        "datePublishedReg": "2016-06-01", 
        "description": "An important regulator of inflammatory signalling is the ubiquitin-editing protein A20 that acts as a break on nuclear factor-\u03baB (NF-\u03baB) activation, but also exerts important cytoprotective functions. A20 knockout mice are cachectic and die prematurely due to excessive multi-organ inflammation. To establish the importance of A20 in liver homeostasis and pathology, we developed a novel mouse line lacking A20 specifically in liver parenchymal cells. These mice spontaneously develop chronic liver inflammation but no fibrosis or hepatocellular carcinomas, illustrating an important role for A20 in normal liver tissue homeostasis. Hepatocyte-specific A20 knockout mice show sustained NF-\u03baB-dependent gene expression in the liver upon tumor necrosis factor (TNF) or lipopolysaccharide injection, as well as hepatocyte apoptosis and lethality upon challenge with sublethal doses of TNF, demonstrating an essential role for A20 in the protection of mice against acute liver failure. Finally, chronic liver inflammation and enhanced hepatocyte apoptosis in hepatocyte-specific A20 knockout mice was associated with increased susceptibility to chemically or high fat-diet-induced hepatocellular carcinoma development. Together, these studies establish A20 as a crucial hepatoprotective factor.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cddis.2016.154", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death", 
        "pagination": "e2250", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e955adccdcc0e8593b81c3989666b49694f5505a6b0f5eea07e51a1fe29af80b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27253414"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101524092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cddis.2016.154"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1048980381"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cddis.2016.154", 
          "https://app.dimensions.ai/details/publication/pub.1048980381"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000551.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/cddis2016154"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.154'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.154'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.154'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cddis.2016.154'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      100 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cddis.2016.154 schema:about N01587443c39342ccaad8dfb789e63cf0
    2 N0405570ef8ec4192ba092ce50d99eea0
    3 N0a53042346d34edc8765b64afbe8482f
    4 N1232575f417c4b4b838bf555f8b53d1b
    5 N2e4a0098725a4958a88311524b20ef7c
    6 N36ee303754f74650bff1b18ab2081d02
    7 N440aff435583456b9c6e6e58d083dc27
    8 N4915932c613d488eb41033b9d663b7f8
    9 N4fe265decdde420a83354d9dc19f56a7
    10 N697ec0c8bf114638ad20f1e84ee2964e
    11 N6f83c03205fb4c8794fb3f1425367355
    12 N772dea8080744b27958ad708693059d2
    13 N8cb00bd5a9b5427abe5cf79b4361675c
    14 N8dc95ad779a3430d983a98a26a9a8913
    15 Na274ac21266645d086aa60d8396c09ed
    16 Nacdbb2d5c7c7477189f974ce9eaee5cf
    17 Nad74035ec85b4e3f83b6c17e00be6932
    18 Nc7a20c28b0f247d08583e614cabf41ad
    19 Nd6a8e2ecfa7d464a9d44d119f6d80141
    20 Nee3075329fd547f49bf37b7483cf8f18
    21 Nfd4d6f394db5451395587af2928b9642
    22 anzsrc-for:11
    23 anzsrc-for:1103
    24 schema:author Nac4be42526f24dbebcaacfb384960d9c
    25 schema:citation sg:pub.10.1007/978-1-4939-0398-6_8
    26 sg:pub.10.1038/32681
    27 sg:pub.10.1038/35104568
    28 sg:pub.10.1038/cdd.2010.47
    29 sg:pub.10.1038/cdd.2015.52
    30 sg:pub.10.1038/nature02924
    31 sg:pub.10.1038/nature04870
    32 sg:pub.10.1038/nature07968
    33 sg:pub.10.1038/nature07969
    34 sg:pub.10.1038/nature16165
    35 sg:pub.10.1038/ncomms6103
    36 sg:pub.10.1038/ni.1714
    37 sg:pub.10.1038/ni1110
    38 sg:pub.10.1038/nrgastro.2010.213
    39 sg:pub.10.1186/s12943-015-0454-6
    40 https://doi.org/10.1002/(sici)1526-968x(200002)26:2<151::aid-gene17>3.0.co;2-e
    41 https://doi.org/10.1002/hep.20701
    42 https://doi.org/10.1002/hep.20741
    43 https://doi.org/10.1002/hep.26197
    44 https://doi.org/10.1016/j.bbrc.2011.06.191
    45 https://doi.org/10.1016/j.bbrc.2012.01.056
    46 https://doi.org/10.1016/j.ccell.2014.09.003
    47 https://doi.org/10.1016/j.ccr.2006.12.016
    48 https://doi.org/10.1016/j.ccr.2009.08.021
    49 https://doi.org/10.1016/j.ccr.2010.03.021
    50 https://doi.org/10.1016/j.cell.2005.04.014
    51 https://doi.org/10.1016/j.cell.2009.03.015
    52 https://doi.org/10.1016/j.cell.2009.12.052
    53 https://doi.org/10.1016/j.celrep.2015.11.009
    54 https://doi.org/10.1016/j.immuni.2008.02.002
    55 https://doi.org/10.1016/j.immuni.2008.10.017
    56 https://doi.org/10.1016/j.it.2013.10.005
    57 https://doi.org/10.1016/s0092-8674(03)00521-x
    58 https://doi.org/10.1053/j.gastro.2011.02.065
    59 https://doi.org/10.1053/j.gastro.2014.04.022
    60 https://doi.org/10.1053/j.gastro.2014.07.018
    61 https://doi.org/10.1053/jhep.2002.31309
    62 https://doi.org/10.1053/jhep.2003.50011
    63 https://doi.org/10.1073/pnas.0909781107
    64 https://doi.org/10.1084/jem.20090528
    65 https://doi.org/10.1084/jem.20092474
    66 https://doi.org/10.1101/gad.284704
    67 https://doi.org/10.1111/j.1365-2559.2006.02416.x
    68 https://doi.org/10.1126/science.279.5358.1954
    69 https://doi.org/10.1126/science.289.5488.2350
    70 https://doi.org/10.1158/2159-8290.cd-11-0172
    71 https://doi.org/10.1371/journal.pone.0017715
    72 https://doi.org/10.1371/journal.pone.0062223
    73 https://doi.org/10.4049/jimmunol.1000930
    74 https://doi.org/10.4049/jimmunol.173.5.2976
    75 schema:datePublished 2016-06
    76 schema:datePublishedReg 2016-06-01
    77 schema:description An important regulator of inflammatory signalling is the ubiquitin-editing protein A20 that acts as a break on nuclear factor-κB (NF-κB) activation, but also exerts important cytoprotective functions. A20 knockout mice are cachectic and die prematurely due to excessive multi-organ inflammation. To establish the importance of A20 in liver homeostasis and pathology, we developed a novel mouse line lacking A20 specifically in liver parenchymal cells. These mice spontaneously develop chronic liver inflammation but no fibrosis or hepatocellular carcinomas, illustrating an important role for A20 in normal liver tissue homeostasis. Hepatocyte-specific A20 knockout mice show sustained NF-κB-dependent gene expression in the liver upon tumor necrosis factor (TNF) or lipopolysaccharide injection, as well as hepatocyte apoptosis and lethality upon challenge with sublethal doses of TNF, demonstrating an essential role for A20 in the protection of mice against acute liver failure. Finally, chronic liver inflammation and enhanced hepatocyte apoptosis in hepatocyte-specific A20 knockout mice was associated with increased susceptibility to chemically or high fat-diet-induced hepatocellular carcinoma development. Together, these studies establish A20 as a crucial hepatoprotective factor.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree true
    81 schema:isPartOf N94faf538ebb141ceafbdd09ce9e4ccbc
    82 Naa49266685f5410e8eddbdcf13074bfa
    83 sg:journal.1042939
    84 schema:name A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
    85 schema:pagination e2250
    86 schema:productId N09be0d61a0144e889214eb2695c12f7a
    87 N0c10141e8aec48fd85df17a86dbe4d81
    88 N25888494daca46d49a5eb44f7b6d2bfb
    89 N5cb5e56f53344ac9b500136a60a7a316
    90 N9447cb6fc698448d9409d9f1b005fc31
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048980381
    92 https://doi.org/10.1038/cddis.2016.154
    93 schema:sdDatePublished 2019-04-10T14:17
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher N0c5eac053e3648378782da373fb8cb7e
    96 schema:url https://www.nature.com/articles/cddis2016154
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N01587443c39342ccaad8dfb789e63cf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Cytoprotection
    102 rdf:type schema:DefinedTerm
    103 N0405570ef8ec4192ba092ce50d99eea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name JNK Mitogen-Activated Protein Kinases
    105 rdf:type schema:DefinedTerm
    106 N09be0d61a0144e889214eb2695c12f7a schema:name dimensions_id
    107 schema:value pub.1048980381
    108 rdf:type schema:PropertyValue
    109 N0a53042346d34edc8765b64afbe8482f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Tumor Necrosis Factor-alpha
    111 rdf:type schema:DefinedTerm
    112 N0c10141e8aec48fd85df17a86dbe4d81 schema:name doi
    113 schema:value 10.1038/cddis.2016.154
    114 rdf:type schema:PropertyValue
    115 N0c5eac053e3648378782da373fb8cb7e schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N104998bf7d8b4cde8497b117cbe8f6ac rdf:first sg:person.01345514644.64
    118 rdf:rest N1cef6b9ee18844f897010ed2e61e12e0
    119 N11b455b6ac53428d84d1d4ac71198ab8 rdf:first sg:person.016542315162.31
    120 rdf:rest N498732d08f7f439fb8d0fac0dcb88da8
    121 N1232575f417c4b4b838bf555f8b53d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Chronic Disease
    123 rdf:type schema:DefinedTerm
    124 N1cef6b9ee18844f897010ed2e61e12e0 rdf:first sg:person.01222056657.55
    125 rdf:rest N355acc91a10f4536b96a261ce88884c2
    126 N25888494daca46d49a5eb44f7b6d2bfb schema:name pubmed_id
    127 schema:value 27253414
    128 rdf:type schema:PropertyValue
    129 N2e4a0098725a4958a88311524b20ef7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Cytokines
    131 rdf:type schema:DefinedTerm
    132 N355acc91a10f4536b96a261ce88884c2 rdf:first sg:person.01310765750.34
    133 rdf:rest N11b455b6ac53428d84d1d4ac71198ab8
    134 N36ee303754f74650bff1b18ab2081d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Mice, Knockout
    136 rdf:type schema:DefinedTerm
    137 N440aff435583456b9c6e6e58d083dc27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Phenotype
    139 rdf:type schema:DefinedTerm
    140 N4915932c613d488eb41033b9d663b7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Mice, Inbred C57BL
    142 rdf:type schema:DefinedTerm
    143 N498732d08f7f439fb8d0fac0dcb88da8 rdf:first sg:person.01057360223.08
    144 rdf:rest N5b5f767678f84fbb989fd95dff8cd833
    145 N4fe265decdde420a83354d9dc19f56a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Liver
    147 rdf:type schema:DefinedTerm
    148 N5b5f767678f84fbb989fd95dff8cd833 rdf:first sg:person.01041207623.23
    149 rdf:rest Nf9bfc7693a3a405089d57898745827ff
    150 N5cb5e56f53344ac9b500136a60a7a316 schema:name nlm_unique_id
    151 schema:value 101524092
    152 rdf:type schema:PropertyValue
    153 N697ec0c8bf114638ad20f1e84ee2964e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Hepatocytes
    155 rdf:type schema:DefinedTerm
    156 N6f83322369114ec8a99a694f5d1db39c rdf:first sg:person.01245227503.66
    157 rdf:rest N75208bb4408146638d3e076b7b35e32b
    158 N6f83c03205fb4c8794fb3f1425367355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Diet, High-Fat
    160 rdf:type schema:DefinedTerm
    161 N75208bb4408146638d3e076b7b35e32b rdf:first sg:person.01337113032.60
    162 rdf:rest rdf:nil
    163 N772dea8080744b27958ad708693059d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Carcinogenesis
    165 rdf:type schema:DefinedTerm
    166 N8cb00bd5a9b5427abe5cf79b4361675c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Liver Neoplasms
    168 rdf:type schema:DefinedTerm
    169 N8dc95ad779a3430d983a98a26a9a8913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Tumor Necrosis Factor alpha-Induced Protein 3
    171 rdf:type schema:DefinedTerm
    172 N9447cb6fc698448d9409d9f1b005fc31 schema:name readcube_id
    173 schema:value e955adccdcc0e8593b81c3989666b49694f5505a6b0f5eea07e51a1fe29af80b
    174 rdf:type schema:PropertyValue
    175 N94faf538ebb141ceafbdd09ce9e4ccbc schema:volumeNumber 7
    176 rdf:type schema:PublicationVolume
    177 Na274ac21266645d086aa60d8396c09ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Fas-Associated Death Domain Protein
    179 rdf:type schema:DefinedTerm
    180 Naa49266685f5410e8eddbdcf13074bfa schema:issueNumber 6
    181 rdf:type schema:PublicationIssue
    182 Nac4be42526f24dbebcaacfb384960d9c rdf:first sg:person.0754423240.47
    183 rdf:rest N104998bf7d8b4cde8497b117cbe8f6ac
    184 Nacdbb2d5c7c7477189f974ce9eaee5cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Apoptosis
    186 rdf:type schema:DefinedTerm
    187 Nad74035ec85b4e3f83b6c17e00be6932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name NF-kappa B
    189 rdf:type schema:DefinedTerm
    190 Nc011e6c04651407f80411a5b8530882f rdf:first sg:person.01176032467.70
    191 rdf:rest N6f83322369114ec8a99a694f5d1db39c
    192 Nc7a20c28b0f247d08583e614cabf41ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Inflammation
    194 rdf:type schema:DefinedTerm
    195 Nd6a8e2ecfa7d464a9d44d119f6d80141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Hepatitis
    197 rdf:type schema:DefinedTerm
    198 Nee3075329fd547f49bf37b7483cf8f18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Animals
    200 rdf:type schema:DefinedTerm
    201 Nf9bfc7693a3a405089d57898745827ff rdf:first sg:person.0707721122.05
    202 rdf:rest Nc011e6c04651407f80411a5b8530882f
    203 Nfd4d6f394db5451395587af2928b9642 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Gene Deletion
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Medical and Health Sciences
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Clinical Sciences
    211 rdf:type schema:DefinedTerm
    212 sg:journal.1042939 schema:issn 2041-4889
    213 schema:name Cell Death & Disease
    214 rdf:type schema:Periodical
    215 sg:person.01041207623.23 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    216 schema:familyName Weber
    217 schema:givenName A
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041207623.23
    219 rdf:type schema:Person
    220 sg:person.01057360223.08 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    221 schema:familyName Sze
    222 schema:givenName M
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057360223.08
    224 rdf:type schema:Person
    225 sg:person.01176032467.70 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
    226 schema:familyName de Bruin
    227 schema:givenName A
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176032467.70
    229 rdf:type schema:Person
    230 sg:person.01222056657.55 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    231 schema:familyName Vereecke
    232 schema:givenName L
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222056657.55
    234 rdf:type schema:Person
    235 sg:person.01245227503.66 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    236 schema:familyName Beyaert
    237 schema:givenName R
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245227503.66
    239 rdf:type schema:Person
    240 sg:person.01310765750.34 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
    241 schema:familyName Youssef
    242 schema:givenName S A
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310765750.34
    244 rdf:type schema:Person
    245 sg:person.01337113032.60 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    246 schema:familyName van Loo
    247 schema:givenName G
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337113032.60
    249 rdf:type schema:Person
    250 sg:person.01345514644.64 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    251 schema:familyName Ghahremani
    252 schema:givenName M Farhang
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345514644.64
    254 rdf:type schema:Person
    255 sg:person.016542315162.31 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    256 schema:familyName Guire
    257 schema:givenName C Mc
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542315162.31
    259 rdf:type schema:Person
    260 sg:person.0707721122.05 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    261 schema:familyName Heikenwalder
    262 schema:givenName M
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707721122.05
    264 rdf:type schema:Person
    265 sg:person.0754423240.47 schema:affiliation https://www.grid.ac/institutes/grid.5342.0
    266 schema:familyName Catrysse
    267 schema:givenName L
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754423240.47
    269 rdf:type schema:Person
    270 sg:pub.10.1007/978-1-4939-0398-6_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039430685
    271 https://doi.org/10.1007/978-1-4939-0398-6_8
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/32681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016562290
    274 https://doi.org/10.1038/32681
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/35104568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027741589
    277 https://doi.org/10.1038/35104568
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/cdd.2010.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029113459
    280 https://doi.org/10.1038/cdd.2010.47
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/cdd.2015.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040513475
    283 https://doi.org/10.1038/cdd.2015.52
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nature02924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163603
    286 https://doi.org/10.1038/nature02924
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nature04870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043364117
    289 https://doi.org/10.1038/nature04870
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nature07968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047607151
    292 https://doi.org/10.1038/nature07968
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nature07969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026224495
    295 https://doi.org/10.1038/nature07969
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nature16165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029945208
    298 https://doi.org/10.1038/nature16165
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/ncomms6103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025440392
    301 https://doi.org/10.1038/ncomms6103
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/ni.1714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019613270
    304 https://doi.org/10.1038/ni.1714
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/ni1110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027908703
    307 https://doi.org/10.1038/ni1110
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nrgastro.2010.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045320248
    310 https://doi.org/10.1038/nrgastro.2010.213
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1186/s12943-015-0454-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018226685
    313 https://doi.org/10.1186/s12943-015-0454-6
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1002/(sici)1526-968x(200002)26:2<151::aid-gene17>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1013272092
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1002/hep.20701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045721178
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1002/hep.20741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016547346
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1002/hep.26197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026862571
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.bbrc.2011.06.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003519663
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.bbrc.2012.01.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012544272
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.ccell.2014.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012515480
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.ccr.2006.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046315996
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.ccr.2009.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013355947
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.ccr.2010.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039581000
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.cell.2005.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038939615
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.cell.2009.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053704255
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.cell.2009.12.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005924236
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.celrep.2015.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017966264
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.immuni.2008.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023404075
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.immuni.2008.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035894017
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.it.2013.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050399618
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/s0092-8674(03)00521-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029513979
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1053/j.gastro.2011.02.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040632699
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1053/j.gastro.2014.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010173198
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1053/j.gastro.2014.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039371323
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1053/jhep.2002.31309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043620765
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1053/jhep.2003.50011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031355451
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1073/pnas.0909781107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013444327
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1084/jem.20090528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013643012
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1084/jem.20092474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040188986
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1101/gad.284704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050734965
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1111/j.1365-2559.2006.02416.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052140174
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1126/science.279.5358.1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062560011
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1126/science.289.5488.2350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571052
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1158/2159-8290.cd-11-0172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041199006
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1371/journal.pone.0017715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044967970
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1371/journal.pone.0062223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037202325
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.4049/jimmunol.1000930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015115879
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.4049/jimmunol.173.5.2976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023577614
    384 rdf:type schema:CreativeWork
    385 https://www.grid.ac/institutes/grid.5342.0 schema:alternateName Ghent University
    386 schema:name Department of Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium
    387 Inflammation Research Center, VIB, Ghent B-9052, Belgium
    388 rdf:type schema:Organization
    389 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
    390 schema:name Dutch Molecular Pathology Center, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht NL-3584, The Netherlands
    391 University Medical Center Groningen, Department of Pediatrics, University of Groningen, Groningen NL-9713, The Netherlands
    392 rdf:type schema:Organization
    393 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
    394 schema:name Institute of Surgical Pathology, University Zurich, Zurich CH-8091, Switzerland
    395 rdf:type schema:Organization
    396 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    397 schema:name Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg D-69120, Germany
    398 Institute of Virology, Technische Universität München, Munich D-81675, Germany
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...