miR-302 regulates pluripotency, teratoma formation and differentiation in stem cells via an AKT1/OCT4-dependent manner View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-01-28

AUTHORS

H-L Li, J-F Wei, L-Y Fan, S-H Wang, L Zhu, T-P Li, G Lin, Y Sun, Z-J Sun, J Ding, X-L Liang, J Li, Q Han, R-C-H Zhao

ABSTRACT

Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and pluripotency, and promotes hPSC differentiation. The underlying mechanism is that the high endogenous expression of miR-302 suppresses the AKT1 expression by directly targeting its 3'UTR and subsequently maintains the pluripotent factor OCT4 at high level. Our findings reveal that miR-302 regulates OCT4 by suppressing AKT1, which provides hPSCs two characteristics related to their potential for clinical applications: the benefit of pluripotency and the hindrance of teratoma formation. More importantly, we demonstrate that miR-302 upregulation cannot lead OCT4 negative human adult mesenchymal stem cells (hMSCs) to acquire the teratoma formation in vivo. Whether miR-302 upregulation can drive hMSCs to acquire a higher differentiation potential is worthy of deep investigation. More... »

PAGES

e2078

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cddis.2015.383

    DOI

    http://dx.doi.org/10.1038/cddis.2015.383

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009433523

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26821070


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    447 Department of Nuclear Medicine, Peking Union Medical College Hospital, Beijing, China.
    448 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.
    449 Peking Union Medical College Hospital, Beijing, China.
    450 rdf:type schema:Organization
    451 https://www.grid.ac/institutes/grid.417303.2 schema:alternateName Xuzhou Medical College
    452 schema:name Department of Cell Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Tissue Engineering Center of Chinese Academy of Medical Sciences, Beijing, China.
    453 Department of Histology and Embryology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou, China.
    454 rdf:type schema:Organization
     




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