Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Jakob Gebel, Laura M Luh, Daniel Coutandin, Christian Osterburg, Frank Löhr, Birgit Schäfer, Ann-Sophie Frombach, Manuela Sumyk, Lena Buchner, Tobias Krojer, Eidarus Salah, Sebastian Mathea, Peter Güntert, Stefan Knapp, Volker Dötsch

ABSTRACT

Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumor-suppressor function of TAp73β. This can in principle be due to blocking of the promoter or by direct interaction between both proteins. p63 and p73 can hetero-oligomerize through their tetramerization domains and a hetero-tetramer consisting of two p63 and two p73 molecules is thermodynamically more stable than both homo-tetramers. Here we show that cells expressing both p63 and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes. Through structure determination of the hetero-tetramer, we reveal why this hetero-tetramer is the thermodynamically preferred species. We have created mutants that exclusively form either hetero-tetramers or homo-tetramers, allowing to investigate the function of these p63/p73 hetero-tetramers. Using these tools, we show that inhibition of TAp73β in squamous cell carcinomas is due to promoter squelching and not direct interaction. More... »

PAGES

1930-1940

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2016.83

DOI

http://dx.doi.org/10.1038/cdd.2016.83

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019238107

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27716744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Multimerization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Protein p73", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gebel", 
        "givenName": "Jakob", 
        "id": "sg:person.01067173101.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067173101.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luh", 
        "givenName": "Laura M", 
        "id": "sg:person.01144440727.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144440727.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coutandin", 
        "givenName": "Daniel", 
        "id": "sg:person.01034567271.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034567271.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osterburg", 
        "givenName": "Christian", 
        "id": "sg:person.0636516101.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636516101.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f6hr", 
        "givenName": "Frank", 
        "id": "sg:person.01261056724.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261056724.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4fer", 
        "givenName": "Birgit", 
        "id": "sg:person.0702574651.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702574651.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frombach", 
        "givenName": "Ann-Sophie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sumyk", 
        "givenName": "Manuela", 
        "id": "sg:person.0752744501.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752744501.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buchner", 
        "givenName": "Lena", 
        "id": "sg:person.01143034530.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143034530.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krojer", 
        "givenName": "Tobias", 
        "id": "sg:person.01266047713.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266047713.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salah", 
        "givenName": "Eidarus", 
        "id": "sg:person.0732210221.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732210221.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mathea", 
        "givenName": "Sebastian", 
        "id": "sg:person.01261517222.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261517222.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00fcntert", 
        "givenName": "Peter", 
        "id": "sg:person.01201353333.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201353333.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK.", 
            "Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knapp", 
        "givenName": "Stefan", 
        "id": "sg:person.0624726333.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624726333.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u00f6tsch", 
        "givenName": "Volker", 
        "id": "sg:person.0640311033.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640311033.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.188.9.1763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002508524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0905867106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007512881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/10.3.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007730373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35003607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009322829", 
          "https://doi.org/10.1038/35003607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35003607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009322829", 
          "https://doi.org/10.1038/35003607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889807021206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012753217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014900702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015127874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.02.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017697427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911408890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020706582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911408890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020706582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80275-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024825914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025075553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025075553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2011.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026846602", 
          "https://doi.org/10.1038/cdd.2011.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2001.4450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027746594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108815200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031009012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.13909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034159715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034408447", 
          "https://doi.org/10.1038/cdd.2009.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034408447", 
          "https://doi.org/10.1038/cdd.2009.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1827.2004.01777.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036545008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10858-009-9333-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037424361", 
          "https://doi.org/10.1007/s10858-009-9333-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10858-009-9333-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037424361", 
          "https://doi.org/10.1007/s10858-009-9333-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889809045701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038911089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889809045701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038911089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2014.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039036820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2009.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040428808", 
          "https://doi.org/10.1038/cddis.2009.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2009.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040428808", 
          "https://doi.org/10.1038/cddis.2009.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2013.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040451793", 
          "https://doi.org/10.1038/cdd.2013.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040688424", 
          "https://doi.org/10.1038/19531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040688424", 
          "https://doi.org/10.1038/19531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80540-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041015753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0010-4655(99)00436-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041683458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10858-015-9924-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042177174", 
          "https://doi.org/10.1007/s10858-015-9924-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pro.2830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043239091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(03)66002-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049969743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050767798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052489131", 
          "https://doi.org/10.1038/19539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052489131", 
          "https://doi.org/10.1038/19539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052565787", 
          "https://doi.org/10.1038/nature05337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052565787", 
          "https://doi.org/10.1038/nature05337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052565787", 
          "https://doi.org/10.1038/nature05337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.2932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053109935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.6.3.3796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299256"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of \u0394Np63\u03b1 inhibits the tumor-suppressor function of TAp73\u03b2. This can in principle be due to blocking of the promoter or by direct interaction between both proteins. p63 and p73 can hetero-oligomerize through their tetramerization domains and a hetero-tetramer consisting of two p63 and two p73 molecules is thermodynamically more stable than both homo-tetramers. Here we show that cells expressing both p63 and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes. Through structure determination of the hetero-tetramer, we reveal why this hetero-tetramer is the thermodynamically preferred species. We have created mutants that exclusively form either hetero-tetramers or homo-tetramers, allowing to investigate the function of these p63/p73 hetero-tetramers. Using these tools, we show that inhibition of TAp73\u03b2 in squamous cell carcinomas is due to promoter squelching and not direct interaction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cdd.2016.83", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "Mechanism of TAp73 inhibition by \u0394Np63 and structural basis of p63/p73 hetero-tetramerization", 
    "pagination": "1930-1940", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5ba9a629f8a193798590dda045c1f9b9456cb926f3e16f4da68dfd27f41ef3f1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27716744"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9437445"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cdd.2016.83"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019238107"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cdd.2016.83", 
      "https://app.dimensions.ai/details/publication/pub.1019238107"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/cdd/journal/v23/n12/full/cdd201683a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.83'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.83'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.83'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.83'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      77 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cdd.2016.83 schema:about N03e5ebb9bd6a4add94375231cab09ad1
2 N228a46ecb700474d93312abf86a95eb6
3 N31778bc0cc7149f99cbc77ecb247cbc0
4 N532806f2193a4d1db569bdb96620ffd0
5 N55f27f65a0a1423a86a2f3986f26b5fa
6 N599aece951fc4bc6bb414f7ef1f37e04
7 N5f7b6b3955a24b4fbd728613ef89f12d
8 N91c6b93b2fad4554ac5e8cce2b6b831b
9 Na114fb91562045f68df044871fb9eb9a
10 Nd0770b8466774a06938c73e886e09bf3
11 Ne306ba3e22774b1580fb253e8f87ec61
12 Nefe2ad25982948de9b741333d418b735
13 Nf39a12c39c5b46498d6c134cf5706afb
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author N79455699fee44fd3b66f2aed9511c925
17 schema:citation sg:pub.10.1007/s10858-009-9333-z
18 sg:pub.10.1007/s10858-015-9924-9
19 sg:pub.10.1038/19531
20 sg:pub.10.1038/19539
21 sg:pub.10.1038/35003607
22 sg:pub.10.1038/cdd.2009.139
23 sg:pub.10.1038/cdd.2011.120
24 sg:pub.10.1038/cdd.2013.23
25 sg:pub.10.1038/cddis.2009.1
26 sg:pub.10.1038/nature05337
27 https://doi.org/10.1002/pro.2830
28 https://doi.org/10.1006/bbrc.2000.2932
29 https://doi.org/10.1006/jmbi.2001.4450
30 https://doi.org/10.1016/j.ccr.2005.12.013
31 https://doi.org/10.1016/j.cell.2011.01.013
32 https://doi.org/10.1016/j.celrep.2016.02.035
33 https://doi.org/10.1016/j.str.2014.11.014
34 https://doi.org/10.1016/s0010-4655(99)00436-1
35 https://doi.org/10.1016/s0065-3233(03)66002-x
36 https://doi.org/10.1016/s0092-8674(00)80540-1
37 https://doi.org/10.1016/s1097-2765(00)80275-0
38 https://doi.org/10.1038/sj.emboj.7601764
39 https://doi.org/10.1073/pnas.0905867106
40 https://doi.org/10.1074/jbc.m108815200
41 https://doi.org/10.1084/jem.188.9.1763
42 https://doi.org/10.1093/hmg/10.3.221
43 https://doi.org/10.1107/s0021889807021206
44 https://doi.org/10.1107/s0021889809045701
45 https://doi.org/10.1107/s0907444909042073
46 https://doi.org/10.1107/s0907444909052925
47 https://doi.org/10.1111/j.1440-1827.2004.01777.x
48 https://doi.org/10.1177/1947601911408890
49 https://doi.org/10.1371/journal.pone.0011572
50 https://doi.org/10.4161/cc.6.3.3796
51 https://doi.org/10.7554/elife.13909
52 schema:datePublished 2016-12
53 schema:datePublishedReg 2016-12-01
54 schema:description Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumor-suppressor function of TAp73β. This can in principle be due to blocking of the promoter or by direct interaction between both proteins. p63 and p73 can hetero-oligomerize through their tetramerization domains and a hetero-tetramer consisting of two p63 and two p73 molecules is thermodynamically more stable than both homo-tetramers. Here we show that cells expressing both p63 and p73 exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes. Through structure determination of the hetero-tetramer, we reveal why this hetero-tetramer is the thermodynamically preferred species. We have created mutants that exclusively form either hetero-tetramers or homo-tetramers, allowing to investigate the function of these p63/p73 hetero-tetramers. Using these tools, we show that inhibition of TAp73β in squamous cell carcinomas is due to promoter squelching and not direct interaction.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N623a38a2dd7244559e631642f77c1616
59 Ned5ee2e6bada41b7a4478e9e85992043
60 sg:journal.1112551
61 schema:name Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization
62 schema:pagination 1930-1940
63 schema:productId N38743df19433455c9e27e0a40929de0f
64 N7b8e486bf3f84916857238f21332be9d
65 N7c2ac05c2d2a4e27ab9004fb85b97cd7
66 N931943acf6cd4d8faa212380306bbc9a
67 Nfacff13183bc4054b81df8343ae2f333
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019238107
69 https://doi.org/10.1038/cdd.2016.83
70 schema:sdDatePublished 2019-04-10T18:56
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N36238b255a384a718abd43ee22e2feb8
73 schema:url http://www.nature.com/cdd/journal/v23/n12/full/cdd201683a.html
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N00555ffc2e074f339bb7be1203277060 rdf:first sg:person.0752744501.48
78 rdf:rest N2f7428bb072d452d9650a0dbcac7b3d0
79 N0363916cf7434b4c94d6f2ccc8cb13dd rdf:first sg:person.0624726333.55
80 rdf:rest N9c23e22bebdf4beaa7f710db8a66aac2
81 N03e5ebb9bd6a4add94375231cab09ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Humans
83 rdf:type schema:DefinedTerm
84 N1544c8e3c4494c5497f404bd9a3e9b97 rdf:first sg:person.01201353333.77
85 rdf:rest N0363916cf7434b4c94d6f2ccc8cb13dd
86 N228a46ecb700474d93312abf86a95eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Animals
88 rdf:type schema:DefinedTerm
89 N2f7428bb072d452d9650a0dbcac7b3d0 rdf:first sg:person.01143034530.91
90 rdf:rest Ndf5641eeb1674977b6be5810c7a0c8c6
91 N31778bc0cc7149f99cbc77ecb247cbc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Transcription, Genetic
93 rdf:type schema:DefinedTerm
94 N36238b255a384a718abd43ee22e2feb8 schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N38743df19433455c9e27e0a40929de0f schema:name pubmed_id
97 schema:value 27716744
98 rdf:type schema:PropertyValue
99 N4401f8ad13414c9c994fa5c01dbdb961 rdf:first sg:person.0702574651.75
100 rdf:rest N8e669180a1c34f20816d6013b3e41422
101 N4f2f546a80c04544860a86695aa80880 rdf:first sg:person.01034567271.91
102 rdf:rest N9904a4169cb14e4e88999ba5b773c07e
103 N532806f2193a4d1db569bdb96620ffd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice
105 rdf:type schema:DefinedTerm
106 N55f27f65a0a1423a86a2f3986f26b5fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Phosphoproteins
108 rdf:type schema:DefinedTerm
109 N599aece951fc4bc6bb414f7ef1f37e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Salts
111 rdf:type schema:DefinedTerm
112 N5f7b6b3955a24b4fbd728613ef89f12d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Amino Acid Sequence
114 rdf:type schema:DefinedTerm
115 N623a38a2dd7244559e631642f77c1616 schema:issueNumber 12
116 rdf:type schema:PublicationIssue
117 N67da42069844487ea6edc63a68a45e45 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
118 schema:familyName Frombach
119 schema:givenName Ann-Sophie
120 rdf:type schema:Person
121 N79455699fee44fd3b66f2aed9511c925 rdf:first sg:person.01067173101.15
122 rdf:rest Nddbdadc8250b4a98858bd362a8d153ba
123 N7b8e486bf3f84916857238f21332be9d schema:name dimensions_id
124 schema:value pub.1019238107
125 rdf:type schema:PropertyValue
126 N7c2ac05c2d2a4e27ab9004fb85b97cd7 schema:name readcube_id
127 schema:value 5ba9a629f8a193798590dda045c1f9b9456cb926f3e16f4da68dfd27f41ef3f1
128 rdf:type schema:PropertyValue
129 N8e669180a1c34f20816d6013b3e41422 rdf:first N67da42069844487ea6edc63a68a45e45
130 rdf:rest N00555ffc2e074f339bb7be1203277060
131 N91c6b93b2fad4554ac5e8cce2b6b831b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Protein Multimerization
133 rdf:type schema:DefinedTerm
134 N931943acf6cd4d8faa212380306bbc9a schema:name doi
135 schema:value 10.1038/cdd.2016.83
136 rdf:type schema:PropertyValue
137 N9904a4169cb14e4e88999ba5b773c07e rdf:first sg:person.0636516101.25
138 rdf:rest Nc9271cc486ab41d79615de876439f25f
139 N9c23e22bebdf4beaa7f710db8a66aac2 rdf:first sg:person.0640311033.49
140 rdf:rest rdf:nil
141 Na114fb91562045f68df044871fb9eb9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Protein Binding
143 rdf:type schema:DefinedTerm
144 Nc517a12f0a8844be96cedfd24f05740e rdf:first sg:person.01261517222.46
145 rdf:rest N1544c8e3c4494c5497f404bd9a3e9b97
146 Nc9271cc486ab41d79615de876439f25f rdf:first sg:person.01261056724.18
147 rdf:rest N4401f8ad13414c9c994fa5c01dbdb961
148 Nd0770b8466774a06938c73e886e09bf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Promoter Regions, Genetic
150 rdf:type schema:DefinedTerm
151 Nddbdadc8250b4a98858bd362a8d153ba rdf:first sg:person.01144440727.52
152 rdf:rest N4f2f546a80c04544860a86695aa80880
153 Ndf5641eeb1674977b6be5810c7a0c8c6 rdf:first sg:person.01266047713.32
154 rdf:rest Nea5cefe8a59b4a86bc8d825d0ae0cd58
155 Ne306ba3e22774b1580fb253e8f87ec61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mutation
157 rdf:type schema:DefinedTerm
158 Nea5cefe8a59b4a86bc8d825d0ae0cd58 rdf:first sg:person.0732210221.19
159 rdf:rest Nc517a12f0a8844be96cedfd24f05740e
160 Ned5ee2e6bada41b7a4478e9e85992043 schema:volumeNumber 23
161 rdf:type schema:PublicationVolume
162 Nefe2ad25982948de9b741333d418b735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Tumor Protein p73
164 rdf:type schema:DefinedTerm
165 Nf39a12c39c5b46498d6c134cf5706afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Trans-Activators
167 rdf:type schema:DefinedTerm
168 Nfacff13183bc4054b81df8343ae2f333 schema:name nlm_unique_id
169 schema:value 9437445
170 rdf:type schema:PropertyValue
171 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
172 schema:name Biological Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
175 schema:name Biochemistry and Cell Biology
176 rdf:type schema:DefinedTerm
177 sg:journal.1112551 schema:issn 1350-9047
178 1476-5403
179 schema:name Cell Death & Differentiation
180 rdf:type schema:Periodical
181 sg:person.01034567271.91 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
182 schema:familyName Coutandin
183 schema:givenName Daniel
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034567271.91
185 rdf:type schema:Person
186 sg:person.01067173101.15 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
187 schema:familyName Gebel
188 schema:givenName Jakob
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067173101.15
190 rdf:type schema:Person
191 sg:person.01143034530.91 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
192 schema:familyName Buchner
193 schema:givenName Lena
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143034530.91
195 rdf:type schema:Person
196 sg:person.01144440727.52 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
197 schema:familyName Luh
198 schema:givenName Laura M
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144440727.52
200 rdf:type schema:Person
201 sg:person.01201353333.77 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
202 schema:familyName Güntert
203 schema:givenName Peter
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201353333.77
205 rdf:type schema:Person
206 sg:person.01261056724.18 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
207 schema:familyName Löhr
208 schema:givenName Frank
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261056724.18
210 rdf:type schema:Person
211 sg:person.01261517222.46 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
212 schema:familyName Mathea
213 schema:givenName Sebastian
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261517222.46
215 rdf:type schema:Person
216 sg:person.01266047713.32 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
217 schema:familyName Krojer
218 schema:givenName Tobias
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266047713.32
220 rdf:type schema:Person
221 sg:person.0624726333.55 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
222 schema:familyName Knapp
223 schema:givenName Stefan
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624726333.55
225 rdf:type schema:Person
226 sg:person.0636516101.25 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
227 schema:familyName Osterburg
228 schema:givenName Christian
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636516101.25
230 rdf:type schema:Person
231 sg:person.0640311033.49 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
232 schema:familyName Dötsch
233 schema:givenName Volker
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640311033.49
235 rdf:type schema:Person
236 sg:person.0702574651.75 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
237 schema:familyName Schäfer
238 schema:givenName Birgit
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702574651.75
240 rdf:type schema:Person
241 sg:person.0732210221.19 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
242 schema:familyName Salah
243 schema:givenName Eidarus
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732210221.19
245 rdf:type schema:Person
246 sg:person.0752744501.48 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
247 schema:familyName Sumyk
248 schema:givenName Manuela
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752744501.48
250 rdf:type schema:Person
251 sg:pub.10.1007/s10858-009-9333-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037424361
252 https://doi.org/10.1007/s10858-009-9333-z
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/s10858-015-9924-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042177174
255 https://doi.org/10.1007/s10858-015-9924-9
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/19531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040688424
258 https://doi.org/10.1038/19531
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/19539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052489131
261 https://doi.org/10.1038/19539
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/35003607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009322829
264 https://doi.org/10.1038/35003607
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/cdd.2009.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034408447
267 https://doi.org/10.1038/cdd.2009.139
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/cdd.2011.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026846602
270 https://doi.org/10.1038/cdd.2011.120
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/cdd.2013.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040451793
273 https://doi.org/10.1038/cdd.2013.23
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/cddis.2009.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040428808
276 https://doi.org/10.1038/cddis.2009.1
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nature05337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052565787
279 https://doi.org/10.1038/nature05337
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/pro.2830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043239091
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1006/bbrc.2000.2932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053109935
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1006/jmbi.2001.4450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027746594
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.ccr.2005.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014900702
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.cell.2011.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025075553
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.celrep.2016.02.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017697427
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.str.2014.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039036820
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0010-4655(99)00436-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041683458
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0065-3233(03)66002-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049969743
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0092-8674(00)80540-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041015753
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s1097-2765(00)80275-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825914
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1038/sj.emboj.7601764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050767798
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.0905867106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007512881
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m108815200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031009012
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1084/jem.188.9.1763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002508524
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/hmg/10.3.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007730373
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1107/s0021889807021206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012753217
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1107/s0021889809045701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038911089
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/j.1440-1827.2004.01777.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036545008
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1177/1947601911408890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020706582
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1371/journal.pone.0011572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015127874
326 rdf:type schema:CreativeWork
327 https://doi.org/10.4161/cc.6.3.3796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299256
328 rdf:type schema:CreativeWork
329 https://doi.org/10.7554/elife.13909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034159715
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
332 schema:name Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK.
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
335 schema:name Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany.
336 Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
337 Nuffield Department of Medicine, Structural Genomics Consortium, Old Road Campus Research Building, Oxford University, Oxford, UK.
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...