Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03-04

AUTHORS

E C Watson, L Whitehead, R H Adams, G Dewson, L Coultas

ABSTRACT

Angiogenesis is essential to match the size of blood vessel networks to the metabolic demands of growing tissues. While many genes and pathways necessary for regulating angiogenesis have been identified, those responsible for endothelial cell (EC) survival during angiogenesis remain largely unknown. We have investigated the in vivo role of myeloid cell leukemia 1 (MCL1), a pro-survival member of the BCL2 family, in EC survival during angiogenesis. EC-specific deletion of Mcl1 resulted in a dose-dependent increase in EC apoptosis in the angiogenic vasculature and a corresponding decline in vessel density. Our results suggest this apoptosis was independent of the BH3-only protein BIM. Despite the known link between apoptosis and blood vessel regression, this was not the cause of reduced vessel density observed in the absence of endothelial MCL1. Rather, the reduction in vessel density was linked to ectopic apoptosis in regions of the angiogenic vasculature where EC proliferation and new vessel growth occurs. We have therefore identified MCL1 as an essential survival factor for ECs that is required for blood vessel production during angiogenesis. More... »

PAGES

1371-1379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2016.20

DOI

http://dx.doi.org/10.1038/cdd.2016.20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010299359

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26943318


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bcl-2-Like Protein 11", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type IV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Cell Leukemia Sequence 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Endothelial Cell Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2 Homologous Antagonist-Killer Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "bcl-2-Associated X Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, ParkvilleVIC, Australia", 
            "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watson", 
        "givenName": "E C", 
        "id": "sg:person.010243272731.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243272731.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia", 
            "Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whitehead", 
        "givenName": "L", 
        "id": "sg:person.01147153612.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147153612.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Medicine, University of M\u00fcnster, D, M\u00fcnster, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, D, M\u00fcnster, Germany", 
            "Faculty of Medicine, University of M\u00fcnster, D, M\u00fcnster, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "R H", 
        "id": "sg:person.0702247561.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC, Parkville, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia", 
            "Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC, Parkville, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dewson", 
        "givenName": "G", 
        "id": "sg:person.01277472545.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277472545.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, ParkvilleVIC, Australia", 
            "Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coultas", 
        "givenName": "L", 
        "id": "sg:person.01125006176.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125006176.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/cdd.2014.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006066463", 
          "https://doi.org/10.1038/cdd.2014.90"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028883419", 
          "https://doi.org/10.1038/nature09002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026857432", 
          "https://doi.org/10.1038/ncb2488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001448882", 
          "https://doi.org/10.1038/nrm3722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026706357", 
          "https://doi.org/10.1038/nmeth.2019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011948458", 
          "https://doi.org/10.1038/nature04478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852941", 
          "https://doi.org/10.1038/nature04479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003236136", 
          "https://doi.org/10.1038/cddis.2013.455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1095-1024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011626141", 
          "https://doi.org/10.1038/nm1095-1024"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-03-04", 
    "datePublishedReg": "2016-03-04", 
    "description": "Angiogenesis is essential to match the size of blood vessel networks to the metabolic demands of growing tissues. While many genes and pathways necessary for regulating angiogenesis have been identified, those responsible for endothelial cell (EC) survival during angiogenesis remain largely unknown. We have investigated the in vivo role of myeloid cell leukemia 1 (MCL1), a pro-survival member of the BCL2 family, in EC survival during angiogenesis. EC-specific deletion of Mcl1 resulted in a dose-dependent increase in EC apoptosis in the angiogenic vasculature and a corresponding decline in vessel density. Our results suggest this apoptosis was independent of the BH3-only protein BIM. Despite the known link between apoptosis and blood vessel regression, this was not the cause of reduced vessel density observed in the absence of endothelial MCL1. Rather, the reduction in vessel density was linked to ectopic apoptosis in regions of the angiogenic vasculature where EC proliferation and new vessel growth occurs. We have therefore identified MCL1 as an essential survival factor for ECs that is required for blood vessel production during angiogenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/cdd.2016.20", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6733543", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "myeloid cell leukemia-1", 
      "endothelial cell survival", 
      "cell survival", 
      "pro-survival protein myeloid cell leukemia 1", 
      "pro-survival members", 
      "EC-specific deletion", 
      "ectopic apoptosis", 
      "protein Bim", 
      "BCL2 family", 
      "essential survival factor", 
      "blood vessel regression", 
      "angiogenic vasculature", 
      "vivo role", 
      "EC survival", 
      "survival factor", 
      "EC apoptosis", 
      "apoptosis", 
      "EC proliferation", 
      "vessel growth", 
      "blood vessel network", 
      "new vessel growth", 
      "angiogenesis", 
      "vessel regression", 
      "metabolic demands", 
      "vessel production", 
      "genes", 
      "BH3", 
      "vessel network", 
      "MCL1", 
      "corresponding decline", 
      "deletion", 
      "survival", 
      "dose-dependent increase", 
      "pathway", 
      "reduced vessel density", 
      "proliferation", 
      "family", 
      "members", 
      "growth", 
      "tissue", 
      "vasculature", 
      "vessel density", 
      "BIM", 
      "role", 
      "production", 
      "absence", 
      "region", 
      "decline", 
      "density", 
      "factors", 
      "link", 
      "size", 
      "EC", 
      "increase", 
      "results", 
      "reduction", 
      "network", 
      "cause", 
      "demand", 
      "regression"
    ], 
    "name": "Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1", 
    "pagination": "1371-1379", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010299359"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cdd.2016.20"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26943318"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cdd.2016.20", 
      "https://app.dimensions.ai/details/publication/pub.1010299359"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_689.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/cdd.2016.20"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.20'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.20'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.20'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2016.20'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      21 PREDICATES      112 URIs      95 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cdd.2016.20 schema:about N0edf62aaa1824548a845dd6857e91fad
2 N21dfa0d19cac42118c298bff85ce0a25
3 N2d18b8b87e544e598bb26020b25c0faa
4 N3bbd983c8d694d2fa2ff4f7c1c2b223a
5 N4a5d8eefcf6a49f3a3123c40f600803d
6 N571b1495532b422d892dfae8ffd4874c
7 N6c32243cf53044ac9ec2c6fe37e53572
8 N81120cd047874188a6e4a5422f1ff769
9 N81bc2e28dbb34ceebf2dd84f4a358110
10 N84f78c9cd01944e89768c3050de2a175
11 N89064597838147fe87fc011d8cecd5cd
12 Nb29f558d2c0e4343bc351ae9ba6d3e7c
13 Nc50744a6ee1a49129135730393712f55
14 Nd713914ec8b042b5b48ad06ba99d53b8
15 Nea2544a737b247a588571487a42b2844
16 Nf07320770b194400b3adcb47de7dd01a
17 Nf0fc17a6e09944cd9dfeba4a3ea86e30
18 Nf71201caf1cf407fa7a86bcdf54142b2
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N938469d6fe1848ed85c31f50b637ab48
22 schema:citation sg:pub.10.1038/cdd.2014.90
23 sg:pub.10.1038/cddis.2013.455
24 sg:pub.10.1038/nature04478
25 sg:pub.10.1038/nature04479
26 sg:pub.10.1038/nature09002
27 sg:pub.10.1038/ncb2488
28 sg:pub.10.1038/nm1095-1024
29 sg:pub.10.1038/nmeth.2019
30 sg:pub.10.1038/nrm3722
31 schema:datePublished 2016-03-04
32 schema:datePublishedReg 2016-03-04
33 schema:description Angiogenesis is essential to match the size of blood vessel networks to the metabolic demands of growing tissues. While many genes and pathways necessary for regulating angiogenesis have been identified, those responsible for endothelial cell (EC) survival during angiogenesis remain largely unknown. We have investigated the in vivo role of myeloid cell leukemia 1 (MCL1), a pro-survival member of the BCL2 family, in EC survival during angiogenesis. EC-specific deletion of Mcl1 resulted in a dose-dependent increase in EC apoptosis in the angiogenic vasculature and a corresponding decline in vessel density. Our results suggest this apoptosis was independent of the BH3-only protein BIM. Despite the known link between apoptosis and blood vessel regression, this was not the cause of reduced vessel density observed in the absence of endothelial MCL1. Rather, the reduction in vessel density was linked to ectopic apoptosis in regions of the angiogenic vasculature where EC proliferation and new vessel growth occurs. We have therefore identified MCL1 as an essential survival factor for ECs that is required for blood vessel production during angiogenesis.
34 schema:genre article
35 schema:isAccessibleForFree true
36 schema:isPartOf N0e82ea249b04472ca759658fd83d341e
37 Nf5e86697a6d6464e86e7738743c273eb
38 sg:journal.1112551
39 schema:keywords BCL2 family
40 BH3
41 BIM
42 EC
43 EC apoptosis
44 EC proliferation
45 EC survival
46 EC-specific deletion
47 MCL1
48 absence
49 angiogenesis
50 angiogenic vasculature
51 apoptosis
52 blood vessel network
53 blood vessel regression
54 cause
55 cell survival
56 corresponding decline
57 decline
58 deletion
59 demand
60 density
61 dose-dependent increase
62 ectopic apoptosis
63 endothelial cell survival
64 essential survival factor
65 factors
66 family
67 genes
68 growth
69 increase
70 link
71 members
72 metabolic demands
73 myeloid cell leukemia-1
74 network
75 new vessel growth
76 pathway
77 pro-survival members
78 pro-survival protein myeloid cell leukemia 1
79 production
80 proliferation
81 protein Bim
82 reduced vessel density
83 reduction
84 region
85 regression
86 results
87 role
88 size
89 survival
90 survival factor
91 tissue
92 vasculature
93 vessel density
94 vessel growth
95 vessel network
96 vessel production
97 vessel regression
98 vivo role
99 schema:name Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1
100 schema:pagination 1371-1379
101 schema:productId N2359047c76cb4d2d96b66edc9efa8df2
102 N288bc548abbb4370bf18081b8b0f08a3
103 Ne1ee9e3900894ec198d2d83af10e1915
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010299359
105 https://doi.org/10.1038/cdd.2016.20
106 schema:sdDatePublished 2022-12-01T06:34
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher Ne6e46e304dca4e718cfd142158bff018
109 schema:url https://doi.org/10.1038/cdd.2016.20
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N0e82ea249b04472ca759658fd83d341e schema:issueNumber 8
114 rdf:type schema:PublicationIssue
115 N0edf62aaa1824548a845dd6857e91fad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mice, Inbred C57BL
117 rdf:type schema:DefinedTerm
118 N158b55ee824b4f08b6c7a14426acbcbd rdf:first sg:person.01125006176.31
119 rdf:rest rdf:nil
120 N21dfa0d19cac42118c298bff85ce0a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cells, Cultured
122 rdf:type schema:DefinedTerm
123 N2359047c76cb4d2d96b66edc9efa8df2 schema:name doi
124 schema:value 10.1038/cdd.2016.20
125 rdf:type schema:PropertyValue
126 N288bc548abbb4370bf18081b8b0f08a3 schema:name pubmed_id
127 schema:value 26943318
128 rdf:type schema:PropertyValue
129 N2d18b8b87e544e598bb26020b25c0faa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice
131 rdf:type schema:DefinedTerm
132 N39beeaa5b7fd4501880ec2fa49f6fb1d rdf:first sg:person.01277472545.58
133 rdf:rest N158b55ee824b4f08b6c7a14426acbcbd
134 N3bbd983c8d694d2fa2ff4f7c1c2b223a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Platelet Endothelial Cell Adhesion Molecule-1
136 rdf:type schema:DefinedTerm
137 N4a5d8eefcf6a49f3a3123c40f600803d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Embryo, Mammalian
139 rdf:type schema:DefinedTerm
140 N571b1495532b422d892dfae8ffd4874c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Neovascularization, Physiologic
142 rdf:type schema:DefinedTerm
143 N6c32243cf53044ac9ec2c6fe37e53572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N77ed2814d55340b88f02c55b6b40bae3 rdf:first sg:person.01147153612.41
147 rdf:rest N961154688d5f482dae2b7c764aad620e
148 N81120cd047874188a6e4a5422f1ff769 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Apoptosis
150 rdf:type schema:DefinedTerm
151 N81bc2e28dbb34ceebf2dd84f4a358110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name bcl-2 Homologous Antagonist-Killer Protein
153 rdf:type schema:DefinedTerm
154 N84f78c9cd01944e89768c3050de2a175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice, Knockout
156 rdf:type schema:DefinedTerm
157 N89064597838147fe87fc011d8cecd5cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Collagen Type IV
159 rdf:type schema:DefinedTerm
160 N938469d6fe1848ed85c31f50b637ab48 rdf:first sg:person.010243272731.23
161 rdf:rest N77ed2814d55340b88f02c55b6b40bae3
162 N961154688d5f482dae2b7c764aad620e rdf:first sg:person.0702247561.03
163 rdf:rest N39beeaa5b7fd4501880ec2fa49f6fb1d
164 Nb29f558d2c0e4343bc351ae9ba6d3e7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Bcl-2-Like Protein 11
166 rdf:type schema:DefinedTerm
167 Nc50744a6ee1a49129135730393712f55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Survival
169 rdf:type schema:DefinedTerm
170 Nd713914ec8b042b5b48ad06ba99d53b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Caspase 3
172 rdf:type schema:DefinedTerm
173 Ne1ee9e3900894ec198d2d83af10e1915 schema:name dimensions_id
174 schema:value pub.1010299359
175 rdf:type schema:PropertyValue
176 Ne6e46e304dca4e718cfd142158bff018 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Nea2544a737b247a588571487a42b2844 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Myeloid Cell Leukemia Sequence 1 Protein
180 rdf:type schema:DefinedTerm
181 Nf07320770b194400b3adcb47de7dd01a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Kidney
183 rdf:type schema:DefinedTerm
184 Nf0fc17a6e09944cd9dfeba4a3ea86e30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name bcl-2-Associated X Protein
186 rdf:type schema:DefinedTerm
187 Nf5e86697a6d6464e86e7738743c273eb schema:volumeNumber 23
188 rdf:type schema:PublicationVolume
189 Nf71201caf1cf407fa7a86bcdf54142b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Endothelial Cells
191 rdf:type schema:DefinedTerm
192 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
193 schema:name Biological Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biochemistry and Cell Biology
197 rdf:type schema:DefinedTerm
198 sg:grant.6733543 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2016.20
199 rdf:type schema:MonetaryGrant
200 sg:journal.1112551 schema:issn 1350-9047
201 1476-5403
202 schema:name Cell Death & Differentiation
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.010243272731.23 schema:affiliation grid-institutes:grid.1008.9
206 schema:familyName Watson
207 schema:givenName E C
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243272731.23
209 rdf:type schema:Person
210 sg:person.01125006176.31 schema:affiliation grid-institutes:grid.1008.9
211 schema:familyName Coultas
212 schema:givenName L
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125006176.31
214 rdf:type schema:Person
215 sg:person.01147153612.41 schema:affiliation grid-institutes:grid.1042.7
216 schema:familyName Whitehead
217 schema:givenName L
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147153612.41
219 rdf:type schema:Person
220 sg:person.01277472545.58 schema:affiliation grid-institutes:grid.1042.7
221 schema:familyName Dewson
222 schema:givenName G
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277472545.58
224 rdf:type schema:Person
225 sg:person.0702247561.03 schema:affiliation grid-institutes:grid.5949.1
226 schema:familyName Adams
227 schema:givenName R H
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03
229 rdf:type schema:Person
230 sg:pub.10.1038/cdd.2014.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006066463
231 https://doi.org/10.1038/cdd.2014.90
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/cddis.2013.455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003236136
234 https://doi.org/10.1038/cddis.2013.455
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nature04478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011948458
237 https://doi.org/10.1038/nature04478
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nature04479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036852941
240 https://doi.org/10.1038/nature04479
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature09002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028883419
243 https://doi.org/10.1038/nature09002
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ncb2488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026857432
246 https://doi.org/10.1038/ncb2488
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nm1095-1024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011626141
249 https://doi.org/10.1038/nm1095-1024
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nmeth.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026706357
252 https://doi.org/10.1038/nmeth.2019
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nrm3722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001448882
255 https://doi.org/10.1038/nrm3722
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.1008.9 schema:alternateName Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia
258 schema:name Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia
259 Development and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, ParkvilleVIC, Australia
260 rdf:type schema:Organization
261 grid-institutes:grid.1042.7 schema:alternateName Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC, Parkville, Australia
262 Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia
263 schema:name Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC, Parkville, Australia
264 Department of Medical Biology, University of Melbourne, 1G Royal Parade, VIC, Australia
265 Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, Australia
266 rdf:type schema:Organization
267 grid-institutes:grid.5949.1 schema:alternateName Faculty of Medicine, University of Münster, D, Münster, Germany
268 schema:name Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, D, Münster, Germany
269 Faculty of Medicine, University of Münster, D, Münster, Germany
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...