CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01

AUTHORS

Zhenqing Liu, Jinghui Guo, Yan Wang, Zhihui Weng, Biao Huang, Mei-Kuen Yu, Xiaohu Zhang, Ping Yuan, Hui Zhao, Wai-Yee Chan, Xiaohua Jiang, Hsiao-Chang Chan

ABSTRACT

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated anion channel capable of conducting both Cl- and HCO3-, mutations of which cause cystic fibrosis (CF), a common autosomal recessive disease. Although CF patients are known to have varied degree of developmental problems, the biological role of CFTR in embryonic development remains elusive. Here, we show that CFTR is functionally expressed in mouse ESCs. CFTR-/- mESCs exhibit dramatic defect in mesendoderm differentiation. In addition, CFTR physically interacts with β-catenin, defect of which leads to premature degradation of β-catenin and suppressed activation of β-catenin signaling. Furthermore, knockdown of CFTR retards the early development of Xenopus laevis with impaired mesoderm/endoderm differentiation and β-catenin signaling. Our study reveals a previously undefined role of CFTR in controlling ESC differentiation and early embryonic development via its interaction with β-catenin, and provides novel insights into the understanding of embryonic development. More... »

PAGES

98-110

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2016.118

DOI

http://dx.doi.org/10.1038/cdd.2016.118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044880301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27834953


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