Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

J H Kim, B U Youn, K Kim, J B Moon, J Lee, K-I I Nam, Y-W Park, D D M O'Leary, K K Kim, N Kim

ABSTRACT

The LIM homeobox 2 (Lhx2) transcription factor Lhx2 has a variety of functions, including neural induction, morphogenesis, and hematopoiesis. Here we show the involvement of Lhx2 in osteoclast differentiation. Lhx2 was strongly expressed in osteoclast precursor cells but its expression was significantly reduced during receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis. Overexpression of Lhx2 in bone marrow-derived monocyte/macrophage lineage cells (BMMs), which are osteoclast precursor cells, attenuated RANKL-induced osteoclast differentiation by inhibiting the induction of nuclear factor of activated T cells c1 (NFATc1). Interestingly, interaction of Lhx2 proteins with c-Fos attenuated the DNA-binding ability of c-Fos and thereby inhibited the transactivation of NFATc1. Furthermore, Lhx2 conditional knockout mice exhibited an osteoporotic bone phenotype, which was related with increased osteoclast formation in vivo. Taken together, our results suggest that Lhx2 acts as a negative regulator of osteoclast formation in vitro and in vivo. The anti-osteoclastogenic effect of Lhx2 may be useful for developing a therapeutic strategy for bone disease. More... »

PAGES

cdd201471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2014.71

DOI

http://dx.doi.org/10.1038/cdd.2014.71

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017325463

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24902903


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Marrow Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Remodeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "LIM-Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NFATC Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoclasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoporosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-fos", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RANK Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea [3] Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "J H", 
        "id": "sg:person.01317336462.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317336462.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youn", 
        "givenName": "B U", 
        "id": "sg:person.0616405403.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616405403.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "K", 
        "id": "sg:person.01123467434.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123467434.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moon", 
        "givenName": "J B", 
        "id": "sg:person.01225563103.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225563103.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "J", 
        "id": "sg:person.0657425377.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657425377.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Department of Anatomy, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nam", 
        "givenName": "K-I I", 
        "id": "sg:person.01356504714.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356504714.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Y-W", 
        "id": "sg:person.015446275624.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015446275624.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Leary", 
        "givenName": "D D M", 
        "id": "sg:person.015563715242.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015563715242.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea [3] Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "K K", 
        "id": "sg:person.0631511345.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631511345.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea [3] Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "N", 
        "id": "sg:person.015757205362.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015757205362.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11154-006-9001-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000274978", 
          "https://doi.org/10.1007/s11154-006-9001-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m408795200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003395233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1151695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004178449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650020617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006353282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.5650020617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006353282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010518032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci35711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010641070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(98)01424-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019065767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.51.36159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027789674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-12-0026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028908997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2013.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030320289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2008.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030662221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032200859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m505815200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034882201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780605", 
          "https://doi.org/10.1038/nm.2007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780605", 
          "https://doi.org/10.1038/nm.2007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.5.2374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037452880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(02)00369-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m313973200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039178819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-07-2798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039782196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(00)00358-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041364554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.7.2720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0400940101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042695739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.1.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044043506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046869289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-09-048249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047307837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047363002", 
          "https://doi.org/10.1038/nn.2427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047363002", 
          "https://doi.org/10.1038/nn.2427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910708600113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049322879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910708600113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049322879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.12.1741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051922586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(99)01883-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053720395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.191.2.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7939685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.20.3.0367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083126132", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10", 
    "datePublishedReg": "2014-10-01", 
    "description": "The LIM homeobox 2 (Lhx2) transcription factor Lhx2 has a variety of functions, including neural induction, morphogenesis, and hematopoiesis. Here we show the involvement of Lhx2 in osteoclast differentiation. Lhx2 was strongly expressed in osteoclast precursor cells but its expression was significantly reduced during receptor activator of nuclear factor-\u03baB ligand (RANKL)-mediated osteoclastogenesis. Overexpression of Lhx2 in bone marrow-derived monocyte/macrophage lineage cells (BMMs), which are osteoclast precursor cells, attenuated RANKL-induced osteoclast differentiation by inhibiting the induction of nuclear factor of activated T cells c1 (NFATc1). Interestingly, interaction of Lhx2 proteins with c-Fos attenuated the DNA-binding ability of c-Fos and thereby inhibited the transactivation of NFATc1. Furthermore, Lhx2 conditional knockout mice exhibited an osteoporotic bone phenotype, which was related with increased osteoclast formation in vivo. Taken together, our results suggest that Lhx2 acts as a negative regulator of osteoclast formation in vitro and in vivo. The anti-osteoclastogenic effect of Lhx2 may be useful for developing a therapeutic strategy for bone disease. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cdd.2014.71", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7454872", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2505553", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts", 
    "pagination": "cdd201471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "528ba7ac46b54c6e8583ef34ae8d704aace35a4ca304c1fbc64e734b7fad582c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24902903"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9437445"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cdd.2014.71"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017325463"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cdd.2014.71", 
      "https://app.dimensions.ai/details/publication/pub.1017325463"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/cdd201471"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2014.71'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2014.71'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2014.71'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2014.71'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      84 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cdd.2014.71 schema:about N1b93c550ef4d49d7ab0967dcbca69786
2 N21707566dd814dc287f8dc36db8c7a6b
3 N4ff6c2c95d304c03b5714f92f947e060
4 N53ff4d8458344d9ca456b12540324684
5 N5f916db597644217bcb9700cf9ea4fdc
6 N7ae98f90f68845a4972ab8ffd4ad3c39
7 N7df9ed45978f45f2a3a2b9702e02fc52
8 N7fbba6bc6dc14f07835367d0617b877a
9 N8ea81a492193463e97876e3b99b85bc5
10 N93f2b12411b6452689cacbc3bd9d814b
11 N9c63dcc7c84f4a9c8c0207fa5d0b1ab4
12 Na1855a9e49744a688c39e30c725d0df9
13 Na4ba709c184b42f7ab8a043c8cf6a16f
14 Na629bf0aa2504852af27615c67fc37c2
15 Nada398943b4f4f1fb290981c24f5d890
16 Nb1ab18918654435ab1fee6d4dc84e8ff
17 Nb285459bb5ea42e5b2c0c30e9f268cfe
18 Nb56168348856496290b480bad6fd7f5e
19 Ncb245bafa5144ebf9520679f352c6c0b
20 Ndaaddb45455c4ba996f5016928aff989
21 Ned2099d86a5449779f33f54e11065364
22 Nfda52e4966d24d82b211c3a120e7a0b1
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N51a0124b62d94c8890270a65f30cc0b5
26 schema:citation sg:pub.10.1007/s11154-006-9001-5
27 sg:pub.10.1038/nm.2007
28 sg:pub.10.1038/nn.2427
29 https://app.dimensions.ai/details/publication/pub.1083126132
30 https://doi.org/10.1002/jbmr.5650020617
31 https://doi.org/10.1016/j.lfs.2013.07.022
32 https://doi.org/10.1016/j.ydbio.2008.12.022
33 https://doi.org/10.1016/s0168-9525(98)01424-3
34 https://doi.org/10.1016/s0168-9525(99)01883-1
35 https://doi.org/10.1016/s1534-5807(02)00369-6
36 https://doi.org/10.1016/s8756-3282(00)00358-6
37 https://doi.org/10.1073/pnas.0400940101
38 https://doi.org/10.1073/pnas.90.1.227
39 https://doi.org/10.1073/pnas.92.7.2720
40 https://doi.org/10.1074/jbc.274.51.36159
41 https://doi.org/10.1074/jbc.m313973200
42 https://doi.org/10.1074/jbc.m408795200
43 https://doi.org/10.1074/jbc.m505815200
44 https://doi.org/10.1084/jem.190.12.1741
45 https://doi.org/10.1084/jem.191.2.275
46 https://doi.org/10.1093/nar/gkt567
47 https://doi.org/10.1126/science.1151695
48 https://doi.org/10.1126/science.7939685
49 https://doi.org/10.1146/annurev.immunol.24.021605.090646
50 https://doi.org/10.1172/jci35711
51 https://doi.org/10.1177/154405910708600113
52 https://doi.org/10.1182/blood-2005-07-2798
53 https://doi.org/10.1182/blood-2006-09-048249
54 https://doi.org/10.1210/edrv.20.3.0367
55 https://doi.org/10.1210/en.2006-1088
56 https://doi.org/10.1371/journal.pgen.1000904
57 https://doi.org/10.1530/eje-12-0026
58 https://doi.org/10.4049/jimmunol.169.5.2374
59 schema:datePublished 2014-10
60 schema:datePublishedReg 2014-10-01
61 schema:description The LIM homeobox 2 (Lhx2) transcription factor Lhx2 has a variety of functions, including neural induction, morphogenesis, and hematopoiesis. Here we show the involvement of Lhx2 in osteoclast differentiation. Lhx2 was strongly expressed in osteoclast precursor cells but its expression was significantly reduced during receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis. Overexpression of Lhx2 in bone marrow-derived monocyte/macrophage lineage cells (BMMs), which are osteoclast precursor cells, attenuated RANKL-induced osteoclast differentiation by inhibiting the induction of nuclear factor of activated T cells c1 (NFATc1). Interestingly, interaction of Lhx2 proteins with c-Fos attenuated the DNA-binding ability of c-Fos and thereby inhibited the transactivation of NFATc1. Furthermore, Lhx2 conditional knockout mice exhibited an osteoporotic bone phenotype, which was related with increased osteoclast formation in vivo. Taken together, our results suggest that Lhx2 acts as a negative regulator of osteoclast formation in vitro and in vivo. The anti-osteoclastogenic effect of Lhx2 may be useful for developing a therapeutic strategy for bone disease.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N7cb7f0018a564d9c9becc4f5178390b0
66 Nf678e0786ca94110ac013ceb3445864a
67 sg:journal.1112551
68 schema:name Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts
69 schema:pagination cdd201471
70 schema:productId N35a26cc2f6e94e259d1aefb665a6b07e
71 N45443d17b341486792c4419b7def5c37
72 N495cb72090f846d68b2ed40f003312a2
73 Nb4818d09091c41dd965f8643c9019851
74 Nd65a097b88d445d3be77180833163611
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017325463
76 https://doi.org/10.1038/cdd.2014.71
77 schema:sdDatePublished 2019-04-10T18:08
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Nc10eb67df876404ab314400756dc7023
80 schema:url http://www.nature.com/articles/cdd201471
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N05d4ea1cf30f4a14b2e8a4c78df6758c rdf:first sg:person.0631511345.03
85 rdf:rest N5d5c4ff73d5b42ccb14ec6ed05a3eb01
86 N1b93c550ef4d49d7ab0967dcbca69786 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Transcription Factors
88 rdf:type schema:DefinedTerm
89 N21707566dd814dc287f8dc36db8c7a6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name NFATC Transcription Factors
91 rdf:type schema:DefinedTerm
92 N35a26cc2f6e94e259d1aefb665a6b07e schema:name nlm_unique_id
93 schema:value 9437445
94 rdf:type schema:PropertyValue
95 N45443d17b341486792c4419b7def5c37 schema:name pubmed_id
96 schema:value 24902903
97 rdf:type schema:PropertyValue
98 N495cb72090f846d68b2ed40f003312a2 schema:name doi
99 schema:value 10.1038/cdd.2014.71
100 rdf:type schema:PropertyValue
101 N4ff6c2c95d304c03b5714f92f947e060 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Osteoporosis
103 rdf:type schema:DefinedTerm
104 N51a0124b62d94c8890270a65f30cc0b5 rdf:first sg:person.01317336462.98
105 rdf:rest N9fbb94c185aa41399af34951daa8a353
106 N53ff4d8458344d9ca456b12540324684 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Osteoclasts
108 rdf:type schema:DefinedTerm
109 N5d5c4ff73d5b42ccb14ec6ed05a3eb01 rdf:first sg:person.015757205362.15
110 rdf:rest rdf:nil
111 N5f916db597644217bcb9700cf9ea4fdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Macrophages
113 rdf:type schema:DefinedTerm
114 N6e90bfcc144347c19f3e153a2ec6495c rdf:first sg:person.0657425377.12
115 rdf:rest Nf3ae18dc5a2a4bdebb27c82af37af1b0
116 N7ae98f90f68845a4972ab8ffd4ad3c39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Proto-Oncogene Proteins c-fos
118 rdf:type schema:DefinedTerm
119 N7cb7f0018a564d9c9becc4f5178390b0 schema:issueNumber 10
120 rdf:type schema:PublicationIssue
121 N7df9ed45978f45f2a3a2b9702e02fc52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice, Knockout
123 rdf:type schema:DefinedTerm
124 N7fbba6bc6dc14f07835367d0617b877a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Bone Remodeling
126 rdf:type schema:DefinedTerm
127 N86a47b3f19f447c1b08eab4fb54321c3 rdf:first sg:person.015446275624.40
128 rdf:rest Nde82f55a07074c45af1d88dc7d71be05
129 N8ea81a492193463e97876e3b99b85bc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Signal Transduction
131 rdf:type schema:DefinedTerm
132 N93f2b12411b6452689cacbc3bd9d814b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name LIM-Homeodomain Proteins
134 rdf:type schema:DefinedTerm
135 N9c63dcc7c84f4a9c8c0207fa5d0b1ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name RANK Ligand
137 rdf:type schema:DefinedTerm
138 N9fbb94c185aa41399af34951daa8a353 rdf:first sg:person.0616405403.13
139 rdf:rest Nddc8cc5fb0794d27a80a4fbd202ae0e2
140 Na1855a9e49744a688c39e30c725d0df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Differentiation
142 rdf:type schema:DefinedTerm
143 Na4ba709c184b42f7ab8a043c8cf6a16f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Osteogenesis
145 rdf:type schema:DefinedTerm
146 Na629bf0aa2504852af27615c67fc37c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Down-Regulation
148 rdf:type schema:DefinedTerm
149 Nada398943b4f4f1fb290981c24f5d890 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mice
151 rdf:type schema:DefinedTerm
152 Nb1ab18918654435ab1fee6d4dc84e8ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cells, Cultured
154 rdf:type schema:DefinedTerm
155 Nb285459bb5ea42e5b2c0c30e9f268cfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Bone Marrow Cells
157 rdf:type schema:DefinedTerm
158 Nb4818d09091c41dd965f8643c9019851 schema:name dimensions_id
159 schema:value pub.1017325463
160 rdf:type schema:PropertyValue
161 Nb56168348856496290b480bad6fd7f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name DNA-Binding Proteins
163 rdf:type schema:DefinedTerm
164 Nc10eb67df876404ab314400756dc7023 schema:name Springer Nature - SN SciGraph project
165 rdf:type schema:Organization
166 Ncb245bafa5144ebf9520679f352c6c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Animals
168 rdf:type schema:DefinedTerm
169 Nd65a097b88d445d3be77180833163611 schema:name readcube_id
170 schema:value 528ba7ac46b54c6e8583ef34ae8d704aace35a4ca304c1fbc64e734b7fad582c
171 rdf:type schema:PropertyValue
172 Ndaaddb45455c4ba996f5016928aff989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Gene Expression Regulation
174 rdf:type schema:DefinedTerm
175 Nddc8cc5fb0794d27a80a4fbd202ae0e2 rdf:first sg:person.01123467434.04
176 rdf:rest Nef67626917b542158a2301c303a0818a
177 Nde82f55a07074c45af1d88dc7d71be05 rdf:first sg:person.015563715242.44
178 rdf:rest N05d4ea1cf30f4a14b2e8a4c78df6758c
179 Ned2099d86a5449779f33f54e11065364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name RNA, Small Interfering
181 rdf:type schema:DefinedTerm
182 Nef67626917b542158a2301c303a0818a rdf:first sg:person.01225563103.30
183 rdf:rest N6e90bfcc144347c19f3e153a2ec6495c
184 Nf3ae18dc5a2a4bdebb27c82af37af1b0 rdf:first sg:person.01356504714.98
185 rdf:rest N86a47b3f19f447c1b08eab4fb54321c3
186 Nf678e0786ca94110ac013ceb3445864a schema:volumeNumber 21
187 rdf:type schema:PublicationVolume
188 Nfda52e4966d24d82b211c3a120e7a0b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name RNA Interference
190 rdf:type schema:DefinedTerm
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:grant.2505553 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2014.71
198 rdf:type schema:MonetaryGrant
199 sg:grant.7454872 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2014.71
200 rdf:type schema:MonetaryGrant
201 sg:journal.1112551 schema:issn 1350-9047
202 1476-5403
203 schema:name Cell Death & Differentiation
204 rdf:type schema:Periodical
205 sg:person.01123467434.04 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
206 schema:familyName Kim
207 schema:givenName K
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123467434.04
209 rdf:type schema:Person
210 sg:person.01225563103.30 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
211 schema:familyName Moon
212 schema:givenName J B
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225563103.30
214 rdf:type schema:Person
215 sg:person.01317336462.98 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
216 schema:familyName Kim
217 schema:givenName J H
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317336462.98
219 rdf:type schema:Person
220 sg:person.01356504714.98 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
221 schema:familyName Nam
222 schema:givenName K-I I
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356504714.98
224 rdf:type schema:Person
225 sg:person.015446275624.40 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
226 schema:familyName Park
227 schema:givenName Y-W
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015446275624.40
229 rdf:type schema:Person
230 sg:person.015563715242.44 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
231 schema:familyName O'Leary
232 schema:givenName D D M
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015563715242.44
234 rdf:type schema:Person
235 sg:person.015757205362.15 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
236 schema:familyName Kim
237 schema:givenName N
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015757205362.15
239 rdf:type schema:Person
240 sg:person.0616405403.13 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
241 schema:familyName Youn
242 schema:givenName B U
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616405403.13
244 rdf:type schema:Person
245 sg:person.0631511345.03 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
246 schema:familyName Kim
247 schema:givenName K K
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631511345.03
249 rdf:type schema:Person
250 sg:person.0657425377.12 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
251 schema:familyName Lee
252 schema:givenName J
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657425377.12
254 rdf:type schema:Person
255 sg:pub.10.1007/s11154-006-9001-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000274978
256 https://doi.org/10.1007/s11154-006-9001-5
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nm.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035780605
259 https://doi.org/10.1038/nm.2007
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nn.2427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047363002
262 https://doi.org/10.1038/nn.2427
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083126132 schema:CreativeWork
265 https://doi.org/10.1002/jbmr.5650020617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006353282
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.lfs.2013.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030320289
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.ydbio.2008.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030662221
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0168-9525(98)01424-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019065767
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0168-9525(99)01883-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053720395
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s1534-5807(02)00369-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705002
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s8756-3282(00)00358-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041364554
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.0400940101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042695739
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.90.1.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044043506
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.92.7.2720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042592139
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1074/jbc.274.51.36159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027789674
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1074/jbc.m313973200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039178819
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.m408795200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003395233
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.m505815200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034882201
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1084/jem.190.12.1741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051922586
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1084/jem.191.2.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438672
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/nar/gkt567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032200859
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.1151695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004178449
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.7939685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650704
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1146/annurev.immunol.24.021605.090646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046869289
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1172/jci35711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010641070
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1177/154405910708600113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049322879
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1182/blood-2005-07-2798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039782196
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1182/blood-2006-09-048249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047307837
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1210/edrv.20.3.0367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238469
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1210/en.2006-1088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248270
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1371/journal.pgen.1000904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010518032
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1530/eje-12-0026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028908997
320 rdf:type schema:CreativeWork
321 https://doi.org/10.4049/jimmunol.169.5.2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037452880
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.14005.30 schema:alternateName Chonnam National University
324 schema:name 1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea [3] Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju, Republic of Korea.
325 1] Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Republic of Korea [2] Department of Pharmacology, Chonnam National University Medical School, Gwangju, Republic of Korea.
326 Department of Anatomy, Chonnam National University Medical School, Gwangju, Republic of Korea.
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.250671.7 schema:alternateName Salk Institute for Biological Studies
329 schema:name Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA, USA.
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.411597.f schema:alternateName Chonnam National University Hospital
332 schema:name Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...