Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05

AUTHORS

A Tchoghandjian, C Jennewein, I Eckhardt, S Momma, D Figarella-Branger, S Fulda

ABSTRACT

Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic BV6, which antagonizes IAP proteins, on differentiation of cancer stem-like cells (CSLCs) derived from primary glioblastoma (GBM) specimens. Here, we identify a novel function of BV6 in regulating differentiation of GBM CSLCs by activating NF-κB. BV6 at non-lethal doses stimulates morphological changes associated with the differentiation of GBM CSLCs. BV6 increases transcriptional activity, mRNA and protein levels of the astrocytic marker GFAP without altering expression of the neuronal marker β-III-tubulin, indicating that BV6 induces astrocytic differentiation of GBM CSLCs. Molecular studies reveal that BV6 triggers processing of the NF-κB subunit p100 to p52, nuclear translocation of p52 and p50 and increased NF-κB DNA-binding. Intriguingly, inhibition of NF-κB by overexpression of dominant-negative IκBα super-repressor (IκBα-SR) blocks the BV6-stimulated increase in GFAP and differentiation. Interestingly, this BV6-stimulated differentiation is associated with reduced expression of stemness markers such as CD133, Nanog and Sox2 in GBM CSLCs. In contrast, BV6 does not alter cell morphology, differentiation and expression of stemness markers in non-malignant neural stem cells. Importantly, BV6 treatment reduces clonogenicity of GBM CSLCs in vitro and in vivo, suppresses their tumorigenicity in orthotopic and subcutaneous mouse models and significantly increases the survival of mice. By identifying a novel role of BV6 in promoting differentiation of GBM CSLCs, these findings provide new insights into Smac mimetic-regulated non-apoptotic functions with important implications for targeting GBM CSLCs. More... »

PAGES

735

References to SciGraph publications

  • 2008-12. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling in NATURE IMMUNOLOGY
  • 2011-08. Crosstalk in NF-κB signaling pathways in NATURE IMMUNOLOGY
  • 2005-10. Betulinic acid as new activator of NF-κB: molecular mechanisms and implications for cancer therapy in ONCOGENE
  • 2008-12. Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK in NATURE IMMUNOLOGY
  • 2006-12. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells in NATURE
  • 2013-03. Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells in CELL DEATH & DISEASE
  • 2013-02. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner in ONCOGENE
  • 2013-07. RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex in ONCOGENE
  • 2008-12. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells in BMC MEDICINE
  • 2011-08. Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo in ONCOGENE
  • 2011-10. Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma in BRITISH JOURNAL OF CANCER
  • 2004-11. Identification of human brain tumour initiating cells in NATURE
  • 2012-08. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1 in NATURE MEDICINE
  • 1999-04. Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma in CELL DEATH & DIFFERENTIATION
  • 2012-02. Targeting IAP proteins for therapeutic intervention in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2012-08. A restricted cell population propagates glioblastoma growth after chemotherapy in NATURE
  • 2007-01. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells in ONCOGENE
  • 2007-07-12. The 2007 WHO Classification of Tumours of the Central Nervous System in ACTA NEUROPATHOLOGICA
  • 2002-08. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cdd.2013.200

    DOI

    http://dx.doi.org/10.1038/cdd.2013.200

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042616141

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24488095


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplastic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligopeptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tchoghandjian", 
            "givenName": "A", 
            "id": "sg:person.01203762303.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203762303.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jennewein", 
            "givenName": "C", 
            "id": "sg:person.01220446253.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220446253.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eckhardt", 
            "givenName": "I", 
            "id": "sg:person.01017251224.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017251224.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute of Neuropathology, Goethe-University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Momma", 
            "givenName": "S", 
            "id": "sg:person.0623434136.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623434136.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "INSERM UMR911, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Figarella-Branger", 
            "givenName": "D", 
            "id": "sg:person.0616165260.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616165260.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulda", 
            "givenName": "S", 
            "id": "sg:person.01331656400.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331656400.85"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1209776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001145043", 
              "https://doi.org/10.1038/sj.onc.1209776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001145043", 
              "https://doi.org/10.1038/sj.onc.1209776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0243-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001430701", 
              "https://doi.org/10.1007/s00401-007-0243-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0243-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001430701", 
              "https://doi.org/10.1007/s00401-007-0243-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002163417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.09436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006077979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006965315", 
              "https://doi.org/10.1038/ni.2065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2013.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007250168", 
              "https://doi.org/10.1038/cddis.2013.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010218312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010218312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011692684", 
              "https://doi.org/10.1038/onc.2011.74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012806954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2009.00888.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015845763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2009.00888.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015845763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diff.2010.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016123899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017708694", 
              "https://doi.org/10.1038/ni.1678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020239862", 
              "https://doi.org/10.1038/nm735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020239862", 
              "https://doi.org/10.1038/nm735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022529403", 
              "https://doi.org/10.1038/nature11287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023224788", 
              "https://doi.org/10.1038/nm.2827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c800128200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024459927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijdevneu.2005.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024704300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.14.12.7695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024709479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025792112", 
              "https://doi.org/10.1038/nrd3627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnr.0000236862.08834.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026916888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnr.0000236862.08834.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026916888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027166093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027948281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027948281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0708576105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028788007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030501285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030501285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2009.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031146887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031254541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032950201", 
              "https://doi.org/10.1038/nature05349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032950201", 
              "https://doi.org/10.1038/nature05349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032950201", 
              "https://doi.org/10.1038/nature05349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032957323", 
              "https://doi.org/10.1038/bjc.2011.387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2008.08.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034024417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1464-410x.2007.06932.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035019849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036164945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2009.00269.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036334530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036583697", 
              "https://doi.org/10.1038/sj.onc.1208842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036583697", 
              "https://doi.org/10.1038/sj.onc.1208842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036583697", 
              "https://doi.org/10.1038/sj.onc.1208842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1741-7015-6-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037637739", 
              "https://doi.org/10.1186/1741-7015-6-14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnr.0b013e3283509a79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038828247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnr.0b013e3283509a79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038828247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040457475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2006.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041322875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042480072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042692074", 
              "https://doi.org/10.1038/sj.cdd.4400503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042692074", 
              "https://doi.org/10.1038/sj.cdd.4400503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047815258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.8.5785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050921566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050959459", 
              "https://doi.org/10.1038/onc.2012.108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(01)00101-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051409830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053056645", 
              "https://doi.org/10.1038/onc.2012.337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-11-0218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053405385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053487240", 
              "https://doi.org/10.1038/ni.1676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2003086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062682624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-01-0065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064122630"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-05", 
        "datePublishedReg": "2014-05-01", 
        "description": "Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic BV6, which antagonizes IAP proteins, on differentiation of cancer stem-like cells (CSLCs) derived from primary glioblastoma (GBM) specimens. Here, we identify a novel function of BV6 in regulating differentiation of GBM CSLCs by activating NF-\u03baB. BV6 at non-lethal doses stimulates morphological changes associated with the differentiation of GBM CSLCs. BV6 increases transcriptional activity, mRNA and protein levels of the astrocytic marker GFAP without altering expression of the neuronal marker \u03b2-III-tubulin, indicating that BV6 induces astrocytic differentiation of GBM CSLCs. Molecular studies reveal that BV6 triggers processing of the NF-\u03baB subunit p100 to p52, nuclear translocation of p52 and p50 and increased NF-\u03baB DNA-binding. Intriguingly, inhibition of NF-\u03baB by overexpression of dominant-negative I\u03baB\u03b1 super-repressor (I\u03baB\u03b1-SR) blocks the BV6-stimulated increase in GFAP and differentiation. Interestingly, this BV6-stimulated differentiation is associated with reduced expression of stemness markers such as CD133, Nanog and Sox2 in GBM CSLCs. In contrast, BV6 does not alter cell morphology, differentiation and expression of stemness markers in non-malignant neural stem cells. Importantly, BV6 treatment reduces clonogenicity of GBM CSLCs in vitro and in vivo, suppresses their tumorigenicity in orthotopic and subcutaneous mouse models and significantly increases the survival of mice. By identifying a novel role of BV6 in promoting differentiation of GBM CSLCs, these findings provide new insights into Smac mimetic-regulated non-apoptotic functions with important implications for targeting GBM CSLCs. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cdd.2013.200", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1112551", 
            "issn": [
              "1350-9047", 
              "1476-5403"
            ], 
            "name": "Cell Death & Differentiation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-\u03baB", 
        "pagination": "735", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "caffa859cfef7dcd07d2a6b12bc41bd2381a68b6201b9587139bd6f6a39067d8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24488095"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9437445"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cdd.2013.200"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042616141"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cdd.2013.200", 
          "https://app.dimensions.ai/details/publication/pub.1042616141"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000437.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/cdd2013200"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.200'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.200'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.200'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.200'


     

    This table displays all metadata directly associated to this object as RDF triples.

    333 TRIPLES      21 PREDICATES      93 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cdd.2013.200 schema:about N040e634e4211480cb92c735b4e2b84bf
    2 N24764d40baf445a8bcd3220748788a1e
    3 N2f436a48184b4a4c9d3be3a6c0ff0475
    4 N3830d1ccb0bb47539f3cd5edbd8992e3
    5 N5705cdd14136477289bb03c15e4a28de
    6 N6ee4ea8e27de42f180d8b99a6de2850d
    7 N71e979c4f2574bf5946e72153c4ed6b3
    8 N73445b1d15f24ac9b9fef9971cb1e3d2
    9 N7f6b3672e7404b33ab5557a7be4fe94f
    10 N98fd2b0ee32146f3ab03a9aa704b46bc
    11 Na71896cbf8754703a4e4e01f4198a098
    12 Nd4b483f0dec049d28a9063dc9b9fdb6a
    13 Ne2c0a0c437d944cc8de740e7def34df4
    14 Nf31e7f5cf8d242ce98e5d7e19903bb38
    15 Nf8047553c14a49c0b2c1a23447a2da0c
    16 anzsrc-for:06
    17 anzsrc-for:0601
    18 schema:author N34f02451cba54b1aad7dd0af5e26188e
    19 schema:citation sg:pub.10.1007/s00401-007-0243-4
    20 sg:pub.10.1038/bjc.2011.387
    21 sg:pub.10.1038/cddis.2013.70
    22 sg:pub.10.1038/nature03128
    23 sg:pub.10.1038/nature05349
    24 sg:pub.10.1038/nature11287
    25 sg:pub.10.1038/ni.1676
    26 sg:pub.10.1038/ni.1678
    27 sg:pub.10.1038/ni.2065
    28 sg:pub.10.1038/nm.2827
    29 sg:pub.10.1038/nm735
    30 sg:pub.10.1038/nrd3627
    31 sg:pub.10.1038/onc.2011.74
    32 sg:pub.10.1038/onc.2012.108
    33 sg:pub.10.1038/onc.2012.337
    34 sg:pub.10.1038/sj.cdd.4400503
    35 sg:pub.10.1038/sj.onc.1208842
    36 sg:pub.10.1038/sj.onc.1209776
    37 sg:pub.10.1186/1741-7015-6-14
    38 https://doi.org/10.1002/ana.22425
    39 https://doi.org/10.1002/glia.21136
    40 https://doi.org/10.1002/glia.21185
    41 https://doi.org/10.1002/jnr.20702
    42 https://doi.org/10.1002/stem.528
    43 https://doi.org/10.1016/j.bbamcr.2006.01.005
    44 https://doi.org/10.1016/j.bbrc.2008.08.107
    45 https://doi.org/10.1016/j.canlet.2009.04.020
    46 https://doi.org/10.1016/j.cell.2007.10.030
    47 https://doi.org/10.1016/j.diff.2010.07.004
    48 https://doi.org/10.1016/j.ijdevneu.2005.11.017
    49 https://doi.org/10.1016/j.molcel.2008.05.014
    50 https://doi.org/10.1016/s1534-5807(01)00101-0
    51 https://doi.org/10.1073/pnas.0708576105
    52 https://doi.org/10.1074/jbc.c800128200
    53 https://doi.org/10.1097/01.wnr.0000236862.08834.50
    54 https://doi.org/10.1097/wnr.0b013e3283509a79
    55 https://doi.org/10.1111/j.1464-410x.2007.06932.x
    56 https://doi.org/10.1111/j.1582-4934.2009.00888.x
    57 https://doi.org/10.1111/j.1750-3639.2009.00269.x
    58 https://doi.org/10.1126/scisignal.2003086
    59 https://doi.org/10.1128/mcb.14.12.7695
    60 https://doi.org/10.1128/mcb.19.8.5785
    61 https://doi.org/10.1158/0008-5472.can-04-1364
    62 https://doi.org/10.1158/0008-5472.can-10-0732
    63 https://doi.org/10.1158/1078-0432.ccr-09-1800
    64 https://doi.org/10.1158/1535-7163.mct-11-0218
    65 https://doi.org/10.1182/blood-2004-01-0065
    66 https://doi.org/10.1371/journal.pone.0021556
    67 https://doi.org/10.1593/neo.09436
    68 schema:datePublished 2014-05
    69 schema:datePublishedReg 2014-05-01
    70 schema:description Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic BV6, which antagonizes IAP proteins, on differentiation of cancer stem-like cells (CSLCs) derived from primary glioblastoma (GBM) specimens. Here, we identify a novel function of BV6 in regulating differentiation of GBM CSLCs by activating NF-κB. BV6 at non-lethal doses stimulates morphological changes associated with the differentiation of GBM CSLCs. BV6 increases transcriptional activity, mRNA and protein levels of the astrocytic marker GFAP without altering expression of the neuronal marker β-III-tubulin, indicating that BV6 induces astrocytic differentiation of GBM CSLCs. Molecular studies reveal that BV6 triggers processing of the NF-κB subunit p100 to p52, nuclear translocation of p52 and p50 and increased NF-κB DNA-binding. Intriguingly, inhibition of NF-κB by overexpression of dominant-negative IκBα super-repressor (IκBα-SR) blocks the BV6-stimulated increase in GFAP and differentiation. Interestingly, this BV6-stimulated differentiation is associated with reduced expression of stemness markers such as CD133, Nanog and Sox2 in GBM CSLCs. In contrast, BV6 does not alter cell morphology, differentiation and expression of stemness markers in non-malignant neural stem cells. Importantly, BV6 treatment reduces clonogenicity of GBM CSLCs in vitro and in vivo, suppresses their tumorigenicity in orthotopic and subcutaneous mouse models and significantly increases the survival of mice. By identifying a novel role of BV6 in promoting differentiation of GBM CSLCs, these findings provide new insights into Smac mimetic-regulated non-apoptotic functions with important implications for targeting GBM CSLCs.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N351eaba4b9224144b96711dc53516651
    75 N5d75575a2ee1421b8314b5d6f70fe453
    76 sg:journal.1112551
    77 schema:name Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB
    78 schema:pagination 735
    79 schema:productId N03d11b81084d45d4adafe5307dbd5b8a
    80 N42496950a66749568cfdc85e1e9942b5
    81 N61fd96853d4544a39f550c9ad6f579b8
    82 N6926465e1d3d42738c2cfbdb6e17d47c
    83 Nea237687a0444f71824c9bf32da883c3
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042616141
    85 https://doi.org/10.1038/cdd.2013.200
    86 schema:sdDatePublished 2019-04-10T22:20
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher Naa8d95f23f80481a9a931fa70a4aa6ed
    89 schema:url https://www.nature.com/articles/cdd2013200
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N03d11b81084d45d4adafe5307dbd5b8a schema:name readcube_id
    94 schema:value caffa859cfef7dcd07d2a6b12bc41bd2381a68b6201b9587139bd6f6a39067d8
    95 rdf:type schema:PropertyValue
    96 N040e634e4211480cb92c735b4e2b84bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Animals
    98 rdf:type schema:DefinedTerm
    99 N24764d40baf445a8bcd3220748788a1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Oligopeptides
    101 rdf:type schema:DefinedTerm
    102 N2e77b1e60ab34477b5e7b965d302c584 rdf:first sg:person.0623434136.84
    103 rdf:rest N4dd509621d34472dabc784c5d9202ddb
    104 N2f436a48184b4a4c9d3be3a6c0ff0475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Mice
    106 rdf:type schema:DefinedTerm
    107 N308c598d52f94444b1fc839e01e271b6 rdf:first sg:person.01017251224.26
    108 rdf:rest N2e77b1e60ab34477b5e7b965d302c584
    109 N34f02451cba54b1aad7dd0af5e26188e rdf:first sg:person.01203762303.45
    110 rdf:rest Na89832efda50422095bc70fb5d6c4896
    111 N351eaba4b9224144b96711dc53516651 schema:issueNumber 5
    112 rdf:type schema:PublicationIssue
    113 N3830d1ccb0bb47539f3cd5edbd8992e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Xenograft Model Antitumor Assays
    115 rdf:type schema:DefinedTerm
    116 N42496950a66749568cfdc85e1e9942b5 schema:name doi
    117 schema:value 10.1038/cdd.2013.200
    118 rdf:type schema:PropertyValue
    119 N4dd509621d34472dabc784c5d9202ddb rdf:first sg:person.0616165260.56
    120 rdf:rest N50b1810ee51b4283b578677b8924e176
    121 N50b1810ee51b4283b578677b8924e176 rdf:first sg:person.01331656400.85
    122 rdf:rest rdf:nil
    123 N540844f4166d47a58dbce70a84ebdc7b schema:name INSERM UMR911, Marseille, France
    124 rdf:type schema:Organization
    125 N5705cdd14136477289bb03c15e4a28de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Cell Line, Tumor
    127 rdf:type schema:DefinedTerm
    128 N5d75575a2ee1421b8314b5d6f70fe453 schema:volumeNumber 21
    129 rdf:type schema:PublicationVolume
    130 N61fd96853d4544a39f550c9ad6f579b8 schema:name pubmed_id
    131 schema:value 24488095
    132 rdf:type schema:PropertyValue
    133 N6926465e1d3d42738c2cfbdb6e17d47c schema:name dimensions_id
    134 schema:value pub.1042616141
    135 rdf:type schema:PropertyValue
    136 N6ee4ea8e27de42f180d8b99a6de2850d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Signal Transduction
    138 rdf:type schema:DefinedTerm
    139 N71e979c4f2574bf5946e72153c4ed6b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Mice, Nude
    141 rdf:type schema:DefinedTerm
    142 N73445b1d15f24ac9b9fef9971cb1e3d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Cell Differentiation
    144 rdf:type schema:DefinedTerm
    145 N7f6b3672e7404b33ab5557a7be4fe94f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Disease Models, Animal
    147 rdf:type schema:DefinedTerm
    148 N98fd2b0ee32146f3ab03a9aa704b46bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Neoplastic Stem Cells
    150 rdf:type schema:DefinedTerm
    151 Na71896cbf8754703a4e4e01f4198a098 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name NF-kappa B
    153 rdf:type schema:DefinedTerm
    154 Na89832efda50422095bc70fb5d6c4896 rdf:first sg:person.01220446253.14
    155 rdf:rest N308c598d52f94444b1fc839e01e271b6
    156 Naa8d95f23f80481a9a931fa70a4aa6ed schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 Nd4b483f0dec049d28a9063dc9b9fdb6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Humans
    160 rdf:type schema:DefinedTerm
    161 Ne2c0a0c437d944cc8de740e7def34df4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Apoptosis
    163 rdf:type schema:DefinedTerm
    164 Nea237687a0444f71824c9bf32da883c3 schema:name nlm_unique_id
    165 schema:value 9437445
    166 rdf:type schema:PropertyValue
    167 Nf31e7f5cf8d242ce98e5d7e19903bb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Brain Neoplasms
    169 rdf:type schema:DefinedTerm
    170 Nf8047553c14a49c0b2c1a23447a2da0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Glioblastoma
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Biological Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Biochemistry and Cell Biology
    178 rdf:type schema:DefinedTerm
    179 sg:journal.1112551 schema:issn 1350-9047
    180 1476-5403
    181 schema:name Cell Death & Differentiation
    182 rdf:type schema:Periodical
    183 sg:person.01017251224.26 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    184 schema:familyName Eckhardt
    185 schema:givenName I
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017251224.26
    187 rdf:type schema:Person
    188 sg:person.01203762303.45 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    189 schema:familyName Tchoghandjian
    190 schema:givenName A
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203762303.45
    192 rdf:type schema:Person
    193 sg:person.01220446253.14 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    194 schema:familyName Jennewein
    195 schema:givenName C
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220446253.14
    197 rdf:type schema:Person
    198 sg:person.01331656400.85 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    199 schema:familyName Fulda
    200 schema:givenName S
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331656400.85
    202 rdf:type schema:Person
    203 sg:person.0616165260.56 schema:affiliation N540844f4166d47a58dbce70a84ebdc7b
    204 schema:familyName Figarella-Branger
    205 schema:givenName D
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616165260.56
    207 rdf:type schema:Person
    208 sg:person.0623434136.84 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    209 schema:familyName Momma
    210 schema:givenName S
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623434136.84
    212 rdf:type schema:Person
    213 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
    214 https://doi.org/10.1007/s00401-007-0243-4
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/bjc.2011.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032957323
    217 https://doi.org/10.1038/bjc.2011.387
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/cddis.2013.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007250168
    220 https://doi.org/10.1038/cddis.2013.70
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
    223 https://doi.org/10.1038/nature03128
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nature05349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032950201
    226 https://doi.org/10.1038/nature05349
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nature11287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022529403
    229 https://doi.org/10.1038/nature11287
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/ni.1676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487240
    232 https://doi.org/10.1038/ni.1676
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/ni.1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017708694
    235 https://doi.org/10.1038/ni.1678
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ni.2065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006965315
    238 https://doi.org/10.1038/ni.2065
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nm.2827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023224788
    241 https://doi.org/10.1038/nm.2827
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nm735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020239862
    244 https://doi.org/10.1038/nm735
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nrd3627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025792112
    247 https://doi.org/10.1038/nrd3627
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/onc.2011.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011692684
    250 https://doi.org/10.1038/onc.2011.74
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/onc.2012.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050959459
    253 https://doi.org/10.1038/onc.2012.108
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/onc.2012.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053056645
    256 https://doi.org/10.1038/onc.2012.337
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/sj.cdd.4400503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042692074
    259 https://doi.org/10.1038/sj.cdd.4400503
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/sj.onc.1208842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036583697
    262 https://doi.org/10.1038/sj.onc.1208842
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/sj.onc.1209776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001145043
    265 https://doi.org/10.1038/sj.onc.1209776
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1186/1741-7015-6-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037637739
    268 https://doi.org/10.1186/1741-7015-6-14
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/ana.22425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047815258
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1002/glia.21136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030501285
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/glia.21185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002163417
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/jnr.20702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027948281
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1002/stem.528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010218312
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.bbamcr.2006.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041322875
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.bbrc.2008.08.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034024417
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.canlet.2009.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031146887
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.cell.2007.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036164945
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.diff.2010.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016123899
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.ijdevneu.2005.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024704300
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.molcel.2008.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027166093
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s1534-5807(01)00101-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051409830
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1073/pnas.0708576105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028788007
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1074/jbc.c800128200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024459927
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1097/01.wnr.0000236862.08834.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026916888
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1097/wnr.0b013e3283509a79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038828247
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1111/j.1464-410x.2007.06932.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035019849
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1582-4934.2009.00888.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015845763
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1111/j.1750-3639.2009.00269.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036334530
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1126/scisignal.2003086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682624
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1128/mcb.14.12.7695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024709479
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1128/mcb.19.8.5785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050921566
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1158/0008-5472.can-04-1364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040457475
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1158/0008-5472.can-10-0732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012806954
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1158/1078-0432.ccr-09-1800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254541
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1158/1535-7163.mct-11-0218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053405385
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1182/blood-2004-01-0065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122630
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1371/journal.pone.0021556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042480072
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1593/neo.09436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006077979
    329 rdf:type schema:CreativeWork
    330 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
    331 schema:name Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, Frankfurt, Germany
    332 Institute of Neuropathology, Goethe-University, Frankfurt, Germany
    333 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...