Immunobiology of mesenchymal stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11-01

AUTHORS

S Ma, N Xie, W Li, B Yuan, Y Shi, Y Wang

ABSTRACT

Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively expanded in vitro. Although their true in situ properties and biological functions remain to be elucidated, these in vitro expanded cells have been shown to possess potential to differentiate into specific cell lineages. It is speculated that MSCs in situ have important roles in tissue cellular homeostasis by replacing dead or dysfunctional cells. Recent studies have demonstrated that in vitro expanded MSCs of various origins have great capacity to modulate immune responses and change the progression of different inflammatory diseases. As tissue injuries are often accompanied by inflammation, inflammatory factors may provide cues to mobilize MSCs to tissue sites with damage. Before carrying out tissue repair functions, MSCs first prepare the microenvironment by modulating inflammatory processes and releasing various growth factors in response to the inflammation status. In this review, we focus on the crosstalk between MSCs and immune responses and their potential clinical applications, especially in inflammatory diseases. More... »

PAGES

216-225

References to SciGraph publications

  • 2005-11-17. Immune cell migration in inflammation: present and future therapeutic targets in NATURE IMMUNOLOGY
  • 2008-11-21. Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production in NATURE MEDICINE
  • 2012-05-20. Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models in NATURE NEUROSCIENCE
  • 2008-04. Endometrial mesenchymal stem cells isolated from the menstrual blood in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 2011-08-08. Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells in JOURNAL OF BIOMEDICAL SCIENCE
  • 2008-09. Mesenchymal stem cells in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2008-05-14. Tolerance strategies for stem-cell-based therapies in NATURE
  • 2003-01-01. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture in LEUKEMIA
  • 2001-04-01. Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function in NATURE MEDICINE
  • 2012-03-16. Mesenchymal stem cells: a double-edged sword in regulating immune responses in CELL DEATH & DIFFERENTIATION
  • 2001-10. Nitric oxide and the immune response in NATURE IMMUNOLOGY
  • 2009-05-12. Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia in MOLECULAR BIOLOGY REPORTS
  • 2008-07-08. A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 in CELL RESEARCH
  • 2012-03-01. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond in GENE THERAPY
  • 2005-04. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells in NATURE MEDICINE
  • 2006-04-21. Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells in CELL DEATH & DIFFERENTIATION
  • 2011-02-12. Methods for the Identification, Characterization and Banking of Human DPSCs: Current Strategies and Perspectives in STEM CELL REVIEWS AND REPORTS
  • 2004-10. Ido expression by dendritic cells: tolerance and tryptophan catabolism in NATURE REVIEWS IMMUNOLOGY
  • 2007-02-27. Immunosuppressive properties of cloned bone marrow mesenchymal stem cells in CELL RESEARCH
  • 2010-04-06. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair in CELL RESEARCH
  • 2008-07-29. VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma in BRITISH JOURNAL OF CANCER
  • 2010-10-04. Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats in LABORATORY INVESTIGATION
  • 2010-04-26. Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α in BMC NEUROSCIENCE
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    35 schema:description Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively expanded in vitro. Although their true in situ properties and biological functions remain to be elucidated, these in vitro expanded cells have been shown to possess potential to differentiate into specific cell lineages. It is speculated that MSCs in situ have important roles in tissue cellular homeostasis by replacing dead or dysfunctional cells. Recent studies have demonstrated that in vitro expanded MSCs of various origins have great capacity to modulate immune responses and change the progression of different inflammatory diseases. As tissue injuries are often accompanied by inflammation, inflammatory factors may provide cues to mobilize MSCs to tissue sites with damage. Before carrying out tissue repair functions, MSCs first prepare the microenvironment by modulating inflammatory processes and releasing various growth factors in response to the inflammation status. In this review, we focus on the crosstalk between MSCs and immune responses and their potential clinical applications, especially in inflammatory diseases.
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