Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-25

AUTHORS

J Su, X Chen, Y Huang, W Li, J Li, K Cao, G Cao, L Zhang, F Li, A I Roberts, H Kang, P Yu, G Ren, W Ji, Y Wang, Y Shi

ABSTRACT

Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) in human and inducible nitric oxide synthase (iNOS) in mouse. In the present study, we isolated MSCs from several mammalian species, each of a different genus, and investigated the involvement of IDO and iNOS during MSC-mediated immunosuppression. The characterization of MSCs from different species was by adherence to tissue culture plastic, morphology, specific marker expression, and differentiation potential. On the basis of the inducibility of IDO and iNOS by inflammatory cytokines in MSCs, the tested mammalian species fall into two distinct groups: IDO utilizers and iNOS utilizers. MSCs from monkey, pig, and human employ IDO to suppress immune responses, whereas MSCs from mouse, rat, rabbit, and hamster utilize iNOS. Interestingly, based on the limited number of species tested, the iNOS-utilizing species all belong to the phylogenetic clade, Glires. Although the evolutionary significance of this divergence is not known, we believe that this study provides critical guidance for choosing appropriate animal models for preclinical studies of MSCs. More... »

PAGES

388-396

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2013.149

DOI

http://dx.doi.org/10.1038/cdd.2013.149

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049087258

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24162664


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplorhini", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immune Tolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoleamine-Pyrrole 2,3,-Dioxygenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide Synthase Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "J", 
        "id": "sg:person.0762666707.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762666707.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "X", 
        "id": "sg:person.011461207157.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011461207157.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Y", 
        "id": "sg:person.0615276714.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615276714.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "W", 
        "id": "sg:person.01253645263.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253645263.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "J", 
        "id": "sg:person.0713106223.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713106223.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "K", 
        "id": "sg:person.01027334623.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027334623.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "G", 
        "id": "sg:person.0777326172.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777326172.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "L", 
        "id": "sg:person.0754657305.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754657305.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "F", 
        "id": "sg:person.01320066132.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320066132.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "A I", 
        "id": "sg:person.014513560412.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513560412.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "P", 
        "id": "sg:person.01003167272.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003167272.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ren", 
        "givenName": "G", 
        "id": "sg:person.07471004757.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07471004757.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China", 
          "id": "http://www.grid.ac/institutes/grid.419010.d", 
          "name": [
            "Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "W", 
        "id": "sg:person.0627313364.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627313364.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.419092.7", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Y", 
        "id": "sg:person.011331265620.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011331265620.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA", 
          "id": "http://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China", 
            "Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Y", 
        "id": "sg:person.014232147077.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014232147077.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/cr.2007.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046784823", 
          "https://doi.org/10.1038/cr.2007.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00239-007-9049-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001429110", 
          "https://doi.org/10.1007/s00239-007-9049-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2010.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032427884", 
          "https://doi.org/10.1038/cr.2010.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2012.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036455041", 
          "https://doi.org/10.1038/cdd.2012.26"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10-25", 
    "datePublishedReg": "2013-10-25", 
    "description": "Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) in human and inducible nitric oxide synthase (iNOS) in mouse. In the present study, we isolated MSCs from several mammalian species, each of a different genus, and investigated the involvement of IDO and iNOS during MSC-mediated immunosuppression. The characterization of MSCs from different species was by adherence to tissue culture plastic, morphology, specific marker expression, and differentiation potential. On the basis of the inducibility of IDO and iNOS by inflammatory cytokines in MSCs, the tested mammalian species fall into two distinct groups: IDO utilizers and iNOS utilizers. MSCs from monkey, pig, and human employ IDO to suppress immune responses, whereas MSCs from mouse, rat, rabbit, and hamster utilize iNOS. Interestingly, based on the limited number of species tested, the iNOS-utilizing species all belong to the phylogenetic clade, Glires. Although the evolutionary significance of this divergence is not known, we believe that this study provides critical guidance for choosing appropriate animal models for preclinical studies of MSCs.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/cdd.2013.149", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4998189", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1112551", 
        "issn": [
          "1350-9047", 
          "1476-5403"
        ], 
        "name": "Cell Death & Differentiation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "mammalian Mesenchymal Stem Cells", 
      "inducible nitric oxide synthase", 
      "mammalian species", 
      "cell-mediated immunosuppression", 
      "phylogenetic distinction", 
      "nitric oxide synthase", 
      "phylogenetic clades", 
      "evolutionary significance", 
      "appropriate animal models", 
      "specific marker expression", 
      "human clinical trials", 
      "involvement of IDO", 
      "different genera", 
      "different species", 
      "mesenchymal stem cells", 
      "animal disease models", 
      "IDO function", 
      "differentiation potential", 
      "inflammatory cytokines", 
      "clinical trials", 
      "oxide synthase", 
      "species", 
      "immune response", 
      "key molecules", 
      "preclinical studies", 
      "stem cells", 
      "animal models", 
      "immunosuppression", 
      "marker expression", 
      "IDO", 
      "culture plastic", 
      "disease models", 
      "distinct groups", 
      "mice", 
      "present study", 
      "clade", 
      "Glires", 
      "genus", 
      "utilizers", 
      "cytokines", 
      "indoleamine", 
      "rats", 
      "divergence", 
      "synthase", 
      "trials", 
      "dioxygenase", 
      "study", 
      "adherence", 
      "inducibility", 
      "hamsters", 
      "expression", 
      "rabbits", 
      "monkeys", 
      "limited number", 
      "cells", 
      "pigs", 
      "involvement", 
      "group", 
      "molecules", 
      "response", 
      "characterization", 
      "significance", 
      "function", 
      "morphology", 
      "critical guidance", 
      "guidance", 
      "basis", 
      "potential", 
      "number", 
      "model", 
      "distinction", 
      "plastic"
    ], 
    "name": "Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species", 
    "pagination": "388-396", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049087258"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cdd.2013.149"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24162664"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cdd.2013.149", 
      "https://app.dimensions.ai/details/publication/pub.1049087258"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_587.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/cdd.2013.149"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.149'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.149'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.149'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2013.149'


 

This table displays all metadata directly associated to this object as RDF triples.

336 TRIPLES      21 PREDICATES      119 URIs      107 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cdd.2013.149 schema:about N10a82d4b453c434e8ff3472c78caad33
2 N16051ff18dfe46a5be9756e54b114f46
3 N175787802c674eb381160d8a2310d248
4 N1f78078efdb84577959211ec4927fe60
5 N3392440c85844d79972a2b16defdeaee
6 N4cfd15b2e02743a6b5c457190ae2fdea
7 N4e7c5f25c7234fb4ac09b19cecfd4c0a
8 N4f4dcd7063a64f49a9c90bf7c590454e
9 N6052478cd35d4ec3a46fd1e65890a2ef
10 N6935cfabcf3545da9af94e0e3905a9bb
11 N73dd6fff1a064a538faaabe2b3883344
12 N73e3766fc16a458cba45c6ffd86f85e5
13 N76609a79554a4a10b67967674d1caf89
14 N92a0d84aa4334b0a89f54d1827828cc2
15 N92c2aa4facd94cab84a42a691f2f19ed
16 N969e653927764e05a5d3b1767574315f
17 N9d132b3d602849bb8b2430030b73449d
18 Na51a1b2d5c1a4bf79d1ab41f958e89b4
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author Nb5b896f0aa8549ee9a4bdc0f72800f61
22 schema:citation sg:pub.10.1007/s00239-007-9049-1
23 sg:pub.10.1038/cdd.2012.26
24 sg:pub.10.1038/cr.2007.4
25 sg:pub.10.1038/cr.2010.44
26 schema:datePublished 2013-10-25
27 schema:datePublishedReg 2013-10-25
28 schema:description Mammalian mesenchymal stem cells (MSCs) have been shown to be strongly immunosuppressive in both animal disease models and human clinical trials. We have reported that the key molecule mediating immunosuppression by MSCs is species dependent: indoleamine 2,3-dioxygenase (IDO) in human and inducible nitric oxide synthase (iNOS) in mouse. In the present study, we isolated MSCs from several mammalian species, each of a different genus, and investigated the involvement of IDO and iNOS during MSC-mediated immunosuppression. The characterization of MSCs from different species was by adherence to tissue culture plastic, morphology, specific marker expression, and differentiation potential. On the basis of the inducibility of IDO and iNOS by inflammatory cytokines in MSCs, the tested mammalian species fall into two distinct groups: IDO utilizers and iNOS utilizers. MSCs from monkey, pig, and human employ IDO to suppress immune responses, whereas MSCs from mouse, rat, rabbit, and hamster utilize iNOS. Interestingly, based on the limited number of species tested, the iNOS-utilizing species all belong to the phylogenetic clade, Glires. Although the evolutionary significance of this divergence is not known, we believe that this study provides critical guidance for choosing appropriate animal models for preclinical studies of MSCs.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf N607f6ae6a8b84e2dafe9b5790df506e8
32 N87487b28da5a4d45a8c7a580b945bd4a
33 sg:journal.1112551
34 schema:keywords Glires
35 IDO
36 IDO function
37 adherence
38 animal disease models
39 animal models
40 appropriate animal models
41 basis
42 cell-mediated immunosuppression
43 cells
44 characterization
45 clade
46 clinical trials
47 critical guidance
48 culture plastic
49 cytokines
50 different genera
51 different species
52 differentiation potential
53 dioxygenase
54 disease models
55 distinct groups
56 distinction
57 divergence
58 evolutionary significance
59 expression
60 function
61 genus
62 group
63 guidance
64 hamsters
65 human clinical trials
66 immune response
67 immunosuppression
68 indoleamine
69 inducibility
70 inducible nitric oxide synthase
71 inflammatory cytokines
72 involvement
73 involvement of IDO
74 key molecules
75 limited number
76 mammalian Mesenchymal Stem Cells
77 mammalian species
78 marker expression
79 mesenchymal stem cells
80 mice
81 model
82 molecules
83 monkeys
84 morphology
85 nitric oxide synthase
86 number
87 oxide synthase
88 phylogenetic clades
89 phylogenetic distinction
90 pigs
91 plastic
92 potential
93 preclinical studies
94 present study
95 rabbits
96 rats
97 response
98 significance
99 species
100 specific marker expression
101 stem cells
102 study
103 synthase
104 trials
105 utilizers
106 schema:name Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species
107 schema:pagination 388-396
108 schema:productId N38b361c6a40d4a95a648c97f058ae88c
109 Na68d2c3137a545b9a3032d6565d26b65
110 Nafe7991ec564429caff0099a1cee926a
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049087258
112 https://doi.org/10.1038/cdd.2013.149
113 schema:sdDatePublished 2022-12-01T06:30
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N9a9ea4dd9a4c4f3ead4ebf18d6a36cde
116 schema:url https://doi.org/10.1038/cdd.2013.149
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N035db2db0887416cb0c3731193a0776f rdf:first sg:person.07471004757.14
121 rdf:rest Nf73d15ea1ac949589580f0cf4a06b965
122 N0f6d6c8166e54586bfd9d5d1fc6d2a79 rdf:first sg:person.014232147077.31
123 rdf:rest rdf:nil
124 N10a82d4b453c434e8ff3472c78caad33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N16051ff18dfe46a5be9756e54b114f46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Rabbits
129 rdf:type schema:DefinedTerm
130 N175787802c674eb381160d8a2310d248 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Indoleamine-Pyrrole 2,3,-Dioxygenase
132 rdf:type schema:DefinedTerm
133 N1d84812ae56245fabd2a14ab1cc68434 rdf:first sg:person.0777326172.14
134 rdf:rest Nd7f2833dc7c242699ade5140ae24d770
135 N1f78078efdb84577959211ec4927fe60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mesenchymal Stem Cells
137 rdf:type schema:DefinedTerm
138 N2f75bfb6a77748fd9b34f10d63891823 rdf:first sg:person.014513560412.12
139 rdf:rest N4037ab9ec8a64b12b08ca6f165d17a29
140 N3392440c85844d79972a2b16defdeaee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Differentiation
142 rdf:type schema:DefinedTerm
143 N38b361c6a40d4a95a648c97f058ae88c schema:name doi
144 schema:value 10.1038/cdd.2013.149
145 rdf:type schema:PropertyValue
146 N3b5f91f51400414d9058751ddfd5f2e7 rdf:first sg:person.01320066132.67
147 rdf:rest N2f75bfb6a77748fd9b34f10d63891823
148 N4037ab9ec8a64b12b08ca6f165d17a29 rdf:first N95200cb458f74200ab76a6ddfbac71de
149 rdf:rest N83961bff2b0343a182d9a4e2a451da36
150 N4cfd15b2e02743a6b5c457190ae2fdea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Haplorhini
152 rdf:type schema:DefinedTerm
153 N4e7c5f25c7234fb4ac09b19cecfd4c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Mice
155 rdf:type schema:DefinedTerm
156 N4f4dcd7063a64f49a9c90bf7c590454e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice, Inbred BALB C
158 rdf:type schema:DefinedTerm
159 N6052478cd35d4ec3a46fd1e65890a2ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Phylogeny
161 rdf:type schema:DefinedTerm
162 N607f6ae6a8b84e2dafe9b5790df506e8 schema:volumeNumber 21
163 rdf:type schema:PublicationVolume
164 N6935cfabcf3545da9af94e0e3905a9bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Swine
166 rdf:type schema:DefinedTerm
167 N71895e0e48454fcc838e7156ce2a28b7 rdf:first sg:person.011331265620.61
168 rdf:rest N0f6d6c8166e54586bfd9d5d1fc6d2a79
169 N73dd6fff1a064a538faaabe2b3883344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Animals
171 rdf:type schema:DefinedTerm
172 N73e3766fc16a458cba45c6ffd86f85e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Rats, Sprague-Dawley
174 rdf:type schema:DefinedTerm
175 N76609a79554a4a10b67967674d1caf89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cricetinae
177 rdf:type schema:DefinedTerm
178 N83961bff2b0343a182d9a4e2a451da36 rdf:first sg:person.01003167272.55
179 rdf:rest N035db2db0887416cb0c3731193a0776f
180 N87487b28da5a4d45a8c7a580b945bd4a schema:issueNumber 3
181 rdf:type schema:PublicationIssue
182 N92a0d84aa4334b0a89f54d1827828cc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Nitric Oxide Synthase Type II
184 rdf:type schema:DefinedTerm
185 N92c2aa4facd94cab84a42a691f2f19ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Rats
187 rdf:type schema:DefinedTerm
188 N95200cb458f74200ab76a6ddfbac71de schema:affiliation grid-institutes:grid.419092.7
189 schema:familyName Kang
190 schema:givenName H
191 rdf:type schema:Person
192 N969e653927764e05a5d3b1767574315f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Immune Tolerance
194 rdf:type schema:DefinedTerm
195 N980503b5243447a1909f6cbd1eee2e37 rdf:first sg:person.01253645263.35
196 rdf:rest Nf492048d202546a09e1be6913c24a25b
197 N9a9ea4dd9a4c4f3ead4ebf18d6a36cde schema:name Springer Nature - SN SciGraph project
198 rdf:type schema:Organization
199 N9d132b3d602849bb8b2430030b73449d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Disease Models, Animal
201 rdf:type schema:DefinedTerm
202 Na51a1b2d5c1a4bf79d1ab41f958e89b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice, Inbred C57BL
204 rdf:type schema:DefinedTerm
205 Na68d2c3137a545b9a3032d6565d26b65 schema:name dimensions_id
206 schema:value pub.1049087258
207 rdf:type schema:PropertyValue
208 Nafe7991ec564429caff0099a1cee926a schema:name pubmed_id
209 schema:value 24162664
210 rdf:type schema:PropertyValue
211 Nb5b896f0aa8549ee9a4bdc0f72800f61 rdf:first sg:person.0762666707.47
212 rdf:rest Ndfc10e6b25474952a39680101ef9a87c
213 Nd7f2833dc7c242699ade5140ae24d770 rdf:first sg:person.0754657305.95
214 rdf:rest N3b5f91f51400414d9058751ddfd5f2e7
215 Ndfc10e6b25474952a39680101ef9a87c rdf:first sg:person.011461207157.38
216 rdf:rest Neb9f9b5bcc6e4381963bcbb28e66f73b
217 Ne8dbdd09c5df4f3e86085ce60251b656 rdf:first sg:person.01027334623.84
218 rdf:rest N1d84812ae56245fabd2a14ab1cc68434
219 Neb9f9b5bcc6e4381963bcbb28e66f73b rdf:first sg:person.0615276714.78
220 rdf:rest N980503b5243447a1909f6cbd1eee2e37
221 Nf492048d202546a09e1be6913c24a25b rdf:first sg:person.0713106223.47
222 rdf:rest Ne8dbdd09c5df4f3e86085ce60251b656
223 Nf73d15ea1ac949589580f0cf4a06b965 rdf:first sg:person.0627313364.32
224 rdf:rest N71895e0e48454fcc838e7156ce2a28b7
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
229 schema:name Immunology
230 rdf:type schema:DefinedTerm
231 sg:grant.2438866 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2013.149
232 rdf:type schema:MonetaryGrant
233 sg:grant.4998189 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2013.149
234 rdf:type schema:MonetaryGrant
235 sg:journal.1112551 schema:issn 1350-9047
236 1476-5403
237 schema:name Cell Death & Differentiation
238 schema:publisher Springer Nature
239 rdf:type schema:Periodical
240 sg:person.01003167272.55 schema:affiliation grid-institutes:grid.419092.7
241 schema:familyName Yu
242 schema:givenName P
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003167272.55
244 rdf:type schema:Person
245 sg:person.01027334623.84 schema:affiliation grid-institutes:grid.419092.7
246 schema:familyName Cao
247 schema:givenName K
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027334623.84
249 rdf:type schema:Person
250 sg:person.011331265620.61 schema:affiliation grid-institutes:grid.419092.7
251 schema:familyName Wang
252 schema:givenName Y
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011331265620.61
254 rdf:type schema:Person
255 sg:person.011461207157.38 schema:affiliation grid-institutes:grid.419092.7
256 schema:familyName Chen
257 schema:givenName X
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011461207157.38
259 rdf:type schema:Person
260 sg:person.01253645263.35 schema:affiliation grid-institutes:grid.419092.7
261 schema:familyName Li
262 schema:givenName W
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253645263.35
264 rdf:type schema:Person
265 sg:person.01320066132.67 schema:affiliation grid-institutes:grid.419092.7
266 schema:familyName Li
267 schema:givenName F
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320066132.67
269 rdf:type schema:Person
270 sg:person.014232147077.31 schema:affiliation grid-institutes:grid.430387.b
271 schema:familyName Shi
272 schema:givenName Y
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014232147077.31
274 rdf:type schema:Person
275 sg:person.014513560412.12 schema:affiliation grid-institutes:grid.430387.b
276 schema:familyName Roberts
277 schema:givenName A I
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513560412.12
279 rdf:type schema:Person
280 sg:person.0615276714.78 schema:affiliation grid-institutes:grid.419092.7
281 schema:familyName Huang
282 schema:givenName Y
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615276714.78
284 rdf:type schema:Person
285 sg:person.0627313364.32 schema:affiliation grid-institutes:grid.419010.d
286 schema:familyName Ji
287 schema:givenName W
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627313364.32
289 rdf:type schema:Person
290 sg:person.0713106223.47 schema:affiliation grid-institutes:grid.419092.7
291 schema:familyName Li
292 schema:givenName J
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713106223.47
294 rdf:type schema:Person
295 sg:person.07471004757.14 schema:affiliation grid-institutes:grid.430387.b
296 schema:familyName Ren
297 schema:givenName G
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07471004757.14
299 rdf:type schema:Person
300 sg:person.0754657305.95 schema:affiliation grid-institutes:grid.430387.b
301 schema:familyName Zhang
302 schema:givenName L
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754657305.95
304 rdf:type schema:Person
305 sg:person.0762666707.47 schema:affiliation grid-institutes:grid.419092.7
306 schema:familyName Su
307 schema:givenName J
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762666707.47
309 rdf:type schema:Person
310 sg:person.0777326172.14 schema:affiliation grid-institutes:grid.419092.7
311 schema:familyName Cao
312 schema:givenName G
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777326172.14
314 rdf:type schema:Person
315 sg:pub.10.1007/s00239-007-9049-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001429110
316 https://doi.org/10.1007/s00239-007-9049-1
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/cdd.2012.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036455041
319 https://doi.org/10.1038/cdd.2012.26
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/cr.2007.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046784823
322 https://doi.org/10.1038/cr.2007.4
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/cr.2010.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032427884
325 https://doi.org/10.1038/cr.2010.44
326 rdf:type schema:CreativeWork
327 grid-institutes:grid.419010.d schema:alternateName Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China
328 schema:name Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China
329 rdf:type schema:Organization
330 grid-institutes:grid.419092.7 schema:alternateName Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China
331 schema:name Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China
332 rdf:type schema:Organization
333 grid-institutes:grid.430387.b schema:alternateName Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA
334 schema:name Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, 08901, NJ, USA
335 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, 200025, Shanghai, China
336 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...