Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

G G Jinesh, W Choi, J B Shah, E K Lee, D L Willis, A M Kamat

ABSTRACT

Caspases mediate apoptosis and have also been implicated in stem-cell biology. How caspases are linked to stem-cell biology is not known. Here, we show that the apoptotic blebs of cancer cells fuse together to form novel structures called 'blebbishields'. Blebbishields form spheres by fusion. Both blebbishield formation and sphere formation involve active caspases and N-linked glycosylation. Sphere formation is enhanced by acidic pH and is counteracted by inhibitors of proton pump, caspases, and cholesterol. The blebbishields from VEGFR2(High) cells are capable of enhanced sphere formation. Blebbishields express transiently downregulated stem-cell markers and the sphere-forming blebbishield-derived cells are tumorigenic. Our study demonstrates that the cancer stem cells can survive after apoptosis by blebbishield formation and subsequent sphere formation. More... »

PAGES

382

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2012.140

DOI

http://dx.doi.org/10.1038/cdd.2012.140

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018561356

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23175184


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