Epithelial cell polarity: a major gatekeeper against cancer? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

C Royer, X Lu

ABSTRACT

The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical-basal polarity and cell-cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy. More... »

PAGES

1470

References to SciGraph publications

  • 2009-08. Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma in ONCOGENE
  • 2008-10. Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction in VIRUS GENES
  • 2000-01. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase in ONCOGENE
  • 2006-08. Expression of Dickkopf genes is strongly reduced in malignant melanoma in ONCOGENE
  • 2008-11. Drosophila asymmetric division, polarity and cancer in ONCOGENE
  • 2006-11. Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control in NATURE CELL BIOLOGY
  • 2008-11. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module in ONCOGENE
  • 1998-01. Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase in NATURE GENETICS
  • 2010-12. Asymmetric cell division: recent developments and their implications for tumour biology in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-01. Expression of Hugl-1 is strongly reduced in malignant melanoma in ONCOGENE
  • 2004-01. Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix in BRITISH JOURNAL OF CANCER
  • 2010-12. The lethal giant larvaetumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy in BMC BIOLOGY
  • 2005-09. Asymmetric cell divisions promote stratification and differentiation of mammalian skin in NATURE
  • 2005-04. ASPP1 and ASPP2 are new transcriptional targets of E2F in CELL DEATH & DIFFERENTIATION
  • 1998-01. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome in NATURE
  • 2005-03. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 in NATURE CELL BIOLOGY
  • 2004-11. The human protein Hugl-1 substitutes for Drosophila Lethal giant larvae tumour suppressor function in vivo in ONCOGENE
  • 2003-12. hScrib is a functional homologue of the Drosophila tumour suppressor Scribble in ONCOGENE
  • 2003-02. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry in NATURE CELL BIOLOGY
  • 2003-04. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl in NATURE CELL BIOLOGY
  • 2010-09. The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction in ONCOGENE
  • 2008-10. Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling in ONCOGENE
  • 1999-10. Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control in ONCOGENE
  • 2008-11. Cell polarity proteins: common targets for tumorigenic human viruses in ONCOGENE
  • 2005-04. Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer in ONCOGENE
  • 2000-08. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 in NATURE CELL BIOLOGY
  • 2005-09. The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cdd.2011.60

    DOI

    http://dx.doi.org/10.1038/cdd.2011.60

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006592214

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21617693


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Dedifferentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Movement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Polarity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial-Mesenchymal Transition", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Ludwig Institute for Cancer Research, Old Road Campus Research Building, University of Oxford, Headington, Oxford OX3 7DQ, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Royer", 
            "givenName": "C", 
            "id": "sg:person.01157436352.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157436352.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Ludwig Institute for Cancer Research, Old Road Campus Research Building, University of Oxford, Headington, Oxford OX3 7DQ, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "X", 
            "id": "sg:person.01045022612.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045022612.52"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bjc.6601465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000441301", 
              "https://doi.org/10.1038/sj.bjc.6601465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000441301", 
              "https://doi.org/10.1038/sj.bjc.6601465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5476.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001605468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002042316", 
              "https://doi.org/10.1038/sj.onc.1203008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002042316", 
              "https://doi.org/10.1038/sj.onc.1203008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.143.1.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002166954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m306324200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002658341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m107880200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004688106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2004.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006163672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2005.01.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006839887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007534413", 
              "https://doi.org/10.1038/ncb948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007534413", 
              "https://doi.org/10.1038/ncb948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.374006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007572953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.13.6670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007864297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2010.01.065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008308529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-2078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e04-09-0827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008552826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557848", 
              "https://doi.org/10.1038/34432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557848", 
              "https://doi.org/10.1038/34432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009303006", 
              "https://doi.org/10.1038/nrm3010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009303006", 
              "https://doi.org/10.1038/nrm3010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3727/096504010x12767359114045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009880443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.00648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010155248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.11.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010543743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200708159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011347949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.141341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011488658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012192572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012404111", 
              "https://doi.org/10.1038/onc.2010.265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012404111", 
              "https://doi.org/10.1038/onc.2010.265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0809080106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012470966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2010.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013330167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2009.02.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013524779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.016634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015127537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2010.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015628916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.02.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016114447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018778194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.10.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019681714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0198-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020155012", 
              "https://doi.org/10.1038/ng0198-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020433824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35019573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021424283", 
              "https://doi.org/10.1038/35019573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35019573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021424283", 
              "https://doi.org/10.1038/35019573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2008.09.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021671043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022217052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000319692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022433441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022667041", 
              "https://doi.org/10.1038/onc.2009.148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022819958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(01)00367-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024202933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024475127", 
              "https://doi.org/10.1038/onc.2008.352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2003.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024792018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025354868", 
              "https://doi.org/10.1038/sj.onc.1209008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025354868", 
              "https://doi.org/10.1038/sj.onc.1209008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025354868", 
              "https://doi.org/10.1038/sj.onc.1209008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.06.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025555859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1178004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026179013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200505127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027549307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027958007", 
              "https://doi.org/10.1038/sj.cdd.4401562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027958007", 
              "https://doi.org/10.1038/sj.cdd.4401562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0248-4900(02)00004-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028439873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028492833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2010.090220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030940474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152372", 
              "https://doi.org/10.1038/nature03922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152372", 
              "https://doi.org/10.1038/nature03922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152372", 
              "https://doi.org/10.1038/nature03922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152372", 
              "https://doi.org/10.1038/nature03922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032828482", 
              "https://doi.org/10.1038/sj.onc.1207154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032828482", 
              "https://doi.org/10.1038/sj.onc.1207154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1105718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033030663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200408064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033094066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0925-4773(97)00658-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033207672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033444506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034620804", 
              "https://doi.org/10.1038/sj.onc.1203309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034620804", 
              "https://doi.org/10.1038/sj.onc.1203309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035028490", 
              "https://doi.org/10.1038/ncb922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035028490", 
              "https://doi.org/10.1038/ncb922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036029035", 
              "https://doi.org/10.1038/sj.onc.1208023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036029035", 
              "https://doi.org/10.1038/sj.onc.1208023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2009.10.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036389554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2443.2002.00590.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037191984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037595058", 
              "https://doi.org/10.1038/sj.onc.1208757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037595058", 
              "https://doi.org/10.1038/sj.onc.1208757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.02938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038078477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m802482200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038550636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2010.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038807508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038877911", 
              "https://doi.org/10.1038/sj.onc.1208520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038877911", 
              "https://doi.org/10.1038/sj.onc.1208520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200311031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039185439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2007.11.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039595242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.02545-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040508177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040994073", 
              "https://doi.org/10.1038/onc.2008.349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01621-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042090625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00758-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042782035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11262-008-0259-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042883709", 
              "https://doi.org/10.1007/s11262-008-0259-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043000345", 
              "https://doi.org/10.1038/ncb1485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043000345", 
              "https://doi.org/10.1038/ncb1485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0004264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044355838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045173407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0906796106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046313872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.09.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046601166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2009.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046830025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2007.11.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046890921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m702279200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047638121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048693720", 
              "https://doi.org/10.1038/sj.onc.1209508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048693720", 
              "https://doi.org/10.1038/sj.onc.1209508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048842159", 
              "https://doi.org/10.1038/onc.2008.219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2010.12.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049045692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049046166", 
              "https://doi.org/10.1038/ncb1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049046166", 
              "https://doi.org/10.1038/ncb1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1741-7007-8-33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049887351", 
              "https://doi.org/10.1186/1741-7007-8-33"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2443.2006.00954.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050014632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2443.2006.00954.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050014632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.20992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050875116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051979527", 
              "https://doi.org/10.1038/onc.2008.341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.043174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052033187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200605092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052995277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1087795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062448406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.96525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062663347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5009/gnl.2010.4.2.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072550899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5009/gnl.2010.4.2.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072550899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075064398", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077826102", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-09", 
        "datePublishedReg": "2011-09-01", 
        "description": "The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical-basal polarity and cell-cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cdd.2011.60", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1112551", 
            "issn": [
              "1350-9047", 
              "1476-5403"
            ], 
            "name": "Cell Death & Differentiation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Epithelial cell polarity: a major gatekeeper against cancer?", 
        "pagination": "1470", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1f661d481845b96a09d913f68ace12f5fc69103e8cb55005a8012d6df0eb98c4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21617693"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9437445"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cdd.2011.60"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1006592214"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cdd.2011.60", 
          "https://app.dimensions.ai/details/publication/pub.1006592214"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/cdd201160"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.60'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.60'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.60'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.60'


     

    This table displays all metadata directly associated to this object as RDF triples.

    445 TRIPLES      21 PREDICATES      139 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cdd.2011.60 schema:about N005c252d52f64e9fae6ff62461affb69
    2 N070fafcb79b647548505668ba67cf2a9
    3 N214c671736b0420ebc3777b4e03ae5c1
    4 N309bfbf09dfc413e85c05651535ccb94
    5 N31d957aec5da405f82f8cd929b062918
    6 N49a126a7d56e446cad3ea4f47f55f03a
    7 N509628aa19bf424088f9691d5cffa078
    8 N6b40aed387174c88805bc145cbca9fb3
    9 N86e91e5472e648fc9e5552335f30815d
    10 N86f3fbe28f8b45179f227cd3bff5be6f
    11 N94b36596c24643b184b5815333824e9f
    12 Ncc33521fb97b4fad964b3cc6d4291042
    13 Ne39fda91a22f43b0a3fc9891a6ac8eae
    14 Nfcd44fbef6c94bb29202f57ee2b43fca
    15 anzsrc-for:06
    16 anzsrc-for:0601
    17 schema:author Ne033ceec3cbb419aa8affbcbedebf2d7
    18 schema:citation sg:pub.10.1007/s11262-008-0259-4
    19 sg:pub.10.1038/34432
    20 sg:pub.10.1038/35019573
    21 sg:pub.10.1038/nature03922
    22 sg:pub.10.1038/ncb1226
    23 sg:pub.10.1038/ncb1485
    24 sg:pub.10.1038/ncb922
    25 sg:pub.10.1038/ncb948
    26 sg:pub.10.1038/ng0198-38
    27 sg:pub.10.1038/nrm3010
    28 sg:pub.10.1038/onc.2008.219
    29 sg:pub.10.1038/onc.2008.341
    30 sg:pub.10.1038/onc.2008.349
    31 sg:pub.10.1038/onc.2008.352
    32 sg:pub.10.1038/onc.2009.148
    33 sg:pub.10.1038/onc.2010.265
    34 sg:pub.10.1038/sj.bjc.6601465
    35 sg:pub.10.1038/sj.cdd.4401562
    36 sg:pub.10.1038/sj.onc.1203008
    37 sg:pub.10.1038/sj.onc.1203309
    38 sg:pub.10.1038/sj.onc.1207154
    39 sg:pub.10.1038/sj.onc.1208023
    40 sg:pub.10.1038/sj.onc.1208520
    41 sg:pub.10.1038/sj.onc.1208757
    42 sg:pub.10.1038/sj.onc.1209008
    43 sg:pub.10.1038/sj.onc.1209508
    44 sg:pub.10.1186/1741-7007-8-33
    45 https://app.dimensions.ai/details/publication/pub.1075064398
    46 https://app.dimensions.ai/details/publication/pub.1077826102
    47 https://doi.org/10.1002/ijc.21982
    48 https://doi.org/10.1002/jcb.20992
    49 https://doi.org/10.1016/j.cell.2006.11.051
    50 https://doi.org/10.1016/j.cell.2008.09.045
    51 https://doi.org/10.1016/j.cell.2009.06.048
    52 https://doi.org/10.1016/j.cell.2009.07.041
    53 https://doi.org/10.1016/j.cell.2010.02.040
    54 https://doi.org/10.1016/j.cub.2008.09.029
    55 https://doi.org/10.1016/j.cub.2009.10.027
    56 https://doi.org/10.1016/j.cub.2010.01.065
    57 https://doi.org/10.1016/j.cub.2010.06.024
    58 https://doi.org/10.1016/j.devcel.2004.05.003
    59 https://doi.org/10.1016/j.devcel.2007.11.005
    60 https://doi.org/10.1016/j.devcel.2007.11.021
    61 https://doi.org/10.1016/j.devcel.2010.06.003
    62 https://doi.org/10.1016/j.devcel.2010.11.012
    63 https://doi.org/10.1016/j.febslet.2005.01.069
    64 https://doi.org/10.1016/j.febslet.2010.12.025
    65 https://doi.org/10.1016/j.gde.2009.12.001
    66 https://doi.org/10.1016/j.molcel.2007.10.028
    67 https://doi.org/10.1016/j.neuron.2009.07.004
    68 https://doi.org/10.1016/j.virol.2003.10.006
    69 https://doi.org/10.1016/j.virol.2009.02.030
    70 https://doi.org/10.1016/j.ygyno.2004.01.025
    71 https://doi.org/10.1016/s0248-4900(02)00004-7
    72 https://doi.org/10.1016/s0925-4773(97)00658-8
    73 https://doi.org/10.1016/s0960-9822(02)00758-3
    74 https://doi.org/10.1016/s1097-2765(01)00367-7
    75 https://doi.org/10.1046/j.1365-2443.2002.00590.x
    76 https://doi.org/10.1073/pnas.0809080106
    77 https://doi.org/10.1073/pnas.0906796106
    78 https://doi.org/10.1073/pnas.94.13.6670
    79 https://doi.org/10.1074/jbc.m107880200
    80 https://doi.org/10.1074/jbc.m110.141341
    81 https://doi.org/10.1074/jbc.m306324200
    82 https://doi.org/10.1074/jbc.m702279200
    83 https://doi.org/10.1074/jbc.m802482200
    84 https://doi.org/10.1083/jcb.143.1.95
    85 https://doi.org/10.1083/jcb.200311031
    86 https://doi.org/10.1083/jcb.200408064
    87 https://doi.org/10.1083/jcb.200505127
    88 https://doi.org/10.1083/jcb.200605092
    89 https://doi.org/10.1083/jcb.200708159
    90 https://doi.org/10.1091/mbc.e04-09-0827
    91 https://doi.org/10.1093/emboj/cdg548
    92 https://doi.org/10.1101/gad.1178004
    93 https://doi.org/10.1101/gad.374006
    94 https://doi.org/10.1111/j.1365-2443.2006.00954.x
    95 https://doi.org/10.1126/science.1087795
    96 https://doi.org/10.1126/science.1105718
    97 https://doi.org/10.1126/science.289.5476.113
    98 https://doi.org/10.1126/science.96525
    99 https://doi.org/10.1128/jvi.02545-06
    100 https://doi.org/10.1128/mcb.01621-07
    101 https://doi.org/10.1158/0008-5472.can-07-5169
    102 https://doi.org/10.1158/0008-5472.can-07-6567
    103 https://doi.org/10.1158/0008-5472.can-09-3458
    104 https://doi.org/10.1158/1078-0432.ccr-08-2078
    105 https://doi.org/10.1159/000319692
    106 https://doi.org/10.1242/dev.00648
    107 https://doi.org/10.1242/jcs.016634
    108 https://doi.org/10.1242/jcs.02938
    109 https://doi.org/10.1242/jcs.043174
    110 https://doi.org/10.1371/journal.pone.0004264
    111 https://doi.org/10.2353/ajpath.2010.090220
    112 https://doi.org/10.3727/096504010x12767359114045
    113 https://doi.org/10.5009/gnl.2010.4.2.292
    114 schema:datePublished 2011-09
    115 schema:datePublishedReg 2011-09-01
    116 schema:description The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation and excessive cell growth are hallmarks of cancer. In this review, we focus on identifying the stages of tumoural development that are affected by the loss or deregulation of epithelial cell polarity. Asymmetric division has recently emerged as a major regulatory mechanism that controls stem cell numbers and differentiation. Links between cell polarity and asymmetric cell division in the context of cancer will be examined. Apical-basal polarity and cell-cell adhesion are tightly interconnected. Hence, how loss of cell polarity in epithelial cells may promote epithelial mesenchymal transition and metastasis will also be discussed. Altogether, we present the argument that loss of epithelial cell polarity may have an important role in both the initiation of tumourigenesis and in later stages of tumour development, favouring the progression of tumours from benign to malignancy.
    117 schema:genre research_article
    118 schema:inLanguage en
    119 schema:isAccessibleForFree true
    120 schema:isPartOf N030c1b1a7010449395a52066a32ae4f4
    121 N27796d22f5d54264a0be06fedfa0c39e
    122 sg:journal.1112551
    123 schema:name Epithelial cell polarity: a major gatekeeper against cancer?
    124 schema:pagination 1470
    125 schema:productId N1709a4d5932c402cbabea44e3384f052
    126 N2672c90bb2fa4a41920341eafad64dc0
    127 N273106c4cbf74c47a58134f1a49e157a
    128 N72fb69fe72164aaeb4a848eef2d7edc9
    129 Ne0c66f88fd934b08b76f12bc48418695
    130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006592214
    131 https://doi.org/10.1038/cdd.2011.60
    132 schema:sdDatePublished 2019-04-10T21:25
    133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    134 schema:sdPublisher N085af76ba0534bfda400b3ceabd9d464
    135 schema:url https://www.nature.com/articles/cdd201160
    136 sgo:license sg:explorer/license/
    137 sgo:sdDataset articles
    138 rdf:type schema:ScholarlyArticle
    139 N005c252d52f64e9fae6ff62461affb69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Phosphorylation
    141 rdf:type schema:DefinedTerm
    142 N030c1b1a7010449395a52066a32ae4f4 schema:volumeNumber 18
    143 rdf:type schema:PublicationVolume
    144 N070fafcb79b647548505668ba67cf2a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Protein-Serine-Threonine Kinases
    146 rdf:type schema:DefinedTerm
    147 N085af76ba0534bfda400b3ceabd9d464 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 N1709a4d5932c402cbabea44e3384f052 schema:name doi
    150 schema:value 10.1038/cdd.2011.60
    151 rdf:type schema:PropertyValue
    152 N214c671736b0420ebc3777b4e03ae5c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Epithelial-Mesenchymal Transition
    154 rdf:type schema:DefinedTerm
    155 N2672c90bb2fa4a41920341eafad64dc0 schema:name pubmed_id
    156 schema:value 21617693
    157 rdf:type schema:PropertyValue
    158 N273106c4cbf74c47a58134f1a49e157a schema:name readcube_id
    159 schema:value 1f661d481845b96a09d913f68ace12f5fc69103e8cb55005a8012d6df0eb98c4
    160 rdf:type schema:PropertyValue
    161 N27796d22f5d54264a0be06fedfa0c39e schema:issueNumber 9
    162 rdf:type schema:PublicationIssue
    163 N309bfbf09dfc413e85c05651535ccb94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Epithelial Cells
    165 rdf:type schema:DefinedTerm
    166 N31d957aec5da405f82f8cd929b062918 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Cell Differentiation
    168 rdf:type schema:DefinedTerm
    169 N49a126a7d56e446cad3ea4f47f55f03a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 N509628aa19bf424088f9691d5cffa078 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Animals
    174 rdf:type schema:DefinedTerm
    175 N6b40aed387174c88805bc145cbca9fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Cell Transformation, Neoplastic
    177 rdf:type schema:DefinedTerm
    178 N72fb69fe72164aaeb4a848eef2d7edc9 schema:name dimensions_id
    179 schema:value pub.1006592214
    180 rdf:type schema:PropertyValue
    181 N86e91e5472e648fc9e5552335f30815d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Cell Proliferation
    183 rdf:type schema:DefinedTerm
    184 N86f3fbe28f8b45179f227cd3bff5be6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Cell Polarity
    186 rdf:type schema:DefinedTerm
    187 N94b36596c24643b184b5815333824e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Neoplasm Metastasis
    189 rdf:type schema:DefinedTerm
    190 Ncc33521fb97b4fad964b3cc6d4291042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Neoplasms
    192 rdf:type schema:DefinedTerm
    193 Ne033ceec3cbb419aa8affbcbedebf2d7 rdf:first sg:person.01157436352.45
    194 rdf:rest Ne66b3f7b99564e2c85b9e28c7bc25a00
    195 Ne0c66f88fd934b08b76f12bc48418695 schema:name nlm_unique_id
    196 schema:value 9437445
    197 rdf:type schema:PropertyValue
    198 Ne39fda91a22f43b0a3fc9891a6ac8eae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Cell Movement
    200 rdf:type schema:DefinedTerm
    201 Ne66b3f7b99564e2c85b9e28c7bc25a00 rdf:first sg:person.01045022612.52
    202 rdf:rest rdf:nil
    203 Nfcd44fbef6c94bb29202f57ee2b43fca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Cell Dedifferentiation
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Biological Sciences
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Biochemistry and Cell Biology
    211 rdf:type schema:DefinedTerm
    212 sg:journal.1112551 schema:issn 1350-9047
    213 1476-5403
    214 schema:name Cell Death & Differentiation
    215 rdf:type schema:Periodical
    216 sg:person.01045022612.52 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    217 schema:familyName Lu
    218 schema:givenName X
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045022612.52
    220 rdf:type schema:Person
    221 sg:person.01157436352.45 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    222 schema:familyName Royer
    223 schema:givenName C
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157436352.45
    225 rdf:type schema:Person
    226 sg:pub.10.1007/s11262-008-0259-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042883709
    227 https://doi.org/10.1007/s11262-008-0259-4
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/34432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008557848
    230 https://doi.org/10.1038/34432
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/35019573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021424283
    233 https://doi.org/10.1038/35019573
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nature03922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032152372
    236 https://doi.org/10.1038/nature03922
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/ncb1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049046166
    239 https://doi.org/10.1038/ncb1226
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ncb1485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043000345
    242 https://doi.org/10.1038/ncb1485
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ncb922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035028490
    245 https://doi.org/10.1038/ncb922
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ncb948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007534413
    248 https://doi.org/10.1038/ncb948
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/ng0198-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020155012
    251 https://doi.org/10.1038/ng0198-38
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nrm3010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009303006
    254 https://doi.org/10.1038/nrm3010
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/onc.2008.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048842159
    257 https://doi.org/10.1038/onc.2008.219
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/onc.2008.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051979527
    260 https://doi.org/10.1038/onc.2008.341
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/onc.2008.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040994073
    263 https://doi.org/10.1038/onc.2008.349
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/onc.2008.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024475127
    266 https://doi.org/10.1038/onc.2008.352
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/onc.2009.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022667041
    269 https://doi.org/10.1038/onc.2009.148
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/onc.2010.265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012404111
    272 https://doi.org/10.1038/onc.2010.265
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/sj.bjc.6601465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000441301
    275 https://doi.org/10.1038/sj.bjc.6601465
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/sj.cdd.4401562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027958007
    278 https://doi.org/10.1038/sj.cdd.4401562
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/sj.onc.1203008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002042316
    281 https://doi.org/10.1038/sj.onc.1203008
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/sj.onc.1203309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034620804
    284 https://doi.org/10.1038/sj.onc.1203309
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/sj.onc.1207154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032828482
    287 https://doi.org/10.1038/sj.onc.1207154
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/sj.onc.1208023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036029035
    290 https://doi.org/10.1038/sj.onc.1208023
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.onc.1208520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038877911
    293 https://doi.org/10.1038/sj.onc.1208520
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/sj.onc.1208757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595058
    296 https://doi.org/10.1038/sj.onc.1208757
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/sj.onc.1209008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025354868
    299 https://doi.org/10.1038/sj.onc.1209008
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/sj.onc.1209508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048693720
    302 https://doi.org/10.1038/sj.onc.1209508
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1186/1741-7007-8-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049887351
    305 https://doi.org/10.1186/1741-7007-8-33
    306 rdf:type schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1075064398 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1077826102 schema:CreativeWork
    309 https://doi.org/10.1002/ijc.21982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020433824
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1002/jcb.20992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050875116
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2006.11.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010543743
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.cell.2008.09.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046601166
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cell.2009.06.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025555859
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.cell.2009.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028492833
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.cell.2010.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016114447
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.cub.2008.09.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021671043
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.cub.2009.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036389554
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.cub.2010.01.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008308529
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.cub.2010.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038807508
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.devcel.2004.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012192572
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.devcel.2007.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039595242
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.devcel.2007.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046890921
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.devcel.2010.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015628916
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.devcel.2010.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013330167
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.febslet.2005.01.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006839887
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.febslet.2010.12.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049045692
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.gde.2009.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046830025
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.molcel.2007.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681714
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.neuron.2009.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022217052
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.virol.2003.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024792018
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.virol.2009.02.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013524779
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.ygyno.2004.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006163672
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/s0248-4900(02)00004-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028439873
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0925-4773(97)00658-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033207672
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s0960-9822(02)00758-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782035
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s1097-2765(01)00367-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024202933
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1046/j.1365-2443.2002.00590.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037191984
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.0809080106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012470966
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1073/pnas.0906796106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046313872
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1073/pnas.94.13.6670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007864297
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1074/jbc.m107880200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004688106
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1074/jbc.m110.141341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011488658
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1074/jbc.m306324200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002658341
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1074/jbc.m702279200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047638121
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1074/jbc.m802482200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038550636
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1083/jcb.143.1.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002166954
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1083/jcb.200311031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039185439
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1083/jcb.200408064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033094066
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1083/jcb.200505127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027549307
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1083/jcb.200605092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052995277
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1083/jcb.200708159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011347949
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1091/mbc.e04-09-0827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008552826
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1093/emboj/cdg548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022819958
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1101/gad.1178004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026179013
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1101/gad.374006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007572953
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/j.1365-2443.2006.00954.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050014632
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1126/science.1087795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448406
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1126/science.1105718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033030663
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1126/science.289.5476.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001605468
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1126/science.96525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062663347
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1128/jvi.02545-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040508177
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1128/mcb.01621-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042090625
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1158/0008-5472.can-07-5169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045173407
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1158/0008-5472.can-07-6567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018778194
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1158/0008-5472.can-09-3458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033444506
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1158/1078-0432.ccr-08-2078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008338020
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1159/000319692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022433441
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1242/dev.00648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010155248
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1242/jcs.016634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015127537
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1242/jcs.02938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038078477
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1242/jcs.043174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052033187
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1371/journal.pone.0004264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044355838
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.2353/ajpath.2010.090220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030940474
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.3727/096504010x12767359114045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009880443
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.5009/gnl.2010.4.2.292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072550899
    442 rdf:type schema:CreativeWork
    443 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    444 schema:name Ludwig Institute for Cancer Research, Old Road Campus Research Building, University of Oxford, Headington, Oxford OX3 7DQ, UK
    445 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...