Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07

AUTHORS

R Rizzi, E Di Pasquale, P Portararo, R Papait, P Cattaneo, M V G Latronico, C Altomare, L Sala, A Zaza, E Hirsch, L Naldini, G Condorelli, C Bearzi

ABSTRACT

Adult mammalian cells can be reprogrammed to a pluripotent state by forcing the expression of a few embryonic transcription factors. The resulting induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers. It is well known that post-natal cardiomyocytes (CMs) lack the capacity to proliferate. Here, we report that neonatal CMs can be reprogrammed to generate iPS cells that express embryonic-specific markers and feature gene-expression profiles similar to those of mouse embryonic stem (mES) cell and cardiac fibroblast (CF)-derived iPS cell populations. CM-derived iPS cells are able to generate chimeric mice and, moreover, re-differentiate toward CMs more efficiently then either CF-derived iPS cells or mES cells. The increased differentiation capacity is possibly related to CM-derived iPS cells retaining an epigenetic memory of the phenotype of their founder cell. CM-derived iPS cells may thus lead to new information on differentiation processes underlying cardiac differentiation and proliferation. More... »

PAGES

1162

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2011.205

DOI

http://dx.doi.org/10.1038/cdd.2011.205

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008180118

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22261617


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