Ontology type: schema:ScholarlyArticle Open Access: True
2012-07
AUTHORSR Rizzi, E Di Pasquale, P Portararo, R Papait, P Cattaneo, M V G Latronico, C Altomare, L Sala, A Zaza, E Hirsch, L Naldini, G Condorelli, C Bearzi
ABSTRACTAdult mammalian cells can be reprogrammed to a pluripotent state by forcing the expression of a few embryonic transcription factors. The resulting induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers. It is well known that post-natal cardiomyocytes (CMs) lack the capacity to proliferate. Here, we report that neonatal CMs can be reprogrammed to generate iPS cells that express embryonic-specific markers and feature gene-expression profiles similar to those of mouse embryonic stem (mES) cell and cardiac fibroblast (CF)-derived iPS cell populations. CM-derived iPS cells are able to generate chimeric mice and, moreover, re-differentiate toward CMs more efficiently then either CF-derived iPS cells or mES cells. The increased differentiation capacity is possibly related to CM-derived iPS cells retaining an epigenetic memory of the phenotype of their founder cell. CM-derived iPS cells may thus lead to new information on differentiation processes underlying cardiac differentiation and proliferation. More... »
PAGES1162
http://scigraph.springernature.com/pub.10.1038/cdd.2011.205
DOIhttp://dx.doi.org/10.1038/cdd.2011.205
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22261617
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{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/cdd.2011.205"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1008180118"
]
}
],
"sameAs": [
"https://doi.org/10.1038/cdd.2011.205",
"https://app.dimensions.ai/details/publication/pub.1008180118"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T21:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000434.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/cdd2011205"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.205'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.205'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.205'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.205'
This table displays all metadata directly associated to this object as RDF triples.
357 TRIPLES
21 PREDICATES
83 URIs
36 LITERALS
24 BLANK NODES