Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05

AUTHORS

P Moudry, C Lukas, L Macurek, B Neumann, J-K Heriche, R Pepperkok, J Ellenberg, Z Hodny, J Lukas, J Bartek

ABSTRACT

53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two human cell lines, we performed an siRNA-based functional high-content microscopy screen for modulators of cellular response to ionizing radiation (IR). Here, we provide the complete results of this screen as an information resource, and validate and functionally characterize one of the identified 'hits': a nuclear pore component NUP153 as a novel factor specifically required for 53BP1 nuclear import. Using a range of cell and molecular biology approaches including live-cell imaging, we show that knockdown of NUP153 prevents 53BP1, but not several other DDR factors, from entering the nuclei in the newly forming daughter cells. This translates into decreased IR-induced 53BP1 focus formation, delayed DNA repair and impaired cell survival after IR. In addition, NUP153 depletion exacerbates DNA damage caused by replication stress. Finally, we show that the C-terminal part of NUP153 is required for effective 53BP1 nuclear import, and that 53BP1 is imported to the nucleus through the NUP153-importin-β interplay. Our data define the structure-function relationships within this emerging 53BP1-NUP153/importin-β pathway and implicate this mechanism in the maintenance of genome integrity. More... »

PAGES

cdd2011150

References to SciGraph publications

  • 2010-03-18. Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome in NATURE
  • 2009-10. The DNA-damage response in human biology and disease in NATURE
  • 2007-03. Molecular mechanism of the nuclear protein import cycle in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-02. Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding in CELL DEATH & DIFFERENTIATION
  • 2002-12. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer in NATURE CELL BIOLOGY
  • 2005-04. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis in NATURE
  • 2005-04. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions in NATURE
  • 2011-10. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance in NATURE CELL BIOLOGY
  • 2010-05. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope in CELL DEATH & DIFFERENTIATION
  • 2010-06. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-09. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia in CELL DEATH & DIFFERENTIATION
  • 1998-09. Amino-terminal sequences that direct nucleoporin Nup153 to the inner surface of the nuclear envelope in CHROMOSOMA
  • 2011-01. Nuclear initiated NF-κB signaling: NEMO and ATM take center stage in CELL RESEARCH
  • 2010-04. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes in NATURE
  • 2004-11. Mapping the dynamic organization of the nuclear pore complex inside single living cells in NATURE CELL BIOLOGY
  • 2010-11. ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response in CELL DEATH & DIFFERENTIATION
  • 2011-03. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cdd.2011.150

    DOI

    http://dx.doi.org/10.1038/cdd.2011.150

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042792530

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22075984


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Nucleus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HeLa Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoblotting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Pore Complex Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Interference", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor p53-Binding Protein 1", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Danish Cancer Society", 
              "id": "https://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic", 
                "Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moudry", 
            "givenName": "P", 
            "id": "sg:person.01337357637.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337357637.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Danish Cancer Society", 
              "id": "https://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lukas", 
            "givenName": "C", 
            "id": "sg:person.0761001313.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761001313.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Macurek", 
            "givenName": "L", 
            "id": "sg:person.01275321607.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321607.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Heidelberg D-69117, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neumann", 
            "givenName": "B", 
            "id": "sg:person.0642307743.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642307743.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Heidelberg D-69117, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heriche", 
            "givenName": "J-K", 
            "id": "sg:person.0661172570.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661172570.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Heidelberg D-69117, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pepperkok", 
            "givenName": "R", 
            "id": "sg:person.0725606734.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725606734.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Heidelberg D-69117, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellenberg", 
            "givenName": "J", 
            "id": "sg:person.01352763231.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352763231.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hodny", 
            "givenName": "Z", 
            "id": "sg:person.0620030707.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620030707.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Danish Cancer Society", 
              "id": "https://www.grid.ac/institutes/grid.417390.8", 
              "name": [
                "Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lukas", 
            "givenName": "J", 
            "id": "sg:person.01235271253.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235271253.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palack\u00fd University, Olomouc", 
              "id": "https://www.grid.ac/institutes/grid.10979.36", 
              "name": [
                "Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic", 
                "Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark", 
                "Institute of Molecular and Translational Medicine, Palacky University, Olomouc CZ-775 15, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartek", 
            "givenName": "J", 
            "id": "sg:person.01167156053.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167156053.40"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/cdd.2010.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000263418", 
              "https://doi.org/10.1038/cdd.2010.56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.151.7.1381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002675122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1140735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004337817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1002603107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004840944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005294665", 
              "https://doi.org/10.1038/nature03485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005294665", 
              "https://doi.org/10.1038/nature03485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/16.21.6535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007040738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007117586", 
              "https://doi.org/10.1038/nature08817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007117586", 
              "https://doi.org/10.1038/nature08817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009692479", 
              "https://doi.org/10.1038/cdd.2009.173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010613520", 
              "https://doi.org/10.1038/cdd.2009.159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011519114", 
              "https://doi.org/10.1038/cr.2010.179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.12.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012869778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201011083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015517042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/dna.2009.0853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015738314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1162790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020090464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020501282", 
              "https://doi.org/10.1038/ncb1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020501282", 
              "https://doi.org/10.1038/ncb1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023086019", 
              "https://doi.org/10.1038/nature08869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023086019", 
              "https://doi.org/10.1038/nature08869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.20.5703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024286965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.152.2.411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024489925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2010.07733.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028003173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029003147", 
              "https://doi.org/10.1038/ncb892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029003147", 
              "https://doi.org/10.1038/ncb892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.134.5.1141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030188831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2011.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031532845", 
              "https://doi.org/10.1038/cdd.2011.18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0802647105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031653184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911270", 
              "https://doi.org/10.1038/nsmb.1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911270", 
              "https://doi.org/10.1038/nsmb.1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033339816", 
              "https://doi.org/10.1038/nrm2114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.024646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034758735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035040826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036989166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041212899", 
              "https://doi.org/10.1038/ncb2201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041866743", 
              "https://doi.org/10.1038/ncb2344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(98)00018-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041936585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200101089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042549134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042627882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e05-08-0715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044563017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004120050301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047668569", 
              "https://doi.org/10.1007/s004120050301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90047-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048828337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e08-08-0883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049817513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2008.02.067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050025121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.12.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050165507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.15.8.1370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064326976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/mend.15.8.0673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064332210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/aging.100127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068670456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.9.19.13138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.9.2.10475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301128"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-05", 
        "datePublishedReg": "2012-05-01", 
        "description": "53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two human cell lines, we performed an siRNA-based functional high-content microscopy screen for modulators of cellular response to ionizing radiation (IR). Here, we provide the complete results of this screen as an information resource, and validate and functionally characterize one of the identified 'hits': a nuclear pore component NUP153 as a novel factor specifically required for 53BP1 nuclear import. Using a range of cell and molecular biology approaches including live-cell imaging, we show that knockdown of NUP153 prevents 53BP1, but not several other DDR factors, from entering the nuclei in the newly forming daughter cells. This translates into decreased IR-induced 53BP1 focus formation, delayed DNA repair and impaired cell survival after IR. In addition, NUP153 depletion exacerbates DNA damage caused by replication stress. Finally, we show that the C-terminal part of NUP153 is required for effective 53BP1 nuclear import, and that 53BP1 is imported to the nucleus through the NUP153-importin-\u03b2 interplay. Our data define the structure-function relationships within this emerging 53BP1-NUP153/importin-\u03b2 pathway and implicate this mechanism in the maintenance of genome integrity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cdd.2011.150", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6888740", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6887330", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3772156", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6891509", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1112551", 
            "issn": [
              "1350-9047", 
              "1476-5403"
            ], 
            "name": "Cell Death & Differentiation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1", 
        "pagination": "cdd2011150", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cbd6bb6f940f16efcb10d1f058423942b1e95bf3def8356cc371453df9ceecba"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22075984"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9437445"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cdd.2011.150"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042792530"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cdd.2011.150", 
          "https://app.dimensions.ai/details/publication/pub.1042792530"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/cdd2011150"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.150'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.150'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.150'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2011.150'


     

    This table displays all metadata directly associated to this object as RDF triples.

    358 TRIPLES      21 PREDICATES      88 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cdd.2011.150 schema:about N00ffa4bb0ed347e8b5541e9b960b9a91
    2 N013e02da582f46c99cd5e261d8b98999
    3 N1868068c29484a4192ac7a756b91c226
    4 N298429c582914b528d3085ffdd63674c
    5 N3c62d789405244bdaf01038fc4262500
    6 N419320a94723497d927f1e4681d3c76d
    7 N524eeca72791457b9cb0d43e58b3be8d
    8 N707fc4cb698d46309a1d9985cdf70163
    9 N9faee6fd3b2c433186fc89fc91731ed1
    10 Nb8e8abef55fa4fcca26ec03dc967e6b9
    11 Nc5cde1fb99e64ab8a937b712a3f60525
    12 Nfd3e52611fb54ccb94c5ec72a51e8089
    13 anzsrc-for:06
    14 anzsrc-for:0601
    15 schema:author N09f9f5113a3b4c14befda37e4d406823
    16 schema:citation sg:pub.10.1007/s004120050301
    17 sg:pub.10.1038/cdd.2009.159
    18 sg:pub.10.1038/cdd.2009.173
    19 sg:pub.10.1038/cdd.2010.56
    20 sg:pub.10.1038/cdd.2011.18
    21 sg:pub.10.1038/cr.2010.179
    22 sg:pub.10.1038/nature03482
    23 sg:pub.10.1038/nature03485
    24 sg:pub.10.1038/nature08467
    25 sg:pub.10.1038/nature08817
    26 sg:pub.10.1038/nature08869
    27 sg:pub.10.1038/ncb1184
    28 sg:pub.10.1038/ncb2201
    29 sg:pub.10.1038/ncb2344
    30 sg:pub.10.1038/ncb892
    31 sg:pub.10.1038/nrm2114
    32 sg:pub.10.1038/nsmb.1831
    33 https://doi.org/10.1016/0092-8674(93)90047-t
    34 https://doi.org/10.1016/j.cell.2008.12.041
    35 https://doi.org/10.1016/j.cell.2008.12.042
    36 https://doi.org/10.1016/j.cell.2010.03.012
    37 https://doi.org/10.1016/j.cell.2011.06.033
    38 https://doi.org/10.1016/j.febslet.2008.02.067
    39 https://doi.org/10.1016/j.molcel.2008.08.018
    40 https://doi.org/10.1016/j.molcel.2010.09.019
    41 https://doi.org/10.1016/s0960-9822(98)00018-9
    42 https://doi.org/10.1073/pnas.0802647105
    43 https://doi.org/10.1073/pnas.1002603107
    44 https://doi.org/10.1074/jbc.m109.024646
    45 https://doi.org/10.1083/jcb.134.5.1141
    46 https://doi.org/10.1083/jcb.151.7.1381
    47 https://doi.org/10.1083/jcb.152.2.411
    48 https://doi.org/10.1083/jcb.200101089
    49 https://doi.org/10.1083/jcb.201011083
    50 https://doi.org/10.1089/dna.2009.0853
    51 https://doi.org/10.1091/mbc.e05-08-0715
    52 https://doi.org/10.1091/mbc.e08-08-0883
    53 https://doi.org/10.1093/emboj/16.21.6535
    54 https://doi.org/10.1093/emboj/20.20.5703
    55 https://doi.org/10.1111/j.1742-4658.2010.07733.x
    56 https://doi.org/10.1126/science.1140735
    57 https://doi.org/10.1126/science.1162790
    58 https://doi.org/10.1210/me.15.8.1370
    59 https://doi.org/10.1210/mend.15.8.0673
    60 https://doi.org/10.18632/aging.100127
    61 https://doi.org/10.4161/cc.9.19.13138
    62 https://doi.org/10.4161/cc.9.2.10475
    63 schema:datePublished 2012-05
    64 schema:datePublishedReg 2012-05-01
    65 schema:description 53BP1 is a mediator of DNA damage response (DDR) and a tumor suppressor whose accumulation on damaged chromatin promotes DNA repair and enhances DDR signaling. Using foci formation of 53BP1 as a readout in two human cell lines, we performed an siRNA-based functional high-content microscopy screen for modulators of cellular response to ionizing radiation (IR). Here, we provide the complete results of this screen as an information resource, and validate and functionally characterize one of the identified 'hits': a nuclear pore component NUP153 as a novel factor specifically required for 53BP1 nuclear import. Using a range of cell and molecular biology approaches including live-cell imaging, we show that knockdown of NUP153 prevents 53BP1, but not several other DDR factors, from entering the nuclei in the newly forming daughter cells. This translates into decreased IR-induced 53BP1 focus formation, delayed DNA repair and impaired cell survival after IR. In addition, NUP153 depletion exacerbates DNA damage caused by replication stress. Finally, we show that the C-terminal part of NUP153 is required for effective 53BP1 nuclear import, and that 53BP1 is imported to the nucleus through the NUP153-importin-β interplay. Our data define the structure-function relationships within this emerging 53BP1-NUP153/importin-β pathway and implicate this mechanism in the maintenance of genome integrity.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree true
    69 schema:isPartOf N105751e03ab14d7588eb9f842b01b04b
    70 Nd8cae1bbfaa74698a3129f8340a6306b
    71 sg:journal.1112551
    72 schema:name Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1
    73 schema:pagination cdd2011150
    74 schema:productId N3517084b6b4a4b96913411e5329ee12b
    75 N3e5f33cda696429388eab2dafed7fcd1
    76 N8903cc7e9de146efb6150d6ec4def715
    77 Ne3e22816f7384ea2b8c3106ce66a688e
    78 Nef5038da61394f1997a85e07114157ef
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042792530
    80 https://doi.org/10.1038/cdd.2011.150
    81 schema:sdDatePublished 2019-04-10T14:48
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher N3550c4f6a027423790459ab2f2d7c2c9
    84 schema:url http://www.nature.com/articles/cdd2011150
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N00ffa4bb0ed347e8b5541e9b960b9a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Immunoprecipitation
    90 rdf:type schema:DefinedTerm
    91 N013e02da582f46c99cd5e261d8b98999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Immunoblotting
    93 rdf:type schema:DefinedTerm
    94 N09f9f5113a3b4c14befda37e4d406823 rdf:first sg:person.01337357637.79
    95 rdf:rest N18c2b1dec4794dada22904f0d7963455
    96 N105751e03ab14d7588eb9f842b01b04b schema:issueNumber 5
    97 rdf:type schema:PublicationIssue
    98 N146500ee25af4b7c85f3bd5e02d2d194 rdf:first sg:person.01235271253.45
    99 rdf:rest N7e8e1d8b16da4d25902d3a36c3b4610c
    100 N1868068c29484a4192ac7a756b91c226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Humans
    102 rdf:type schema:DefinedTerm
    103 N18c2b1dec4794dada22904f0d7963455 rdf:first sg:person.0761001313.22
    104 rdf:rest N80b5e214207a4841ba5206036e5fd672
    105 N298429c582914b528d3085ffdd63674c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name RNA Interference
    107 rdf:type schema:DefinedTerm
    108 N3517084b6b4a4b96913411e5329ee12b schema:name doi
    109 schema:value 10.1038/cdd.2011.150
    110 rdf:type schema:PropertyValue
    111 N3550c4f6a027423790459ab2f2d7c2c9 schema:name Springer Nature - SN SciGraph project
    112 rdf:type schema:Organization
    113 N3c62d789405244bdaf01038fc4262500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Intracellular Signaling Peptides and Proteins
    115 rdf:type schema:DefinedTerm
    116 N3ddc223642b24735b7b43e7194df334f rdf:first sg:person.01352763231.78
    117 rdf:rest N9bf5fe4f5c4541c8a003f0bad3a7947b
    118 N3e5f33cda696429388eab2dafed7fcd1 schema:name nlm_unique_id
    119 schema:value 9437445
    120 rdf:type schema:PropertyValue
    121 N419320a94723497d927f1e4681d3c76d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Tumor Suppressor p53-Binding Protein 1
    123 rdf:type schema:DefinedTerm
    124 N524eeca72791457b9cb0d43e58b3be8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Cell Line, Tumor
    126 rdf:type schema:DefinedTerm
    127 N707fc4cb698d46309a1d9985cdf70163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Protein Binding
    129 rdf:type schema:DefinedTerm
    130 N732c34cff53743aa88598625b4baabd0 rdf:first sg:person.0725606734.53
    131 rdf:rest N3ddc223642b24735b7b43e7194df334f
    132 N7e8e1d8b16da4d25902d3a36c3b4610c rdf:first sg:person.01167156053.40
    133 rdf:rest rdf:nil
    134 N80b5e214207a4841ba5206036e5fd672 rdf:first sg:person.01275321607.07
    135 rdf:rest N95bad4a7dc1c4aebaba360c9e747cfaf
    136 N8903cc7e9de146efb6150d6ec4def715 schema:name readcube_id
    137 schema:value cbd6bb6f940f16efcb10d1f058423942b1e95bf3def8356cc371453df9ceecba
    138 rdf:type schema:PropertyValue
    139 N95bad4a7dc1c4aebaba360c9e747cfaf rdf:first sg:person.0642307743.41
    140 rdf:rest Ne482dbe8b52244c2a042a7c965d4e432
    141 N9bf5fe4f5c4541c8a003f0bad3a7947b rdf:first sg:person.0620030707.91
    142 rdf:rest N146500ee25af4b7c85f3bd5e02d2d194
    143 N9faee6fd3b2c433186fc89fc91731ed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Nuclear Pore Complex Proteins
    145 rdf:type schema:DefinedTerm
    146 Nb8e8abef55fa4fcca26ec03dc967e6b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name HeLa Cells
    148 rdf:type schema:DefinedTerm
    149 Nc5cde1fb99e64ab8a937b712a3f60525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Genome, Human
    151 rdf:type schema:DefinedTerm
    152 Nd8cae1bbfaa74698a3129f8340a6306b schema:volumeNumber 19
    153 rdf:type schema:PublicationVolume
    154 Ne3e22816f7384ea2b8c3106ce66a688e schema:name dimensions_id
    155 schema:value pub.1042792530
    156 rdf:type schema:PropertyValue
    157 Ne482dbe8b52244c2a042a7c965d4e432 rdf:first sg:person.0661172570.64
    158 rdf:rest N732c34cff53743aa88598625b4baabd0
    159 Nef5038da61394f1997a85e07114157ef schema:name pubmed_id
    160 schema:value 22075984
    161 rdf:type schema:PropertyValue
    162 Nfd3e52611fb54ccb94c5ec72a51e8089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Cell Nucleus
    164 rdf:type schema:DefinedTerm
    165 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    166 schema:name Biological Sciences
    167 rdf:type schema:DefinedTerm
    168 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Biochemistry and Cell Biology
    170 rdf:type schema:DefinedTerm
    171 sg:grant.3772156 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2011.150
    172 rdf:type schema:MonetaryGrant
    173 sg:grant.6887330 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2011.150
    174 rdf:type schema:MonetaryGrant
    175 sg:grant.6888740 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2011.150
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.6891509 http://pending.schema.org/fundedItem sg:pub.10.1038/cdd.2011.150
    178 rdf:type schema:MonetaryGrant
    179 sg:journal.1112551 schema:issn 1350-9047
    180 1476-5403
    181 schema:name Cell Death & Differentiation
    182 rdf:type schema:Periodical
    183 sg:person.01167156053.40 schema:affiliation https://www.grid.ac/institutes/grid.10979.36
    184 schema:familyName Bartek
    185 schema:givenName J
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167156053.40
    187 rdf:type schema:Person
    188 sg:person.01235271253.45 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
    189 schema:familyName Lukas
    190 schema:givenName J
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235271253.45
    192 rdf:type schema:Person
    193 sg:person.01275321607.07 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    194 schema:familyName Macurek
    195 schema:givenName L
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321607.07
    197 rdf:type schema:Person
    198 sg:person.01337357637.79 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
    199 schema:familyName Moudry
    200 schema:givenName P
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337357637.79
    202 rdf:type schema:Person
    203 sg:person.01352763231.78 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    204 schema:familyName Ellenberg
    205 schema:givenName J
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352763231.78
    207 rdf:type schema:Person
    208 sg:person.0620030707.91 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    209 schema:familyName Hodny
    210 schema:givenName Z
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620030707.91
    212 rdf:type schema:Person
    213 sg:person.0642307743.41 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    214 schema:familyName Neumann
    215 schema:givenName B
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642307743.41
    217 rdf:type schema:Person
    218 sg:person.0661172570.64 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    219 schema:familyName Heriche
    220 schema:givenName J-K
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661172570.64
    222 rdf:type schema:Person
    223 sg:person.0725606734.53 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    224 schema:familyName Pepperkok
    225 schema:givenName R
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725606734.53
    227 rdf:type schema:Person
    228 sg:person.0761001313.22 schema:affiliation https://www.grid.ac/institutes/grid.417390.8
    229 schema:familyName Lukas
    230 schema:givenName C
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761001313.22
    232 rdf:type schema:Person
    233 sg:pub.10.1007/s004120050301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047668569
    234 https://doi.org/10.1007/s004120050301
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/cdd.2009.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010613520
    237 https://doi.org/10.1038/cdd.2009.159
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/cdd.2009.173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009692479
    240 https://doi.org/10.1038/cdd.2009.173
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/cdd.2010.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000263418
    243 https://doi.org/10.1038/cdd.2010.56
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/cdd.2011.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031532845
    246 https://doi.org/10.1038/cdd.2011.18
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/cr.2010.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011519114
    249 https://doi.org/10.1038/cr.2010.179
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
    252 https://doi.org/10.1038/nature03482
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nature03485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005294665
    255 https://doi.org/10.1038/nature03485
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
    258 https://doi.org/10.1038/nature08467
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nature08817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007117586
    261 https://doi.org/10.1038/nature08817
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nature08869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023086019
    264 https://doi.org/10.1038/nature08869
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ncb1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020501282
    267 https://doi.org/10.1038/ncb1184
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ncb2201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041212899
    270 https://doi.org/10.1038/ncb2201
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/ncb2344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041866743
    273 https://doi.org/10.1038/ncb2344
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/ncb892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029003147
    276 https://doi.org/10.1038/ncb892
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nrm2114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033339816
    279 https://doi.org/10.1038/nrm2114
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nsmb.1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032911270
    282 https://doi.org/10.1038/nsmb.1831
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/0092-8674(93)90047-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1048828337
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.cell.2008.12.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012869778
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.cell.2008.12.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050165507
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.cell.2010.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035040826
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.cell.2011.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042627882
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.febslet.2008.02.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050025121
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.molcel.2008.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036989166
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0960-9822(98)00018-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041936585
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1073/pnas.0802647105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031653184
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1073/pnas.1002603107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004840944
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1074/jbc.m109.024646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034758735
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1083/jcb.134.5.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030188831
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1083/jcb.151.7.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002675122
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1083/jcb.152.2.411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024489925
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1083/jcb.200101089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042549134
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1083/jcb.201011083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015517042
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1089/dna.2009.0853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015738314
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1091/mbc.e05-08-0715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044563017
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1091/mbc.e08-08-0883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049817513
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/emboj/16.21.6535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007040738
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1093/emboj/20.20.5703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024286965
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1111/j.1742-4658.2010.07733.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028003173
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1126/science.1140735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004337817
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1126/science.1162790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020090464
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1210/me.15.8.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064326976
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1210/mend.15.8.0673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332210
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.18632/aging.100127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068670456
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.4161/cc.9.19.13138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301079
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.4161/cc.9.2.10475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301128
    343 rdf:type schema:CreativeWork
    344 https://www.grid.ac/institutes/grid.10979.36 schema:alternateName Palacký University, Olomouc
    345 schema:name Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic
    346 Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark
    347 Institute of Molecular and Translational Medicine, Palacky University, Olomouc CZ-775 15, Czech Republic
    348 rdf:type schema:Organization
    349 https://www.grid.ac/institutes/grid.417390.8 schema:alternateName Danish Cancer Society
    350 schema:name Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic
    351 Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen DK-2100, Denmark
    352 rdf:type schema:Organization
    353 https://www.grid.ac/institutes/grid.418827.0 schema:alternateName Institute of Molecular Genetics
    354 schema:name Department of Genome Integrity, Institute of Molecular Genetics, v.v.i., Academy of Sciences of the Czech Republic, Prague CZ-142 20, Czech Republic
    355 rdf:type schema:Organization
    356 https://www.grid.ac/institutes/grid.4709.a schema:alternateName European Molecular Biology Laboratory
    357 schema:name European Molecular Biology Laboratory (EMBL), Heidelberg D-69117, Germany
    358 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...