Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09-30

AUTHORS

K Eto, S Goto, W Nakashima, Y Ura, S-I Abe

ABSTRACT

The programmed cell death 4 (Pdcd4), a translation inhibitor, plays an essential role in tumor suppression, but its role in apoptosis remains unclear. Here we show that Pdcd4 is a critical suppressor of apoptosis by inhibiting the translation of procaspase-3 mRNA. Pdcd4 protein decreased more rapidly through microRNA-mediated translational repression following apoptotic stimuli than did the activation of procaspase-3, cleavage of poly(ADP)ribose polymerase (PARP) by active caspase-3, and nuclear fragmentation. Strikingly, the loss of Pdcd4 by the specific RNA interference increased procaspase-3 expression, leading to its activation and PARP cleavage even without apoptotic stimuli, and sensitized the cells to apoptosis. Thus, our findings provide insight into a novel mechanism for Pdcd4 as a regulator of apoptosis. More... »

PAGES

573-581

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2011.126

DOI

http://dx.doi.org/10.1038/cdd.2011.126

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044836882

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21959934


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