The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

N Edison, D Zuri, I Maniv, B Bornstein, T Lev, Y Gottfried, S Kemeny, M Garcia-Fernandez, J Kagan, S Larisch

ABSTRACT

ARTS (Sept4_i2) is a pro-apoptotic tumor suppressor protein that functions as an antagonist of X-linked IAP (XIAP) to promote apoptosis. It is generally thought that mitochondrial outer membrane permeabilization (MOMP) occurs before activation of caspases and is required for it. Here, we show that ARTS initiates caspase activation upstream of MOMP. In living cells, ARTS is localized to the mitochondrial outer membrane. In response to apoptotic signals, ARTS translocates rapidly to the cytosol in a caspase-independent manner, where it binds XIAP and promotes caspase activation. This translocation precedes the release of cytochrome C and SMAC/Diablo, and ARTS function is required for the normal timing of MOMP. We also show that ARTS-induced caspase activation leads to cleavage of the pro-apoptotic Bcl-2 family protein Bid, known to promote MOMP. We propose that translocation of ARTS initiates a first wave of caspase activation that can promote MOMP. This leads to the subsequent release of additional mitochondrial factors, including cytochrome C and SMAC/Diablo, which then amplifies the caspase cascade and causes apoptosis. More... »

PAGES

cdd2011112

References to SciGraph publications

  • 2010-09. Mitochondria and cell death: outer membrane permeabilization and beyond in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2011-09. ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists in APOPTOSIS
  • 1997-07. X-linked IAP is a direct inhibitor of cell-death proteases in NATURE
  • 2008-11. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis in NATURE CELL BIOLOGY
  • 2008-04. Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis in APOPTOSIS
  • 2006-09. Mechanisms of cytochrome c release from mitochondria in CELL DEATH & DIFFERENTIATION
  • 2004-07. Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients in ONCOGENE
  • 2002-01. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity in CELL DEATH & DIFFERENTIATION
  • 2000-12. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif in NATURE CELL BIOLOGY
  • 2009-08. XIAP discriminates between type I and type II FAS-induced apoptosis in NATURE
  • 2002-06. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 in NATURE CELL BIOLOGY
  • 2002-06. Apoptosis: IAP proteins: blocking the road to death's door in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-08. Which came first, the cytochrome c release or the mitochondrial fission? in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cdd.2011.112

    DOI

    http://dx.doi.org/10.1038/cdd.2011.112

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052680126

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21869827


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