Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

M B Roig, R Roset, L Ortet, N A Balsiger, A Anfosso, L Cabellos, M Garrido, F Alameda, H J M Brady, G Gil-Gómez

ABSTRACT

We have identified an early step common to pathways activated by different forms of intrinsic apoptosis stimuli. It requires de novo synthesis of a novel cyclin, cyclin O, that forms active complexes primarily with Cdk2 upon apoptosis induction in lymphoid cells. Cyclin O expression precedes glucocorticoid and gamma-radiation-induced apoptosis in vivo in mouse thymus and spleen, and its overexpression induces caspase-dependent apoptosis in cultured cells. Knocking down the endogenous expression of cyclin O by shRNA leads to the inhibition of glucocorticoid and DNA damage-induced apoptosis due to a failure in the activation of apical caspases while leaving CD95 death receptor-mediated apoptosis intact. Our data demonstrate that apoptosis induction in lymphoid cells is one of the physiological roles of cyclin O and it does not act by perturbing a normal cellular process such as the cell cycle, the DNA damage checkpoints or transcriptional response to glucocorticoids. More... »

PAGES

cdd2008145

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cdd.2008.145

DOI

http://dx.doi.org/10.1038/cdd.2008.145

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038955910

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18927588


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cdd.2008.145'


 

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