Mouse models for studying prostate cancer bone metastasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-17

AUTHORS

Jinlu Dai, Janine Hensel, Ning Wang, Marianna Kruithof-de Julio, Yusuke Shiozawa

ABSTRACT

Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis. More... »

PAGES

777

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/bonekey.2016.4

DOI

http://dx.doi.org/10.1038/bonekey.2016.4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030121236

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26916039


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