Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-03

AUTHORS

S Yamasaki, R Suzuki, K Hatano, K Fukushima, H Iida, S Morishima, Y Suehiro, T Fukuda, N Uchida, H Uchiyama, H Ikeda, A Yokota, K Tsukasaki, H Yamaguchi, J Kuroda, H Nakamae, Y Adachi, K-i Matsuoka, Y Nakamura, Y Atsuta, J Suzumiya

ABSTRACT

Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) represent severe late effects in patients receiving hematopoietic cell transplantation (HCT) for lymphoma. The choice between high-dose therapy with autologous HCT and allogeneic HCT with reduced-intensity conditioning remains controversial in patients with relapsed lymphoma. We retrospectively analyzed incidence and risk factors for the development of t-AML/MDS in lymphoma patients treated with autologous or allogeneic HCT. A total of 13 810 lymphoma patients who received autologous (n=9963) or allogeneic (n=3847) HCT between 1985 and 2012 were considered. At a median overall survival (OS) of 52 and 46 months in autologous and allogeneic HCT groups, respectively, lymphoma patients receiving autologous HCT (1.38% at 3 years after autologous HCT) had a significant risk for developing t-AML/MDS compared to allogeneic HCT (0.37% at 3 years after allogeneic HCT, P<0.001). Significant risk factors for the development of t-AML/MDS after autologous and allogeneic HCT were high-stage risk at HCT (P=0.04) or secondary malignancies (P<0.001) and receiving cord blood stem cell (P=0.03) or involved field radiotherapy (P=0.002), respectively. Strategies that carefully select lymphoma patients for autologous HCT, by excluding lymphoma patients with high-stage risk at HCT, may allow the identification of individual lymphoma patients at particular high risk for t-AML/MDS. More... »

PAGES

969-976

Journal

TITLE

Bone Marrow Transplantation

ISSUE

7

VOLUME

52

Author Affiliations

  • Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
  • Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan
  • Division of Hematology and Cell Therapy, Jichi Medical University, Shimotsuke, Japan
  • Division of Hematology, Rinku General Medical Center, Izumisano, Japan
  • Division of Cell Therapy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
  • Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan
  • Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
  • Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
  • Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University Hospital, Sapporo, Japan
  • Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Hematology Division, National Cancer Center Hospital East, Kashiwa, Japan
  • Department of Hematology, Nippon Medical School, Tokyo, Japan
  • Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Department of Hematology, Osaka City University Hospital, Osaka, Japan
  • Department of Internal Medicine, Japan Community Health Care Organization Kobe Central Hospital, Kobe, Japan
  • Division of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
  • Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/bmt.2017.52

    DOI

    http://dx.doi.org/10.1038/bmt.2017.52

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084508959

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28368379


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Allografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myelodysplastic Syndromes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Second Primary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415613.4", 
              "name": [
                "Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamasaki", 
            "givenName": "S", 
            "id": "sg:person.01242043214.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242043214.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412567.3", 
              "name": [
                "Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "R", 
            "id": "sg:person.014632774322.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632774322.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Cell Therapy, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology and Cell Therapy, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatano", 
            "givenName": "K", 
            "id": "sg:person.01364103035.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364103035.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Rinku General Medical Center, Izumisano, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Division of Hematology, Rinku General Medical Center, Izumisano, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukushima", 
            "givenName": "K", 
            "id": "sg:person.0603726437.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603726437.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cell Therapy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410840.9", 
              "name": [
                "Division of Cell Therapy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iida", 
            "givenName": "H", 
            "id": "sg:person.0630501143.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630501143.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256115.4", 
              "name": [
                "Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morishima", 
            "givenName": "S", 
            "id": "sg:person.0611462106.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611462106.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470350.5", 
              "name": [
                "Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suehiro", 
            "givenName": "Y", 
            "id": "sg:person.014472427001.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014472427001.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "T", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchida", 
            "givenName": "N", 
            "id": "sg:person.010150414102.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010150414102.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415604.2", 
              "name": [
                "Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchiyama", 
            "givenName": "H", 
            "id": "sg:person.01274040335.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274040335.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470107.5", 
              "name": [
                "Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikeda", 
            "givenName": "H", 
            "id": "sg:person.010444341213.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010444341213.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459433.c", 
              "name": [
                "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokota", 
            "givenName": "A", 
            "id": "sg:person.01317232725.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232725.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, National Cancer Center Hospital East, Kashiwa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Hematology Division, National Cancer Center Hospital East, Kashiwa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsukasaki", 
            "givenName": "K", 
            "id": "sg:person.01356462526.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Nippon Medical School, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410821.e", 
              "name": [
                "Department of Hematology, Nippon Medical School, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamaguchi", 
            "givenName": "H", 
            "id": "sg:person.012564764352.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012564764352.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272458.e", 
              "name": [
                "Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuroda", 
            "givenName": "J", 
            "id": "sg:person.01204610767.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204610767.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Osaka City University Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470114.7", 
              "name": [
                "Department of Hematology, Osaka City University Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamae", 
            "givenName": "H", 
            "id": "sg:person.01014223462.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Japan Community Health Care Organization Kobe Central Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415605.3", 
              "name": [
                "Department of Internal Medicine, Japan Community Health Care Organization Kobe Central Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adachi", 
            "givenName": "Y", 
            "id": "sg:person.07464206032.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07464206032.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Oncology, Okayama University Hospital, Okayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412342.2", 
              "name": [
                "Division of Hematology and Oncology, Okayama University Hospital, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuoka", 
            "givenName": "K-i", 
            "id": "sg:person.01125116105.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125116105.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan", 
              "id": "http://www.grid.ac/institutes/grid.268397.1", 
              "name": [
                "Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Y", 
            "id": "sg:person.015237642517.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015237642517.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.511247.4", 
              "name": [
                "Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsuta", 
            "givenName": "Y", 
            "id": "sg:person.01146754030.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412567.3", 
              "name": [
                "Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzumiya", 
            "givenName": "J", 
            "id": "sg:person.01271210744.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271210744.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1532/ijh97.06239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054504897", 
              "https://doi.org/10.1532/ijh97.06239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-015-1894-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036307316", 
              "https://doi.org/10.1007/s12185-015-1894-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020152838", 
              "https://doi.org/10.1038/bmt.2015.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005101697", 
              "https://doi.org/10.1038/sj.bmt.1705547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032571317", 
              "https://doi.org/10.1038/bmt.2015.338"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-04-03", 
        "datePublishedReg": "2017-04-03", 
        "description": "Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) represent severe late effects in patients receiving hematopoietic cell transplantation (HCT) for lymphoma. The choice between high-dose therapy with autologous HCT and allogeneic HCT with reduced-intensity conditioning remains controversial in patients with relapsed lymphoma. We retrospectively analyzed incidence and risk factors for the development of t-AML/MDS in lymphoma patients treated with autologous or allogeneic HCT. A total of 13\u2009810 lymphoma patients who received autologous (n=9963) or allogeneic (n=3847) HCT between 1985 and 2012 were considered. At a median overall survival (OS) of 52 and 46 months in autologous and allogeneic HCT groups, respectively, lymphoma patients receiving autologous HCT (1.38% at 3 years after autologous HCT) had a significant risk for developing t-AML/MDS compared to allogeneic HCT (0.37% at 3 years after allogeneic HCT, P<0.001). Significant risk factors for the development of t-AML/MDS after autologous and allogeneic HCT were high-stage risk at HCT (P=0.04) or secondary malignancies (P<0.001) and receiving cord blood stem cell (P=0.03) or involved field radiotherapy (P=0.002), respectively. Strategies that carefully select lymphoma patients for autologous HCT, by excluding lymphoma patients with high-stage risk at HCT, may allow the identification of individual lymphoma patients at particular high risk for t-AML/MDS.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/bmt.2017.52", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096890", 
            "issn": [
              "0268-3369", 
              "1476-5365"
            ], 
            "name": "Bone Marrow Transplantation", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "52"
          }
        ], 
        "keywords": [
          "t-AML/MDS", 
          "autologous hematopoietic cell transplantation", 
          "hematopoietic cell transplantation", 
          "therapy-related acute myeloid leukemia", 
          "allogeneic hematopoietic cell transplantation", 
          "lymphoma patients", 
          "acute myeloid leukemia", 
          "overall survival", 
          "myelodysplastic syndrome", 
          "cell transplantation", 
          "risk factors", 
          "myeloid leukemia", 
          "cord blood stem cells", 
          "high-dose therapy", 
          "median overall survival", 
          "reduced-intensity conditioning", 
          "significant risk factors", 
          "severe late effects", 
          "blood stem cells", 
          "particular high risk", 
          "relapsed lymphoma", 
          "HCT group", 
          "secondary malignancies", 
          "field radiotherapy", 
          "late effects", 
          "high risk", 
          "patients", 
          "lymphoma", 
          "significant risk", 
          "transplantation", 
          "syndrome", 
          "risk", 
          "leukemia", 
          "stem cells", 
          "MDS", 
          "malignancy", 
          "radiotherapy", 
          "therapy", 
          "incidence", 
          "months", 
          "survival", 
          "factors", 
          "total", 
          "cells", 
          "group", 
          "development", 
          "conditioning", 
          "effect", 
          "identification", 
          "strategies", 
          "choice"
        ], 
        "name": "Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma", 
        "pagination": "969-976", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084508959"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/bmt.2017.52"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28368379"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/bmt.2017.52", 
          "https://app.dimensions.ai/details/publication/pub.1084508959"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:36", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_738.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/bmt.2017.52"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.52'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.52'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.52'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/bmt.2017.52'


     

    This table displays all metadata directly associated to this object as RDF triples.

    405 TRIPLES      21 PREDICATES      100 URIs      85 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/bmt.2017.52 schema:about N04c4ef761a494b73b7eaffda5d34ed2e
    2 N0c952b359acc47dc860c4643f4dbf2b4
    3 N2f59dfb5da054c488b3562fd072bf56e
    4 N3832360f5012420faa6a1aa154d03b12
    5 N5107885351fc4343a3e4afa453fdda70
    6 N535d4d08e91c473db488fafb68347c0a
    7 N636e8bbef5c5461e8a4bab2bec322f0f
    8 N704f8ca74a4544078d9b2bb421fee633
    9 N7e4297e5837d444fb927bb6791b9d213
    10 N85f0fbb9845b45b888a81852eb821720
    11 N91eda21579d4423880debcc1d90ecc44
    12 Na7f75c714b3f4659b00b0d6aaacc2387
    13 Nc1bca7b2904744f9be3ced9710bac91c
    14 Nc75ed3b57c4f49b280694173ab593ee8
    15 Nc85adac529b94478af03ef847c00ae15
    16 Nd22de52a762e4d34882cb6ff21b3b85d
    17 Nf622e6a1f5be462fad4582ee232248e5
    18 anzsrc-for:11
    19 anzsrc-for:1102
    20 anzsrc-for:1112
    21 schema:author Nb5a7e4fcf7404cf08e0d74a6c89033b8
    22 schema:citation sg:pub.10.1007/s12185-015-1894-x
    23 sg:pub.10.1038/bmt.2012.244
    24 sg:pub.10.1038/bmt.2015.151
    25 sg:pub.10.1038/bmt.2015.338
    26 sg:pub.10.1038/sj.bmt.1705547
    27 sg:pub.10.1532/ijh97.06239
    28 schema:datePublished 2017-04-03
    29 schema:datePublishedReg 2017-04-03
    30 schema:description Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) represent severe late effects in patients receiving hematopoietic cell transplantation (HCT) for lymphoma. The choice between high-dose therapy with autologous HCT and allogeneic HCT with reduced-intensity conditioning remains controversial in patients with relapsed lymphoma. We retrospectively analyzed incidence and risk factors for the development of t-AML/MDS in lymphoma patients treated with autologous or allogeneic HCT. A total of 13 810 lymphoma patients who received autologous (n=9963) or allogeneic (n=3847) HCT between 1985 and 2012 were considered. At a median overall survival (OS) of 52 and 46 months in autologous and allogeneic HCT groups, respectively, lymphoma patients receiving autologous HCT (1.38% at 3 years after autologous HCT) had a significant risk for developing t-AML/MDS compared to allogeneic HCT (0.37% at 3 years after allogeneic HCT, P<0.001). Significant risk factors for the development of t-AML/MDS after autologous and allogeneic HCT were high-stage risk at HCT (P=0.04) or secondary malignancies (P<0.001) and receiving cord blood stem cell (P=0.03) or involved field radiotherapy (P=0.002), respectively. Strategies that carefully select lymphoma patients for autologous HCT, by excluding lymphoma patients with high-stage risk at HCT, may allow the identification of individual lymphoma patients at particular high risk for t-AML/MDS.
    31 schema:genre article
    32 schema:isAccessibleForFree false
    33 schema:isPartOf N114d0542504f4a64b2ca61b7810cd054
    34 Na58055ba3f934758ac5bbc6eff440480
    35 sg:journal.1096890
    36 schema:keywords HCT group
    37 MDS
    38 acute myeloid leukemia
    39 allogeneic hematopoietic cell transplantation
    40 autologous hematopoietic cell transplantation
    41 blood stem cells
    42 cell transplantation
    43 cells
    44 choice
    45 conditioning
    46 cord blood stem cells
    47 development
    48 effect
    49 factors
    50 field radiotherapy
    51 group
    52 hematopoietic cell transplantation
    53 high risk
    54 high-dose therapy
    55 identification
    56 incidence
    57 late effects
    58 leukemia
    59 lymphoma
    60 lymphoma patients
    61 malignancy
    62 median overall survival
    63 months
    64 myelodysplastic syndrome
    65 myeloid leukemia
    66 overall survival
    67 particular high risk
    68 patients
    69 radiotherapy
    70 reduced-intensity conditioning
    71 relapsed lymphoma
    72 risk
    73 risk factors
    74 secondary malignancies
    75 severe late effects
    76 significant risk
    77 significant risk factors
    78 stem cells
    79 strategies
    80 survival
    81 syndrome
    82 t-AML/MDS
    83 therapy
    84 therapy-related acute myeloid leukemia
    85 total
    86 transplantation
    87 schema:name Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma
    88 schema:pagination 969-976
    89 schema:productId N22bae6a57a024f8eb39e836fb638a7d3
    90 N501f9202dbbb4f12bda6ff8d5c1b280d
    91 Nab39db1ed03d4c27a56b697278d6e022
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084508959
    93 https://doi.org/10.1038/bmt.2017.52
    94 schema:sdDatePublished 2022-12-01T06:36
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher Na52deb4625ab4f62806274c8ad12c2a1
    97 schema:url https://doi.org/10.1038/bmt.2017.52
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N04c4ef761a494b73b7eaffda5d34ed2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Lymphoma
    103 rdf:type schema:DefinedTerm
    104 N066f25f412444232944dab985c3d6052 rdf:first sg:person.01356462526.00
    105 rdf:rest N9a647393dd6541a4b52e44f3c1af094c
    106 N0c952b359acc47dc860c4643f4dbf2b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Humans
    108 rdf:type schema:DefinedTerm
    109 N0db525c4915d489083322984dcc13811 rdf:first sg:person.01125116105.34
    110 rdf:rest N3cb80663dee14824a394d850b91fb258
    111 N114d0542504f4a64b2ca61b7810cd054 schema:issueNumber 7
    112 rdf:type schema:PublicationIssue
    113 N1f631d9496834c52b4510f5898b18da6 rdf:first sg:person.016452523632.46
    114 rdf:rest N6d383aaf6adb496da5eb6dd993fcf64d
    115 N2141c52c9e7941ffa630be71d5bbcdc3 rdf:first sg:person.01317232725.31
    116 rdf:rest N066f25f412444232944dab985c3d6052
    117 N22bae6a57a024f8eb39e836fb638a7d3 schema:name doi
    118 schema:value 10.1038/bmt.2017.52
    119 rdf:type schema:PropertyValue
    120 N2f59dfb5da054c488b3562fd072bf56e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Aged, 80 and over
    122 rdf:type schema:DefinedTerm
    123 N3832360f5012420faa6a1aa154d03b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Adult
    125 rdf:type schema:DefinedTerm
    126 N3cb80663dee14824a394d850b91fb258 rdf:first sg:person.015237642517.01
    127 rdf:rest Nbc16156c97194193b812ed0c2140eab7
    128 N3d57a530349e44b6bb77075f6f0378b5 rdf:first sg:person.0611462106.25
    129 rdf:rest Nc59a800d07254f42a55257e786a8a031
    130 N3f70cceb9cd640f88f3f333f97c4acaa rdf:first sg:person.01014223462.98
    131 rdf:rest Ndcbeebf4704c4d52b332279e9c3a08f1
    132 N497910570b2a455d8a5cf65eb8d3946e rdf:first sg:person.01204610767.63
    133 rdf:rest N3f70cceb9cd640f88f3f333f97c4acaa
    134 N501f9202dbbb4f12bda6ff8d5c1b280d schema:name dimensions_id
    135 schema:value pub.1084508959
    136 rdf:type schema:PropertyValue
    137 N5107885351fc4343a3e4afa453fdda70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Hematopoietic Stem Cell Transplantation
    139 rdf:type schema:DefinedTerm
    140 N535d4d08e91c473db488fafb68347c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Middle Aged
    142 rdf:type schema:DefinedTerm
    143 N636e8bbef5c5461e8a4bab2bec322f0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Neoplasms, Second Primary
    145 rdf:type schema:DefinedTerm
    146 N6d383aaf6adb496da5eb6dd993fcf64d rdf:first sg:person.010150414102.18
    147 rdf:rest Nc324e6210252451ca0ec8c2de02e161d
    148 N704f8ca74a4544078d9b2bb421fee633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Myelodysplastic Syndromes
    150 rdf:type schema:DefinedTerm
    151 N733b1316885a4b18bac0ff51b3ba0f8f rdf:first sg:person.0603726437.48
    152 rdf:rest Ne50830aa08b84f27a55cf6863d33a8c9
    153 N7e4297e5837d444fb927bb6791b9d213 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Aged
    155 rdf:type schema:DefinedTerm
    156 N85f0fbb9845b45b888a81852eb821720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Male
    158 rdf:type schema:DefinedTerm
    159 N8c3ae9e4f3644e41aea320562e356c49 rdf:first sg:person.014632774322.04
    160 rdf:rest Nd003d325a7b74ffc9838c4a72c5631e0
    161 N91eda21579d4423880debcc1d90ecc44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Risk Factors
    163 rdf:type schema:DefinedTerm
    164 N9a647393dd6541a4b52e44f3c1af094c rdf:first sg:person.012564764352.86
    165 rdf:rest N497910570b2a455d8a5cf65eb8d3946e
    166 Na52deb4625ab4f62806274c8ad12c2a1 schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 Na58055ba3f934758ac5bbc6eff440480 schema:volumeNumber 52
    169 rdf:type schema:PublicationVolume
    170 Na6a9243c747845738d7863c7d496c68c rdf:first sg:person.010444341213.14
    171 rdf:rest N2141c52c9e7941ffa630be71d5bbcdc3
    172 Na7f75c714b3f4659b00b0d6aaacc2387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Follow-Up Studies
    174 rdf:type schema:DefinedTerm
    175 Nab39db1ed03d4c27a56b697278d6e022 schema:name pubmed_id
    176 schema:value 28368379
    177 rdf:type schema:PropertyValue
    178 Naf4f7e4337a44b168fd7e8444dd0923a rdf:first sg:person.01271210744.11
    179 rdf:rest rdf:nil
    180 Nb5a7e4fcf7404cf08e0d74a6c89033b8 rdf:first sg:person.01242043214.01
    181 rdf:rest N8c3ae9e4f3644e41aea320562e356c49
    182 Nbc16156c97194193b812ed0c2140eab7 rdf:first sg:person.01146754030.08
    183 rdf:rest Naf4f7e4337a44b168fd7e8444dd0923a
    184 Nc1bca7b2904744f9be3ced9710bac91c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Leukemia, Myeloid, Acute
    186 rdf:type schema:DefinedTerm
    187 Nc324e6210252451ca0ec8c2de02e161d rdf:first sg:person.01274040335.15
    188 rdf:rest Na6a9243c747845738d7863c7d496c68c
    189 Nc59a800d07254f42a55257e786a8a031 rdf:first sg:person.014472427001.40
    190 rdf:rest N1f631d9496834c52b4510f5898b18da6
    191 Nc75ed3b57c4f49b280694173ab593ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Female
    193 rdf:type schema:DefinedTerm
    194 Nc85adac529b94478af03ef847c00ae15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Adolescent
    196 rdf:type schema:DefinedTerm
    197 Nd003d325a7b74ffc9838c4a72c5631e0 rdf:first sg:person.01364103035.06
    198 rdf:rest N733b1316885a4b18bac0ff51b3ba0f8f
    199 Nd22de52a762e4d34882cb6ff21b3b85d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Allografts
    201 rdf:type schema:DefinedTerm
    202 Ndcbeebf4704c4d52b332279e9c3a08f1 rdf:first sg:person.07464206032.81
    203 rdf:rest N0db525c4915d489083322984dcc13811
    204 Ne50830aa08b84f27a55cf6863d33a8c9 rdf:first sg:person.0630501143.07
    205 rdf:rest N3d57a530349e44b6bb77075f6f0378b5
    206 Nf622e6a1f5be462fad4582ee232248e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Autografts
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Cardiorespiratory Medicine and Haematology
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Oncology and Carcinogenesis
    217 rdf:type schema:DefinedTerm
    218 sg:journal.1096890 schema:issn 0268-3369
    219 1476-5365
    220 schema:name Bone Marrow Transplantation
    221 schema:publisher Springer Nature
    222 rdf:type schema:Periodical
    223 sg:person.01014223462.98 schema:affiliation grid-institutes:grid.470114.7
    224 schema:familyName Nakamae
    225 schema:givenName H
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223462.98
    227 rdf:type schema:Person
    228 sg:person.010150414102.18 schema:affiliation grid-institutes:grid.410813.f
    229 schema:familyName Uchida
    230 schema:givenName N
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010150414102.18
    232 rdf:type schema:Person
    233 sg:person.010444341213.14 schema:affiliation grid-institutes:grid.470107.5
    234 schema:familyName Ikeda
    235 schema:givenName H
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010444341213.14
    237 rdf:type schema:Person
    238 sg:person.01125116105.34 schema:affiliation grid-institutes:grid.412342.2
    239 schema:familyName Matsuoka
    240 schema:givenName K-i
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125116105.34
    242 rdf:type schema:Person
    243 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.511247.4
    244 schema:familyName Atsuta
    245 schema:givenName Y
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
    247 rdf:type schema:Person
    248 sg:person.01204610767.63 schema:affiliation grid-institutes:grid.272458.e
    249 schema:familyName Kuroda
    250 schema:givenName J
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204610767.63
    252 rdf:type schema:Person
    253 sg:person.01242043214.01 schema:affiliation grid-institutes:grid.415613.4
    254 schema:familyName Yamasaki
    255 schema:givenName S
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242043214.01
    257 rdf:type schema:Person
    258 sg:person.012564764352.86 schema:affiliation grid-institutes:grid.410821.e
    259 schema:familyName Yamaguchi
    260 schema:givenName H
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012564764352.86
    262 rdf:type schema:Person
    263 sg:person.01271210744.11 schema:affiliation grid-institutes:grid.412567.3
    264 schema:familyName Suzumiya
    265 schema:givenName J
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271210744.11
    267 rdf:type schema:Person
    268 sg:person.01274040335.15 schema:affiliation grid-institutes:grid.415604.2
    269 schema:familyName Uchiyama
    270 schema:givenName H
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274040335.15
    272 rdf:type schema:Person
    273 sg:person.01317232725.31 schema:affiliation grid-institutes:grid.459433.c
    274 schema:familyName Yokota
    275 schema:givenName A
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232725.31
    277 rdf:type schema:Person
    278 sg:person.01356462526.00 schema:affiliation grid-institutes:grid.497282.2
    279 schema:familyName Tsukasaki
    280 schema:givenName K
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356462526.00
    282 rdf:type schema:Person
    283 sg:person.01364103035.06 schema:affiliation grid-institutes:grid.410804.9
    284 schema:familyName Hatano
    285 schema:givenName K
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364103035.06
    287 rdf:type schema:Person
    288 sg:person.014472427001.40 schema:affiliation grid-institutes:grid.470350.5
    289 schema:familyName Suehiro
    290 schema:givenName Y
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014472427001.40
    292 rdf:type schema:Person
    293 sg:person.014632774322.04 schema:affiliation grid-institutes:grid.412567.3
    294 schema:familyName Suzuki
    295 schema:givenName R
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632774322.04
    297 rdf:type schema:Person
    298 sg:person.015237642517.01 schema:affiliation grid-institutes:grid.268397.1
    299 schema:familyName Nakamura
    300 schema:givenName Y
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015237642517.01
    302 rdf:type schema:Person
    303 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    304 schema:familyName Fukuda
    305 schema:givenName T
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    307 rdf:type schema:Person
    308 sg:person.0603726437.48 schema:affiliation grid-institutes:None
    309 schema:familyName Fukushima
    310 schema:givenName K
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603726437.48
    312 rdf:type schema:Person
    313 sg:person.0611462106.25 schema:affiliation grid-institutes:grid.256115.4
    314 schema:familyName Morishima
    315 schema:givenName S
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611462106.25
    317 rdf:type schema:Person
    318 sg:person.0630501143.07 schema:affiliation grid-institutes:grid.410840.9
    319 schema:familyName Iida
    320 schema:givenName H
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630501143.07
    322 rdf:type schema:Person
    323 sg:person.07464206032.81 schema:affiliation grid-institutes:grid.415605.3
    324 schema:familyName Adachi
    325 schema:givenName Y
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07464206032.81
    327 rdf:type schema:Person
    328 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
    329 https://doi.org/10.1007/s12185-015-1894-x
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    332 https://doi.org/10.1038/bmt.2012.244
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/bmt.2015.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020152838
    335 https://doi.org/10.1038/bmt.2015.151
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/bmt.2015.338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032571317
    338 https://doi.org/10.1038/bmt.2015.338
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/sj.bmt.1705547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005101697
    341 https://doi.org/10.1038/sj.bmt.1705547
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1532/ijh97.06239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054504897
    344 https://doi.org/10.1532/ijh97.06239
    345 rdf:type schema:CreativeWork
    346 grid-institutes:None schema:alternateName Division of Hematology, Rinku General Medical Center, Izumisano, Japan
    347 schema:name Division of Hematology, Rinku General Medical Center, Izumisano, Japan
    348 rdf:type schema:Organization
    349 grid-institutes:grid.256115.4 schema:alternateName Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan
    350 schema:name Department of Hematology and Oncology, Fujita Health University School of Medicine, Toyoake, Japan
    351 rdf:type schema:Organization
    352 grid-institutes:grid.268397.1 schema:alternateName Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan
    353 schema:name Third Department of Internal of Medicine, Yamaguchi University School of Medicine, Ube, Japan
    354 rdf:type schema:Organization
    355 grid-institutes:grid.272242.3 schema:alternateName Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    356 schema:name Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    357 rdf:type schema:Organization
    358 grid-institutes:grid.272458.e schema:alternateName Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    359 schema:name Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    360 rdf:type schema:Organization
    361 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology and Cell Therapy, Jichi Medical University, Shimotsuke, Japan
    362 schema:name Division of Hematology and Cell Therapy, Jichi Medical University, Shimotsuke, Japan
    363 rdf:type schema:Organization
    364 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    365 schema:name Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    366 rdf:type schema:Organization
    367 grid-institutes:grid.410821.e schema:alternateName Department of Hematology, Nippon Medical School, Tokyo, Japan
    368 schema:name Department of Hematology, Nippon Medical School, Tokyo, Japan
    369 rdf:type schema:Organization
    370 grid-institutes:grid.410840.9 schema:alternateName Division of Cell Therapy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    371 schema:name Division of Cell Therapy, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    372 rdf:type schema:Organization
    373 grid-institutes:grid.412342.2 schema:alternateName Division of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
    374 schema:name Division of Hematology and Oncology, Okayama University Hospital, Okayama, Japan
    375 rdf:type schema:Organization
    376 grid-institutes:grid.412567.3 schema:alternateName Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan
    377 schema:name Department of Oncology and Haematology, Shimane University Hospital, Izumo, Japan
    378 rdf:type schema:Organization
    379 grid-institutes:grid.415604.2 schema:alternateName Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
    380 schema:name Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan
    381 rdf:type schema:Organization
    382 grid-institutes:grid.415605.3 schema:alternateName Department of Internal Medicine, Japan Community Health Care Organization Kobe Central Hospital, Kobe, Japan
    383 schema:name Department of Internal Medicine, Japan Community Health Care Organization Kobe Central Hospital, Kobe, Japan
    384 rdf:type schema:Organization
    385 grid-institutes:grid.415613.4 schema:alternateName Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
    386 schema:name Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
    387 rdf:type schema:Organization
    388 grid-institutes:grid.459433.c schema:alternateName Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    389 schema:name Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    390 rdf:type schema:Organization
    391 grid-institutes:grid.470107.5 schema:alternateName Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University Hospital, Sapporo, Japan
    392 schema:name Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University Hospital, Sapporo, Japan
    393 rdf:type schema:Organization
    394 grid-institutes:grid.470114.7 schema:alternateName Department of Hematology, Osaka City University Hospital, Osaka, Japan
    395 schema:name Department of Hematology, Osaka City University Hospital, Osaka, Japan
    396 rdf:type schema:Organization
    397 grid-institutes:grid.470350.5 schema:alternateName Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
    398 schema:name Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
    399 rdf:type schema:Organization
    400 grid-institutes:grid.497282.2 schema:alternateName Hematology Division, National Cancer Center Hospital East, Kashiwa, Japan
    401 schema:name Hematology Division, National Cancer Center Hospital East, Kashiwa, Japan
    402 rdf:type schema:Organization
    403 grid-institutes:grid.511247.4 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    404 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    405 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...